HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/json
Vary: Accept
{
"count": 4617,
"next": "https://mitotox.org/api/records/list?page=47",
"previous": "https://mitotox.org/api/records/list?page=45",
"results": [
{
"rec_id": "RC04944",
"func": "F020403",
"targ": null,
"compound": "D0089: Nefazodone",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "10",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": true
},
{
"rec_id": "RC04945",
"func": "F020403",
"targ": null,
"compound": "D0374: Niclosamide",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "1.4",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": false
},
{
"rec_id": "RC04946",
"func": "F020403",
"targ": null,
"compound": "D0377: Nitrofurantoin",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "Assessment of the function of individual mitochondrial complexes using Agilent Seahorse XFe24",
"species": "",
"animal_model": "permeabilized LUHMES cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": false
},
{
"rec_id": "RC04947",
"func": "F020403",
"targ": "T019",
"compound": "D0289: Oligomycin",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "8.7",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": true
},
{
"rec_id": "RC04948",
"func": "F020403",
"targ": null,
"compound": "D0097: Phenformin",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "27",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": true
},
{
"rec_id": "RC04949",
"func": "F020403",
"targ": null,
"compound": "D1470: Phenylglyoxal hydrate",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "1.3",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": false
},
{
"rec_id": "RC04950",
"func": "F020403",
"targ": "T004",
"compound": "D1055: picoxystrobin",
"paper": "326",
"func_act": "",
"targ_act": "inhibit",
"dose": "50µM ",
"time": "",
"method": "Assessment of the function of individual mitochondrial complexes using Agilent Seahorse XFe24",
"species": "",
"animal_model": "permeabilized LUHMES cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC04951",
"func": "F020403",
"targ": "T004",
"compound": "D1073: pyraclostrobin",
"paper": "326",
"func_act": "",
"targ_act": "inhibit",
"dose": "50µM ",
"time": "",
"method": "Assessment of the function of individual mitochondrial complexes using Agilent Seahorse XFe24",
"species": "",
"animal_model": "permeabilized LUHMES cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC04952",
"func": "F020403",
"targ": null,
"compound": "D0297: Pyridaben",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "75000",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": true
},
{
"rec_id": "RC04953",
"func": "F020403",
"targ": null,
"compound": "D1465: Pyrimidifen",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "10000",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": true
},
{
"rec_id": "RC04954",
"func": "F020403",
"targ": "T001",
"compound": "D0229: Rotenone",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "51",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": true
},
{
"rec_id": "RC04955",
"func": "F020403",
"targ": null,
"compound": "D1469: Salinomycin",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "3.7",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": true
},
{
"rec_id": "RC04956",
"func": "F020403",
"targ": "T005",
"compound": "D0232: Sodium Azide",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "11",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": true
},
{
"rec_id": "RC04957",
"func": "F020403",
"targ": null,
"compound": "D0163: Cyanide",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "5.2",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": true
},
{
"rec_id": "RC04958",
"func": "F020403",
"targ": "T001",
"compound": "D0153: Tebufenpyrad",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "2700",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": true
},
{
"rec_id": "RC04959",
"func": "F020403",
"targ": "T002",
"compound": "D1466: Thifluzamide",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "2",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": false
},
{
"rec_id": "RC04961",
"func": "F020403",
"targ": null,
"compound": "D1152: triphenyltin hydroxide",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "0.9",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": false
},
{
"rec_id": "RC04962",
"func": "F020403",
"targ": null,
"compound": "D0303: UK-5099",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "1.7",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": false
},
{
"rec_id": "RC04963",
"func": "F020403",
"targ": null,
"compound": "D0270: Valinomycin",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "1",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": false
},
{
"rec_id": "RC04964",
"func": "F010401",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "331",
"func_act": "induce",
"targ_act": "",
"dose": "10–75 μM",
"time": "",
"method": "Mitochondrial swelling as the indicator of mitochondrial permeability transition (MPT) was estimated from the decrease in absorbance at 540 nm.",
"species": "male CD-1 mice",
"animal_model": "isolated liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC04965",
"func": "F010401",
"targ": null,
"compound": "D0026: Ciglitazone",
"paper": "331",
"func_act": "induce",
"targ_act": "",
"dose": "10–75 μM",
"time": "",
"method": "Mitochondrial swelling as the indicator of mitochondrial permeability transition (MPT) was estimated from the decrease in absorbance at 540 nm.",
"species": "male CD-1 mice",
"animal_model": "isolated liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC04966",
"func": "F010401",
"targ": null,
"compound": "D0108: Rosiglitazone",
"paper": "331",
"func_act": "induce",
"targ_act": "",
"dose": "50 μM",
"time": "",
"method": "Mitochondrial swelling as the indicator of mitochondrial permeability transition (MPT) was estimated from the decrease in absorbance at 540 nm.",
"species": "male CD-1 mice",
"animal_model": "isolated liver mitochondria",
"criteria": "",
"result": false
},
{
"rec_id": "RC04967",
"func": "F010401",
"targ": null,
"compound": "D0098: Pioglitazone",
"paper": "331",
"func_act": "induce",
"targ_act": "",
"dose": "50 μM",
"time": "",
"method": "Mitochondrial swelling as the indicator of mitochondrial permeability transition (MPT) was estimated from the decrease in absorbance at 540 nm.",
"species": "male CD-1 mice",
"animal_model": "isolated liver mitochondria",
"criteria": "",
"result": false
},
{
"rec_id": "RC04968",
"func": "F01",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "331",
"func_act": "decrease",
"targ_act": "",
"dose": "10–50 μM",
"time": "3min",
"method": "The electrical transmembrane potential of mitochondria was monitored spectrophotometrically with the cationic dye, rhodamine 123, and monitored at the 505/535 nm.",
"species": "male CD-1 mice",
"animal_model": "isolated liver mitochondria",
"criteria": "p < 0.05, significantly different from the control ",
"result": true
},
{
"rec_id": "RC04969",
"func": "F01",
"targ": null,
"compound": "D0026: Ciglitazone",
"paper": "331",
"func_act": "decrease",
"targ_act": "",
"dose": "10–50 μM",
"time": "3min",
"method": "The electrical transmembrane potential of mitochondria was monitored spectrophotometrically with the cationic dye, rhodamine 123, and monitored at the 505/535 nm.",
"species": "male CD-1 mice",
"animal_model": "isolated liver mitochondria",
"criteria": "p < 0.05, significantly different from the control ",
"result": true
},
{
"rec_id": "RC04970",
"func": "F01",
"targ": null,
"compound": "D0108: Rosiglitazone",
"paper": "331",
"func_act": "decrease",
"targ_act": "",
"dose": "10–50 μM",
"time": "3min",
"method": "The electrical transmembrane potential of mitochondria was monitored spectrophotometrically with the cationic dye, rhodamine 123, and monitored at the 505/535 nm.",
"species": "male CD-1 mice",
"animal_model": "isolated liver mitochondria",
"criteria": "",
"result": false
},
{
"rec_id": "RC04971",
"func": "F01",
"targ": null,
"compound": "D0098: Pioglitazone",
"paper": "331",
"func_act": "decrease",
"targ_act": "",
"dose": "10–25 μM",
"time": "3min",
"method": "The electrical transmembrane potential of mitochondria was monitored spectrophotometrically with the cationic dye, rhodamine 123, and monitored at the 505/535 nm.",
"species": "male CD-1 mice",
"animal_model": "isolated liver mitochondria",
"criteria": "",
"result": false
},
{
"rec_id": "RC04972",
"func": "F01",
"targ": null,
"compound": "D0098: Pioglitazone",
"paper": "331",
"func_act": "decrease",
"targ_act": "",
"dose": "50 μM",
"time": "3min",
"method": "The electrical transmembrane potential of mitochondria was monitored spectrophotometrically with the cationic dye, rhodamine 123, and monitored at the 505/535 nm.",
"species": "male CD-1 mice",
"animal_model": "isolated liver mitochondria",
"criteria": "p < 0.05, significantly different from the control ",
"result": true
},
{
"rec_id": "RC04973",
"func": "F02110302",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "331",
"func_act": "decrease",
"targ_act": "",
"dose": "50 μM",
"time": "",
"method": "Assessment of mitochondrial Ca2+ efflux with arsenazo III at 675/685 nm.",
"species": "male CD-1 mice",
"animal_model": "isolated liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC04974",
"func": "F02110302",
"targ": null,
"compound": "D0026: Ciglitazone",
"paper": "331",
"func_act": "decrease",
"targ_act": "",
"dose": "50 μM",
"time": "",
"method": "Assessment of mitochondrial Ca2+ efflux with arsenazo III at 675/685 nm.",
"species": "male CD-1 mice",
"animal_model": "isolated liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC04975",
"func": "F02110302",
"targ": null,
"compound": "D0108: Rosiglitazone",
"paper": "331",
"func_act": "decrease",
"targ_act": "",
"dose": "50 μM",
"time": "",
"method": "Assessment of mitochondrial Ca2+ efflux with arsenazo III at 675/685 nm.",
"species": "male CD-1 mice",
"animal_model": "isolated liver mitochondria",
"criteria": "",
"result": false
},
{
"rec_id": "RC04976",
"func": "F02110302",
"targ": null,
"compound": "D0098: Pioglitazone",
"paper": "331",
"func_act": "decrease",
"targ_act": "",
"dose": "50 μM",
"time": "",
"method": "Assessment of mitochondrial Ca2+ efflux with arsenazo III at 675/685 nm.",
"species": "male CD-1 mice",
"animal_model": "isolated liver mitochondria",
"criteria": "",
"result": false
},
{
"rec_id": "RC04977",
"func": "F010401",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "225",
"func_act": "induce",
"targ_act": "",
"dose": "10 µM",
"time": "6hr",
"method": "Co2+-calcein assays; MPT pore opening was determined by measuring intensity of calcein fluorescence in the mitochondria quenched by cobalt and normalizing cell number of hoechst33342.",
"species": "ZDF fa/fa rat vs ZDF lean rat",
"animal_model": "hepatocytes",
"criteria": " significantly different from ZDF lean rats (p < 0.05) ",
"result": true
},
{
"rec_id": "RC04978",
"func": "F0303",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "225",
"func_act": "induce",
"targ_act": "",
"dose": "10 µM",
"time": "",
"method": "Mitochondrial swelling as an indicator of MPT was determined by the decrease in absorbance at 540 nm on a UV-2550 spectrophotometer.",
"species": "ZDF fa/fa rat vs ZDF lean rat",
"animal_model": "isolated liver mitochondria",
"criteria": " significantly different from ZDF lean rats (p < 0.05) ",
"result": true
},
{
"rec_id": "RC04979",
"func": "F01",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "225",
"func_act": "decrease",
"targ_act": "",
"dose": "10-50 µM",
"time": "",
"method": "The transmembrane potential of the mitochondria was monitored spectrophotometrically using rhodamine-123.",
"species": "ZDF fa/fa rat & ZDF lean rat",
"animal_model": "isolated liver mitochondria",
"criteria": "significantly different from control group (p < 0.05)",
"result": true
},
{
"rec_id": "RC04980",
"func": "F01",
"targ": null,
"compound": "D0098: Pioglitazone",
"paper": "225",
"func_act": "decrease",
"targ_act": "",
"dose": "25-50 µM",
"time": "",
"method": "The transmembrane potential of the mitochondria was monitored spectrophotometrically using rhodamine-123.",
"species": "ZDF fa/fa rat & ZDF lean rat",
"animal_model": "isolated liver mitochondria",
"criteria": "significantly different from control group (p < 0.05)",
"result": true
},
{
"rec_id": "RC04981",
"func": "F01",
"targ": null,
"compound": "D0097: Phenformin",
"paper": "225",
"func_act": "decrease",
"targ_act": "",
"dose": "100-300 μM",
"time": "",
"method": "The transmembrane potential of the mitochondria was monitored spectrophotometrically using rhodamine-123.",
"species": "ZDF fa/fa rat & ZDF lean rat",
"animal_model": "isolated liver mitochondria",
"criteria": "significantly different from control group (p < 0.05)",
"result": true
},
{
"rec_id": "RC04982",
"func": "F02010201",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "225",
"func_act": "decrease",
"targ_act": "",
"dose": "10-50 μM",
"time": "",
"method": "OCR and measured using a fluorescent oxygen probe (Presens)",
"species": "ZDF fa/fa rat & ZDF lean rat",
"animal_model": "isolated liver mitochondria",
"criteria": "significantly different from control (p < 0.05)",
"result": true
},
{
"rec_id": "RC04983",
"func": "F02010201",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "225",
"func_act": "",
"targ_act": "",
"dose": "10-50 μM",
"time": "",
"method": "OCR and measured using a fluorescent oxygen probe (Presens)",
"species": "ZDF fa/fa rat & ZDF lean rat",
"animal_model": "isolated liver mitochondria",
"criteria": "",
"result": false
},
{
"rec_id": "RC04984",
"func": "F02010201",
"targ": null,
"compound": "D0098: Pioglitazone",
"paper": "225",
"func_act": "decrease",
"targ_act": "",
"dose": "25-50 μM",
"time": "",
"method": "OCR and measured using a fluorescent oxygen probe (Presens)",
"species": "ZDF fa/fa rat & ZDF lean rat",
"animal_model": "isolated liver mitochondria",
"criteria": "significantly different from control (p < 0.05)",
"result": true
},
{
"rec_id": "RC04985",
"func": "F02010201",
"targ": null,
"compound": "D0098: Pioglitazone",
"paper": "225",
"func_act": "",
"targ_act": "",
"dose": "10-50 μM",
"time": "",
"method": "OCR and measured using a fluorescent oxygen probe (Presens)",
"species": "ZDF fa/fa rat & ZDF lean rat",
"animal_model": "isolated liver mitochondria",
"criteria": "",
"result": false
},
{
"rec_id": "RC04986",
"func": "F02010201",
"targ": null,
"compound": "D0097: Phenformin",
"paper": "225",
"func_act": "",
"targ_act": "",
"dose": "30-300 μM",
"time": "",
"method": "OCR and measured using a fluorescent oxygen probe (Presens)",
"species": "ZDF fa/fa rat & ZDF lean rat",
"animal_model": "isolated liver mitochondria",
"criteria": "",
"result": false
},
{
"rec_id": "RC04987",
"func": "F02010201",
"targ": null,
"compound": "D0097: Phenformin",
"paper": "225",
"func_act": "",
"targ_act": "",
"dose": "30-300 μM",
"time": "",
"method": "OCR and measured using a fluorescent oxygen probe (Presens)",
"species": "ZDF fa/fa rat & ZDF lean rat",
"animal_model": "isolated liver mitochondria",
"criteria": "",
"result": false
},
{
"rec_id": "RC04988",
"func": "F022101",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "225",
"func_act": "lower",
"targ_act": "",
"dose": "10 µM",
"time": "",
"method": "Measurement of reduced/oxidized glutathione (GSH/GSSG): the reduced/oxidized glutathione (GSH/GSSG) concentration of the samples was determined from a standard curve using the enzymatic method and a Multiskan JX system.",
"species": "ZDF fa/fa rat vs ZDF lean rat",
"animal_model": "isolated mitochondria",
"criteria": "significantly different from ZDF lean rats (p < 0.05).",
"result": true
},
{
"rec_id": "RC04989",
"func": "F022101",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "225",
"func_act": "lower",
"targ_act": "",
"dose": "10 µM",
"time": "",
"method": "Measurement of reduced/oxidized glutathione (GSH/GSSG): the reduced/oxidized glutathione (GSH/GSSG) concentration of the samples was determined from a standard curve using the enzymatic method and a Multiskan JX system.",
"species": "ZDF fa/fa rat vs ZDF lean rat",
"animal_model": "liver homogenate",
"criteria": "",
"result": false
},
{
"rec_id": "RC04990",
"func": "F020603",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "225",
"func_act": "",
"targ_act": "",
"dose": "10 µM",
"time": "",
"method": "lipid peroxidation was measured from thiobarbituric acid-reactive substances (TBARS) formation at 480-570 nm.",
"species": "ZDF fa/fa rat vs ZDF lean rat",
"animal_model": "isolated mitochondria and liver homogenates",
"criteria": "",
"result": false
},
{
"rec_id": "RC04991",
"func": "F020605",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "225",
"func_act": "peroxidation",
"targ_act": "",
"dose": "10 µM",
"time": "",
"method": "Oxidation of mitochondrial phospholipids was measured by HPLC analysis. Peak area ratio (235/206 nm) shows relative peroxidative phospholipid content. Peak areas at 206 nm and 235 nm analyze non-peroxidative and peroxidative phospholipid.",
"species": "ZDF fa/fa rat vs ZDF lean rat",
"animal_model": "isolated mitochondria",
"criteria": "significantly different from ZDF lean rats (p < 0.05)",
"result": true
},
{
"rec_id": "RC04992",
"func": "F0303",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "225",
"func_act": "increase",
"targ_act": "",
"dose": "10 µM",
"time": "",
"method": "Measurement of MPT using vesicle-fused mitochondria ( isolated mitochondria were preincubated with micellized phospholipid containing CL or CLOOH,and then a swelling assay was performed. )",
"species": "Wistar rat",
"animal_model": "Isolated rat liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC04993",
"func": "F030602",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "332",
"func_act": "abnormal",
"targ_act": "",
"dose": "25 µM",
"time": "",
"method": "Images from transmission electron microscopy ",
"species": "",
"animal_model": "HepG2 cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC04994",
"func": "F0303",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "332",
"func_act": "",
"targ_act": "",
"dose": "25 µM",
"time": "",
"method": "confocal laser scanning microscopy (MitoTracker Red)",
"species": "",
"animal_model": "HepG2 cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC04995",
"func": "F01",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "332",
"func_act": "decrease",
"targ_act": "",
"dose": ">25 µM",
"time": "30min",
"method": "JC1",
"species": "",
"animal_model": "HepG2 cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC04996",
"func": "F021203",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "332",
"func_act": "decrease",
"targ_act": "",
"dose": ">25 µM",
"time": "1 and 2 hr",
"method": "Cellular ATP concentrations were measured with a ATP Bioluminescent Somatic Cell Assay Kit",
"species": "",
"animal_model": "HepG2 cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC04997",
"func": "F01",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "330",
"func_act": "decrease",
"targ_act": "",
"dose": "100 µM",
"time": "5min",
"method": "Tetramethylrhodamine methyl ester (TMRE)",
"species": "",
"animal_model": "HepG2 cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC04998",
"func": "F01",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "330",
"func_act": "decrease",
"targ_act": "",
"dose": " 61.9 µM",
"time": "3hr",
"method": "stained with a Mitotracker red dye, and then fixed with paraformaldehyde",
"species": "",
"animal_model": "HepG2 cells",
"criteria": "IC50",
"result": true
},
{
"rec_id": "RC04999",
"func": "F070104",
"targ": "T409",
"compound": "D0124: Troglitazone",
"paper": "330",
"func_act": "",
"targ_act": "activation",
"dose": "100 µM",
"time": "24hr",
"method": "Apo-One homogeneous caspase 3 assay kit",
"species": "",
"animal_model": "HepG2 cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC05000",
"func": null,
"targ": "T021001",
"compound": "D1479: aminocarnitine",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "76.4/27.3",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05001",
"func": null,
"targ": "T021001",
"compound": "D1480: palmitoylaminocarnitine",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "2.67/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05002",
"func": null,
"targ": "T021001",
"compound": "D1481: ST1326",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "1.05/1.45",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05003",
"func": null,
"targ": "T021001",
"compound": "D1482: ST2425",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "1.70/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05004",
"func": null,
"targ": "T021001",
"compound": "D0302: Trimetazidine",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05005",
"func": null,
"targ": "T021001",
"compound": "D0096: Perhexiline",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05006",
"func": null,
"targ": "T021001",
"compound": "D0005: Amiodarone",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05007",
"func": null,
"targ": "T021001",
"compound": "D0290: Oxfenicine",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05008",
"func": null,
"targ": "T021001",
"compound": "D1483: oxfenicine metabolite",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05009",
"func": null,
"targ": "T021001",
"compound": "D1484: RO-25-0187",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "2.4/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05010",
"func": null,
"targ": "T021002",
"compound": "D1479: aminocarnitine",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05011",
"func": null,
"targ": "T021002",
"compound": "D1480: palmitoylaminocarnitine",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "21.7",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05012",
"func": null,
"targ": "T021002",
"compound": "D1481: ST1326",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "5.4",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05013",
"func": null,
"targ": "T021002",
"compound": "D1482: ST2425",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "85.3",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05014",
"func": null,
"targ": "T021002",
"compound": "D0302: Trimetazidine",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05015",
"func": null,
"targ": "T021002",
"compound": "D0096: Perhexiline",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05016",
"func": null,
"targ": "T021002",
"compound": "D0005: Amiodarone",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05017",
"func": null,
"targ": "T021002",
"compound": "D0290: Oxfenicine",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05018",
"func": null,
"targ": "T021002",
"compound": "D1483: oxfenicine metabolite",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "60.3",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05019",
"func": null,
"targ": "T021002",
"compound": "D1484: RO-25-0187",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "0.16",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05020",
"func": null,
"targ": "T022",
"compound": "D1479: aminocarnitine",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "3.9/5.1",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05021",
"func": null,
"targ": "T022",
"compound": "D1480: palmitoylaminocarnitine",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "0.14",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05022",
"func": null,
"targ": "T022",
"compound": "D1481: ST1326",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "0.16/0.38",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05023",
"func": null,
"targ": "T022",
"compound": "D1482: ST2425",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "5.4/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05024",
"func": null,
"targ": "T022",
"compound": "D0302: Trimetazidine",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05025",
"func": null,
"targ": "T022",
"compound": "D0096: Perhexiline",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "72.8/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05026",
"func": null,
"targ": "T022",
"compound": "D0005: Amiodarone",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05027",
"func": null,
"targ": "T022",
"compound": "D0290: Oxfenicine",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05028",
"func": null,
"targ": "T022",
"compound": "D1483: oxfenicine metabolite",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05029",
"func": null,
"targ": "T022",
"compound": "D1484: RO-25-0187",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "4.7/>100",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05030",
"func": "F02060201",
"targ": null,
"compound": "D1485: TDGA",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "0.31",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05031",
"func": "F02060201",
"targ": null,
"compound": "D1486: POCA",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "59.7",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05032",
"func": "F02060201",
"targ": null,
"compound": "D0264: Etomoxir",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "2.76",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05033",
"func": "F02060201",
"targ": null,
"compound": "D1487: DET",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "5.6",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05034",
"func": "F02060201",
"targ": null,
"compound": "D1479: aminocarnitine",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "0.97",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05035",
"func": "F02060201",
"targ": null,
"compound": "D1480: palmitoylaminocarnitine",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "0.11",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05036",
"func": "F02060201",
"targ": null,
"compound": "D1481: ST1326",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "1.1",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05037",
"func": "F02060201",
"targ": null,
"compound": "D1482: ST2425",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "0.21",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05038",
"func": "F02060201",
"targ": null,
"compound": "D0302: Trimetazidine",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "47.1",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05039",
"func": "F02060201",
"targ": null,
"compound": "D0096: Perhexiline",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "14.8",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05040",
"func": "F02060201",
"targ": null,
"compound": "D0005: Amiodarone",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "16.6",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05041",
"func": "F02060201",
"targ": null,
"compound": "D0290: Oxfenicine",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": ">100",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05042",
"func": "F02060201",
"targ": null,
"compound": "D1483: oxfenicine metabolite",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "25.8",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05043",
"func": "F02060201",
"targ": null,
"compound": "D1484: RO-25-0187",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "1.5",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05044",
"func": "F02060101",
"targ": null,
"compound": "D1485: TDGA",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "<0.05/0.04",
"time": "",
"method": "Fatty acid oxidation (FAO) was determined by measuring 14CO2 release from 14C-labeled palmitate",
"species": "human/rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
}
]
}