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Drug

D0054 | Felbamate

Molecular Formula C11H14N2O4
Molecular Weight 238.24
Structure
State solid
Clearance * 26 +/- 3 mL/hr/kg [single 1200 mg dose] * 30 +/- 8 mL/hr/kg [multiple daily doses of 3600 mg]
Volume of distribution * 756±82 mL/kg
Protein binding 20-36%
Half life 20-23 hours
Absorption >90%
Trade names Felbatol
Description anticonvulsant

N

N03AX10 Felbamate


[N03AX] Other antiepileptics


[N03A] ANTIEPILEPTICS


[N03] ANTIEPILEPTICS


[N] Nervous system

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 27 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


Reported as not meeting GHS hazard criteria by 1 of 27 companies. For more detailed information, please visit ECHA C&L website


Of the 1 notification(s) provided by 26 of 27 companies with hazard statement code(s):


H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]


H334 (100%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P261, P272, P280, P285, P302+P352, P304+P341, P321, P333+P313, P342+P311, P363, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

  • Convulsion

  • Epilepsy

  • Lennox-Gastaut syndrome

  • Partial seizures

  • Abdominal pain

  • Acne

  • Affect lability

  • Alanine aminotransferase increased

  • Anxiety

  • Asthenia

  • Ataxia

  • Body temperature increased

  • Chest pain

  • Constipation

  • Cough

  • Decreased appetite

  • Depressed level of consciousness

  • Depression

  • Dermatitis

  • Diarrhoea

  • Diplopia

  • Dizziness

  • Dry mouth

  • Dysgeusia

  • Dyspepsia

  • Face oedema

  • Fatigue

  • Gait disturbance

  • Gastrointestinal pain

  • Haemoglobin

  • Haemorrhage

  • Headache

  • Hiccups

  • Hypophosphataemia

  • Insomnia

  • Leukopenia

  • Mental disability

  • Miosis

  • Mood swings

  • Musculoskeletal discomfort

  • Myalgia

  • Nausea

  • Nervousness

  • Otitis media

  • Pain

  • Paraesthesia

  • Pharyngitis

  • Purpura

  • Rash

  • Rhinitis

  • Sinusitis

  • Somnolence

  • Stupor

  • Tension

  • Thinking abnormal

  • Tremor

  • Upper respiratory tract infection

  • Urinary incontinence

  • Urinary tract infection

  • Vascular purpura

  • Visual impairment

  • Vomiting

  • Weight decreased

    • (3-aminocarbonyloxy-2-phenyl-propyl) carbamate (3-carbamoyloxy-1,1,3,3-tetradeuterio-2-phenylpropyl) carbamate (3-carbamoyloxy-2-phenylpropyl) carbamate
    1,3-Propanediol, 2-phenyl-, dicarbamate 2-?methyl-?4-?(4-?methyl-?1-?piperazinyl)-?10H-?thieno[2,?3-?b][1,?5]benzodiazepine 2-Phenyl-1,3-propanediol dicarbamate
    2-Phenyl-1,3-propanedioldicarbamate 2-Phenylpropane-1,3-diyl dicarbamate 25451-15-4
    3-(carbamoyloxy)-2-phenylpropyl carbamate 4-06-00-05993 (Beilstein Handbook Reference) 451F154
    A817858 AB0011540 AB00382985-18
    AB00382985_19 AB1008593 AC-8197
    ACN-054465 ADD 03055 ADD-03055
    AKOS015895100 ANW-65602 AOB5042
    API0002680 AX8130043 BCP27941
    BDBM50088430 BIDD:GT0463 BN0583
    BPBio1_001258 BRD-K99107520-001-01-9 BRD-K99107520-001-09-2
    BRD-K99107520-001-18-3 BRN 3345236 Biomol-NT_000203
    C-14192 C07501 C11H14N2O4
    CAS-25451-15-4 CC-28364 CCG-204614
    CHEBI:4995 CHEMBL1094 CS-2068
    Carbamic acid 3-carbamoyloxy-2-phenyl-propyl ester Carbamic acid, 2-phenyltrimethylene ester D00536
    DB-046702 DB00949 DSSTox_CID_3041
    DSSTox_GSID_23041 DSSTox_RID_76847 DTXSID9023041
    EINECS 247-001-4 EN300-119542 EU-0100524
    EX-A591 F 0778 FT-0630517
    Felbamate (USAN/INN) Felbamate [USAN:INN] Felbamate, United States Pharmacopeia (USP) Reference Standard
    Felbamato Felbamato [Spanish] Felbamatum
    Felbamatum [Latin] Felbamyl Felbatol
    Felbatol (TN) GTPL5473 HMS2093P19
    HMS2234H06 HMS3261J09 HMS3266L12
    HMS3370I06 HMS3411P21 HMS3657I11
    HMS3675P21 HMS3715D20 HSDB 7525
    HY-B0184 J90036 K-6677
    KS-00001F6O KS-1171 LP00524
    LS-120706 Lopac-F-0778 Lopac0_000524
    MCULE-2661497722 MFCD00865296 MLS000028465
    MLS001077299 NCGC00015429-01 NCGC00015429-02
    NCGC00015429-03 NCGC00015429-04 NCGC00015429-05
    NCGC00015429-06 NCGC00015429-07 NCGC00015429-08
    NCGC00015429-09 NCGC00015429-10 NCGC00015429-11
    NCGC00015429-14 NCGC00023092-02 NCGC00023092-04
    NCGC00023092-05 NCGC00023092-06 NCGC00255275-01
    NCGC00261209-01 NSC-759866 NSC759866
    Opera_ID_1738 Pharmakon1600-01505600 Prestwick0_000919
    Q-100326 Q421301 SBI-0050507.P002
    SC-46002 SCHEMBL34947 SMR000058448
    SR-01000000089 SR-01000000089-2 SR-01000000089-4
    SR-01000000089-7 SW197633-2 TC-154347
    Taloxa Tocris-0869 Tox21_110145
    Tox21_110145_1 Tox21_302368 Tox21_500524
    UNII-X72RBB02N8 W 554 W-554
    WKGXYQFOCVYPAC-UHFFFAOYSA-N X72RBB02N8 Z1541638522
    ZINC1530803 carbamic acid (3-carbamoyloxy-2-phenylpropyl) ester carbamic acid 2-phenyltrimethylene ester
    felbamate s1330

    DrugBank Name Felbamate
    DrugBank DB00949
    CAS Number 106817-52-1, 1177501-39-1, 132539-06-1, 25451-15-4
    PubChem Compound 3331
    KEGG Compound ID C07501
    KEGG Drug D00536
    PubChem.Substance 46506375
    ChEBI 4995
    PharmGKB PA449590
    ChemSpider 3214
    BindingDB 50088430.0
    TTD DAP000093
    Wikipedia Felbamate

    1. Dykens et al. (2007)