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},
{
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},
{
"rec_id": "RC00797",
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"compound": "D0080: Metformin",
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"animal_model": "hepatocytes",
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"result": true
},
{
"rec_id": "RC00798",
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"targ": "T387",
"compound": "D0080: Metformin",
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"targ_act": "increase",
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"animal_model": "hepatocytes",
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"result": true
},
{
"rec_id": "RC00799",
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"compound": "D0458: buformin",
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"func_act": "increase",
"targ_act": "increase",
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"method": "ROS measurement",
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"result": true
},
{
"rec_id": "RC00800",
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"targ": "T387",
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"animal_model": "hepatocytes",
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"result": true
},
{
"rec_id": "RC00801",
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"targ": null,
"compound": "D0080: Metformin",
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"func_act": "decrease",
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"dose": "500 μM ",
"time": "24 hours",
"method": "Measurement of mitochondrial membrane potential",
"species": "human",
"animal_model": "hepatocytes",
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"result": false
},
{
"rec_id": "RC00802",
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"targ": null,
"compound": "D0080: Metformin",
"paper": "15",
"func_act": "decrease",
"targ_act": "",
"dose": "1 mM",
"time": "24 hours",
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"animal_model": "hepatocytes",
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"result": true
},
{
"rec_id": "RC00803",
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"targ": null,
"compound": "D0080: Metformin",
"paper": "15",
"func_act": "decrease",
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"dose": "2 mM",
"time": "24 hours",
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"animal_model": "hepatocytes",
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"result": true
},
{
"rec_id": "RC00804",
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"compound": "D0458: buformin",
"paper": "15",
"func_act": "decrease",
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"dose": "75 μM ",
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"result": true
},
{
"rec_id": "RC00805",
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"targ": null,
"compound": "D0097: Phenformin",
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"dose": "12.5 μM ",
"time": "24 hours",
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"animal_model": "hepatocytes",
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"result": true
},
{
"rec_id": "RC00806",
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"compound": "D0080: Metformin",
"paper": "15",
"func_act": "affect",
"targ_act": "decrease",
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"animal_model": "hepatocytes",
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"result": false
},
{
"rec_id": "RC00807",
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"compound": "D0080: Metformin",
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"result": true
},
{
"rec_id": "RC00808",
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"compound": "D0080: Metformin",
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"animal_model": "hepatocytes",
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"result": true
},
{
"rec_id": "RC00809",
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"targ": "T400",
"compound": "D0458: buformin",
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"func_act": "affect",
"targ_act": "decrease",
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"time": "24 hours",
"method": "Measurement of mitochondrial membrane potential",
"species": "human",
"animal_model": "hepatocytes",
"criteria": "",
"result": true
},
{
"rec_id": "RC00810",
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"method": "Measurement of mitochondrial membrane potential",
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"result": true
},
{
"rec_id": "RC00811",
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"compound": "D0096: Perhexiline",
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"result": true
},
{
"rec_id": "RC00812",
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"compound": "D0096: Perhexiline",
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"method": "Measurement of beta oxidation",
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},
{
"rec_id": "RC00813",
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"compound": "D0096: Perhexiline",
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"func_act": "decrease",
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"result": true
},
{
"rec_id": "RC00814",
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"compound": "D0096: Perhexiline",
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"func_act": "increase",
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},
{
"rec_id": "RC00815",
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"compound": "D0096: Perhexiline",
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"result": true
},
{
"rec_id": "RC00816",
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"compound": "D0096: Perhexiline",
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},
{
"rec_id": "RC00817",
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"compound": "D0096: Perhexiline",
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"dose": "400 μM",
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},
{
"rec_id": "RC00818",
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"compound": "D0096: Perhexiline",
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"result": false
},
{
"rec_id": "RC00819",
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"compound": "D0096: Perhexiline",
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"dose": "100 μM",
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"method": "Measurement of oxygen uptake",
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"criteria": "p < 0.01",
"result": true
},
{
"rec_id": "RC00820",
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"targ": null,
"compound": "D0096: Perhexiline",
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"method": "Measurement of oxygen uptake",
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"result": true
},
{
"rec_id": "RC00821",
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"compound": "D0096: Perhexiline",
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"dose": "400 μM",
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},
{
"rec_id": "RC00824",
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"compound": "D0096: Perhexiline",
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"result": true
},
{
"rec_id": "RC00825",
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"targ": null,
"compound": "D0096: Perhexiline",
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"dose": "50 μM",
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},
{
"rec_id": "RC00826",
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"compound": "D0096: Perhexiline",
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"dose": "100 μM",
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"result": true
},
{
"rec_id": "RC00827",
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"compound": "D0096: Perhexiline",
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"dose": "200 μM",
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"result": true
},
{
"rec_id": "RC00828",
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"compound": "D0096: Perhexiline",
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"dose": "400 μM",
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"result": true
},
{
"rec_id": "RC00829",
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"compound": "D0096: Perhexiline",
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"dose": "50 μM",
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},
{
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"compound": "D0096: Perhexiline",
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"dose": "100 μM",
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"result": true
},
{
"rec_id": "RC00831",
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"compound": "D0096: Perhexiline",
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"result": true
},
{
"rec_id": "RC00832",
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"compound": "D0096: Perhexiline",
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"dose": "400 μM",
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"result": true
},
{
"rec_id": "RC00833",
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"compound": "D0096: Perhexiline",
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"dose": "200 μM",
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},
{
"rec_id": "RC00834",
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"compound": "D0096: Perhexiline",
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},
{
"rec_id": "RC00835",
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"compound": "D0096: Perhexiline",
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"dose": "200 μM",
"time": "5 minutes preincubation",
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},
{
"rec_id": "RC00896",
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"time": "",
"method": "",
"species": "",
"animal_model": "",
"criteria": "",
"result": true
},
{
"rec_id": "RC00836",
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"compound": "D0096: Perhexiline",
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"dose": "200 μM",
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"result": true
},
{
"rec_id": "RC00838",
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"compound": "D0096: Perhexiline",
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"result": true
},
{
"rec_id": "RC00840",
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"compound": "D0096: Perhexiline",
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"result": true
},
{
"rec_id": "RC00841",
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"compound": "D0096: Perhexiline",
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"result": false
},
{
"rec_id": "RC00842",
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"compound": "D0096: Perhexiline",
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},
{
"rec_id": "RC00843",
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"compound": "D0096: Perhexiline",
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"animal_model": "liver mitochondria",
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"result": true
},
{
"rec_id": "RC00844",
"func": "F02060101",
"targ": "T030",
"compound": "D0096: Perhexiline",
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"targ_act": "inhibitor",
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"method": "Measurement of activities of acyl-CoA dehydrogenases",
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"animal_model": "liver mitochondria",
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"result": true
},
{
"rec_id": "RC00845",
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"compound": "D0096: Perhexiline",
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"targ_act": "inhibitor",
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"result": true
}
]
}
