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"func": "F020403",
"targ": null,
"compound": "D0006: Amitriptyline",
"paper": "50",
"func_act": "",
"targ_act": "",
"dose": "70.9 ± 16.8, 72.0 ± 5.3, 1, 68.1 ± 9.1, 67.0 ± 11.6, 1",
"time": "4hr",
"method": "high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ).",
"species": "",
"animal_model": "H9c2 cells",
"criteria": "glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla )",
"result": true
},
{
"rec_id": "RC04883",
"func": "F020403",
"targ": null,
"compound": "D0024: Chlorpromazine",
"paper": "50",
"func_act": "",
"targ_act": "",
"dose": "36.6 ± 19.4, 48.4 ± 11.9, 0.8, 17.3 ± 7.6, 25.3 ± 10.8, 0.7",
"time": "4hr",
"method": "high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ).",
"species": "",
"animal_model": "H9c2 cells",
"criteria": "glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla )",
"result": true
},
{
"rec_id": "RC04884",
"func": "F020403",
"targ": null,
"compound": "D0060: Fluoxetine",
"paper": "50",
"func_act": "",
"targ_act": "",
"dose": "63.4 ± 8.1, 43.1 ± 9.6 ,1.5, 58.0 ± 15.1, 63.3 ± 26.2, 0.9",
"time": "4hr",
"method": "high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ).",
"species": "",
"animal_model": "H9c2 cells",
"criteria": "glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla )",
"result": true
},
{
"rec_id": "RC04885",
"func": "F020403",
"targ": null,
"compound": "D0067: Idarubicin",
"paper": "50",
"func_act": "",
"targ_act": "",
"dose": "7.9 ± 3.3 , 4.2 ± 2.0, 1.9, 11.5 ± 5.7 ,6.2 ± 4.0, 1.9",
"time": "4hr",
"method": "high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ).",
"species": "",
"animal_model": "H9c2 cells",
"criteria": "glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla )",
"result": true
},
{
"rec_id": "RC04886",
"func": "F020403",
"targ": null,
"compound": "D0461: imipramine",
"paper": "50",
"func_act": "",
"targ_act": "",
"dose": "91.6 ± 18.2, 84.1 ± 10.3, 1.1, 71.4 ± 22.4, 90.3 ± 11.7, 0.8",
"time": "4hr",
"method": "high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ).",
"species": "",
"animal_model": "H9c2 cells",
"criteria": "glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla )",
"result": true
},
{
"rec_id": "RC04888",
"func": "F020403",
"targ": null,
"compound": "D0448: mefloquine",
"paper": "50",
"func_act": "",
"targ_act": "",
"dose": "2.9 ± 1.1, 2.3 ± 1.0, 1.4 ,3.4 ± 1.3, 3.6 ± 2.2, 1.2",
"time": "4hr",
"method": "high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ).",
"species": "",
"animal_model": "H9c2 cells",
"criteria": "glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla )",
"result": true
},
{
"rec_id": "RC04889",
"func": "F020403",
"targ": null,
"compound": "D0194: Menadione",
"paper": "50",
"func_act": "",
"targ_act": "",
"dose": "18.0 ± 7.2, 14.7 ± 7.9 ,1.2, 19.5 ± 8.3, 14.0 ± 8.7, 1.4",
"time": "4hr",
"method": "high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ).",
"species": "",
"animal_model": "H9c2 cells",
"criteria": "glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla )",
"result": true
},
{
"rec_id": "RC04892",
"func": "F020403",
"targ": null,
"compound": "D1463: Nortriptyline",
"paper": "50",
"func_act": "",
"targ_act": "",
"dose": "62.0 ± 18.7, 57.8 ± 28.3, 1.1, 65.3 ± 25.0, 49.2 ± 23.0, 1.3",
"time": "4hr",
"method": "high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ).",
"species": "",
"animal_model": "H9c2 cells",
"criteria": "glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla )",
"result": true
},
{
"rec_id": "RC04893",
"func": "F020403",
"targ": null,
"compound": "D0441: paroxetine",
"paper": "50",
"func_act": "",
"targ_act": "",
"dose": "37.5 ± 15.9, 36.9 ± 27.9, 1, 37.1 ± 11.3, 32.3 ± 17.8, 1.2",
"time": "4hr",
"method": "high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ).",
"species": "",
"animal_model": "H9c2 cells",
"criteria": "glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla )",
"result": true
},
{
"rec_id": "RC04894",
"func": "F020403",
"targ": null,
"compound": "D0471: sertraline",
"paper": "50",
"func_act": "",
"targ_act": "",
"dose": "30.7 ± 4.7, 24.7 ± 16.0, 1.2, 29.1 ± 12.0, 23.6 ± 19.2, 1.2",
"time": "4hr",
"method": "high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ).",
"species": "",
"animal_model": "H9c2 cells",
"criteria": "glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla )",
"result": true
},
{
"rec_id": "RC04895",
"func": "F020403",
"targ": null,
"compound": "D0116: Tamoxifen",
"paper": "50",
"func_act": "",
"targ_act": "",
"dose": "97.9 ± 28.0, 64.4 ± 11.4, 1.5, 75.2 ± 8.4, 43.9 ± 7.8, 1.7",
"time": "4hr",
"method": "high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ).",
"species": "",
"animal_model": "H9c2 cells",
"criteria": "glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla )",
"result": true
},
{
"rec_id": "RC04896",
"func": "F020403",
"targ": null,
"compound": "D0119: Thioridazine",
"paper": "50",
"func_act": "",
"targ_act": "",
"dose": "31.0 ± 5.9, 27.7 ± 19.8 ,1.4, 24.4 ± 5.7, 21.9 ± 18.0, 1.6",
"time": "4hr",
"method": "high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ).",
"species": "",
"animal_model": "H9c2 cells",
"criteria": "glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla )",
"result": true
},
{
"rec_id": "RC04897",
"func": "F020403",
"targ": null,
"compound": "D0062: Flutamide",
"paper": "50",
"func_act": "",
"targ_act": "",
"dose": "300.0 ± 0, 78.3 ± 24.8, 4.1, 266 ± 58.9 , 62.6 ± 27.3, 5",
"time": "24hr",
"method": "high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ).",
"species": "",
"animal_model": "H9c2 cells",
"criteria": "glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla )",
"result": true
},
{
"rec_id": "RC04898",
"func": "F020403",
"targ": null,
"compound": "D0425: Nilutamide",
"paper": "50",
"func_act": "",
"targ_act": "",
"dose": "250 ± 86.6, 44.0 ± 12.0 , 5.7 , 300.0 ± 0, 15.6 ± 9.9 , 19.2",
"time": "24hr",
"method": "high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ).",
"species": "",
"animal_model": "H9c2 cells",
"criteria": "glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla )",
"result": true
},
{
"rec_id": "RC04899",
"func": "F020403",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "50",
"func_act": "",
"targ_act": "",
"dose": "300.00 ± 0 , 1.4 ± 0.1, 219.8, 300.0 ± 0, 1.9 ± 0.1, 156.7",
"time": "24hr",
"method": "high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ).",
"species": "",
"animal_model": "H9c2 cells",
"criteria": "glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla )",
"result": true
},
{
"rec_id": "RC04900",
"func": "F020403",
"targ": null,
"compound": "D0472: zoniporide",
"paper": "50",
"func_act": "",
"targ_act": "",
"dose": "300.00 ± 0, 22.1 ± 14.3, 13.6, 300.0 ± 0, 21.6 ± 5.1, 13.9",
"time": "24hr",
"method": "high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ).",
"species": "",
"animal_model": "H9c2 cells",
"criteria": "glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla )",
"result": true
},
{
"rec_id": "RC04901",
"func": "F020403",
"targ": null,
"compound": "D0009: Antimycin A",
"paper": "325",
"func_act": "",
"targ_act": "",
"dose": "5.9 (42.1nM/7.1nM)",
"time": "24hr",
"method": "ATP levels in high-glucose (25 mM) or galactose (10 mM) medium",
"species": "",
"animal_model": "L6",
"criteria": "glucose/galactose IC50 ratio",
"result": true
},
{
"rec_id": "RC04902",
"func": "F020403",
"targ": null,
"compound": "D0009: Antimycin A",
"paper": "325",
"func_act": "",
"targ_act": "",
"dose": "10.7 (176.5nM/16.5nM)",
"time": "24hr",
"method": "ATP levels in high-glucose (25 mM) or galactose (10 mM) medium",
"species": "",
"animal_model": "H9c2",
"criteria": "glucose/galactose IC50 ratio",
"result": true
},
{
"rec_id": "RC04903",
"func": "F020403",
"targ": null,
"compound": "D0009: Antimycin A",
"paper": "325",
"func_act": "",
"targ_act": "",
"dose": "17.7(58.1nM/3.3nM)",
"time": "24hr",
"method": "ATP levels in high-glucose (25 mM) or galactose (10 mM) medium",
"species": "",
"animal_model": "HepG2",
"criteria": "glucose/galactose IC50 ratio",
"result": true
},
{
"rec_id": "RC04904",
"func": "F020403",
"targ": null,
"compound": "D1467: 1-Octylguanidine",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "4.3",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": true
},
{
"rec_id": "RC04905",
"func": "F020403",
"targ": null,
"compound": "D0129: 2,4-dinitrophenol",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "2.1",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": false
},
{
"rec_id": "RC04906",
"func": "F020403",
"targ": null,
"compound": "D1378: 3-Bromopyruvate",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "1",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": false
},
{
"rec_id": "RC04907",
"func": "F020403",
"targ": "T004",
"compound": "D0132: 3-NPA",
"paper": "326",
"func_act": "",
"targ_act": "inhibit",
"dose": "",
"time": "",
"method": "Assessment of the function of individual mitochondrial complexes using Agilent Seahorse XFe24",
"species": "",
"animal_model": "permeabilized LUHMES cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": true
},
{
"rec_id": "RC04908",
"func": "F020403",
"targ": null,
"compound": "D0309: Albendazole",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "1",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": false
},
{
"rec_id": "RC04909",
"func": "F020403",
"targ": "T004",
"compound": "D0009: Antimycin A",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "12000",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": true
},
{
"rec_id": "RC04910",
"func": "F020403",
"targ": "T002",
"compound": "D0524: atpenin a5",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "1.2",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": false
},
{
"rec_id": "RC04911",
"func": "F020403",
"targ": "T004",
"compound": "D0541: azoxystrobin",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "3.6",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": true
},
{
"rec_id": "RC04912",
"func": "F020403",
"targ": null,
"compound": "D1468: BAM15",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "1.4",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": false
},
{
"rec_id": "RC04913",
"func": "F020403",
"targ": "T001",
"compound": "D0251: Berberine",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "7",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": true
},
{
"rec_id": "RC04914",
"func": "F020403",
"targ": null,
"compound": "D1473: Bortezomib",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "0.9",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": false
},
{
"rec_id": "RC04915",
"func": "F020403",
"targ": null,
"compound": "D1401: Brefeldin A",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "0.7",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": false
},
{
"rec_id": "RC04916",
"func": "F020403",
"targ": null,
"compound": "D0325: Capsaicin",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "Assessment of the function of individual mitochondrial complexes using Agilent Seahorse XFe24",
"species": "",
"animal_model": "permeabilized LUHMES cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": false
},
{
"rec_id": "RC04917",
"func": "F020403",
"targ": null,
"compound": "D1475: Carbaryl",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "Assessment of the function of individual mitochondrial complexes using Agilent Seahorse XFe24",
"species": "",
"animal_model": "permeabilized LUHMES cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": false
},
{
"rec_id": "RC04918",
"func": "F020403",
"targ": "T002",
"compound": "D0256: Carboxin",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "3.1",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": true
},
{
"rec_id": "RC04919",
"func": "F020403",
"targ": null,
"compound": "D0156: CCCP",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "1.2",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": false
},
{
"rec_id": "RC04920",
"func": "F020403",
"targ": null,
"compound": "D0029: Cisplatin",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "1",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": false
},
{
"rec_id": "RC04921",
"func": "F020403",
"targ": null,
"compound": "D1372: colchicine",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "0.5",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": false
},
{
"rec_id": "RC04922",
"func": "F0105",
"targ": null,
"compound": "D1476: Cyazofamid",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "50µM ",
"time": "",
"method": "Assessment of the function of individual mitochondrial complexes using Agilent Seahorse XFe24",
"species": "",
"animal_model": "permeabilized LUHMES cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": true
},
{
"rec_id": "RC04923",
"func": "F020403",
"targ": null,
"compound": "D1474: Cytochalasin D",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "1.5",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": false
},
{
"rec_id": "RC04924",
"func": "F020403",
"targ": "T001",
"compound": "D0221: Deguelin",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "450",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": true
},
{
"rec_id": "RC04926",
"func": "F020403",
"targ": null,
"compound": "D0172: Diethylstilbestrol",
"paper": "326",
"func_act": "",
"targ_act": "",
"dose": "1",
"time": "",
"method": "Glc–Gal–NeuriTox assay",
"species": "",
"animal_model": "LUHMES (Lund human mesencephalic) cells",
"criteria": " EC25(NA) [Glc/Gal]",
"result": false
},
{
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]
}
