HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/json
Vary: Accept
{
"count": 4617,
"next": "https://mitotox.org/api/records/list?format=api&page=35",
"previous": "https://mitotox.org/api/records/list?format=api&page=33",
"results": [
{
"rec_id": "RC03481",
"func": "F0108",
"targ": "T181",
"compound": "D1276: dihydroxyacetone phosphate",
"paper": "162",
"func_act": "decrease",
"targ_act": "inhibitor",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03482",
"func": null,
"targ": "T110",
"compound": "D0438: aminooxyacetate",
"paper": "198",
"func_act": "",
"targ_act": "inhibitor",
"dose": "",
"time": "",
"method": "",
"species": "Dunkin-Hartley strain guinea pigs",
"animal_model": "Synaptosomes from cerebral cortices",
"criteria": "",
"result": true
},
{
"rec_id": "RC03483",
"func": "F010603",
"targ": null,
"compound": "D0439: Bafilomycin A1",
"paper": "199",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "male Wistar rats",
"animal_model": "liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03484",
"func": "F0703",
"targ": "T416",
"compound": "D0439: Bafilomycin A1",
"paper": "200",
"func_act": "inhibit",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03485",
"func": "F0701",
"targ": "T411",
"compound": "D0439: Bafilomycin A1",
"paper": "200",
"func_act": "induce",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "pediatric B ALL cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC03486",
"func": "F0701",
"targ": "T403",
"compound": "D0439: Bafilomycin A1",
"paper": "200",
"func_act": "induce",
"targ_act": "induce binding",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03487",
"func": "F010602",
"targ": null,
"compound": "D0270: Valinomycin",
"paper": "201",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03488",
"func": "F010602",
"targ": null,
"compound": "D0954: gramicidin",
"paper": "201",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03489",
"func": "F010603",
"targ": null,
"compound": "D0375: Nigericin",
"paper": "201",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03490",
"func": "F010604",
"targ": null,
"compound": "D1283: monensin",
"paper": "201",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03491",
"func": "F010604",
"targ": null,
"compound": "D1282: dianemycin",
"paper": "201",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03492",
"func": "F010605",
"targ": null,
"compound": "D1279: A23187",
"paper": "201",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03493",
"func": "F010605",
"targ": null,
"compound": "D1278: ionomycin",
"paper": "201",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03494",
"func": "F010606",
"targ": null,
"compound": "D1280: X-537A",
"paper": "201",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03495",
"func": "F010605",
"targ": null,
"compound": "D1278: ionomycin",
"paper": "202",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "Efflux of mitochondrial Mg2+ was determined by dual wavelength spectroscopy in the presence of 100 PM Eriochrome Blue SE, an indicating dye for free Mg",
"species": "rat",
"animal_model": "liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03496",
"func": "F02010202",
"targ": null,
"compound": "D1278: ionomycin",
"paper": "202",
"func_act": "increase",
"targ_act": "",
"dose": "",
"time": "",
"method": "Oxygen consumption and medium pH were monitored simultaneously with a dual channel Gilson oxygraph equipped with a Clark electrode (Yellow Springs Instruments) and a combination pH electrode (Beckman No. 39030).",
"species": "rat",
"animal_model": "liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03497",
"func": "F010605",
"targ": null,
"compound": "D1279: A23187",
"paper": "203",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03498",
"func": null,
"targ": "T221",
"compound": "D1281: AJ-9677",
"paper": "204",
"func_act": "",
"targ_act": "inducer",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03499",
"func": null,
"targ": "T221",
"compound": "D1281: AJ-9677",
"paper": "214",
"func_act": "",
"targ_act": "inducer",
"dose": "0.1 mg/kg body weight",
"time": "",
"method": "Western blot (a primary antibody against rat UCP1 ); Oxygen consumption of isolated adipocytes was measured polarographically with a Clark-style oxygen electrode ",
"species": "dog",
"animal_model": "adipocytes",
"criteria": "",
"result": true
},
{
"rec_id": "RC03500",
"func": "F0107",
"targ": null,
"compound": "D1382: acylindolones",
"paper": "204",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03501",
"func": "F0105",
"targ": null,
"compound": "D1382: acylindolones",
"paper": "204",
"func_act": "increase",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03502",
"func": "F010501",
"targ": null,
"compound": "D1301: toxoflavin",
"paper": "204",
"func_act": "increase",
"targ_act": "",
"dose": "",
"time": "",
"method": "RST assay( Respiratory Screening Technology)-measurement of oxygen consumption in isolated mitochondria using a phosphorescent oxygen-sensitive probe A65N-1",
"species": "rat ",
"animal_model": "liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03503",
"func": "F010501",
"targ": null,
"compound": "D1302: tesimide",
"paper": "204",
"func_act": "increase",
"targ_act": "",
"dose": "",
"time": "",
"method": "RST assay( Respiratory Screening Technology)-measurement of oxygen consumption in isolated mitochondria using a phosphorescent oxygen-sensitive probe A65N-1",
"species": "rat ",
"animal_model": "liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03504",
"func": "F010501",
"targ": null,
"compound": "D0194: Menadione",
"paper": "204",
"func_act": "increase",
"targ_act": "",
"dose": "",
"time": "",
"method": "RST assay( Respiratory Screening Technology)-measurement of oxygen consumption in isolated mitochondria using a phosphorescent oxygen-sensitive probe A65N-1",
"species": "rat ",
"animal_model": "liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03505",
"func": "F010701",
"targ": null,
"compound": "D0047: Entacapone",
"paper": "204",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "RST assay( Respiratory Screening Technology)-measurement of oxygen consumption in isolated mitochondria using a phosphorescent oxygen-sensitive probe A65N-1",
"species": "rat ",
"animal_model": "liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03506",
"func": "F010701",
"targ": null,
"compound": "D0121: Tolcapone",
"paper": "204",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "RST assay( Respiratory Screening Technology)-measurement of oxygen consumption in isolated mitochondria using a phosphorescent oxygen-sensitive probe A65N-1",
"species": "rat ",
"animal_model": "liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03507",
"func": "F010501",
"targ": null,
"compound": "D0129: 2,4-dinitrophenol",
"paper": "204",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "RST assay( Respiratory Screening Technology)-measurement of oxygen consumption in isolated mitochondria using a phosphorescent oxygen-sensitive probe A65N-1",
"species": "rat ",
"animal_model": "liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03508",
"func": "F010701",
"targ": null,
"compound": "D1303: Anthranilic acid ",
"paper": "204",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "RST assay( Respiratory Screening Technology)-measurement of oxygen consumption in isolated mitochondria using a phosphorescent oxygen-sensitive probe A65N-1",
"species": "rat ",
"animal_model": "liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03509",
"func": "F010701",
"targ": null,
"compound": "D1304: Fluoromethylsulphonanilide ",
"paper": "204",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "RST assay( Respiratory Screening Technology)-measurement of oxygen consumption in isolated mitochondria using a phosphorescent oxygen-sensitive probe A65N-1",
"species": "rat ",
"animal_model": "liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03603",
"func": "F0402",
"targ": null,
"compound": "D0183: H2O2",
"paper": "218",
"func_act": "decrease",
"targ_act": "",
"dose": "50 μM",
"time": "",
"method": "Time lapse fluorescence microscopy",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03510",
"func": "F010701",
"targ": null,
"compound": "D1305: Nitrophenol ",
"paper": "204",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "RST assay( Respiratory Screening Technology)-measurement of oxygen consumption in isolated mitochondria using a phosphorescent oxygen-sensitive probe A65N-1",
"species": "rat ",
"animal_model": "liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03511",
"func": "F010701",
"targ": null,
"compound": "D1306: Nitrosulphonanilide ",
"paper": "204",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "RST assay( Respiratory Screening Technology)-measurement of oxygen consumption in isolated mitochondria using a phosphorescent oxygen-sensitive probe A65N-1",
"species": "rat ",
"animal_model": "liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03512",
"func": "F010701",
"targ": null,
"compound": "D1307: Phenylhydrazone ",
"paper": "204",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "RST assay( Respiratory Screening Technology)-measurement of oxygen consumption in isolated mitochondria using a phosphorescent oxygen-sensitive probe A65N-1",
"species": "rat ",
"animal_model": "liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03513",
"func": "F010701",
"targ": null,
"compound": "D0109: Salicylic acid",
"paper": "204",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "RST assay( Respiratory Screening Technology)-measurement of oxygen consumption in isolated mitochondria using a phosphorescent oxygen-sensitive probe A65N-1",
"species": "rat ",
"animal_model": "liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03514",
"func": "F010701",
"targ": null,
"compound": "D1309: Thiadiazinedione ",
"paper": "204",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "RST assay( Respiratory Screening Technology)-measurement of oxygen consumption in isolated mitochondria using a phosphorescent oxygen-sensitive probe A65N-1",
"species": "rat ",
"animal_model": "liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03515",
"func": "F010701",
"targ": null,
"compound": "D1310: Thiazolinedione ",
"paper": "204",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "RST assay( Respiratory Screening Technology)-measurement of oxygen consumption in isolated mitochondria using a phosphorescent oxygen-sensitive probe A65N-1",
"species": "rat ",
"animal_model": "liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03516",
"func": "F0109",
"targ": null,
"compound": "D1311: Hydronaphthoquinone ",
"paper": "204",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "RST assay( Respiratory Screening Technology)-measurement of oxygen consumption in isolated mitochondria using a phosphorescent oxygen-sensitive probe A65N-1",
"species": "rat ",
"animal_model": "liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03517",
"func": "F0109",
"targ": null,
"compound": "D1312: Naphthoquinone ",
"paper": "204",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "RST assay( Respiratory Screening Technology)-measurement of oxygen consumption in isolated mitochondria using a phosphorescent oxygen-sensitive probe A65N-1",
"species": "rat ",
"animal_model": "liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03518",
"func": "F0107",
"targ": null,
"compound": "D1313: 2‐Anilinobenzoic acid",
"paper": "223",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03519",
"func": "F0107",
"targ": null,
"compound": "D1314: 2‐(Dialkylamino)‐N‐(2,6‐dimethylphenylacetamide",
"paper": "223",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03520",
"func": "F0107",
"targ": null,
"compound": "D1315: Perfluorinated carboxylic acid",
"paper": "223",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03521",
"func": "F0107",
"targ": null,
"compound": "D1316: Perfluorinated sulfonamide",
"paper": "223",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03522",
"func": "F0109",
"targ": null,
"compound": "D1317: Hydroxynaphthoquinones",
"paper": "204",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03523",
"func": "F0109",
"targ": null,
"compound": "D1312: Naphthoquinone ",
"paper": "204",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03524",
"func": "F0109",
"targ": null,
"compound": "D1318: Anthracene‐9,10‐diones",
"paper": "223",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03525",
"func": "F0109",
"targ": null,
"compound": "D1319: Quinones",
"paper": "224",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03526",
"func": "F010401",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "225",
"func_act": "",
"targ_act": "",
"dose": "10 µM",
"time": "6hr",
"method": "The loss of mitochondrial calcein and Hoechst 33342 nuclear fluorescence using a fluorescence microscope as an indicator of MPT for rat primary hepatocyte . Mitochondrial swelling as an indicator of MPT for isolated mitochondria.",
"species": "type 2 diabetes mellitus model rat",
"animal_model": "primary hepatocytes or isolated mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03527",
"func": "F06",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "226",
"func_act": "damage",
"targ_act": "",
"dose": "",
"time": "",
"method": "Assay for mtDNA damage: MtDNA damage was assessed as the diminished intensity in the 16.5 kb restriction band, as compared to control bands.",
"species": "human",
"animal_model": "hepatocytes",
"criteria": "",
"result": true
},
{
"rec_id": "RC03528",
"func": "F021203",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "226",
"func_act": "decrease",
"targ_act": "",
"dose": "",
"time": "",
"method": "ATP bioluminescence assay",
"species": "human",
"animal_model": "hepatocytes",
"criteria": "",
"result": true
},
{
"rec_id": "RC03529",
"func": "F05",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "226",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "cell viability assay",
"species": "human",
"animal_model": "hepatocytes",
"criteria": "",
"result": true
},
{
"rec_id": "RC03530",
"func": "F0701",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "226",
"func_act": "induce",
"targ_act": "",
"dose": "",
"time": "",
"method": "cell viability assay",
"species": "human",
"animal_model": "hepatocytes",
"criteria": "",
"result": true
},
{
"rec_id": "RC03531",
"func": "F02060101",
"targ": "T027",
"compound": "D0124: Troglitazone",
"paper": "227",
"func_act": "affect",
"targ_act": "not specified",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03532",
"func": "F02060101",
"targ": "T021",
"compound": "D0126: Valproic Acid",
"paper": "227",
"func_act": "affect",
"targ_act": "inhibit",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03533",
"func": "F02060101",
"targ": "T021",
"compound": "D0005: Amiodarone",
"paper": "227",
"func_act": "affect",
"targ_act": "inhibit",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03534",
"func": "F02060101",
"targ": "T021",
"compound": "D0116: Tamoxifen",
"paper": "227",
"func_act": "affect",
"targ_act": "inhibit",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03535",
"func": "F02060101",
"targ": "T021",
"compound": "D0116: Tamoxifen",
"paper": "227",
"func_act": "affect",
"targ_act": "inhibit",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03536",
"func": "F020103",
"targ": null,
"compound": "D0096: Perhexiline",
"paper": "227",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03537",
"func": "F02060101",
"targ": null,
"compound": "D0096: Perhexiline",
"paper": "238",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "rat",
"animal_model": "hepatocytes",
"criteria": "",
"result": true
},
{
"rec_id": "RC03538",
"func": "F02060101",
"targ": null,
"compound": "D0003: Acetaminophen",
"paper": "227",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03539",
"func": "F02060101",
"targ": null,
"compound": "D0109: Salicylic acid",
"paper": "227",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03540",
"func": "F02060101",
"targ": null,
"compound": "D0065: Ibuprofen",
"paper": "227",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03541",
"func": "F02060101",
"targ": null,
"compound": "D1332: buprenorphine",
"paper": "235",
"func_act": "affect",
"targ_act": "",
"dose": " 100 μM",
"time": "",
"method": " the mitochondrial membrane potential assessed by the fluorescence of safranine. ",
"species": "rat",
"animal_model": "liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03542",
"func": "F02060101",
"targ": null,
"compound": "D1331: Tianeptine",
"paper": "237",
"func_act": "affect",
"targ_act": "",
"dose": "0.0625 mmol/kg i.p.",
"time": "",
"method": "in vivo",
"species": "mouse",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03543",
"func": "F0203",
"targ": null,
"compound": "D1331: Tianeptine",
"paper": "237",
"func_act": "affect",
"targ_act": "",
"dose": "0.5 mM",
"time": "",
"method": "The activity of the tricarboxylic acid cycle, assessed as the in vitro formation of [14C]CO2 from [1-14C]acetylcoenzyme A in vitro. ",
"species": "mouse",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03544",
"func": "F02060101",
"targ": null,
"compound": "D0432: tetracyclines",
"paper": "236",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03545",
"func": "F0203",
"targ": null,
"compound": "D0432: tetracyclines",
"paper": "236",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "Tricarboxylic acid cycle activity was assessed by the in vitro formation of [14C]CO2 from [1-14C]acetylcoenzyme A by mouse liver mitochondria.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03546",
"func": "F02060101",
"targ": null,
"compound": "D0065: Ibuprofen",
"paper": "239",
"func_act": "affect",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03547",
"func": "F02060101",
"targ": "T021",
"compound": "D0096: Perhexiline",
"paper": "240",
"func_act": "affect",
"targ_act": "inhibit",
"dose": "77 μmol/L",
"time": "",
"method": "CPT-1 activity was measured by the formation of palmitoyl-[3H]-carnitine from palmitoyl-CoA and [3H]-I- carnitine,",
"species": "rat",
"animal_model": "cardiac mitochondria",
"criteria": "IC50",
"result": true
},
{
"rec_id": "RC03548",
"func": "F02060101",
"targ": "T021",
"compound": "D0096: Perhexiline",
"paper": "240",
"func_act": "affect",
"targ_act": "inhibit",
"dose": "148 μmol/L",
"time": "",
"method": "CPT-1 activity was measured by the formation of palmitoyl-[3H]-carnitine from palmitoyl-CoA and [3H]-I- carnitine,",
"species": "rat",
"animal_model": "hepatic mitochondria",
"criteria": "IC50",
"result": true
},
{
"rec_id": "RC03549",
"func": "F02060101",
"targ": "T021",
"compound": "D0005: Amiodarone",
"paper": "240",
"func_act": "affect",
"targ_act": "inhibit",
"dose": "228 μmol/L",
"time": "",
"method": "CPT-1 activity was measured by the formation of palmitoyl-[3H]-carnitine from palmitoyl-CoA and [3H]-I- carnitine,",
"species": "rat",
"animal_model": "cardiac and hepatic mitochondria",
"criteria": "IC50",
"result": true
},
{
"rec_id": "RC03550",
"func": "F02060101",
"targ": null,
"compound": "D0003: Acetaminophen",
"paper": "227",
"func_act": "",
"targ_act": "",
"dose": ">400μM",
"time": ">400",
"method": "Measurement of oxygen consumption in the presence of ADP (state 3) and the different substrates was carried out on the Mitologics screening platform",
"species": "mice",
"animal_model": "Lean mice vs Ob/ob mice",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC03551",
"func": "F02060101",
"targ": null,
"compound": "D1375: Carbamazepine",
"paper": "227",
"func_act": "",
"targ_act": "",
"dose": ">400μM",
"time": "341",
"method": "Measurement of oxygen consumption in the presence of ADP (state 3) and the different substrates was carried out on the Mitologics screening platform",
"species": "mice",
"animal_model": "Lean mice vs Ob/ob mice",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC03552",
"func": "F02060101",
"targ": null,
"compound": "D0038: Diclofenac",
"paper": "227",
"func_act": "",
"targ_act": "",
"dose": "47μM",
"time": "11*",
"method": "Measurement of oxygen consumption in the presence of ADP (state 3) and the different substrates was carried out on the Mitologics screening platform",
"species": "mice",
"animal_model": "Lean mice vs Ob/ob mice",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC03553",
"func": "F02060101",
"targ": null,
"compound": "D0065: Ibuprofen",
"paper": "227",
"func_act": "",
"targ_act": "",
"dose": "287μM",
"time": "80*",
"method": "Measurement of oxygen consumption in the presence of ADP (state 3) and the different substrates was carried out on the Mitologics screening platform",
"species": "mice",
"animal_model": "Lean mice vs Ob/ob mice",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC03604",
"func": "F0105",
"targ": null,
"compound": "D0069: Indomethacin",
"paper": "197",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "rat",
"animal_model": "heart",
"criteria": "",
"result": true
},
{
"rec_id": "RC03554",
"func": "F02060101",
"targ": null,
"compound": "D1374: Irinotecan",
"paper": "227",
"func_act": "",
"targ_act": "",
"dose": "6μM",
"time": "10",
"method": "Measurement of oxygen consumption in the presence of ADP (state 3) and the different substrates was carried out on the Mitologics screening platform",
"species": "mice",
"animal_model": "Lean mice vs Ob/ob mice",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC03555",
"func": "F02060101",
"targ": null,
"compound": "D0082: Methotrexate",
"paper": "227",
"func_act": "",
"targ_act": "",
"dose": "44μM",
"time": "42",
"method": "Measurement of oxygen consumption in the presence of ADP (state 3) and the different substrates was carried out on the Mitologics screening platform",
"species": "mice",
"animal_model": "Lean mice vs Ob/ob mice",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC03556",
"func": "F02060101",
"targ": null,
"compound": "D0109: Salicylic acid",
"paper": "227",
"func_act": "",
"targ_act": "",
"dose": ">400μM",
"time": ">400",
"method": "Measurement of oxygen consumption in the presence of ADP (state 3) and the different substrates was carried out on the Mitologics screening platform",
"species": "mice",
"animal_model": "Lean mice vs Ob/ob mice",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC03557",
"func": "F02060101",
"targ": null,
"compound": "D0116: Tamoxifen",
"paper": "227",
"func_act": "",
"targ_act": "",
"dose": "4μM",
"time": "11",
"method": "Measurement of oxygen consumption in the presence of ADP (state 3) and the different substrates was carried out on the Mitologics screening platform",
"species": "mice",
"animal_model": "Lean mice vs Ob/ob mice",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC03558",
"func": "F02060101",
"targ": null,
"compound": "D0128: Zidovudine",
"paper": "227",
"func_act": "",
"targ_act": "",
"dose": "79μM",
"time": "83",
"method": "Measurement of oxygen consumption in the presence of ADP (state 3) and the different substrates was carried out on the Mitologics screening platform",
"species": "mice",
"animal_model": "Lean mice vs Ob/ob mice",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC03559",
"func": "F02110301",
"targ": "T205",
"compound": "D1333: SB202190",
"paper": "233",
"func_act": "increase",
"targ_act": "activate",
"dose": " 10 μM",
"time": "",
"method": "mitochondrial Ca2+ uptake",
"species": "",
"animal_model": "intact and in permeabilized HeLa cells (MM5 cells expressing mitmutAEQ )",
"criteria": "",
"result": true
},
{
"rec_id": "RC03560",
"func": "F02110301",
"targ": "T205",
"compound": "D0969: kaempferol",
"paper": "234",
"func_act": "increase",
"targ_act": "activate",
"dose": "1μM",
"time": "",
"method": "The HeLa cell clone MM5 expressing mitochondrially targeted mutated aequorin was used for [Ca2+]M measurements. [Ca2+]c measurements were carried out using HeLa cells transiently transfected with the plasmid for cytosolic aequorin. ",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03561",
"func": "F02110301",
"targ": "T205",
"compound": "D0969: kaempferol",
"paper": "234",
"func_act": "increase",
"targ_act": "activate",
"dose": "7μM",
"time": "",
"method": "The HeLa cell clone MM5 expressing mitochondrially targeted mutated aequorin was used for [Ca2+]M measurements. [Ca2+]c measurements were carried out using HeLa cells transiently transfected with the plasmid for cytosolic aequorin. ",
"species": "",
"animal_model": "",
"criteria": "EC50",
"result": true
},
{
"rec_id": "RC03562",
"func": "F02110301",
"targ": "T205",
"compound": "D1077: quercetin",
"paper": "234",
"func_act": "increase",
"targ_act": "activate",
"dose": "21 μM",
"time": "",
"method": "mitochondrial Ca2+ uptake",
"species": "",
"animal_model": "",
"criteria": "EC50",
"result": true
},
{
"rec_id": "RC03563",
"func": "F02110301",
"targ": "T205",
"compound": "D0951: genistein",
"paper": "234",
"func_act": "increase",
"targ_act": "activate",
"dose": "37μM",
"time": "",
"method": "mitochondrial Ca2+ uptake",
"species": "",
"animal_model": "",
"criteria": "EC50",
"result": true
},
{
"rec_id": "RC03564",
"func": "F02110302",
"targ": "T206",
"compound": "D0258: CGP37157",
"paper": "241",
"func_act": "",
"targ_act": "",
"dose": "1 μmol/L",
"time": "",
"method": "mitochondrial Ca2+ monitored by mitochondrial-targeted Ca2+ biosensor mtRCamp1h.",
"species": "",
"animal_model": "periodically paced rat ventricular myocytes (VMs) under β-adrenergic stimulation",
"criteria": "",
"result": true
},
{
"rec_id": "RC03565",
"func": "F02110302",
"targ": "T205",
"compound": "D0969: kaempferol",
"paper": "241",
"func_act": "",
"targ_act": "",
"dose": "10 μmol/L",
"time": "",
"method": "mitochondrial Ca2+ monitored by mitochondrial-targeted Ca2+ biosensor mtRCamp1h.",
"species": "",
"animal_model": "periodically paced rat ventricular myocytes (VMs) under β-adrenergic stimulation",
"criteria": "",
"result": true
},
{
"rec_id": "RC03566",
"func": "F0501",
"targ": null,
"compound": "D0258: CGP37157",
"paper": "241",
"func_act": "",
"targ_act": "",
"dose": "1 μmol/L",
"time": "",
"method": "redox-sensitive OMM-HyPer and ERroGFP_iE biosensors",
"species": "rat",
"animal_model": "ventricular myocytes",
"criteria": "",
"result": true
},
{
"rec_id": "RC03567",
"func": "F0501",
"targ": null,
"compound": "D0969: kaempferol",
"paper": "241",
"func_act": "",
"targ_act": "",
"dose": "10 μmol/L",
"time": "",
"method": "redox-sensitive OMM-HyPer and ERroGFP_iE biosensors",
"species": "rat",
"animal_model": "ventricular myocytes",
"criteria": "",
"result": true
},
{
"rec_id": "RC03568",
"func": "F02110301",
"targ": "T206",
"compound": "D0258: CGP37157",
"paper": "241",
"func_act": "",
"targ_act": "inhibit",
"dose": "1 μmol/L",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03569",
"func": "F02110301",
"targ": "T205",
"compound": "D0299: Ru360",
"paper": "241",
"func_act": "",
"targ_act": "inhibit",
"dose": "2 μmol/L",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03570",
"func": "F0505",
"targ": null,
"compound": "D1334: MitoTEMPO",
"paper": "241",
"func_act": "",
"targ_act": "",
"dose": " 20 μmol/L",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03571",
"func": "F05",
"targ": null,
"compound": "D0003: Acetaminophen",
"paper": "243",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03572",
"func": "F0506",
"targ": null,
"compound": "D0285: Acetylcysteine",
"paper": "244",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "rho-GFP (Redox-sensitive GFP)",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03573",
"func": "F020103",
"targ": "T002007",
"compound": "D0524: atpenin a5",
"paper": "192",
"func_act": "affect",
"targ_act": "inhibitor",
"dose": "",
"time": "",
"method": "",
"species": "bovine",
"animal_model": "heart mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03574",
"func": "F020103",
"targ": "T002007",
"compound": "D0256: Carboxin",
"paper": "192",
"func_act": "affect",
"targ_act": "inhibitor",
"dose": "",
"time": "",
"method": "",
"species": "bovine",
"animal_model": "heart mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03575",
"func": "F020103",
"targ": "T002007",
"compound": "D0404: Thenoyltrifluoroacetone",
"paper": "192",
"func_act": "affect",
"targ_act": "inhibitor",
"dose": "",
"time": "",
"method": "",
"species": "bovine",
"animal_model": "heart mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03576",
"func": "F020103",
"targ": "T002007",
"compound": "D0530: HQNO",
"paper": "192",
"func_act": "affect",
"targ_act": "inhibitor",
"dose": "",
"time": "",
"method": "",
"species": "bovine",
"animal_model": "heart mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03577",
"func": null,
"targ": "T235",
"compound": "D0128: Zidovudine",
"paper": "196",
"func_act": "",
"targ_act": "downregulate",
"dose": "",
"time": "",
"method": "",
"species": "human",
"animal_model": "U2OS cell",
"criteria": "",
"result": true
},
{
"rec_id": "RC03578",
"func": null,
"targ": "T236",
"compound": "D0128: Zidovudine",
"paper": "196",
"func_act": "",
"targ_act": "downregulate",
"dose": "",
"time": "",
"method": "",
"species": "human",
"animal_model": "U2OS cell",
"criteria": "",
"result": true
}
]
}
