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Drug

D0042 | Dofetilide

Molecular Formula C19H27N3O5S2
Molecular Weight 441.6
Structure
State solid
Volume of distribution * 3 L/kg
Protein binding 60% -70%
Half life 10 hours
Absorption >90%
Trade names Tikosyn
Description class III antiarrhythmic agent

C

C01BD04 Dofetilide


[C01BD] Antiarrhythmics, class III


[C01B] ANTIARRHYTHMICS, CLASS I AND III


[C01] CARDIAC THERAPY


[C] Cardiovascular system

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 70 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H302 (98.57%): Harmful if swallowed [Warning Acute toxicity, oral]


H360 (100%): May damage fertility or the unborn child [Danger Reproductive toxicity]


H373 (42.86%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]


H411 (44.29%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P201, P202, P260, P264, P270, P273, P281, P301+P312, P308+P313, P314, P330, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

  • Arrhythmia supraventricular

  • Atrial fibrillation

  • Atrial flutter

  • Cardiac disorder

  • Cardiac flutter

  • Sinus rhythm

  • Ventricular arrhythmia

  • Abdominal pain

  • Atrioventricular block

  • Back pain

  • Bundle branch block

  • Chest pain

  • Dermatitis

  • Diarrhoea

  • Dizziness

  • Dyspnoea

  • Gastrointestinal pain

  • Headache

  • Influenza

  • Injury

  • Insomnia

  • Nausea

  • Rash

  • Respiratory tract infection

  • Torsade de pointes

  • Ventricular arrhythmia

  • Ventricular fibrillation

  • Ventricular tachycardia

    • (Dofetilide) N-[4-(2-{[2-(4-Methanesulfonylamino-phenyl)-ethyl]-methylamino}-ethoxy)-phenyl]-methanesulfonamide 1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane 1-(4-Methansulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane
    1-(4-methanesulfonamidophenoxy)-2-(N-(4-methanesulfonamidophenethyl)-N-methylamine)ethane 1-MSPMPE 115256-11-6
    256D116 A10328 A803396
    AB0004775 AB00639976-06 AB00639976-08
    AB00639976_09 AB2000201 AC-385
    ACT04222 AK161932 AKOS005259921
    API0002471 BCP04770 BCP0726000009
    BCP9000619 BDBM50031720 BRD-K86887724-001-05-6
    C-22372 C07751 C19H27N3O5S2
    CAS-115256-11-6 CC-27363 CCG-101037
    CHEBI:4681 CHEMBL473 CPD000466333
    CS-2200 CTK8F9356 D00647
    DB-041252 DB00204 DSSTox_CID_26433
    DSSTox_GSID_46433 DSSTox_RID_81610 DTXSID5046433
    Dofetilida Dofetilida [INN-Spanish] Dofetilide
    Dofetilide (JAN/USAN/INN) Dofetilide (Tikosyn) Dofetilide [USAN:BAN:INN]
    Dofetilide [USAN:USP:INN:BAN] Dofetilide(Tikosyn) Dofetilide, >=98% (HPLC)
    Dofetilide, United States Pharmacopeia (USP) Reference Standard Dofetilidum Dofetilidum [INN-Latin]
    FT-0631076 GTPL2604 HMS2051N14
    HMS2089F03 HMS2232H19 HMS3261G03
    HMS3370B18 HMS3393N14 HMS3655A17
    HMS3715H20 HSDB 7927 HY-B0232
    I881 IXTMWRCNAAVVAI-UHFFFAOYSA-N J-003271
    KS-00000XNN LS-90151 MFCD00869707
    MLS000759442 MLS001424185 MLS006010154
    MRF-0000317 Methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl)phenyl) Methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl)phenyl)-
    Methanesulfonamide, N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]- N-(4-(2-(methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide N-(4-{2-[methyl(2-{4-[(methylsulfonyl)amino]phenoxy}ethyl)amino]ethyl}phenyl)methanesulfonamide
    N-[4-(2-{2-[4-(methanesulphonamido)phenoxyl]-N-methylethylamino}ethyl)phenyl]-methanesulphonamide N-[4-(2-{[2-(4-METHANESULFONYLAMINO-PHENYL)-ETHYL]-METHYL-AMINO}-ETHOXY)-PHENYL]-METHANESULFONAMIDE DOFETILIDE N-[4-(2-{[2-(4-Methanesulfonylamino-phenyl)-ethyl]-methyl-amino}-ethoxy)-phenyl]-methanesulfonamide (UK-68798)
    N-[4-(2-{[2-(4-Methanesulfonylamino-phenyl)-ethyl]-methyl-amino}-ethoxy)-phenyl]-methanesulfonamide (dofetilide) N-[4-(2-{[2-(4-methanesulfonamidophenoxy)ethyl](methyl)amino}ethyl)phenyl]methanesulfonamide N-[4-(2-{[2-(4-methanesulfonylamino-phenoxy)-ethyl]-methyl-amino}-ethyl)-phenyl]-methanesulfonamide
    N-[4-[2-[2-(4-methanesulfonamidophenyl)ethyl-methylamino]ethoxy]phenyl]methanesulfonamide N-[4-[2-[2-[4-(methanesulfonamido)phenoxy]ethyl-methylamino]ethyl]phenyl]methanesulfonamide N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide
    N-[4-[2-[methyl-[2-[4-(methylsulfonylamino)phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide NC00287 NCGC00164549-01
    NCGC00164549-02 NCGC00261036-01 Q3712521
    R4Z9X1N2ND SAM001246621 SC-76467
    SCHEMBL16135 SMR000466333 SR-01000759368
    SR-01000759368-4 ST24046670 SW197667-2
    Tikosyn Tikosyn (TN) Tikosyn;UK68798
    Tox21_112178 Tox21_112178_1 Tox21_500351
    UK 68,798 UK 68789 UK 68798
    UK-68,798 UK-68798 UK68798
    UNII-R4Z9X1N2ND Xelide ZINC000000596731
    ZINC596731 beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide s1658

    DrugBank Name Dofetilide
    DrugBank DB00204
    CAS Number 115256-11-6, 1189700-56-8
    PubChem Compound 71329
    KEGG Compound ID C07751
    KEGG Drug D00647
    PubChem.Substance 46509127
    ChEBI 4681
    PharmGKB PA449389
    ChemSpider 64435
    BindingDB 50031720.0
    TTD DAP000495
    Wikipedia Dofetilide

    1. Dykens et al. (2007)