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Drug

D0061 | Fluphenazine

Molecular Formula C22H26F3N3OS
Molecular Weight 437.5
Structure
State liquid

N

N05AB02 Fluphenazine


[N05AB] Phenothiazines with piperazine structure


[N05A] ANTIPSYCHOTICS


[N05] PSYCHOLEPTICS


[N] Nervous system

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 202 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]


H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]


H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]


H330 (100%): Fatal if inhaled [Danger Acute toxicity, inhalation]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P260, P264, P270, P271, P280, P284, P301+P310, P302+P352, P304+P340, P305+P351+P338, P310, P320, P321, P330, P332+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
human TDLo oral 2800ug/kg/2W- (2.8mg/kg) musculoskeletal: other changes British Medical Journal. Vol. 2, Pg. 1071, 1966.
mouse LD50 intraperitoneal 89mg/kg (89mg/kg) "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 24, 1972.
mouse LD50 oral 220mg/kg (220mg/kg) "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 24, 1972.
guinea pig LD50 intraperitoneal 299mg/kg (299mg/kg) Pharmazie. Vol. 38, Pg. 749, 1983.
mouse LD50 oral 330mg/kg (330mg/kg) Drugs in Japan Vol. 6, Pg. 702, 1982.
mouse LD50 intravenous 56mg/kg (56mg/kg) U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00179,

  • Convulsion

  • Psychotic disorder

  • Renal failure

  • Renal impairment

    • 0680AC 1-(2-Hydroxyethyl)-4-(3-(trifluoromethyl-10-phenothiazinyl)propyl)-piperazine 1-(2-Hydroxyethyl)-4-[3-(trifluoromethyl-10-phenothiazinyl)propyl]piperazine
    1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)- 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)- (9CI) 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-
    1-Piperazineethanol, 4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]- 1-Piperazineethanol, 4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]- 10-(3'-(4"-(beta-Hydroxyethyl)-1"-piperazinyl)-propyl)-3-trifluoromethylphenothiazine
    10-(3'-(4''-(beta-Hydroxyethyl)-1''-piperazinyl)-propyl)-3-trifluoromethylphenothiazine 10-(3-(2-Hydroxyethyl)piperazinopropyl)-2-(trifluoromethyl)phenothiazine 1451-EP2272537A2
    1451-EP2298776A1 2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethanol 2-(4-(3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl)-1-piperazinyl)ethanol
    2-(4-(3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl)-1-piperazinyl)ethanol # 2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethan-1-ol 2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethanol
    2-(Trifluoromethyl)-10-(3-(1-(beta-hydroxyethyl)-4-pipe razinyl)propyl)phenothiazine 2-(Trifluoromethyl)-10-(3-(1-(beta-hydroxyethyl)-4-piperazinyl)propyl)phenothiazine 2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]propyl]-1-piperazinyl]ethanol
    2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]propyl]-1-piperazinyl]ethanol;hydrochloride 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol dihydrochloride
    2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol;hydrochloride 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazino]ethanol;hydrochloride 4-(3-(-Trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol
    4-(3-(2-(Trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperazineethanol 4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1-Piperazineethanol 4-(3-(2-Trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol
    4-[3-(2-Trifluoromethyl-10-phenothiazyl)-propyl]-1-piperazineethanol 4-[3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazineethanol 69-23-8
    78126-11-1 A 4077 A836405
    AB00053587 AB00053587-18 AB00053587_19
    AKOS001659031 API0006719 AX8130619
    Anatensol (Salt/Mix) BCP21399 BDBM78433
    BG0198 BIDD:PXR0184 BPBio1_000352
    BPBio1_001187 BRD-K55127134-001-01-7 BRD-K55127134-300-05-4
    BRD-K55127134-300-07-0 BSPBio_000320 BSPBio_003100
    Biomol-NT_000023 C07010 C22H26F3N3OS
    CAS-146-56-5 CAS-69-23-8 CCG-204645
    CHEBI:5123 CHEMBL726 CTK8F9822
    Calmansial ChemDiv1_024180 D07977
    DB00623 DSSTox_CID_3068 DSSTox_GSID_23068
    DSSTox_RID_76862 DTXSID2023068 Dapotum
    DivK1c_000511 EINECS 200-702-9 Elinol
    FLUPHENAZINE Flufenazin Flufenazina
    Flufenazina [DCIT] Fluorfenazine Fluorfenazine pound (3/4)<<EnAa pound(c)
    Fluorophenazine Fluorphenazine Fluphenazin
    Fluphenazine (INN) Fluphenazine [INN:BAN] Fluphenazinum
    Fluphenazinum [INN-Latin] Ftorphenazine GTPL204
    HMS2089C16 HMS655L02 HSDB 3334
    IDI1_000511 KBio1_000511 KBio2_000769
    KBio2_002386 KBio2_003337 KBio2_004954
    KBio2_005905 KBio2_007522 KBio3_002320
    KBio3_002865 KBioGR_001375 KBioGR_002386
    KBioSS_000769 KBioSS_002391 L000257
    LS-112565 Lopac-F-4765 Lopac0_000555
    MCULE-7579992672 MFCD00242759 MLS001076508
    MRF-0000359 Moditen (TN) Moditen (Tabl or elixir)
    NCGC00015436-01 NCGC00015436-02 NCGC00015436-03
    NCGC00015436-04 NCGC00015436-05 NCGC00015436-06
    NCGC00015436-07 NCGC00015436-08 NCGC00015436-09
    NCGC00015436-11 NCGC00024429-03 NCGC00024429-04
    NINDS_000511 NSC 62323 NSC62323
    PLDUPXSUYLZYBN-UHFFFAOYSA-N Pacinol Permitil (Salt/Mix)
    Phenothiazine, 10-(3-(4-(2-hydroxyethyl)-1-piperazinyl)propyl)-2-(trifluoromethyl)- Phthorphenazine Prestwick0_000320
    Prestwick1_000320 Prestwick2_000320 Prestwick3_000320
    Probes1_000254 Probes2_000295 Prolixin (Salt/Mix)
    Prolixine (Salt/Mix) Q58376 S 94
    S79426A41Z S94 SBI-0050538.P003
    SCHEMBL19221 SPBio_001277 SPBio_002539
    SQ 4918 SR-01000003048-5 STK050763
    Sevinol Siqualine Siqualon
    Spectrum2_001199 Spectrum3_001420 Spectrum4_000828
    Spectrum5_001536 Spectrum_000289 Tensofin (Salt/Mix)
    Tox21_110146 Tox21_110146_1 Triflumethazine
    UNII-S79426A41Z Valamina Vespazine
    Yespazine ZINC19203912 cMAP_000035
    cid_3372 cid_6602611 flufenazine

    DrugBank Name Fluphenazine
    DrugBank DB00623
    CAS Number 146-56-5, 69-23-8, 71320-77-9, 78126-11-1
    PubChem Compound 3372
    KEGG Compound ID C07010
    KEGG Drug D07977
    PubChem.Substance 46506645
    ChEBI 5123
    PharmGKB PA449676
    ChemSpider 3255
    BindingDB 78433.0
    TTD DCL000806
    Wikipedia Fluphenazine
    DPD 8007|20269|8013

    1. Chan et al. (2005)