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"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04386",
"func": null,
"targ": "T408",
"compound": "D0124: Troglitazone",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 400 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04388",
"func": null,
"targ": "T408",
"compound": "D0126: Valproic Acid",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 800 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04391",
"func": null,
"targ": "T408",
"compound": "D0128: Zidovudine",
"paper": "36",
"func_act": "",
"targ_act": "release",
"dose": "> 200 µM",
"time": "30 mins",
"method": "Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline)",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04392",
"func": "F0201",
"targ": "T001",
"compound": "D0003: Acetaminophen",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "348.5 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04393",
"func": "F0201",
"targ": "T001",
"compound": "D0010: Acetylsalicylic acid",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "> 800 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04394",
"func": "F0201",
"targ": "T001",
"compound": "D0465: alpidem",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "25.6 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04395",
"func": "F0201",
"targ": "T001",
"compound": "D1293: Amantadine",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "> 400 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04396",
"func": "F0201",
"targ": "T001",
"compound": "D1294: Ambroxol",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "> 400 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04397",
"func": "F0201",
"targ": "T001",
"compound": "D0005: Amiodarone",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "45.92 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04398",
"func": "F0201",
"targ": null,
"compound": "D1295: Amoxicillin",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "90.8 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04399",
"func": "F0201",
"targ": "T001",
"compound": "D1296: Ampicillin",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "> 400 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04400",
"func": "F0201",
"targ": "T001",
"compound": "D1297: Antipyrine",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "> 400 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04401",
"func": "F0201",
"targ": "T001",
"compound": "D0008: Arsenic trioxide",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "< 50 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04402",
"func": "F0201",
"targ": "T001",
"compound": "D1298: Biotin",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "44.5 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04403",
"func": "F0201",
"targ": "T001",
"compound": "D1299: lumiracoxib",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "> 400 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04404",
"func": "F0201",
"targ": "T001",
"compound": "D0805: bisacodyl",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "50.9 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04405",
"func": "F0201",
"targ": "T001",
"compound": "D0913: estradiol acetate",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "> 200 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04406",
"func": "F0201",
"targ": "T001",
"compound": "D0016: Bupivacaine",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "60.6 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04407",
"func": "F0201",
"targ": "T001",
"compound": "D0752: Busulfan",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "169.8 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04408",
"func": "F0201",
"targ": "T001",
"compound": "D1357: Butein",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "29.6 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04409",
"func": "F0201",
"targ": "T001",
"compound": "D1390: Caffeine",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "> 400 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04410",
"func": "F0201",
"targ": "T001",
"compound": "D0325: Capsaicin",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "15 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04411",
"func": "F0201",
"targ": "T001",
"compound": "D1375: Carbamazepine",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "53.4 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04412",
"func": "F0201",
"targ": "T001",
"compound": "D1391: Cefixime",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "41.8 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04413",
"func": "F0201",
"targ": "T001",
"compound": "D1392: Chlorambucil",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "138.7 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04414",
"func": "F0201",
"targ": null,
"compound": "D0259: Ciprofloxacin",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "195.0 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04415",
"func": "F0201",
"targ": "T001",
"compound": "D1393: Clodronate",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "> 400 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04416",
"func": "F0201",
"targ": "T001",
"compound": "D0422: Clotrimazole",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "2.9 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04418",
"func": "F0201",
"targ": "T001",
"compound": "D0859: curcumin",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "> 200 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04421",
"func": "F0201",
"targ": "T001",
"compound": "D0036: Daunorubicin",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "12.8 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04422",
"func": "F0201",
"targ": "T001",
"compound": "D0871: dexamethasone valerate",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "> 200 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04423",
"func": "F0201",
"targ": "T001",
"compound": "D0262: Diazoxide",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "4.9 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04424",
"func": "F0201",
"targ": "T001",
"compound": "D0038: Diclofenac",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "9.1 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04425",
"func": "F0201",
"targ": "T001",
"compound": "D0040: Diflunisal",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "9.8 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04428",
"func": "F0201",
"targ": "T001",
"compound": "D0043: Doxorubicin",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "15.9 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04431",
"func": "F0201",
"targ": "T001",
"compound": "D0470: erlotinib",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "328.8 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04435",
"func": "F0201",
"targ": "T001",
"compound": "D0417: Fluconazole",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "> 400 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04436",
"func": "F0201",
"targ": "T001",
"compound": "D0057: Flufenamic Acid",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "1.7 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04437",
"func": "F0201",
"targ": "T001",
"compound": "D0062: Flutamide",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "ND",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04439",
"func": "F0201",
"targ": "T001",
"compound": "D0440: gefitinib",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "269.6 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04440",
"func": "F0201",
"targ": "T001",
"compound": "D0951: genistein",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "81.3 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04442",
"func": "F0201",
"targ": "T001",
"compound": "D0266: Glimepiride",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "16.6 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04443",
"func": "F0201",
"targ": "T001",
"compound": "D0268: Gossypol",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "30.3 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04445",
"func": "F0201",
"targ": "T001",
"compound": "D0065: Ibuprofen",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "170.1 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04446",
"func": "F0201",
"targ": "T001",
"compound": "D1377: Imatinib",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "ND",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04447",
"func": "F0201",
"targ": null,
"compound": "D0461: imipramine",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "75.5 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04448",
"func": "F0201",
"targ": "T001",
"compound": "D0069: Indomethacin",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "25.2 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04449",
"func": "F0201",
"targ": "T001",
"compound": "D0071: Isoniazid",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "59.8 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04450",
"func": "F0201",
"targ": "T001",
"compound": "D0073: Ketoconazole",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "> 400 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
}
]
}
