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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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"compound": "D0423: N-deacetyl ketoconazole",
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},
{
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"targ": "T076",
"compound": "D0423: N-deacetyl ketoconazole",
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"result": true
},
{
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"targ": "T076",
"compound": "D0423: N-deacetyl ketoconazole",
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"result": true
},
{
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"compound": "D0423: N-deacetyl ketoconazole",
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},
{
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},
{
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},
{
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},
{
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"compound": "D0423: N-deacetyl ketoconazole",
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"criteria": "p < 0.05",
"result": true
},
{
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"compound": "D0423: N-deacetyl ketoconazole",
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"result": true
},
{
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"compound": "D0423: N-deacetyl ketoconazole",
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"targ_act": "leakage",
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"result": false
},
{
"rec_id": "RC03605",
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"compound": "D0038: Diclofenac",
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"func_act": "",
"targ_act": "",
"dose": "",
"time": "",
"method": "",
"species": "rat",
"animal_model": "heart",
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"result": true
},
{
"rec_id": "RC00577",
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"targ": "T076",
"compound": "D0423: N-deacetyl ketoconazole",
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"time": "2 hours",
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"animal_model": "hepatocytes",
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},
{
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"compound": "D0423: N-deacetyl ketoconazole",
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"targ_act": "leakage",
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"method": "Measurement of LDH activities",
"species": "rat",
"animal_model": "hepatocytes",
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"result": false
},
{
"rec_id": "RC00579",
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"targ": "T076",
"compound": "D0423: N-deacetyl ketoconazole",
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"species": "rat",
"animal_model": "hepatocytes",
"criteria": "p < 0.05",
"result": true
},
{
"rec_id": "RC00580",
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"targ": "T076",
"compound": "D0423: N-deacetyl ketoconazole",
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"targ_act": "leakage",
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"animal_model": "hepatocytes",
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"result": true
},
{
"rec_id": "RC00581",
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"targ": "T076",
"compound": "D0423: N-deacetyl ketoconazole",
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"species": "rat",
"animal_model": "hepatocytes",
"criteria": "p < 0.05",
"result": true
},
{
"rec_id": "RC00582",
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"compound": "D0423: N-deacetyl ketoconazole",
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"time": "4 hours",
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"species": "rat",
"animal_model": "hepatocytes",
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},
{
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"compound": "D0423: N-deacetyl ketoconazole",
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"method": "Measurement of LDH activities",
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"animal_model": "hepatocytes",
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},
{
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"targ": "T076",
"compound": "D0423: N-deacetyl ketoconazole",
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"result": true
},
{
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"compound": "D0423: N-deacetyl ketoconazole",
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"result": true
},
{
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"compound": "D0423: N-deacetyl ketoconazole",
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"method": "Measurement of LDH activities",
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"animal_model": "hepatocytes",
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"result": true
},
{
"rec_id": "RC00587",
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"compound": "D0423: N-deacetyl ketoconazole",
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"result": true
},
{
"rec_id": "RC00588",
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"result": true
},
{
"rec_id": "RC00589",
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"compound": "D0423: N-deacetyl ketoconazole",
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"animal_model": "hepatocytes",
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"result": true
},
{
"rec_id": "RC00590",
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"compound": "D0423: N-deacetyl ketoconazole",
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"animal_model": "hepatocytes",
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"result": true
},
{
"rec_id": "RC00591",
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"targ": "T076",
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"result": true
},
{
"rec_id": "RC00592",
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"compound": "D0423: N-deacetyl ketoconazole",
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"result": true
},
{
"rec_id": "RC00593",
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"targ": "T076",
"compound": "D0423: N-deacetyl ketoconazole",
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"result": true
},
{
"rec_id": "RC00597",
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"targ": "T234",
"compound": "D0194: Menadione",
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"result": true
},
{
"rec_id": "RC00598",
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"compound": "D0446: phylloquinone",
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"func_act": "affect",
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"dose": ">200 μM",
"time": "1 hours",
"method": "Meassurement of DNA polymerase gamma activity",
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"criteria": "IC50",
"result": false
},
{
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"compound": "D0447: menaquinones",
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"dose": ">200 μM",
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"method": "Meassurement of DNA polymerase gamma activity",
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"result": false
},
{
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"compound": "D0080: Metformin",
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"func_act": "decrease",
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"dose": "0.05 mM",
"time": "24 hours",
"method": "Meassurement of mitochondrial respiration",
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"result": false
},
{
"rec_id": "RC00623",
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"compound": "D0080: Metformin",
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"func_act": "decrease",
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"dose": "0.5 mM",
"time": "24 hours",
"method": "Meassurement of mitochondrial respiration",
"species": "human",
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"criteria": "p < 0.05",
"result": false
},
{
"rec_id": "RC00624",
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"compound": "D0080: Metformin",
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"func_act": "decrease",
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"dose": "5 mM",
"time": "24 hours",
"method": "Meassurement of mitochondrial respiration",
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"animal_model": "MCF7",
"criteria": "p < 0.05",
"result": true
},
{
"rec_id": "RC00625",
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"targ": null,
"compound": "D0080: Metformin",
"paper": "172",
"func_act": "decrease",
"targ_act": "",
"dose": "0.05 mM",
"time": "24 hours",
"method": "Meassurement of coupled respiration",
"species": "human",
"animal_model": "MCF7",
"criteria": "p < 0.05",
"result": false
},
{
"rec_id": "RC00626",
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"targ": null,
"compound": "D0080: Metformin",
"paper": "172",
"func_act": "decrease",
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"dose": "0.5 mM",
"time": "24 hours",
"method": "Meassurement of coupled respiration",
"species": "human",
"animal_model": "MCF7",
"criteria": "p < 0.05",
"result": true
},
{
"rec_id": "RC00627",
"func": "F020103",
"targ": null,
"compound": "D0080: Metformin",
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"func_act": "decrease",
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"dose": "5 mM",
"time": "24 hours",
"method": "Meassurement of coupled respiration",
"species": "human",
"animal_model": "MCF7",
"criteria": "p < 0.05",
"result": true
},
{
"rec_id": "RC00628",
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"targ": null,
"compound": "D0080: Metformin",
"paper": "172",
"func_act": "decrease",
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"dose": "0.05 mM",
"time": "24 hours",
"method": "Meassurement of uncoupled respiration",
"species": "human",
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"criteria": "p < 0.05",
"result": false
},
{
"rec_id": "RC00629",
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"compound": "D0080: Metformin",
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"func_act": "decrease",
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"dose": "0.5 mM",
"time": "24 hours",
"method": "Meassurement of uncoupled respiration",
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]
}
