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"func_act": "",
"targ_act": "inhibit",
"dose": "1 μM ",
"time": "",
"method": "Mitochondrial complex III assay (ubiquinol‐cytochrome c oxidoreductase)",
"species": "rat",
"animal_model": "isolated kidney mitochondria",
"criteria": "24%",
"result": true
},
{
"rec_id": "RC03858",
"func": "F070105",
"targ": null,
"compound": "D0505: tacrolimus",
"paper": "323",
"func_act": "",
"targ_act": "",
"dose": "1 μM ",
"time": "",
"method": "The amount of cytochrome c was measured using a Quantikine® M Rat/Mouse Cytochrome c immunoassay after addition of drugs in energized mitochondrial (3 min) or after Ca2+‐induced mitochondrial swelling (3 min). ",
"species": "rat",
"animal_model": "isolated kidney mitochondria",
"criteria": "",
"result": false
},
{
"rec_id": "RC03859",
"func": "F070105",
"targ": null,
"compound": "D0434: rapamycin",
"paper": "323",
"func_act": "",
"targ_act": "",
"dose": "1 μM ",
"time": "",
"method": "The amount of cytochrome c was measured using a Quantikine® M Rat/Mouse Cytochrome c immunoassay after addition of drugs in energized mitochondrial (3 min) or after Ca2+‐induced mitochondrial swelling (3 min). ",
"species": "rat",
"animal_model": "isolated kidney mitochondria",
"criteria": "",
"result": false
},
{
"rec_id": "RC03860",
"func": null,
"targ": "T118",
"compound": "D1464: JW47",
"paper": "324",
"func_act": "",
"targ_act": "bind",
"dose": "504.5 ± 9.2 nM (CypA), 298.0 ± 17.9 nM( K133I CypD)",
"time": "",
"method": "Fluorescence Polarization Assay to measure affinity of ligands to cyclophilins (fluorescein-PEG-CsA ligand as the probe)",
"species": "",
"animal_model": "",
"criteria": "Ki",
"result": true
},
{
"rec_id": "RC03861",
"func": null,
"targ": "T118",
"compound": "D0261: Cyclosporin A",
"paper": "324",
"func_act": "",
"targ_act": "bind",
"dose": "22.5 ± 4.3nM (CypA), 1.4 ± 1.6 nM( K133I CypD)",
"time": "",
"method": "Fluorescence Polarization Assay to measure affinity of ligands to cyclophilins (fluorescein-PEG-CsA ligand as the probe)",
"species": "",
"animal_model": "",
"criteria": "Ki",
"result": true
},
{
"rec_id": "RC03862",
"func": "F010401",
"targ": null,
"compound": "D1464: JW47",
"paper": "324",
"func_act": "inhibit",
"targ_act": "",
"dose": "10nM",
"time": "",
"method": "Assess Ca2+-mediated PT pore formation by Calcium Retention Capacity Assay (Fluo-5N fluorescence was measured in the extramitochondrial solution following repeated additions of Ca2+)",
"species": "rat",
"animal_model": "liver mitochondria",
"criteria": "half-maximal inhibition",
"result": true
},
{
"rec_id": "RC03863",
"func": "F010401",
"targ": null,
"compound": "D0261: Cyclosporin A",
"paper": "324",
"func_act": "inhibit",
"targ_act": "",
"dose": "40nM",
"time": "",
"method": "Assess Ca2+-mediated PT pore formation by Calcium Retention Capacity Assay (Fluo-5N fluorescence was measured in the extramitochondrial solution following repeated additions of Ca2+)",
"species": "rat",
"animal_model": "liver mitochondria",
"criteria": "half-maximal inhibition",
"result": true
},
{
"rec_id": "RC03864",
"func": "F01",
"targ": null,
"compound": "D1464: JW47",
"paper": "324",
"func_act": "",
"targ_act": "",
"dose": "40nM",
"time": "",
"method": "mitochondrial membrane potential was measured in tetramethylrhodamine methyl ester (TMRM)-loaded neurons using ImageXpress MicroXL, and in rhodamine-123 loaded isolated mitochondria using a fluorescent plate reader",
"species": "rat",
"animal_model": "rat cortical neurons and isolated rat liver mitochondria",
"criteria": "",
"result": false
},
{
"rec_id": "RC03865",
"func": "F01",
"targ": null,
"compound": "D0261: Cyclosporin A",
"paper": "324",
"func_act": "",
"targ_act": "",
"dose": "40nM",
"time": "",
"method": "mitochondrial membrane potential was measured in tetramethylrhodamine methyl ester (TMRM)-loaded neurons using ImageXpress MicroXL, and in rhodamine-123 loaded isolated mitochondria using a fluorescent plate reader",
"species": "rat",
"animal_model": "rat cortical neurons and isolated rat liver mitochondria",
"criteria": "",
"result": false
},
{
"rec_id": "RC03866",
"func": "F021201",
"targ": null,
"compound": "D1464: JW47",
"paper": "324",
"func_act": "",
"targ_act": "",
"dose": "200nM",
"time": "",
"method": " ATP production ( Cell Titer Glo reagent)",
"species": "rat",
"animal_model": "rat cortical neurons and isolated rat liver mitochondria",
"criteria": "",
"result": false
},
{
"rec_id": "RC03867",
"func": "F021201",
"targ": null,
"compound": "D0261: Cyclosporin A",
"paper": "324",
"func_act": "",
"targ_act": "",
"dose": "1 μM",
"time": "",
"method": " ATP production ( Cell Titer Glo reagent)",
"species": "rat",
"animal_model": "rat cortical neurons and isolated rat liver mitochondria",
"criteria": "",
"result": false
},
{
"rec_id": "RC03868",
"func": "F020102",
"targ": null,
"compound": "D1464: JW47",
"paper": "324",
"func_act": "",
"targ_act": "",
"dose": "200nM",
"time": "",
"method": "oxygen consumption (Oroboros Oxygraph-2K)",
"species": "rat",
"animal_model": "rat cortical neurons and isolated rat liver mitochondria",
"criteria": "",
"result": false
},
{
"rec_id": "RC03869",
"func": "F020102",
"targ": null,
"compound": "D0261: Cyclosporin A",
"paper": "324",
"func_act": "",
"targ_act": "",
"dose": "1 μM",
"time": "",
"method": "oxygen consumption (Oroboros Oxygraph-2K)",
"species": "rat",
"animal_model": "rat cortical neurons and isolated rat liver mitochondria",
"criteria": "",
"result": false
},
{
"rec_id": "RC03870",
"func": "F01",
"targ": null,
"compound": "D1464: JW47",
"paper": "324",
"func_act": "",
"targ_act": "",
"dose": "1 μM",
"time": "",
"method": "mitochondrial membrane potential was measured in tetramethylrhodamine methyl ester (TMRM)-loaded neurons using ImageXpress MicroXL, and in rhodamine-123 loaded isolated mitochondria using a fluorescent plate reader",
"species": "rat",
"animal_model": "rat cortical neurons and isolated rat liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC03875",
"func": "F030801",
"targ": "T260",
"compound": "D1415: Xanthohumol",
"paper": "283",
"func_act": "block",
"targ_act": "ligand",
"dose": "30μM",
"time": "24hr",
"method": "using the MAP1LC3II/I ratio to monitor the autophagic flux; quantifiedPMPCB staining ",
"species": "",
"animal_model": "MCF7 cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC03876",
"func": "F0108",
"targ": null,
"compound": "D0331: Clofarabine",
"paper": "284",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03877",
"func": "F0604",
"targ": null,
"compound": "D1414: doxycycline",
"paper": "285",
"func_act": "inhibitor",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "",
"animal_model": "143B osteosarcoma cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC03878",
"func": "F031001",
"targ": null,
"compound": "D1414: doxycycline",
"paper": "285",
"func_act": "inhibitor",
"targ_act": "",
"dose": "15 µg/ml",
"time": "6 days",
"method": "BN PAGE analysis, In-gel complex I activity and western blotting ",
"species": "",
"animal_model": "143B osteosarcoma cells ",
"criteria": "",
"result": true
},
{
"rec_id": "RC03879",
"func": "F031001",
"targ": null,
"compound": "D0023: Chloramphenicol",
"paper": "286",
"func_act": "inhibitor",
"targ_act": "",
"dose": "50 μg/ml",
"time": "5 days",
"method": "Blue Native Gel",
"species": "",
"animal_model": "143B osteosarcoma cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC03880",
"func": "F031001",
"targ": null,
"compound": "D0023: Chloramphenicol",
"paper": "287",
"func_act": "inhibitor",
"targ_act": "",
"dose": "50µg/mL",
"time": "4 days",
"method": "complex I de novo assembly analysed by BN-PAGE",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03881",
"func": "F0604",
"targ": null,
"compound": "D0023: Chloramphenicol",
"paper": "288",
"func_act": "inhibitor",
"targ_act": "",
"dose": "",
"time": "",
"method": "haplo-insufficiency profiling (HIP), a well-validated chemical genomics platform developed in the yeast S. Cerevisiae.",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03882",
"func": "F0604",
"targ": null,
"compound": "D0077: Linezolid",
"paper": "288",
"func_act": "inhibitor",
"targ_act": "",
"dose": "",
"time": "",
"method": "haplo-insufficiency profiling (HIP), a well-validated chemical genomics platform developed in the yeast S. Cerevisiae.",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03883",
"func": "F0604",
"targ": null,
"compound": "D1417: tigecycline",
"paper": "288",
"func_act": "inhibitor",
"targ_act": "",
"dose": "",
"time": "",
"method": "haplo-insufficiency profiling (HIP), a well-validated chemical genomics platform developed in the yeast S. Cerevisiae.",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03884",
"func": "F0604",
"targ": null,
"compound": "D1417: tigecycline",
"paper": "288",
"func_act": "inhibitor",
"targ_act": "",
"dose": "2.5-10μM",
"time": "48hr",
"method": "weatern blot (protein levels of Cox-1, Cox-2, Cox-4, Grp78, XIAP, Actin, and tubulin)",
"species": "",
"animal_model": "TEX, OCI-AML2, and two AML patients' cells ",
"criteria": "",
"result": true
},
{
"rec_id": "RC03885",
"func": "F0221",
"targ": null,
"compound": "D1416: MG-132",
"paper": "289",
"func_act": "deplete GSH",
"targ_act": "",
"dose": "20 μM",
"time": "24 hr",
"method": "The total glutathione (reduced form GSH + oxidized form GSSG) was determined using glutathione reductase",
"species": "rat",
"animal_model": "PC12 cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC03886",
"func": "F0504",
"targ": null,
"compound": "D1416: MG-132",
"paper": "289",
"func_act": "increase",
"targ_act": "",
"dose": "20 μM",
"time": "24 hr",
"method": "Measurement of intracellular ROS formation with DCFH2-DA",
"species": "rat",
"animal_model": "PC12 cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC03887",
"func": "F070104",
"targ": null,
"compound": "D1416: MG-132",
"paper": "289",
"func_act": "increase",
"targ_act": "",
"dose": "20 μM",
"time": "24 hr",
"method": "Measurement of caspase-3 activity with ApoAlert™ CPP32/Caspase-3 assay kit",
"species": "rat",
"animal_model": "PC12 cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC03888",
"func": "F070105",
"targ": null,
"compound": "D1416: MG-132",
"paper": "289",
"func_act": "increase",
"targ_act": "",
"dose": "20 μM",
"time": "24 hr",
"method": "Measurement of cytochrome c release using a solid-phase, enzyme-linked immunosorbent assay kit for the detection of cytochrome c.",
"species": "rat",
"animal_model": "PC12 cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC03889",
"func": "F0221",
"targ": null,
"compound": "D1418: 3-morpholinosydnonimine",
"paper": "289",
"func_act": "restore GSH",
"targ_act": "",
"dose": "150 μM",
"time": "24 hr",
"method": "The total glutathione (reduced form GSH + oxidized form GSSG) was determined using glutathione reductase",
"species": "rat",
"animal_model": "PC12 cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC03890",
"func": "F0504",
"targ": null,
"compound": "D1418: 3-morpholinosydnonimine",
"paper": "289",
"func_act": "decrease",
"targ_act": "",
"dose": "150 μM",
"time": "24 hr",
"method": "Measurement of intracellular ROS formation with DCFH2-DA",
"species": "rat",
"animal_model": "PC12 cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC03891",
"func": "F021001",
"targ": null,
"compound": "D1416: MG-132",
"paper": "291",
"func_act": "increase",
"targ_act": "",
"dose": "20 μM",
"time": "6 hr",
"method": "Total ubiquitin, Lysine 48-linked polyubiquitin and Lysine 63-linked polyubiquitin levels were assessed in whole cell extracts by western blotting.",
"species": "",
"animal_model": "HeLa cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC03892",
"func": "F030603",
"targ": null,
"compound": "D1416: MG-132",
"paper": "291",
"func_act": "induce",
"targ_act": "",
"dose": "20 μM",
"time": "6 hr",
"method": "The cells were stained with MitoTracker Green FM and MitoSOX Red dyes followed by image acquisition on a confocal microscope.",
"species": "",
"animal_model": "HeLa cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC03893",
"func": "F0201",
"targ": null,
"compound": "D1416: MG-132",
"paper": "291",
"func_act": "inhibit",
"targ_act": "",
"dose": "20 μM",
"time": "6 hr",
"method": "Mitochondrial respiration was calculated by measuring oxygen consumption rate (OCR) and proton flux under a series of conditions using a Seahorse Flux analyzer.",
"species": "",
"animal_model": "HeLa cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC03894",
"func": "F030801",
"targ": null,
"compound": "D1416: MG-132",
"paper": "291",
"func_act": "",
"targ_act": "",
"dose": "20 μM",
"time": "6 hr",
"method": "mitophagy fluorescence reporter Mitokeima",
"species": "",
"animal_model": "HeLa cells",
"criteria": "",
"result": false
},
{
"rec_id": "RC03896",
"func": "F010401",
"targ": null,
"compound": "D1419: Cinnamic anilides",
"paper": "290",
"func_act": "induce",
"targ_act": "",
"dose": "",
"time": "",
"method": "swellilng assay, Rhodamine 123 (Rh123) uptake assay, Calcium retention capacity assay",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC03897",
"func": "F030604",
"targ": null,
"compound": "D1420: Hydrazine",
"paper": "292",
"func_act": "induce",
"targ_act": "",
"dose": "2 mM",
"time": "22-24 h",
"method": "",
"species": "",
"animal_model": "primary culture rat hepatocytes, RL-34(JCRB 0247), COS-1(JCRB 9082) IAR-20(JCRB 0610)",
"criteria": "",
"result": true
},
{
"rec_id": "RC03898",
"func": "F030604",
"targ": null,
"compound": "D0183: H2O2",
"paper": "292",
"func_act": "induce",
"targ_act": "",
"dose": "0.2mM",
"time": "22hr",
"method": "",
"species": "",
"animal_model": "rimary culture rat hepatocytes, RL-34,COS-1, IAR-20",
"criteria": "",
"result": true
},
{
"rec_id": "RC03899",
"func": "F030604",
"targ": null,
"compound": "D0023: Chloramphenicol",
"paper": "292",
"func_act": "induce",
"targ_act": "",
"dose": "200-300µg/ml",
"time": "22hr",
"method": "",
"species": "",
"animal_model": "primary culture rat hepatocytes, RL-34,COS-1, IAR-20",
"criteria": "",
"result": true
},
{
"rec_id": "RC03900",
"func": "F030604",
"targ": null,
"compound": "D0179: Ethidium Bromide",
"paper": "292",
"func_act": "induce",
"targ_act": "",
"dose": "200-300 µg/ml, 2",
"time": "22h",
"method": "",
"species": "",
"animal_model": "RL-34, COS-1, IAR-20L cells (mouse fibrob-lasts)",
"criteria": "",
"result": true
},
{
"rec_id": "RC03901",
"func": "F030604",
"targ": null,
"compound": "D1421: Erythromycin",
"paper": "292",
"func_act": "induce",
"targ_act": "",
"dose": "200 µg/ml",
"time": "22 h",
"method": "",
"species": "",
"animal_model": "primary culture rat hepatocytes, RL-34,COS-1, IAR-20",
"criteria": "",
"result": true
},
{
"rec_id": "RC03902",
"func": "F030604",
"targ": null,
"compound": "D0069: Indomethacin",
"paper": "292",
"func_act": "induce",
"targ_act": "",
"dose": "0.3-0.5 mM",
"time": "22 h",
"method": "",
"species": "",
"animal_model": "primary culture rat hep-atocytes, RL-34,COS-1, IAR-20",
"criteria": "",
"result": true
},
{
"rec_id": "RC03903",
"func": "F030604",
"targ": null,
"compound": "D0178: Ethanol",
"paper": "292",
"func_act": "induce",
"targ_act": "",
"dose": "12.5-500 mM",
"time": "5min",
"method": "",
"species": "rat",
"animal_model": "cardiac myocytes",
"criteria": "",
"result": true
},
{
"rec_id": "RC03904",
"func": "F030604",
"targ": null,
"compound": "D0178: Ethanol",
"paper": "292",
"func_act": "induce",
"targ_act": "",
"dose": "1-3%",
"time": "6hr",
"method": "",
"species": "",
"animal_model": "RL-34",
"criteria": "",
"result": true
}
]
}
