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"dose": "339.5 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04205",
"func": "F0108",
"targ": null,
"compound": "D0364: Lonidamine",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "138.1 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04206",
"func": "F0108",
"targ": null,
"compound": "D0467: lovastatin",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "43.6 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04207",
"func": "F0108",
"targ": null,
"compound": "D1299: lumiracoxib",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "148.8 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04208",
"func": "F0108",
"targ": null,
"compound": "D0192: Manganese",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "> 800 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04209",
"func": "F0108",
"targ": null,
"compound": "D0078: Mefenamic acid",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "49.7 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04211",
"func": "F0108",
"targ": null,
"compound": "D0080: Metformin",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "388.4 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04215",
"func": "F0108",
"targ": null,
"compound": "D0083: Mitomycin",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "> 200 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04216",
"func": "F0108",
"targ": null,
"compound": "D0084: Mitoxantrone",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "7 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04221",
"func": "F0108",
"targ": null,
"compound": "D0091: Nicotine",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "> 400 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04222",
"func": "F0108",
"targ": null,
"compound": "D1015: nifuroxazide",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "388.2 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04224",
"func": "F0108",
"targ": null,
"compound": "D0092: Nimesulide",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "10.1 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04225",
"func": "F0108",
"targ": null,
"compound": "D0377: Nitrofurantoin",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "442.5 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04229",
"func": "F0108",
"targ": null,
"compound": "D0096: Perhexiline",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "3.2 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04232",
"func": "F0108",
"targ": null,
"compound": "D0099: Piroxicam",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "101.7 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04233",
"func": "F0108",
"targ": null,
"compound": "D0442: pravastatin",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "> 200 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04234",
"func": "F0108",
"targ": null,
"compound": "D1071: propylparaben",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "162.8 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04236",
"func": "F0108",
"targ": null,
"compound": "D0391: Pyrazinamide",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "> 400 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04238",
"func": "F0108",
"targ": null,
"compound": "D0398: resveratrol",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "395.4 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04239",
"func": "F0108",
"targ": null,
"compound": "D1083: riboflavin",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04240",
"func": "F0108",
"targ": null,
"compound": "D1084: rifampicin",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "> 800 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04241",
"func": "F0108",
"targ": null,
"compound": "D0474: ritonavir",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "24.8 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04244",
"func": "F0108",
"targ": null,
"compound": "D0109: Salicylic acid",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "304.3 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04246",
"func": "F0108",
"targ": null,
"compound": "D0111: Simvastatin",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "76.5 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04247",
"func": "F0108",
"targ": null,
"compound": "D1098: sorafenib",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "0.5 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04252",
"func": "F0108",
"targ": null,
"compound": "D0115: Sulindac",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "> 200 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04255",
"func": "F0108",
"targ": null,
"compound": "D0116: Tamoxifen",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "2.9 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04259",
"func": "F0108",
"targ": null,
"compound": "D0121: Tolcapone",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "3.9 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04261",
"func": "F0108",
"targ": null,
"compound": "D0122: Tolfenamic Acid",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "263.8 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04262",
"func": "F0108",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "3.4 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04264",
"func": "F0108",
"targ": null,
"compound": "D0126: Valproic Acid",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "267.2 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04267",
"func": "F0108",
"targ": null,
"compound": "D0128: Zidovudine",
"paper": "36",
"func_act": "decrease",
"targ_act": "",
"dose": "416.1 µM",
"time": "30 mins",
"method": "Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04270",
"func": null,
"targ": "T408",
"compound": "D0465: alpidem",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "394.7 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04271",
"func": null,
"targ": "T408",
"compound": "D1293: Amantadine",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 400 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04272",
"func": null,
"targ": "T408",
"compound": "D1294: Ambroxol",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 400 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04273",
"func": null,
"targ": "T408",
"compound": "D0005: Amiodarone",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "< 50 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04274",
"func": null,
"targ": "T408",
"compound": "D1295: Amoxicillin",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 400 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04275",
"func": null,
"targ": "T408",
"compound": "D1296: Ampicillin",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 400 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04276",
"func": null,
"targ": "T408",
"compound": "D1297: Antipyrine",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 400 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04277",
"func": null,
"targ": "T408",
"compound": "D0008: Arsenic trioxide",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 200 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04278",
"func": null,
"targ": "T408",
"compound": "D1298: Biotin",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "< 50 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04279",
"func": null,
"targ": "T408",
"compound": "D1299: lumiracoxib",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 400 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04280",
"func": null,
"targ": "T408",
"compound": "D0805: bisacodyl",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 400 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04281",
"func": null,
"targ": "T408",
"compound": "D0913: estradiol acetate",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 200 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04282",
"func": null,
"targ": "T408",
"compound": "D0016: Bupivacaine",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 800 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04283",
"func": null,
"targ": "T408",
"compound": "D0752: Busulfan",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 400 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04284",
"func": null,
"targ": "T408",
"compound": "D1357: Butein",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 200 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04285",
"func": null,
"targ": "T408",
"compound": "D1390: Caffeine",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 400 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04286",
"func": null,
"targ": "T408",
"compound": "D0325: Capsaicin",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 200 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04287",
"func": null,
"targ": "T408",
"compound": "D1375: Carbamazepine",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 400 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04288",
"func": null,
"targ": "T408",
"compound": "D1391: Cefixime",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 400 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04289",
"func": null,
"targ": "T408",
"compound": "D1392: Chlorambucil",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 200 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04290",
"func": null,
"targ": "T408",
"compound": "D0259: Ciprofloxacin",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 400 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04291",
"func": null,
"targ": "T408",
"compound": "D1393: Clodronate",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 400 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04292",
"func": null,
"targ": "T408",
"compound": "D0422: Clotrimazole",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 800 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04294",
"func": null,
"targ": "T408",
"compound": "D0859: curcumin",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 200 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04297",
"func": null,
"targ": "T408",
"compound": "D0036: Daunorubicin",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "47.2 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
}
]
}
