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{
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{
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{
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{
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{
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"compound": "D0126: Valproic Acid",
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{
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"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "ND",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04522",
"func": "F0201",
"targ": null,
"compound": "D1295: Amoxicillin",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "188.8 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04523",
"func": "F0201",
"targ": null,
"compound": "D1296: Ampicillin",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "161.2 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04524",
"func": "F0201",
"targ": "T002",
"compound": "D1297: Antipyrine",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "> 400 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04525",
"func": "F0201",
"targ": "T002",
"compound": "D0008: Arsenic trioxide",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "0.9 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04653",
"func": "F010401",
"targ": null,
"compound": "D0461: imipramine",
"paper": "306",
"func_act": "Decrease",
"targ_act": "",
"dose": "50 µM",
"time": "1 hour",
"method": "High-content screening assay",
"species": "Human",
"animal_model": "HepG2",
"criteria": "MEC",
"result": true
},
{
"rec_id": "RC04654",
"func": "F010401",
"targ": null,
"compound": "D1434: Maprotiline",
"paper": "306",
"func_act": "Decrease",
"targ_act": "",
"dose": "5 µM",
"time": "1 hour",
"method": "High-content screening assay",
"species": "Human",
"animal_model": "HepG2",
"criteria": "MEC",
"result": true
},
{
"rec_id": "RC04655",
"func": "F010401",
"targ": null,
"compound": "D0229: Rotenone",
"paper": "306",
"func_act": "Decrease",
"targ_act": "",
"dose": "5 µM",
"time": "1 hour",
"method": "High-content screening assay",
"species": "Human",
"animal_model": "HepG2",
"criteria": "MEC",
"result": true
},
{
"rec_id": "RC04526",
"func": "F0201",
"targ": "T002",
"compound": "D1298: Biotin",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "ND",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04527",
"func": "F0201",
"targ": "T002",
"compound": "D1299: lumiracoxib",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "> 400 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04528",
"func": "F0201",
"targ": "T002",
"compound": "D0805: bisacodyl",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "52.5 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04529",
"func": "F0201",
"targ": "T002",
"compound": "D0913: estradiol acetate",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "> 200 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04530",
"func": "F0201",
"targ": "T002",
"compound": "D0016: Bupivacaine",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "> 800 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04531",
"func": "F0201",
"targ": "T002",
"compound": "D0752: Busulfan",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "ND",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04532",
"func": "F0201",
"targ": "T002",
"compound": "D1357: Butein",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "ND",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04533",
"func": "F0201",
"targ": "T002",
"compound": "D1390: Caffeine",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "> 400 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04534",
"func": "F0201",
"targ": "T002",
"compound": "D0325: Capsaicin",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "15.7 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04535",
"func": "F0201",
"targ": null,
"compound": "D1375: Carbamazepine",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "170.8 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04536",
"func": "F0201",
"targ": "T002",
"compound": "D1391: Cefixime",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "216.8 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04537",
"func": "F0201",
"targ": "T002",
"compound": "D1392: Chlorambucil",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "140.9 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04538",
"func": "F0201",
"targ": "T002",
"compound": "D0259: Ciprofloxacin",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "ND",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04539",
"func": "F0201",
"targ": "T002",
"compound": "D1393: Clodronate",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "227.2 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04540",
"func": "F0201",
"targ": "T002",
"compound": "D0422: Clotrimazole",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "ND",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04542",
"func": "F0201",
"targ": "T002",
"compound": "D0859: curcumin",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "> 200 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04545",
"func": "F0201",
"targ": "T002",
"compound": "D0036: Daunorubicin",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "10.9 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04546",
"func": "F0201",
"targ": "T002",
"compound": "D0871: dexamethasone valerate",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "> 200 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04656",
"func": "F010401",
"targ": null,
"compound": "D0116: Tamoxifen",
"paper": "306",
"func_act": "Decrease",
"targ_act": "",
"dose": "100 µM",
"time": "1 hour",
"method": "High-content screening assay",
"species": "Human",
"animal_model": "HepG2",
"criteria": "MEC",
"result": true
},
{
"rec_id": "RC04657",
"func": "F010401",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "306",
"func_act": "Decrease",
"targ_act": "",
"dose": "5 µM",
"time": "1 hour",
"method": "High-content screening assay",
"species": "Human",
"animal_model": "HepG2",
"criteria": "MEC",
"result": true
},
{
"rec_id": "RC04547",
"func": "F0201",
"targ": "T002",
"compound": "D0262: Diazoxide",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "ND",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04548",
"func": "F0201",
"targ": "T002",
"compound": "D0038: Diclofenac",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "29.8 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04549",
"func": "F0201",
"targ": "T002",
"compound": "D0040: Diflunisal",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "ND",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04552",
"func": "F0201",
"targ": "T002",
"compound": "D0043: Doxorubicin",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "ND",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04555",
"func": "F0201",
"targ": null,
"compound": "D0470: erlotinib",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "17.4 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04559",
"func": "F0201",
"targ": "T002",
"compound": "D0417: Fluconazole",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "186.6 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04560",
"func": "F0201",
"targ": "T002",
"compound": "D0057: Flufenamic Acid",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "ND",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04561",
"func": "F0201",
"targ": "T002",
"compound": "D0062: Flutamide",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "ND",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04563",
"func": "F0201",
"targ": "T002",
"compound": "D0440: gefitinib",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "ND",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04564",
"func": "F0201",
"targ": "T002",
"compound": "D0951: genistein",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "ND",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04566",
"func": "F0201",
"targ": "T002",
"compound": "D0266: Glimepiride",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "ND",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04567",
"func": "F0201",
"targ": "T002",
"compound": "D0268: Gossypol",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "ND",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04569",
"func": "F0201",
"targ": "T002",
"compound": "D0065: Ibuprofen",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "132.1 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04570",
"func": "F0201",
"targ": "T002",
"compound": "D1377: Imatinib",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "ND",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04571",
"func": "F0201",
"targ": null,
"compound": "D0461: imipramine",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "18.3 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04572",
"func": "F0201",
"targ": "T002",
"compound": "D0069: Indomethacin",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "ND",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04573",
"func": "F0201",
"targ": "T002",
"compound": "D0071: Isoniazid",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "ND",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04574",
"func": "F0201",
"targ": "T002",
"compound": "D0073: Ketoconazole",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "2.9 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04658",
"func": "F010401",
"targ": null,
"compound": "D1379: atorvastatin",
"paper": "306",
"func_act": "Decrease",
"targ_act": "",
"dose": "50 µM",
"time": "1 hour",
"method": "High-content screening assay",
"species": "Human",
"animal_model": "HepG2",
"criteria": "MEC",
"result": true
},
{
"rec_id": "RC04659",
"func": "F010401",
"targ": null,
"compound": "D0021: Cerivastatin",
"paper": "306",
"func_act": "Decrease",
"targ_act": "",
"dose": "10 µM",
"time": "1 hour",
"method": "High-content screening assay",
"species": "Human",
"animal_model": "HepG2",
"criteria": "MEC",
"result": true
},
{
"rec_id": "RC04660",
"func": "F010401",
"targ": null,
"compound": "D0945: fluvastatin",
"paper": "306",
"func_act": "Decrease",
"targ_act": "",
"dose": "10 µM",
"time": "1 hour",
"method": "High-content screening assay",
"species": "Human",
"animal_model": "HepG2",
"criteria": "MEC",
"result": true
},
{
"rec_id": "RC04575",
"func": "F0201",
"targ": "T002",
"compound": "D0075: Lamivudine",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "317.4 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04576",
"func": "F0201",
"targ": null,
"compound": "D0076: Lidocaine",
"paper": "36",
"func_act": "increase",
"targ_act": "",
"dose": "188.2 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04577",
"func": "F0201",
"targ": "T002",
"compound": "D0364: Lonidamine",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "ND",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04578",
"func": "F0201",
"targ": "T002",
"compound": "D0467: lovastatin",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "6.2 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04579",
"func": "F0201",
"targ": "T002",
"compound": "D1299: lumiracoxib",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "12 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04580",
"func": "F0201",
"targ": "T002",
"compound": "D0192: Manganese",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "> 400 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04581",
"func": "F0201",
"targ": "T002",
"compound": "D0078: Mefenamic acid",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "ND",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04583",
"func": "F0201",
"targ": "T002",
"compound": "D0080: Metformin",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "351.8 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04587",
"func": "F0201",
"targ": "T002",
"compound": "D0083: Mitomycin",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "ND",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04588",
"func": "F0201",
"targ": "T002",
"compound": "D0084: Mitoxantrone",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "ND",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
},
{
"rec_id": "RC04593",
"func": "F0201",
"targ": "T002",
"compound": "D0091: Nicotine",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "312 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04594",
"func": "F0201",
"targ": "T002",
"compound": "D1015: nifuroxazide",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "3.7 µM",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": true
},
{
"rec_id": "RC04596",
"func": "F0201",
"targ": "T002",
"compound": "D0092: Nimesulide",
"paper": "36",
"func_act": "decrease",
"targ_act": "inhibit",
"dose": "ND",
"time": "60 mins",
"method": "Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.",
"species": "mouse",
"animal_model": "liver mitochondria",
"criteria": "EC20",
"result": false
}
]
}
