J
J02AX04 Caspofungin
[J02AX] Other antimycotics for systemic use
[J02A] ANTIMYCOTICS FOR SYSTEMIC USE
[J02] ANTIMYCOTICS FOR SYSTEMIC USE
[J] Antiinfectives for systemic use
Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
---|---|---|---|---|---|---|---|---|
LIPID PEROXIDATION | Aspergillus fumigatus | lipid peroxidation using the thiobarbituric acid assay: the formation of malondialdehydes (MDAs) by antifungal drug-derived ROS in A. fumigatus was determined using the thiobarbituric acid (TBA) assay. | Negative | 304 | ||||
LIPID PEROXIDATION | Aspergillus fumigatus | mitochondrion-specific lipid peroxidation probe MitoPerOx | Negative | 304 | ||||
ROS PRODUCTION | 0.5mg/ml | Aspergillus fumigatus | oxidant-sensing fluorescent probe 2′,7′-dichlorofluorescin diacetate t | Negative | 304 | |||