Drug

D0058 | Flunarizine

Molecular Formula C26H26F2N2
Molecular Weight 404.5
Structure
State solid
Protein binding 99% bound to plasma proteins
Half life 18 days
Absorption 85% following oral administration.
Trade names Sibelium
Description calcium antagonist; selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity

N

N07CA03 Flunarizine


[N07CA] Antivertigo preparations


[N07C] ANTIVERTIGO PREPARATIONS


[N07] OTHER NERVOUS SYSTEM DRUGS


[N] Nervous system


Organism Test type Route Dose (normalized dose) Effect Source
rat LD50 oral 503mg/kg (503mg/kg) Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1408, 1975.
dog LD50 oral > 2gm/kg (2000mg/kg) Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1735, 1982.
mouse LD50 intravenous 27mg/kg (27mg/kg) Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1735, 1982.
mouse LD50 intraperitoneal 379mg/kg (379mg/kg) Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1735, 1982.
mouse LD50 subcutaneous > 2550mg/kg (2550mg/kg) Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1735, 1982.
rat LD50 intraperitoneal 305mg/kg (305mg/kg) Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1735, 1982.
mouse LD50 oral 285mg/kg (285mg/kg) European Patent Application. Vol. #0187639,
rat LD50 subcutaneous 1793mg/kg (1793mg/kg) Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1735, 1982.
rat LD50 intravenous 35mg/kg (35mg/kg) Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1735, 1982.


  • (E)-1-(Bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)piperazine (E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine 1-(Bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine
    1-[BIS(4-FLUOROPHENYL)METHYL]-4-CINNAMYLPIPERAZINE 1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propenyl]piperazine 1-[Bis-(4-fluoro-phenyl)-methyl]-4-((E)-3-phenyl-allyl)-piperazine
    1-[Bis-(4-fluoro-phenyl)-methyl]-4-(3-phenyl-allyl)-piperazine 1-[Bis-(4-fluoro-phenyl)-methyl]-4-(3-phenyl-allyl)-piperazine(Flunarizine) 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
    1-[bis(4-fluorophenyl)methyl]-4-[(E)-cinnamyl]piperazine 1-[bis-(4-Fluorophenyl)methyl]-4-cinnamylpiperazine 118378-EP2270011A1
    118378-EP2275420A1 118378-EP2280008A2 118378-EP2298764A1
    118378-EP2298765A1 4-((2E)-3-phenylprop-2-enyl)-1-[bis(4-fluorophenyl)methyl]piperazine 40218-96-0
    52468-60-7 AB00053586-15 AB00053586_16
    AB00053586_17 AC-1283 ACM40218960
    AKOS015960783 API0002726 AX8130500
    BCBcMAP01_000120 BDBM50017702 BPBio1_000336
    BRD-K12184470-300-01-8 BRD-K29582677-001-02-7 BRD-K29582677-300-05-6
    BRD-K29582677-300-06-4 BSPBio_000304 BSPBio_001341
    BSPBio_003096 C26H26F2N2 CAS-52468-60-7
    CC-28469 CCG-204617 CHEBI:135652
    CHEBI:92209 CHEMBL30008 D07971
    DB04841 DSSTox_CID_25616 DSSTox_GSID_45616
    DSSTox_RID_81005 DTXSID6045616 EINECS 254-842-0
    EINECS 257-937-5 Flunarazine Flunarizin
    Flunarizina Flunarizina [INN-Spanish] Flunarizine (INN)
    Flunarizine [INN:BAN] Flunarizine2HCl Flunarizinum
    Flunarizinum [INN-Latin] HMS1361D03 HMS1791D03
    HMS1989D03 HMS2089H21 IDI1_000043
    IDI1_033811 LS-110464 Lopac0_000527
    NCGC00018102-04 NCGC00018102-05 NCGC00018102-06
    NCGC00018102-07 NCGC00018102-08 NCGC00018102-09
    NCGC00018102-10 NCGC00018102-12 NCGC00024308-04
    NCGC00024308-05 NCGC00024308-06 NCGC00024308-07
    Narzine Piperazine, 1-(bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)- Piperazine, 1-(bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)-, (E)-
    Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)-, (E)- Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propenyl]- Prestwick2_000312
    Prestwick3_000312 Q416237 R7PLA2DM0J
    SBI-0050510.P003 SCHEMBL43440 SCHEMBL43441
    SMANXXCATUTDDT-QPJJXVBHSA-N ST024768 STL477617
    Sibelium Sibelium (TN) Spectrum5_001570
    Tox21_110825 Tox21_110825_1 UNII-R7PLA2DM0J
    ZINC19360739 cid_6365505 flunarizine

    DrugBank Name Flunarizine
    DrugBank DB04841
    CAS Number 27064-95-5, 30484-77-6, 40218-96-0, 52468-60-7, 5343-57-7
    PubChem Compound 941361
    KEGG Drug D01303
    PubChem.Substance 46507129
    ChEBI 135652
    PharmGKB PA164776636
    ChemSpider 819216
    BindingDB 50017702.0
    TTD DAP000142
    Wikipedia Flunarizine
    DPD 11229|1252

    1. Chan et al. (2005)