HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/json
Vary: Accept
{
"count": 4617,
"next": "https://mitotox.org/api/records/list?format=api&page=37",
"previous": "https://mitotox.org/api/records/list?format=api&page=35",
"results": [
{
"rec_id": "RC03695",
"func": "F050501",
"targ": null,
"compound": "D0412: Ubidecarenone",
"paper": "248",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03696",
"func": "F050501",
"targ": null,
"compound": "D0371: Mitoquinone",
"paper": "248",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03698",
"func": "F0308",
"targ": null,
"compound": "D0217: Ozone",
"paper": "247",
"func_act": "",
"targ_act": "",
"dose": "1 μg O 3/mL",
"time": "",
"method": "",
"species": "",
"animal_model": "HeLa cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC03699",
"func": "F0308",
"targ": null,
"compound": "D0217: Ozone",
"paper": "247",
"func_act": "",
"targ_act": "",
"dose": "10 μg O 3/mL",
"time": "",
"method": "",
"species": "",
"animal_model": "HeLa cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC03700",
"func": "F0308",
"targ": null,
"compound": "D0091: Nicotine",
"paper": "247",
"func_act": "",
"targ_act": "",
"dose": "10 mM",
"time": "",
"method": "",
"species": "Human",
"animal_model": "Human embryonal carcinoma cells (NT2/D1)",
"criteria": "",
"result": true
},
{
"rec_id": "RC03701",
"func": "F0308",
"targ": null,
"compound": "D0029: Cisplatin",
"paper": "247",
"func_act": "",
"targ_act": "",
"dose": "3 mg/kg bodyweight",
"time": "twice a week for 2 weeks",
"method": "",
"species": "Mouse",
"animal_model": "Mouse tibial nerves and dorsal root ganglia (L1–L4)",
"criteria": "",
"result": true
},
{
"rec_id": "RC03702",
"func": "F0308",
"targ": null,
"compound": "D0043: Doxorubicin",
"paper": "247",
"func_act": "",
"targ_act": "",
"dose": "7.2 μM DXR for 24 hrs",
"time": "",
"method": "",
"species": "Human",
"animal_model": "fibroblasts",
"criteria": "",
"result": true
},
{
"rec_id": "RC03703",
"func": "F0308",
"targ": null,
"compound": "D0193: MDMA",
"paper": "247",
"func_act": "",
"targ_act": "",
"dose": "20 μM MDMA mixture for 24 hrs",
"time": "",
"method": "",
"species": "",
"animal_model": "Mouse primary hippocampal neurons",
"criteria": "",
"result": true
},
{
"rec_id": "RC03704",
"func": "F0308",
"targ": null,
"compound": "D0081: Metamfetamine",
"paper": "247",
"func_act": "",
"targ_act": "",
"dose": "0.5, 1, 2 mM Meth for 24 hrs",
"time": "",
"method": "",
"species": "",
"animal_model": "Human neuroblastoma SH- SY5Y",
"criteria": "",
"result": true
},
{
"rec_id": "RC03705",
"func": "F0308",
"targ": null,
"compound": "D0226: Perfluorooctanoic acid",
"paper": "247",
"func_act": "",
"targ_act": "",
"dose": "In utero exposure (GD 1–17) to 1 mg/kg bodyweight dam",
"time": "",
"method": "",
"species": "",
"animal_model": "Post-natal day 91 mouse livers",
"criteria": "",
"result": true
},
{
"rec_id": "RC03706",
"func": "F0308",
"targ": null,
"compound": "D0152: Cadmium",
"paper": "247",
"func_act": "",
"targ_act": "",
"dose": "In vitro: 12uM CdCl2 In vivo: 2mg/kg CdCl2",
"time": "",
"method": "",
"species": "",
"animal_model": "Rat hepatocytes",
"criteria": "",
"result": true
},
{
"rec_id": "RC03707",
"func": "F0308",
"targ": null,
"compound": "D0192: Manganese",
"paper": "247",
"func_act": "",
"targ_act": "",
"dose": "Infusion of 1 μM MnCl2",
"time": "",
"method": "",
"species": "",
"animal_model": "Rat glia",
"criteria": "",
"result": true
},
{
"rec_id": "RC03708",
"func": "F0308",
"targ": null,
"compound": "D0200: Methylmercury",
"paper": "247",
"func_act": "",
"targ_act": "",
"dose": "20 μM",
"time": "",
"method": "",
"species": "",
"animal_model": "Human HepG2 cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC03709",
"func": "F0308",
"targ": null,
"compound": "D0157: Chlorpyrifos",
"paper": "247",
"func_act": "",
"targ_act": "",
"dose": "30 μM",
"time": "",
"method": "",
"species": "",
"animal_model": "Human stem cell-derived neural progenitor cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC03710",
"func": "F0308",
"targ": null,
"compound": "D0129: 2,4-dinitrophenol",
"paper": "247",
"func_act": "",
"targ_act": "",
"dose": "50 μM DNP at 3 hours post fertilization (hpf)",
"time": "",
"method": "",
"species": "",
"animal_model": "Danio rerio",
"criteria": "",
"result": true
},
{
"rec_id": "RC03711",
"func": "F0308",
"targ": null,
"compound": "D0156: CCCP",
"paper": "247",
"func_act": "",
"targ_act": "",
"dose": "20 μM CCCP for 1 to 3 hours",
"time": "",
"method": "",
"species": "",
"animal_model": "HeLa cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC03712",
"func": "F0308",
"targ": null,
"compound": "D0181: FCCP",
"paper": "247",
"func_act": "",
"targ_act": "",
"dose": "10 μM FCCP for 48 to 72 hours",
"time": "",
"method": "",
"species": "",
"animal_model": "HeLa cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC03713",
"func": "F0308",
"targ": null,
"compound": "D1361: Ultraviolet B",
"paper": "247",
"func_act": "",
"targ_act": "",
"dose": "100 mJ/cm2",
"time": "",
"method": "",
"species": "human",
"animal_model": "Normal epidermal keratinocytes",
"criteria": "",
"result": true
},
{
"rec_id": "RC03714",
"func": "F0308",
"targ": null,
"compound": "D1362: Ultraviolet C",
"paper": "247",
"func_act": "",
"targ_act": "",
"dose": "60 mJ/cm2",
"time": "",
"method": "",
"species": "Mouse",
"animal_model": "embryonic fibroblasts",
"criteria": "",
"result": true
},
{
"rec_id": "RC03716",
"func": null,
"targ": "T005",
"compound": "D0154: Carbon Monoxide",
"paper": "254",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03717",
"func": "F0105",
"targ": null,
"compound": "D0223: Pentachlorophenol",
"paper": "253",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03718",
"func": "F030801",
"targ": null,
"compound": "D1348: Wortmannin",
"paper": "252",
"func_act": "",
"targ_act": "",
"dose": "100 nM",
"time": "",
"method": "Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.",
"species": "",
"animal_model": "SH-SY5Y neuroblastoma cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC03719",
"func": "F030801",
"targ": null,
"compound": "D1366: hydroxychloroquine",
"paper": "252",
"func_act": "",
"targ_act": "",
"dose": "30 μM",
"time": "",
"method": "Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.",
"species": "",
"animal_model": "SH-SY5Y neuroblastoma cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC03720",
"func": "F030801",
"targ": null,
"compound": "D1367: 3-methyladenine",
"paper": "252",
"func_act": "",
"targ_act": "",
"dose": "10 mM",
"time": "",
"method": "Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.",
"species": "",
"animal_model": "SH-SY5Y neuroblastoma cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC03721",
"func": "F030801",
"targ": null,
"compound": "D0439: Bafilomycin A1",
"paper": "252",
"func_act": "",
"targ_act": "",
"dose": "50 nM",
"time": "",
"method": "Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.",
"species": "",
"animal_model": "SH-SY5Y neuroblastoma cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC03722",
"func": "F030801",
"targ": null,
"compound": "D0156: CCCP",
"paper": "252",
"func_act": "",
"targ_act": "",
"dose": "10 μM or 25 μM",
"time": "",
"method": "Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.",
"species": "",
"animal_model": "mouse embryonic fibroblasts (MEFs) and SH-SY5Y cells ",
"criteria": "",
"result": true
},
{
"rec_id": "RC03723",
"func": "F030801",
"targ": null,
"compound": "D1365: earle’s balanced salt solution",
"paper": "252",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03724",
"func": "F030801",
"targ": "T416",
"compound": "D0434: rapamycin",
"paper": "252",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye",
"species": "mouse",
"animal_model": "embryonic retinas ",
"criteria": "",
"result": true
},
{
"rec_id": "RC03725",
"func": "F08",
"targ": "T416",
"compound": "D0434: rapamycin",
"paper": "252",
"func_act": "",
"targ_act": "",
"dose": "200 nM",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03726",
"func": "F030801",
"targ": "T118",
"compound": "D0261: Cyclosporin A",
"paper": "252",
"func_act": "block",
"targ_act": "inhibitor",
"dose": "5 μM",
"time": "",
"method": "Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye",
"species": "",
"animal_model": "mouse embryonic fibroblasts (MEFs) and SH-SY5Y cells ",
"criteria": "",
"result": true
},
{
"rec_id": "RC03727",
"func": "F030801",
"targ": null,
"compound": "D1364: Nicotinamide",
"paper": "252",
"func_act": "induce",
"targ_act": "",
"dose": "5 mM",
"time": "6h",
"method": "Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.",
"species": "",
"animal_model": "SH-SY5Y cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC03728",
"func": "F030801",
"targ": null,
"compound": "D1363: fisetin",
"paper": "252",
"func_act": "induce",
"targ_act": "",
"dose": "10 μM",
"time": "6h",
"method": "Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.",
"species": "",
"animal_model": "SH-SY5Y cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC03729",
"func": "F0701",
"targ": null,
"compound": "D1368: oxaliplatin",
"paper": "262",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03730",
"func": "F0701",
"targ": null,
"compound": "D1383: mimosine",
"paper": "270",
"func_act": "",
"targ_act": "",
"dose": "0.3 mM",
"time": "",
"method": "",
"species": "",
"animal_model": "U-937 leukemia cell line.",
"criteria": "",
"result": true
},
{
"rec_id": "RC03731",
"func": "F030501",
"targ": null,
"compound": "D1385: Dyclonine",
"paper": "269",
"func_act": "induce",
"targ_act": "",
"dose": "",
"time": "",
"method": "Mitochondrial morphology and neurite area measurements",
"species": "mouse",
"animal_model": "neuron",
"criteria": "",
"result": true
},
{
"rec_id": "RC03732",
"func": "F030501",
"targ": null,
"compound": "D1386: Benoxinate",
"paper": "269",
"func_act": "induce",
"targ_act": "",
"dose": "",
"time": "",
"method": "Mitochondrial morphology and neurite area measurements",
"species": "mouse",
"animal_model": "neuron",
"criteria": "",
"result": true
},
{
"rec_id": "RC03733",
"func": "F030501",
"targ": null,
"compound": "D1387: Phenyl aminosalicylate",
"paper": "269",
"func_act": "induce",
"targ_act": "",
"dose": "",
"time": "",
"method": "Mitochondrial morphology and neurite area measurements",
"species": "mouse",
"animal_model": "neuron",
"criteria": "",
"result": true
},
{
"rec_id": "RC03734",
"func": "F030501",
"targ": null,
"compound": "D0951: genistein",
"paper": "269",
"func_act": "induce",
"targ_act": "",
"dose": "",
"time": "",
"method": "Mitochondrial morphology and neurite area measurements",
"species": "mouse",
"animal_model": "neuron",
"criteria": "",
"result": true
},
{
"rec_id": "RC03735",
"func": "F030501",
"targ": null,
"compound": "D0019: Celecoxib",
"paper": "269",
"func_act": "induce",
"targ_act": "",
"dose": "",
"time": "",
"method": "Mitochondrial morphology and neurite area measurements",
"species": "mouse",
"animal_model": "neuron",
"criteria": "",
"result": true
},
{
"rec_id": "RC03736",
"func": "F030501",
"targ": null,
"compound": "D1388: Yohimbine",
"paper": "269",
"func_act": "induce",
"targ_act": "",
"dose": "",
"time": "",
"method": "Mitochondrial morphology and neurite area measurements",
"species": "mouse",
"animal_model": "neuron",
"criteria": "",
"result": true
},
{
"rec_id": "RC03737",
"func": "F02010202",
"targ": null,
"compound": "D1388: Yohimbine",
"paper": "269",
"func_act": "increase",
"targ_act": "",
"dose": "",
"time": "",
"method": "Oxygen consumption rate (OCR) or extracellular acidification rate (ECAR) measurements from permeabilized neurons and isolated brain mitochondria were performed using the XF96 Extracellular Flux analyzer (Seahorse Bioscience).",
"species": "mouse",
"animal_model": "neuron",
"criteria": "",
"result": true
},
{
"rec_id": "RC03738",
"func": "F02010202",
"targ": null,
"compound": "D1385: Dyclonine",
"paper": "269",
"func_act": "increase",
"targ_act": "",
"dose": "",
"time": "",
"method": "Oxygen consumption rate (OCR) or extracellular acidification rate (ECAR) measurements from permeabilized neurons and isolated brain mitochondria were performed using the XF96 Extracellular Flux analyzer (Seahorse Bioscience).",
"species": "mouse",
"animal_model": "neuron",
"criteria": "",
"result": true
},
{
"rec_id": "RC03739",
"func": "F030501",
"targ": null,
"compound": "D1040: penfluridol",
"paper": "269",
"func_act": "induce",
"targ_act": "",
"dose": "",
"time": "",
"method": "Mitochondrial morphology and neurite area measurements",
"species": "mouse",
"animal_model": "neuron",
"criteria": "",
"result": true
},
{
"rec_id": "RC03740",
"func": "F030501",
"targ": null,
"compound": "D0493: pimozide",
"paper": "269",
"func_act": "induce",
"targ_act": "",
"dose": "",
"time": "",
"method": "Mitochondrial morphology and neurite area measurements",
"species": "mouse",
"animal_model": "neuron",
"criteria": "",
"result": true
},
{
"rec_id": "RC03741",
"func": "F030501",
"targ": null,
"compound": "D1389: Doxepin",
"paper": "269",
"func_act": "induce",
"targ_act": "",
"dose": "",
"time": "",
"method": "Mitochondrial morphology and neurite area measurements",
"species": "mouse",
"animal_model": "neuron",
"criteria": "",
"result": true
},
{
"rec_id": "RC03742",
"func": null,
"targ": "T080002",
"compound": "D1356: Dichloroacetate",
"paper": "255",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "IC50",
"result": true
},
{
"rec_id": "RC03743",
"func": null,
"targ": "T080002",
"compound": "D1369: 2-chloroproprionate",
"paper": "255",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03744",
"func": null,
"targ": "T080",
"compound": "D1370: Nov3r",
"paper": "255",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03745",
"func": null,
"targ": "T080002",
"compound": "D1355: Pfz3",
"paper": "255",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03746",
"func": null,
"targ": "T080001",
"compound": "D1350: AZD7545",
"paper": "255",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "IC50",
"result": true
},
{
"rec_id": "RC03747",
"func": null,
"targ": "T080003",
"compound": "D0443: radicicol",
"paper": "255",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03748",
"func": null,
"targ": "T080001",
"compound": "D1349: Dicoumarol",
"paper": "256",
"func_act": "",
"targ_act": "",
"dose": "19.42 μM",
"time": "",
"method": "",
"species": "",
"animal_model": "ovarian cancer cell line SKOV3",
"criteria": "IC50",
"result": true
},
{
"rec_id": "RC03749",
"func": null,
"targ": "T080001",
"compound": "D1350: AZD7545",
"paper": "256",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03750",
"func": null,
"targ": "T080001",
"compound": "D1351: VER-246608",
"paper": "256",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03751",
"func": null,
"targ": "T080001",
"compound": "D1352: JX06",
"paper": "256",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03752",
"func": null,
"targ": "T080001",
"compound": "D0443: radicicol",
"paper": "256",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03753",
"func": "F08",
"targ": "T419",
"compound": "D1353: ZLN005",
"paper": "260",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03754",
"func": "F08",
"targ": "T121",
"compound": "D1373: Gamitrinib",
"paper": "264",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03755",
"func": "F08",
"targ": "T416",
"compound": "D0921: everolimus",
"paper": "266",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03756",
"func": "F030802",
"targ": null,
"compound": "D1077: quercetin",
"paper": "263",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "HepG",
"criteria": "",
"result": true
},
{
"rec_id": "RC03757",
"func": "F030802",
"targ": null,
"compound": "D1077: quercetin",
"paper": "265",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "brain",
"criteria": "",
"result": true
},
{
"rec_id": "RC03758",
"func": "F08",
"targ": "T422",
"compound": "D0398: resveratrol",
"paper": "267",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03759",
"func": "F020601",
"targ": null,
"compound": "D1394: Dronedarone",
"paper": "271",
"func_act": "inhibit",
"targ_act": "",
"dose": "10µM",
"time": "24hr",
"method": "",
"species": "",
"animal_model": "isolated rat liver mitochondria, and the human hepatoma cell line HepG2",
"criteria": "",
"result": true
},
{
"rec_id": "RC03760",
"func": "F020601",
"targ": null,
"compound": "D0005: Amiodarone",
"paper": "271",
"func_act": "inhibit",
"targ_act": "",
"dose": "20µM",
"time": "24hr",
"method": "",
"species": "",
"animal_model": "isolated rat liver mitochondria, and the human hepatoma cell line HepG2",
"criteria": "",
"result": true
},
{
"rec_id": "RC03761",
"func": "F02110301",
"targ": null,
"compound": "D0302: Trimetazidine",
"paper": "274",
"func_act": "increase",
"targ_act": "",
"dose": "10-100µM",
"time": "",
"method": "",
"species": "rat ",
"animal_model": "isolated cardiac mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03762",
"func": null,
"targ": "T086001",
"compound": "D1274: ranolazine",
"paper": "275",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03763",
"func": "F02110112",
"targ": "T084",
"compound": "D0126: Valproic Acid",
"paper": "279",
"func_act": "inhibitor",
"targ_act": "inhibit",
"dose": "0.5–2 mM",
"time": "3min",
"method": "The rate of the radiolabeled substrate [1-14C]-pyruvate uptake by ISMV was measured in the presence or absence of an inwardly directed proton gradient.",
"species": "rat",
"animal_model": "inverted submitochondrial vesicles (ISMV) from rat liver isolated mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03764",
"func": "F02110112",
"targ": null,
"compound": "D1405: alpha-Cyano-4-hydroxycinnamate",
"paper": "279",
"func_act": "inhibitor",
"targ_act": "",
"dose": "1mM",
"time": "3min",
"method": "The rate of the radiolabeled substrate [1-14C]-pyruvate uptake by ISMV was measured in the presence or absence of an inwardly directed proton gradient.",
"species": "rat",
"animal_model": "inverted submitochondrial vesicles (ISMV) from rat liver isolated mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03765",
"func": "F02110112",
"targ": null,
"compound": "D1405: alpha-Cyano-4-hydroxycinnamate",
"paper": "280",
"func_act": "inhibitor",
"targ_act": "",
"dose": "0.05mM",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": ">90% inhibition",
"result": true
},
{
"rec_id": "RC03766",
"func": "F02110112",
"targ": null,
"compound": "D0248: Alpha-Cyanocinnamate",
"paper": "280",
"func_act": "inhibitor",
"targ_act": "",
"dose": "0.05mM",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": ">90% inhibition",
"result": true
},
{
"rec_id": "RC03767",
"func": null,
"targ": "T085",
"compound": "D1405: alpha-Cyano-4-hydroxycinnamate",
"paper": "280",
"func_act": "",
"targ_act": "inhibit",
"dose": "2mM",
"time": "",
"method": "",
"species": "",
"animal_model": "fat cell",
"criteria": "25% inhibition",
"result": true
},
{
"rec_id": "RC03768",
"func": null,
"targ": "T085",
"compound": "D0248: Alpha-Cyanocinnamate",
"paper": "280",
"func_act": "",
"targ_act": "inhibit",
"dose": "2mM",
"time": "",
"method": "",
"species": "",
"animal_model": "fat cell",
"criteria": "65%inhibition",
"result": true
},
{
"rec_id": "RC03769",
"func": null,
"targ": "T104",
"compound": "D1405: alpha-Cyano-4-hydroxycinnamate",
"paper": "280",
"func_act": "",
"targ_act": "inhibit",
"dose": "0.05mM",
"time": "",
"method": "",
"species": "",
"animal_model": "fat cell",
"criteria": "15% inhibition",
"result": true
},
{
"rec_id": "RC03770",
"func": null,
"targ": "T104",
"compound": "D0248: Alpha-Cyanocinnamate",
"paper": "280",
"func_act": "",
"targ_act": "inhibit",
"dose": "2mM",
"time": "",
"method": "",
"species": "",
"animal_model": "fat cell",
"criteria": "23%inhibition",
"result": true
},
{
"rec_id": "RC03771",
"func": null,
"targ": "T081",
"compound": "D0248: Alpha-Cyanocinnamate",
"paper": "280",
"func_act": "",
"targ_act": "inhibit",
"dose": "0.05mM",
"time": "",
"method": "",
"species": "rabbit",
"animal_model": "muscle",
"criteria": "25% inhibition",
"result": true
},
{
"rec_id": "RC03772",
"func": "F020601",
"targ": null,
"compound": "D1274: ranolazine",
"paper": "273",
"func_act": "stimulate",
"targ_act": "",
"dose": "25μM",
"time": "24hr",
"method": "quantifies the conversion of [9,10-3H(N)]-palmitic acid to 3H2O with diffusion",
"species": "",
"animal_model": "T47D cells",
"criteria": "Student’s two-tail t-test, where p < 0.05 ",
"result": true
},
{
"rec_id": "RC03773",
"func": "F020601",
"targ": null,
"compound": "D0302: Trimetazidine",
"paper": "273",
"func_act": "stimulate",
"targ_act": "",
"dose": "100 μM",
"time": "24hr",
"method": "quantifies the conversion of [9,10-3H(N)]-palmitic acid to 3H2O with diffusion",
"species": "",
"animal_model": "T47D cells",
"criteria": "Student’s two-tail t-test, where p < 0.05",
"result": true
},
{
"rec_id": "RC03774",
"func": "F020601",
"targ": null,
"compound": "D0264: Etomoxir",
"paper": "273",
"func_act": "inhibition",
"targ_act": "",
"dose": "0.1 to 50 μM",
"time": "24hr",
"method": "quantifies the conversion of [9,10-3H(N)]-palmitic acid to 3H2O with diffusion",
"species": "",
"animal_model": "MCF-7 and T47D cells",
"criteria": "Student’s two-tail t-test, where p < 0.05",
"result": true
},
{
"rec_id": "RC03775",
"func": "F020601",
"targ": null,
"compound": "D0290: Oxfenicine",
"paper": "273",
"func_act": "inhibition",
"targ_act": "",
"dose": "1.5 to 4.5mM",
"time": "24hr",
"method": "quantifies the conversion of [9,10-3H(N)]-palmitic acid to 3H2O with diffusion",
"species": "",
"animal_model": "T47D cells",
"criteria": "Student’s two-tail t-test, where p < 0.05",
"result": true
},
{
"rec_id": "RC03776",
"func": "F020601",
"targ": null,
"compound": "D0096: Perhexiline",
"paper": "273",
"func_act": "inhibition",
"targ_act": "",
"dose": "0.2 to 0.4",
"time": "24hr",
"method": "quantifies the conversion of [9,10-3H(N)]-palmitic acid to 3H2O with diffusion",
"species": "",
"animal_model": "MCF-7 and T47D cells",
"criteria": "Student’s two-tail t-test, where p < 0.05",
"result": false
},
{
"rec_id": "RC03780",
"func": "F02060101",
"targ": null,
"compound": "D1407: Carnitine",
"paper": "273",
"func_act": "stimulate",
"targ_act": "",
"dose": "0.5mM",
"time": "24hr",
"method": "quantifies the conversion of [9,10-3H(N)]-palmitic acid to 3H2O with diffusion",
"species": "",
"animal_model": "U-937, MCF-7, and T47D",
"criteria": "",
"result": true
},
{
"rec_id": "RC03781",
"func": "F02060101",
"targ": "T047",
"compound": "D1354: AICAR",
"paper": "273",
"func_act": "stimulate",
"targ_act": "inactivation",
"dose": "1mM",
"time": "24hr",
"method": "quantifies the conversion of [9,10-3H(N)]-palmitic acid to 3H2O with diffusion",
"species": "",
"animal_model": "U-937, MCF-7, and T47D",
"criteria": "",
"result": true
},
{
"rec_id": "RC03782",
"func": "F02060101",
"targ": "T417",
"compound": "D1354: AICAR",
"paper": "273",
"func_act": "stimulate",
"targ_act": "activation",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03783",
"func": "F030804",
"targ": "T489",
"compound": "D1395: piceatannol",
"paper": "276",
"func_act": "",
"targ_act": "down regulate",
"dose": "",
"time": "48hr",
"method": "Relative luciferase activity was determined in Mfn1−/− MEFs carrying the Mfn1 promoter reporter",
"species": "",
"animal_model": "Mfn1−/− MEFs stably expressing an Mfn1 promoter reporter construct ",
"criteria": "",
"result": true
},
{
"rec_id": "RC03784",
"func": null,
"targ": "T489",
"compound": "D1396: Tetramethylpyrazine",
"paper": "276",
"func_act": "",
"targ_act": "down regulate",
"dose": "",
"time": "48hr",
"method": "Relative luciferase activity was determined in Mfn1−/− MEFs carrying the Mfn1 promoter reporter",
"species": "",
"animal_model": "Mfn1−/− MEFs stably expressing an Mfn1 promoter reporter construct ",
"criteria": "",
"result": true
},
{
"rec_id": "RC03785",
"func": null,
"targ": "T489",
"compound": "D1397: U74389G",
"paper": "276",
"func_act": "",
"targ_act": "down regulate",
"dose": "",
"time": "48hr",
"method": "Relative luciferase activity was determined in Mfn1−/− MEFs carrying the Mfn1 promoter reporter",
"species": "",
"animal_model": "Mfn1−/− MEFs stably expressing an Mfn1 promoter reporter construct ",
"criteria": "",
"result": true
},
{
"rec_id": "RC03786",
"func": null,
"targ": "T489",
"compound": "D1398: Tanshinone IIA",
"paper": "276",
"func_act": "",
"targ_act": "up regulate",
"dose": "",
"time": "48hr",
"method": "Relative luciferase activity was determined in Mfn1−/− MEFs carrying the Mfn1 promoter reporter",
"species": "",
"animal_model": "Mfn1−/− MEFs stably expressing an Mfn1 promoter reporter construct ",
"criteria": "",
"result": true
},
{
"rec_id": "RC03787",
"func": null,
"targ": "T489",
"compound": "D1399: Terbinafine",
"paper": "276",
"func_act": "",
"targ_act": "up regulate",
"dose": "",
"time": "48hr",
"method": "Relative luciferase activity was determined in Mfn1−/− MEFs carrying the Mfn1 promoter reporter",
"species": "",
"animal_model": "Mfn1−/− MEFs stably expressing an Mfn1 promoter reporter construct ",
"criteria": "",
"result": true
},
{
"rec_id": "RC03788",
"func": "F0703",
"targ": null,
"compound": "D0229: Rotenone",
"paper": "277",
"func_act": "induce",
"targ_act": "",
"dose": "1µM",
"time": "overnight",
"method": "Cyto-ID Autophagy Detection dye and Autophagy compound library in a microplate-based assay",
"species": "",
"animal_model": "HeLa cells",
"criteria": ">2 fold increase",
"result": true
},
{
"rec_id": "RC03789",
"func": "F0703",
"targ": null,
"compound": "D1022: nocodazole",
"paper": "277",
"func_act": "induce",
"targ_act": "",
"dose": "1µM",
"time": "overnight",
"method": "Cyto-ID Autophagy Detection dye and Autophagy compound library in a microplate-based assay",
"species": "",
"animal_model": "HeLa cells",
"criteria": ">2 fold increase",
"result": true
},
{
"rec_id": "RC03790",
"func": "F0703",
"targ": null,
"compound": "D1400: Chloroquine",
"paper": "277",
"func_act": "induce",
"targ_act": "",
"dose": "1µM",
"time": "overnight",
"method": "Cyto-ID Autophagy Detection dye and Autophagy compound library in a microplate-based assay",
"species": "",
"animal_model": "HeLa cells",
"criteria": ">2 fold increase",
"result": true
},
{
"rec_id": "RC03791",
"func": "F0703",
"targ": null,
"compound": "D1401: Brefeldin A",
"paper": "277",
"func_act": "induce",
"targ_act": "",
"dose": "1µM",
"time": "overnight",
"method": "Cyto-ID Autophagy Detection dye and Autophagy compound library in a microplate-based assay",
"species": "",
"animal_model": "HeLa cells",
"criteria": ">2 fold increase",
"result": true
},
{
"rec_id": "RC03792",
"func": "F0703",
"targ": null,
"compound": "D1402: Tunicamycin",
"paper": "277",
"func_act": "induce",
"targ_act": "",
"dose": "1µM",
"time": "overnight",
"method": "Cyto-ID Autophagy Detection dye and Autophagy compound library in a microplate-based assay",
"species": "",
"animal_model": "HeLa cells",
"criteria": ">2 fold increase",
"result": true
},
{
"rec_id": "RC03793",
"func": "F0703",
"targ": null,
"compound": "D0449: thapsigargin",
"paper": "277",
"func_act": "induce",
"targ_act": "",
"dose": "1µM",
"time": "overnight",
"method": "Cyto-ID Autophagy Detection dye and Autophagy compound library in a microplate-based assay",
"species": "",
"animal_model": "HeLa cells",
"criteria": ">2 fold increase",
"result": true
},
{
"rec_id": "RC03794",
"func": "F0703",
"targ": null,
"compound": "D1403: Gingerol",
"paper": "277",
"func_act": "induce",
"targ_act": "",
"dose": "1µM",
"time": "overnight",
"method": "Cyto-ID Autophagy Detection dye and Autophagy compound library in a microplate-based assay",
"species": "",
"animal_model": "HeLa cells",
"criteria": ">2 fold increase",
"result": true
},
{
"rec_id": "RC03795",
"func": "F0703",
"targ": null,
"compound": "D1404: Staurosporine",
"paper": "277",
"func_act": "induce",
"targ_act": "",
"dose": "1µM",
"time": "overnight",
"method": "Cyto-ID Autophagy Detection dye and Autophagy compound library in a microplate-based assay",
"species": "",
"animal_model": "HeLa cells",
"criteria": ">2 fold increase",
"result": true
},
{
"rec_id": "RC03796",
"func": "F0109",
"targ": null,
"compound": "D0043: Doxorubicin",
"paper": "278",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03797",
"func": "F0109",
"targ": null,
"compound": "D0071: Isoniazid",
"paper": "278",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03798",
"func": "F0109",
"targ": null,
"compound": "D1411: Gentamicin",
"paper": "278",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03799",
"func": "F0109",
"targ": null,
"compound": "D0194: Menadione",
"paper": "278",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
}
]
}