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Induction of Mitochondrial Reactive Oxygen Species Production by Itraconazole, Terbinafine, and Amphotericin B as a Mode of Action against Aspergillus fumigatus. |
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Antimicrobial Agents and Chemotherapy |
2017 |
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A bioenergetics assay for studying the effects of environmental stressors on mitochondrial function in vivo in zebrafish larvae. |
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Comparative Biochemistry and Physiology. Toxicology & Pharmacology |
2017 |
10.1016/j.cbpc.2016.12.001 |
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DS16570511 is a small-molecule inhibitor of the mitochondrial calcium uniporter. |
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Cell death discovery |
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10.1038/cddiscovery.2017.45 |
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Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis. |
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The Journal of Biological Chemistry |
2016 |
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mTOR inhibitors in cancer therapy. |
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Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death. |
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The Journal of Clinical Investigation |
2016 |
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Drug induced mitochondrial dysfunction: Mechanisms and adverse clinical consequences. |
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Mitochondrion |
2016 |
10.1016/j.mito.2016.10.005 |
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Diclofenac induces proteasome and mitochondrial dysfunction in murine cardiomyocytes and hearts. |
Ghosh, Rajeshwary; Goswami, Sumanta K; Feitoza, Luis Felipe B B; Hammock, Bruce; Gomes, Aldrin V |
International Journal of Cardiology |
2016 |
10.1016/j.ijcard.2016.08.233 |
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Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson's disease model induced by MPTP. |
Filichia, Emily; Hoffer, Barry; Qi, Xin; Luo, Yu |
Scientific Reports |
2016 |
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Mitochondrial toxicity of selective COX-2 inhibitors via inhibition of oxidative phosphorylation (ATP synthesis) in rat liver mitochondria. |
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Toxicology in Vitro |
2016 |
10.1016/j.tiv.2015.12.003 |
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A combined in vitro approach to improve the prediction of mitochondrial toxicants. |
Eakins, Julie; Bauch, Caroline; Woodhouse, Heather; Park, Benjamin; Bevan, Samantha; Dilworth, Clive; Walker, Paul |
Toxicology in Vitro |
2016 |
10.1016/j.tiv.2016.03.016 |
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Shutting down the pore: The search for small molecule inhibitors of the mitochondrial permeability transition. |
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Biochimica et Biophysica Acta |
2016 |
10.1016/j.bbabio.2016.02.016 |
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Mitochondrial toxicity of diclofenac and its metabolites via inhibition of oxidative phosphorylation (ATP synthesis) in rat liver mitochondria: Possible role in drug induced liver injury (DILI). |
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Toxicology in Vitro |
2016 |
10.1016/j.tiv.2015.11.020 |
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Triclosan is a mitochondrial uncoupler in live zebrafish. |
Shim, Juyoung; Weatherly, Lisa M; Luc, Richard H; Dorman, Maxwell T; Neilson, Andy; Ng, Ryan; Kim, Carol H; Millard, Paul J; Gosse, Julie A |
Journal of Applied Toxicology |
2016 |
10.1002/jat.3311 |
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Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors |
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The Journal of Clinical Investigation |
2016 |
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Identification of small molecule inhibitors of human cytochrome c oxidase that target chemoresistant glioma cells. |
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The Journal of Biological Chemistry |
2016 |
10.1074/jbc.M116.749978 |
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Mitofusins deficiency elicits mitochondrial metabolic reprogramming to pluripotency. |
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Cell Death and Differentiation |
2015 |
10.1038/cdd.2015.43 |
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Bioenergetic disruption of human micro-vascular endothelial cells by antipsychotics. |
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Biochemical and Biophysical Research Communications |
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10.1016/j.bbrc.2015.03.122 |
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Teratogenic, bioenergetic, and behavioral effects of exposure to total particulate matter on early development of zebrafish (Danio rerio) are not mimicked by nicotine. |
Massarsky, Andrey; Jayasundara, Nishad; Bailey, Jordan M; Oliveri, Anthony N; Levin, Edward D; Prasad, G L; Di Giulio, Richard T |
Neurotoxicology and Teratology |
2015 |
10.1016/j.ntt.2015.09.006 |
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Cytotoxicity of phenothiazine derivatives associated with mitochondrial dysfunction: a structure-activity investigation. |
de Faria, Priscila A; Bettanin, Fernanda; Cunha, Rodrigo L O R; Paredes-Gamero, Edgar J; Homem-de-Mello, Paula; Nantes, Iseli L; Rodrigues, Tiago |
Toxicology |
2015 |
10.1016/j.tox.2015.02.004 |
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Multiple compound-related adverse properties contribute to liver injury caused by endothelin receptor antagonists. |
Kenna, J Gerry; Stahl, Simone H; Eakins, Julie A; Foster, Alison J; Andersson, Linda C; Bergare, Jonas; Billger, Martin; Elebring, Marie; Elmore, Charles S; Thompson, Richard A |
The Journal of Pharmacology and Experimental Therapeutics |
2015 |
10.1124/jpet.114.220491 |
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Tetrathiomolybdate inhibits mitochondrial complex IV and mediates degradation of hypoxia-inducible factor-1α in cancer cells. |
Kim, Kyu Kwang; Abelman, Sarah; Yano, Naohiro; Ribeiro, Jennifer R; Singh, Rakesh K; Tipping, Marla; Moore, Richard G |
Scientific Reports |
2015 |
10.1038/srep14296 |
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Toxicity and Loss of Mitochondrial Membrane Potential Induced by Alkyl Gallates in Trypanosoma cruzi. |
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2015 |
10.1155/2015/924670 |
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The cellular and molecular progression of mitochondrial dysfunction induced by 2,4-dinitrophenol in developing zebrafish embryos. |
Bestman, Jennifer E; Stackley, Krista D; Rahn, Jennifer J; Williamson, Tucker J; Chan, Sherine S L |
Differentiation; Research in Biological Diversity |
2015 |
10.1016/j.diff.2015.01.001 |
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High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins. |
Tolosa, Laia; Carmona, Antonio; Castell, Jos? V; G?mez-Lech?n, M Jos?; Donato, M Teresa |
Archives of Toxicology |
2015 |
10.1007/s00204-014-1334-3 |
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Lipid abundance in zebrafish embryos is regulated by complementary actions of the endocannabinoid system and retinoic acid pathway. |
Fraher, Daniel; Ellis, Megan K; Morrison, Shona; McGee, Sean L; Ward, Alister C; Walder, Ken; Gibert, Yann |
Endocrinology |
2015 |
10.1210/EN.2015-1315 |
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Discovery and synthesis of crop protection products |
Xiong, Li; Shen, Yan-Qing; Jiang, Li-Na; Zhu, Xiao-Lei; Yang, Wen-Chao; Huang, Wei; Yang, Guang-Fu |
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2015 |
10.1021/bk-2015-1204.ch013 |
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Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition. |
Schirris, Tom J J; Renkema, G Herma; Ritschel, Tina; Voermans, Nicol C; Bilos, Albert; van Engelen, Baziel G M; Brandt, Ulrich; Koopman, Werner J H; Beyrath, Julien D; Rodenburg, Richard J; Willems, Peter H G M; Smeitink, Jan A M; Russel, Frans G M |
Cell Metabolism |
2015 |
10.1016/j.cmet.2015.08.002 |
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Bafilomycin A1 targets both autophagy and apoptosis pathways in pediatric B-cell acute lymphoblastic leukemia. |
Yuan, Na; Song, Lin; Zhang, Suping; Lin, Weiwei; Cao, Yan; Xu, Fei; Fang, Yixuan; Wang, Zhen; Zhang, Han; Li, Xin; Wang, Zhijian; Cai, Jinyang; Wang, Jian; Zhang, Yi; Mao, Xinliang; Zhao, Wenli; Hu, Shaoyan; Chen, Suning; Wang, Jianrong |
Haematologica |
2015 |
10.3324/haematol.2014.113324 |
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Development of an in silico profiler for mitochondrial toxicity |
Nelms, Mark D; Mellor, Claire L; Cronin, Mark T D; Madden, Judith C; Enoch, Steven J |
Chemical Research in Toxicology |
2015 |
10.1021/acs.chemrestox.5b00275 |
