MITOTOX

Drug

D1427 | caspofungin

Properties

Molecular Formula	C52H88N10O15
Molecular Weight	1093.3
Structure
State	solid
Clearance	* 12 mL/min [After single IV administration]
Route of elimination	After single intravenous administration of [3H] caspofungin acetate, excretion of caspofungin and its metabolites in humans was 35% of dose in feces and 41% of dose in urine.
Protein binding	0.97
Half life	9-11 hours
Absorption	92% tissue distribution within 36-48 hours after intravenous infusion
Description	antifungal

Therapeutic Classification Source: DrugBank

J

J02AX04 Caspofungin

[J02AX] Other antimycotics for systemic use

[J02A] ANTIMYCOTICS FOR SYSTEMIC USE

[J02] ANTIMYCOTICS FOR SYSTEMIC USE

[J] Antiinfectives for systemic use

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
LIPID PEROXIDATION			Aspergillus fumigatus		lipid peroxidation using the thiobarbituric acid assay: the formation of malondialdehydes (MDAs) by antifungal drug-derived ROS in A. fumigatus was determined using the thiobarbituric acid (TBA) assay.	Negative		304
LIPID PEROXIDATION			Aspergillus fumigatus		mitochondrion-specific lipid peroxidation probe MitoPerOx	Negative		304
ROS PRODUCTION	0.5mg/ml		Aspergillus fumigatus		oxidant-sensing fluorescent probe 2′,7′-dichlorofluorescin diacetate t	Negative		304

Indications Source: SIDER

External IDs

DrugBank	DB00520
PubChem Compound	2826718

References