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"targ": null,
"compound": "D0005: Amiodarone",
"paper": "4",
"func_act": "increase",
"targ_act": "",
"dose": "1 μmol/L",
"time": "8 hours",
"method": "Apoptosis measurement",
"species": "rat; Sprague–Dawley",
"animal_model": "hepatocytes",
"criteria": "p < 0.05",
"result": false
},
{
"rec_id": "RC00435",
"func": "F070102",
"targ": null,
"compound": "D0005: Amiodarone",
"paper": "4",
"func_act": "increase",
"targ_act": "",
"dose": "100 μmol/L",
"time": "8 hours",
"method": "Apoptosis measurement",
"species": "rat; Sprague–Dawley",
"animal_model": "hepatocytes",
"criteria": "p < 0.05",
"result": true
},
{
"rec_id": "RC00436",
"func": "F070102",
"targ": null,
"compound": "D0418: benzarone",
"paper": "4",
"func_act": "increase",
"targ_act": "",
"dose": "1 μmol/L",
"time": "8 hours",
"method": "Apoptosis measurement",
"species": "rat; Sprague–Dawley",
"animal_model": "hepatocytes",
"criteria": "p < 0.05",
"result": false
},
{
"rec_id": "RC00437",
"func": "F070102",
"targ": null,
"compound": "D0418: benzarone",
"paper": "4",
"func_act": "increase",
"targ_act": "",
"dose": "100 μmol/L",
"time": "8 hours",
"method": "Apoptosis measurement",
"species": "rat; Sprague–Dawley",
"animal_model": "hepatocytes",
"criteria": "p < 0.05",
"result": true
},
{
"rec_id": "RC00438",
"func": "F070102",
"targ": null,
"compound": "D0419: benzbromarone",
"paper": "4",
"func_act": "increase",
"targ_act": "",
"dose": "1 μmol/L",
"time": "8 hours",
"method": "Apoptosis measurement",
"species": "rat; Sprague–Dawley",
"animal_model": "hepatocytes",
"criteria": "p < 0.05",
"result": false
},
{
"rec_id": "RC00439",
"func": "F070102",
"targ": null,
"compound": "D0419: benzbromarone",
"paper": "4",
"func_act": "increase",
"targ_act": "",
"dose": "100 μmol/L",
"time": "8 hours",
"method": "Apoptosis measurement",
"species": "rat; Sprague–Dawley",
"animal_model": "hepatocytes",
"criteria": "p < 0.01",
"result": true
},
{
"rec_id": "RC00440",
"func": "F070102",
"targ": null,
"compound": "D0421: 2‐Butylbenzofuran",
"paper": "4",
"func_act": "increase",
"targ_act": "",
"dose": "1 μmol/L",
"time": "8 hours",
"method": "Apoptosis measurement",
"species": "rat; Sprague–Dawley",
"animal_model": "hepatocytes",
"criteria": "p < 0.05",
"result": false
},
{
"rec_id": "RC00441",
"func": "F070102",
"targ": null,
"compound": "D0421: 2‐Butylbenzofuran",
"paper": "4",
"func_act": "increase",
"targ_act": "",
"dose": "100 μmol/L",
"time": "8 hours",
"method": "Apoptosis measurement",
"species": "rat; Sprague–Dawley",
"animal_model": "hepatocytes",
"criteria": "p < 0.05",
"result": false
},
{
"rec_id": "RC00442",
"func": "F070102",
"targ": null,
"compound": "D0420: Benzofuran",
"paper": "4",
"func_act": "increase",
"targ_act": "",
"dose": "1 μmol/L",
"time": "8 hours",
"method": "Apoptosis measurement",
"species": "rat; Sprague–Dawley",
"animal_model": "hepatocytes",
"criteria": "p < 0.05",
"result": false
},
{
"rec_id": "RC00443",
"func": "F070102",
"targ": null,
"compound": "D0420: Benzofuran",
"paper": "4",
"func_act": "increase",
"targ_act": "",
"dose": "100 μmol/L",
"time": "8 hours",
"method": "Apoptosis measurement",
"species": "rat; Sprague–Dawley",
"animal_model": "hepatocytes",
"criteria": "p < 0.05",
"result": false
},
{
"rec_id": "RC00444",
"func": "F070101",
"targ": null,
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "",
"dose": "30 μmol/L",
"time": "24 hours",
"method": "Apoptosis measurement",
"species": "human",
"animal_model": "CAL27",
"criteria": "p < 0.05",
"result": true
},
{
"rec_id": "RC00445",
"func": "F070101",
"targ": null,
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "",
"dose": "30 μmol/L",
"time": "24 hours",
"method": "Apoptosis measurement",
"species": "human",
"animal_model": "SCC25",
"criteria": "p < 0.05",
"result": true
},
{
"rec_id": "RC00446",
"func": "F070101",
"targ": null,
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "",
"dose": "30 μmol/L",
"time": "24 hours",
"method": "Apoptosis measurement",
"species": "human",
"animal_model": "UM1",
"criteria": "p < 0.05",
"result": true
},
{
"rec_id": "RC00447",
"func": "F070101",
"targ": null,
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "",
"dose": "40 μmol/L",
"time": "24 hours",
"method": "Apoptosis measurement",
"species": "human",
"animal_model": "CAL27",
"criteria": "p < 0.01",
"result": true
},
{
"rec_id": "RC00448",
"func": "F070101",
"targ": null,
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "",
"dose": "40 μmol/L",
"time": "24 hours",
"method": "Apoptosis measurement",
"species": "human",
"animal_model": "SCC25",
"criteria": "p < 0.01",
"result": true
},
{
"rec_id": "RC00449",
"func": "F070101",
"targ": null,
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "",
"dose": "40 μmol/L",
"time": "24 hours",
"method": "Apoptosis measurement",
"species": "human",
"animal_model": "UM1",
"criteria": "p < 0.01",
"result": true
},
{
"rec_id": "RC00450",
"func": "F070102",
"targ": null,
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "",
"dose": "30 μmol/L",
"time": "24 hours",
"method": "Apoptosis measurement",
"species": "human",
"animal_model": "CAL27",
"criteria": "p < 0.05",
"result": true
},
{
"rec_id": "RC03601",
"func": "F0402",
"targ": null,
"compound": "D0232: Sodium Azide",
"paper": "217",
"func_act": "decrease",
"targ_act": "",
"dose": "25 mM",
"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC00451",
"func": "F070102",
"targ": null,
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "",
"dose": "30 μmol/L",
"time": "24 hours",
"method": "Apoptosis measurement",
"species": "human",
"animal_model": "SCC25",
"criteria": "p < 0.05",
"result": true
},
{
"rec_id": "RC00452",
"func": "F070102",
"targ": null,
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "",
"dose": "30 μmol/L",
"time": "24 hours",
"method": "Apoptosis measurement",
"species": "human",
"animal_model": "UM1",
"criteria": "p < 0.05",
"result": true
},
{
"rec_id": "RC00453",
"func": "F070102",
"targ": null,
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "",
"dose": "40 μmol/L",
"time": "24 hours",
"method": "Apoptosis measurement",
"species": "human",
"animal_model": "CAL27",
"criteria": "p < 0.01",
"result": true
},
{
"rec_id": "RC00454",
"func": "F070102",
"targ": null,
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "",
"dose": "40 μmol/L",
"time": "24 hours",
"method": "Apoptosis measurement",
"species": "human",
"animal_model": "SCC25",
"criteria": "p < 0.01",
"result": true
},
{
"rec_id": "RC00455",
"func": "F070102",
"targ": null,
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "",
"dose": "40 μmol/L",
"time": "24 hours",
"method": "Apoptosis measurement",
"species": "human",
"animal_model": "UM1",
"criteria": "p < 0.01",
"result": true
},
{
"rec_id": "RC00456",
"func": "F0701",
"targ": "T403",
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "inhibitor",
"dose": "40 µM",
"time": "12 hours",
"method": "western blot",
"species": "human",
"animal_model": "CAL27",
"criteria": "2.1875-fold decrease",
"result": true
},
{
"rec_id": "RC00457",
"func": "F0701",
"targ": "T403",
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "inhibitor",
"dose": "40 µM",
"time": "12 hours",
"method": "western blot",
"species": "human",
"animal_model": "UM1",
"criteria": "1.35-fold decrease",
"result": true
},
{
"rec_id": "RC00458",
"func": "F0701",
"targ": "T403",
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "inhibitor",
"dose": "40 µM",
"time": "24 hours",
"method": "western blot",
"species": "human",
"animal_model": "CAL27",
"criteria": "3.1818-fold decrease",
"result": true
},
{
"rec_id": "RC00459",
"func": "F0701",
"targ": "T403",
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "inhibitor",
"dose": "40 µM",
"time": "24 hours",
"method": "western blot",
"species": "human",
"animal_model": "UM1",
"criteria": "1.5-fold decrease",
"result": true
},
{
"rec_id": "RC00460",
"func": "F0701",
"targ": "T403",
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "inhibitor",
"dose": "40 µM",
"time": "48 hours",
"method": "western blot",
"species": "human",
"animal_model": "CAL27",
"criteria": "3.3333-fold decrease",
"result": true
},
{
"rec_id": "RC00461",
"func": "F0701",
"targ": "T403",
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "inhibitor",
"dose": "40 µM",
"time": "48 hours",
"method": "western blot",
"species": "human",
"animal_model": "UM1",
"criteria": "1.5882-fold decrease",
"result": true
},
{
"rec_id": "RC00462",
"func": "F0701",
"targ": "T404",
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "activate",
"dose": "40 µM",
"time": "12 hours",
"method": "western blot",
"species": "human",
"animal_model": "CAL27",
"criteria": "1.3953-fold increase",
"result": true
},
{
"rec_id": "RC00463",
"func": "F0701",
"targ": "T404",
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "activate",
"dose": "40 µM",
"time": "12 hours",
"method": "western blot",
"species": "human",
"animal_model": "UM1",
"criteria": "No increase",
"result": false
},
{
"rec_id": "RC00464",
"func": "F0701",
"targ": "T404",
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "activate",
"dose": "40 µM",
"time": "24 hours",
"method": "western blot",
"species": "human",
"animal_model": "CAL27",
"criteria": "1.3953-fold increase",
"result": true
},
{
"rec_id": "RC00465",
"func": "F0701",
"targ": "T404",
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "activate",
"dose": "40 µM",
"time": "24 hours",
"method": "western blot",
"species": "human",
"animal_model": "UM1",
"criteria": "1.2623-fold increase",
"result": true
},
{
"rec_id": "RC00466",
"func": "F0701",
"targ": "T404",
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "activate",
"dose": "40 µM",
"time": "48 hours",
"method": "western blot",
"species": "human",
"animal_model": "CAL27",
"criteria": "2.3256-fold increase",
"result": true
},
{
"rec_id": "RC00467",
"func": "F0701",
"targ": "T404",
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "activate",
"dose": "40 µM",
"time": "48 hours",
"method": "western blot",
"species": "human",
"animal_model": "UM1",
"criteria": "1.6223-fold increase",
"result": true
},
{
"rec_id": "RC00468",
"func": "F0701",
"targ": "T403",
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "inhibitor",
"dose": "150 mg/kg/day ",
"time": "6 days a week for two weeks",
"method": "Immunohistochemistry",
"species": "human",
"animal_model": "CAL27(xenograft tumors)/mouse",
"criteria": "1.5-fold decrease",
"result": true
},
{
"rec_id": "RC00469",
"func": "F0701",
"targ": "T404",
"compound": "D0422: Clotrimazole",
"paper": "5",
"func_act": "increase",
"targ_act": "activate",
"dose": "150 mg/kg/day ",
"time": "6 days a week for two weeks",
"method": "western blot analysis",
"species": "human",
"animal_model": "CAL27(xenograft tumors)/mouse",
"criteria": "2.0-fold increase",
"result": true
},
{
"rec_id": "RC00470",
"func": "F0104",
"targ": null,
"compound": "D0038: Diclofenac",
"paper": "6",
"func_act": "increase",
"targ_act": "",
"dose": "12.5 μmol/L",
"time": "10 minutes",
"method": "Assessment of MPT",
"species": "rat",
"animal_model": "liver mitochondria",
"criteria": "not mentioned",
"result": true
},
{
"rec_id": "RC00471",
"func": "F0104",
"targ": null,
"compound": "D0038: Diclofenac",
"paper": "6",
"func_act": "increase",
"targ_act": "",
"dose": "25 μmol/L",
"time": "10 minutes",
"method": "Assessment of MPT",
"species": "rat",
"animal_model": "liver mitochondria",
"criteria": "not mentioned",
"result": true
},
{
"rec_id": "RC00472",
"func": "F0104",
"targ": null,
"compound": "D0038: Diclofenac",
"paper": "6",
"func_act": "increase",
"targ_act": "",
"dose": "50 μmol/L",
"time": "10 minutes",
"method": "Assessment of MPT",
"species": "rat",
"animal_model": "liver mitochondria",
"criteria": "not mentioned",
"result": true
},
{
"rec_id": "RC00473",
"func": "F0104",
"targ": null,
"compound": "D0038: Diclofenac",
"paper": "6",
"func_act": "increase",
"targ_act": "",
"dose": "100 μmol/L",
"time": "10 minutes",
"method": "Assessment of MPT",
"species": "rat",
"animal_model": "liver mitochondria",
"criteria": "not mentioned",
"result": true
},
{
"rec_id": "RC00474",
"func": "F02110302",
"targ": null,
"compound": "D0038: Diclofenac",
"paper": "6",
"func_act": "decrease",
"targ_act": "",
"dose": "50 μmol/L",
"time": "2 minutes",
"method": "Assessment of Mitochondrial Ca2+ Efflux; Energized with succinate",
"species": "rat",
"animal_model": "liver mitochondria",
"criteria": "not mentioned",
"result": true
},
{
"rec_id": "RC00475",
"func": "F02110302",
"targ": null,
"compound": "D0261: Cyclosporin A",
"paper": "6",
"func_act": "decrease",
"targ_act": "",
"dose": "1 μmol/L",
"time": "2 minutes",
"method": "Assessment of Mitochondrial Ca2+ Efflux; Incubated in the presence of Diclofenac(50 μmol/L); Energized with succinate",
"species": "rat",
"animal_model": "liver mitochondria",
"criteria": "not mentioned",
"result": false
},
{
"rec_id": "RC00476",
"func": "F02110302",
"targ": null,
"compound": "D0426: DPPD",
"paper": "6",
"func_act": "decrease",
"targ_act": "",
"dose": "1 μmol/L",
"time": "2 minutes",
"method": "Assessment of Mitochondrial Ca2+ Efflux; Incubated in the presence of Diclofenac(50 μmol/L); Energized with succinate",
"species": "rat",
"animal_model": "liver mitochondria",
"criteria": "not mentioned",
"result": false
},
{
"rec_id": "RC00477",
"func": "F0108",
"targ": null,
"compound": "D0038: Diclofenac",
"paper": "6",
"func_act": "decrease",
"targ_act": "",
"dose": "50 μmol/L",
"time": "3 minutes",
"method": "Assessment of Mitochondrial Membrane Potential; incubated in the presence of Ca2+",
"species": "rat",
"animal_model": "liver mitochondria",
"criteria": "p < 0.01",
"result": true
},
{
"rec_id": "RC00478",
"func": "F0108",
"targ": null,
"compound": "D0038: Diclofenac",
"paper": "6",
"func_act": "decrease",
"targ_act": "",
"dose": "50 μmol/L",
"time": "3 minutes",
"method": "Assessment of Mitochondrial Membrane Potential; incubated in the absence of Ca2+",
"species": "rat",
"animal_model": "liver mitochondria",
"criteria": "p < 0.05",
"result": false
},
{
"rec_id": "RC00479",
"func": "F0101",
"targ": null,
"compound": "D0261: Cyclosporin A",
"paper": "6",
"func_act": "decrease",
"targ_act": "",
"dose": "1 μmol/L",
"time": "3 minutes",
"method": "Assessment of Mitochondrial Membrane Potential; coincubated with diclofenac",
"species": "rat",
"animal_model": "liver mitochondria",
"criteria": "p < 0.05",
"result": true
},
{
"rec_id": "RC00480",
"func": "F0101",
"targ": null,
"compound": "D0426: DPPD",
"paper": "6",
"func_act": "decrease",
"targ_act": "",
"dose": "1 μmol/L",
"time": "3 minutes",
"method": "Assessment of Mitochondrial Membrane Potential; coincubated with diclofenac",
"species": "rat",
"animal_model": "liver mitochondria",
"criteria": "p < 0.05",
"result": true
}
]
}
