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"method": "The transmembrane potential of the mitochondria was monitored spectrophotometrically using rhodamine-123.",
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"compound": "D0124: Troglitazone",
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"result": false
},
{
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"compound": "D0098: Pioglitazone",
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{
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"compound": "D0098: Pioglitazone",
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"result": false
},
{
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"targ": null,
"compound": "D0097: Phenformin",
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"dose": "30-300 μM",
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"result": false
},
{
"rec_id": "RC04987",
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"targ": null,
"compound": "D0097: Phenformin",
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"dose": "30-300 μM",
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{
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"compound": "D0124: Troglitazone",
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"method": "Measurement of reduced/oxidized glutathione (GSH/GSSG): the reduced/oxidized glutathione (GSH/GSSG) concentration of the samples was determined from a standard curve using the enzymatic method and a Multiskan JX system.",
"species": "ZDF fa/fa rat vs ZDF lean rat",
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{
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"compound": "D0124: Troglitazone",
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{
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"compound": "D0124: Troglitazone",
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"method": "lipid peroxidation was measured from thiobarbituric acid-reactive substances (TBARS) formation at 480-570 nm.",
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"time": "",
"method": "Measurement of MPT using vesicle-fused mitochondria ( isolated mitochondria were preincubated with micellized phospholipid containing CL or CLOOH,and then a swelling assay was performed. )",
"species": "Wistar rat",
"animal_model": "Isolated rat liver mitochondria",
"criteria": "",
"result": true
},
{
"rec_id": "RC04993",
"func": "F030602",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "332",
"func_act": "abnormal",
"targ_act": "",
"dose": "25 µM",
"time": "",
"method": "Images from transmission electron microscopy ",
"species": "",
"animal_model": "HepG2 cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC04994",
"func": "F0303",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "332",
"func_act": "",
"targ_act": "",
"dose": "25 µM",
"time": "",
"method": "confocal laser scanning microscopy (MitoTracker Red)",
"species": "",
"animal_model": "HepG2 cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC04995",
"func": "F01",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "332",
"func_act": "decrease",
"targ_act": "",
"dose": ">25 µM",
"time": "30min",
"method": "JC1",
"species": "",
"animal_model": "HepG2 cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC04996",
"func": "F021203",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "332",
"func_act": "decrease",
"targ_act": "",
"dose": ">25 µM",
"time": "1 and 2 hr",
"method": "Cellular ATP concentrations were measured with a ATP Bioluminescent Somatic Cell Assay Kit",
"species": "",
"animal_model": "HepG2 cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC04997",
"func": "F01",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "330",
"func_act": "decrease",
"targ_act": "",
"dose": "100 µM",
"time": "5min",
"method": "Tetramethylrhodamine methyl ester (TMRE)",
"species": "",
"animal_model": "HepG2 cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC04998",
"func": "F01",
"targ": null,
"compound": "D0124: Troglitazone",
"paper": "330",
"func_act": "decrease",
"targ_act": "",
"dose": " 61.9 µM",
"time": "3hr",
"method": "stained with a Mitotracker red dye, and then fixed with paraformaldehyde",
"species": "",
"animal_model": "HepG2 cells",
"criteria": "IC50",
"result": true
},
{
"rec_id": "RC04999",
"func": "F070104",
"targ": "T409",
"compound": "D0124: Troglitazone",
"paper": "330",
"func_act": "",
"targ_act": "activation",
"dose": "100 µM",
"time": "24hr",
"method": "Apo-One homogeneous caspase 3 assay kit",
"species": "",
"animal_model": "HepG2 cells",
"criteria": "",
"result": true
},
{
"rec_id": "RC05000",
"func": null,
"targ": "T021001",
"compound": "D1479: aminocarnitine",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "76.4/27.3",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05001",
"func": null,
"targ": "T021001",
"compound": "D1480: palmitoylaminocarnitine",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "2.67/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05002",
"func": null,
"targ": "T021001",
"compound": "D1481: ST1326",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "1.05/1.45",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05003",
"func": null,
"targ": "T021001",
"compound": "D1482: ST2425",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "1.70/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05004",
"func": null,
"targ": "T021001",
"compound": "D0302: Trimetazidine",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05005",
"func": null,
"targ": "T021001",
"compound": "D0096: Perhexiline",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05006",
"func": null,
"targ": "T021001",
"compound": "D0005: Amiodarone",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05007",
"func": null,
"targ": "T021001",
"compound": "D0290: Oxfenicine",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05008",
"func": null,
"targ": "T021001",
"compound": "D1483: oxfenicine metabolite",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05009",
"func": null,
"targ": "T021001",
"compound": "D1484: RO-25-0187",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "2.4/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05010",
"func": null,
"targ": "T021002",
"compound": "D1479: aminocarnitine",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05011",
"func": null,
"targ": "T021002",
"compound": "D1480: palmitoylaminocarnitine",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "21.7",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05012",
"func": null,
"targ": "T021002",
"compound": "D1481: ST1326",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "5.4",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05013",
"func": null,
"targ": "T021002",
"compound": "D1482: ST2425",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "85.3",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05014",
"func": null,
"targ": "T021002",
"compound": "D0302: Trimetazidine",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05015",
"func": null,
"targ": "T021002",
"compound": "D0096: Perhexiline",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05016",
"func": null,
"targ": "T021002",
"compound": "D0005: Amiodarone",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05017",
"func": null,
"targ": "T021002",
"compound": "D0290: Oxfenicine",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05018",
"func": null,
"targ": "T021002",
"compound": "D1483: oxfenicine metabolite",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "60.3",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05019",
"func": null,
"targ": "T021002",
"compound": "D1484: RO-25-0187",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "0.16",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05020",
"func": null,
"targ": "T022",
"compound": "D1479: aminocarnitine",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "3.9/5.1",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05021",
"func": null,
"targ": "T022",
"compound": "D1480: palmitoylaminocarnitine",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "0.14",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05022",
"func": null,
"targ": "T022",
"compound": "D1481: ST1326",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "0.16/0.38",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05023",
"func": null,
"targ": "T022",
"compound": "D1482: ST2425",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "5.4/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05024",
"func": null,
"targ": "T022",
"compound": "D0302: Trimetazidine",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05025",
"func": null,
"targ": "T022",
"compound": "D0096: Perhexiline",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "72.8/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05026",
"func": null,
"targ": "T022",
"compound": "D0005: Amiodarone",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05027",
"func": null,
"targ": "T022",
"compound": "D0290: Oxfenicine",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05028",
"func": null,
"targ": "T022",
"compound": "D1483: oxfenicine metabolite",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": ">100/−",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": false
},
{
"rec_id": "RC05029",
"func": null,
"targ": "T022",
"compound": "D1484: RO-25-0187",
"paper": "333",
"func_act": "",
"targ_act": "inhibition",
"dose": "4.7/>100",
"time": "",
"method": "spectrophotometric assay with DTNB",
"species": "human/rat",
"animal_model": "recombinant Pichia pastoris Membrane Preparations ",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05030",
"func": "F02060201",
"targ": null,
"compound": "D1485: TDGA",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "0.31",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05031",
"func": "F02060201",
"targ": null,
"compound": "D1486: POCA",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "59.7",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05032",
"func": "F02060201",
"targ": null,
"compound": "D0264: Etomoxir",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "2.76",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05033",
"func": "F02060201",
"targ": null,
"compound": "D1487: DET",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "5.6",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05034",
"func": "F02060201",
"targ": null,
"compound": "D1479: aminocarnitine",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "0.97",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05035",
"func": "F02060201",
"targ": null,
"compound": "D1480: palmitoylaminocarnitine",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "0.11",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05036",
"func": "F02060201",
"targ": null,
"compound": "D1481: ST1326",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "1.1",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05037",
"func": "F02060201",
"targ": null,
"compound": "D1482: ST2425",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "0.21",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05038",
"func": "F02060201",
"targ": null,
"compound": "D0302: Trimetazidine",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "47.1",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05039",
"func": "F02060201",
"targ": null,
"compound": "D0096: Perhexiline",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "14.8",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05040",
"func": "F02060201",
"targ": null,
"compound": "D0005: Amiodarone",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "16.6",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05041",
"func": "F02060201",
"targ": null,
"compound": "D0290: Oxfenicine",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": ">100",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05042",
"func": "F02060201",
"targ": null,
"compound": "D1483: oxfenicine metabolite",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "25.8",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05043",
"func": "F02060201",
"targ": null,
"compound": "D1484: RO-25-0187",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "1.5",
"time": "",
"method": "ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako)",
"species": "Wistar rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
},
{
"rec_id": "RC05044",
"func": "F02060101",
"targ": null,
"compound": "D1485: TDGA",
"paper": "333",
"func_act": "inhibition",
"targ_act": "",
"dose": "<0.05/0.04",
"time": "",
"method": "Fatty acid oxidation (FAO) was determined by measuring 14CO2 release from 14C-labeled palmitate",
"species": "human/rat",
"animal_model": "hepatocytes",
"criteria": "IC50 (μM)",
"result": true
}
]
}
