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"time": "",
"method": "evaluate mitochondrial calcium loading capacity using the fluorescence probe Calcium Green 5N",
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"criteria": "",
"result": true
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"criteria": "EC20",
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"compound": "D1295: Amoxicillin",
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"criteria": "EC20",
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"compound": "D1297: Antipyrine",
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"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
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"func": "F0303",
"targ": null,
"compound": "D0008: Arsenic trioxide",
"paper": "36",
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"animal_model": "liver mitochondria",
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"func": "F0303",
"targ": null,
"compound": "D1298: Biotin",
"paper": "36",
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"dose": "5.6 µM",
"time": "30 mins",
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"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
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"func": "F0303",
"targ": null,
"compound": "D1299: lumiracoxib",
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"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
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"func": "F0303",
"targ": null,
"compound": "D0805: bisacodyl",
"paper": "36",
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"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
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"targ": null,
"compound": "D0913: estradiol acetate",
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"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
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"compound": "D0016: Bupivacaine",
"paper": "36",
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"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
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{
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"func": "F0303",
"targ": null,
"compound": "D0752: Busulfan",
"paper": "36",
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"species": "mouse",
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"compound": "D1357: Butein",
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"criteria": "EC20",
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"compound": "D1390: Caffeine",
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"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
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"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
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"compound": "D1375: Carbamazepine",
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"compound": "D1392: Chlorambucil",
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"species": "mouse",
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"compound": "D0259: Ciprofloxacin",
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"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
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"compound": "D1393: Clodronate",
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"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
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"compound": "D0422: Clotrimazole",
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"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
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"compound": "D0859: curcumin",
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"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
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{
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"targ": null,
"compound": "D0036: Daunorubicin",
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"time": "30 mins",
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"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
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"targ": null,
"compound": "D0871: dexamethasone valerate",
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"species": "mouse",
"animal_model": "liver mitochondria",
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"compound": "D0262: Diazoxide",
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"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04063",
"func": "F0303",
"targ": null,
"compound": "D0417: Fluconazole",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 400 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04064",
"func": "F0303",
"targ": null,
"compound": "D0057: Flufenamic Acid",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 200 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04065",
"func": "F0303",
"targ": null,
"compound": "D0062: Flutamide",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 800 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04067",
"func": "F0303",
"targ": null,
"compound": "D0440: gefitinib",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "63.6 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04068",
"func": "F0303",
"targ": null,
"compound": "D0951: genistein",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 200 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04070",
"func": "F0303",
"targ": null,
"compound": "D0266: Glimepiride",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "ND",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04071",
"func": "F0303",
"targ": null,
"compound": "D0268: Gossypol",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 10 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04268",
"func": null,
"targ": "T408",
"compound": "D0003: Acetaminophen",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 400 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04073",
"func": "F0303",
"targ": null,
"compound": "D0065: Ibuprofen",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 200 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04074",
"func": "F0303",
"targ": null,
"compound": "D1377: Imatinib",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "ND",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04075",
"func": "F0303",
"targ": null,
"compound": "D0461: imipramine",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "274.4 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04076",
"func": "F0303",
"targ": null,
"compound": "D0069: Indomethacin",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 800 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04077",
"func": "F0303",
"targ": null,
"compound": "D0071: Isoniazid",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 800 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04078",
"func": "F0303",
"targ": null,
"compound": "D0073: Ketoconazole",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 400 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04079",
"func": "F0303",
"targ": null,
"compound": "D0075: Lamivudine",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 400 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04080",
"func": "F0303",
"targ": null,
"compound": "D0076: Lidocaine",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 800 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04081",
"func": "F0303",
"targ": null,
"compound": "D0364: Lonidamine",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "660 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04082",
"func": "F0303",
"targ": null,
"compound": "D0467: lovastatin",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "71.5 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04083",
"func": "F0303",
"targ": null,
"compound": "D1299: lumiracoxib",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 200 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04084",
"func": "F0303",
"targ": null,
"compound": "D0192: Manganese",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 800 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04085",
"func": "F0303",
"targ": null,
"compound": "D0078: Mefenamic acid",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 400 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04087",
"func": "F0303",
"targ": null,
"compound": "D0080: Metformin",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 400 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04091",
"func": "F0303",
"targ": null,
"compound": "D0083: Mitomycin",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "ND",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04092",
"func": "F0303",
"targ": null,
"compound": "D0084: Mitoxantrone",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "ND",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04097",
"func": "F0303",
"targ": null,
"compound": "D0091: Nicotine",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 400 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04098",
"func": "F0303",
"targ": null,
"compound": "D1015: nifuroxazide",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 400 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04100",
"func": "F0303",
"targ": null,
"compound": "D0092: Nimesulide",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 200 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04101",
"func": "F0303",
"targ": null,
"compound": "D0377: Nitrofurantoin",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 800 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04105",
"func": "F0303",
"targ": null,
"compound": "D0096: Perhexiline",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "14.8 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04108",
"func": "F0303",
"targ": null,
"compound": "D0099: Piroxicam",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 200 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04109",
"func": "F0303",
"targ": null,
"compound": "D0442: pravastatin",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 200 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04110",
"func": "F0303",
"targ": null,
"compound": "D1071: propylparaben",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 800 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04112",
"func": "F0303",
"targ": null,
"compound": "D0391: Pyrazinamide",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 400 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04269",
"func": null,
"targ": "T408",
"compound": "D0010: Acetylsalicylic acid",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 200 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04114",
"func": "F0303",
"targ": null,
"compound": "D0398: resveratrol",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 200 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04115",
"func": "F0303",
"targ": null,
"compound": "D1083: riboflavin",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "672.3 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04116",
"func": "F0303",
"targ": null,
"compound": "D1084: rifampicin",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 800 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04117",
"func": "F0303",
"targ": null,
"compound": "D0474: ritonavir",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "ND",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04120",
"func": "F0303",
"targ": null,
"compound": "D0109: Salicylic acid",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 400 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04122",
"func": "F0303",
"targ": null,
"compound": "D0111: Simvastatin",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "173.2 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04123",
"func": "F0303",
"targ": null,
"compound": "D1098: sorafenib",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "ND",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04128",
"func": "F0303",
"targ": null,
"compound": "D0115: Sulindac",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 200 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04131",
"func": "F0303",
"targ": null,
"compound": "D0116: Tamoxifen",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "9 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04135",
"func": "F0303",
"targ": null,
"compound": "D0121: Tolcapone",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 400 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04137",
"func": "F0303",
"targ": null,
"compound": "D0122: Tolfenamic Acid",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 800 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04138",
"func": "F0303",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 200 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04140",
"func": "F0303",
"targ": null,
"compound": "D0126: Valproic Acid",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 800 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04143",
"func": "F0303",
"targ": null,
"compound": "D0128: Zidovudine",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "> 200 µM",
"time": "30 mins",
"method": "swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling )",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04144",
"func": "F0108",
"targ": null,
"compound": "D0003: Acetaminophen",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "> 200 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04145",
"func": "F0108",
"targ": null,
"compound": "D0010: Acetylsalicylic acid",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "335.5 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04146",
"func": "F0108",
"targ": null,
"compound": "D0465: alpidem",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "83.7 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04147",
"func": "F0108",
"targ": null,
"compound": "D1293: Amantadine",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "261.2 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04148",
"func": "F0108",
"targ": null,
"compound": "D1294: Ambroxol",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "> 200 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
}
]
}
