Drug

D0066 | Ibutilide

Molecular Formula C20H36N2O3S
Molecular Weight 384.6
Structure
State solid
Clearance * 29 mL/min/kg
Volume of distribution * 11 L/kg
Route of elimination In healthy male volunteers, about 82% of a 0.01 mg/kg dose of [14C] ibutilide fumarate was excreted in the urine (about 7% of the dose as unchanged ibutilide) and the remainder (about 19%) was recovered in the feces.
Protein binding 0.4
Half life 6 hours (ranges from 2-12 hours)
Absorption Rapid after intravenous injection

C

C01BD05 Ibutilide


[C01BD] Antiarrhythmics, class III


[C01B] ANTIARRHYTHMICS, CLASS I AND III


[C01] CARDIAC THERAPY


[C] Cardiovascular system


Organism Test type Route Dose (normalized dose) Effect Source
rat LD oral > 500mg/kg (500mg/kg) Teratology, The International Journal of Abnormal Development. Vol. 49, Pg. 406, 1994.
rat LD50 intravenous 94200ug/kg (94.2mg/kg) Teratology, The International Journal of Abnormal Development. Vol. 49, Pg. 406, 1994.

  • Arrhythmia

  • Arrhythmia supraventricular

  • Atrial fibrillation

  • Atrial flutter

  • Sinus rhythm

  • Bundle branch block (0.019)

  • Ventricular arrhythmia (0.002)

  • Atrioventricular block

  • Bradycardia

  • Headache

  • Hypotension

  • Nausea

  • Palpitations

  • Tachycardia

  • Ventricular extrasystoles

  • Ventricular tachycardia

  • 122647-31-8 136591-58-7 647I318
    AB01568246_01 ALOBUEHUHMBRLE-UHFFFAOYSA-N API0006228
    BDBM50131432 C-21412 C07753
    C20H36N2O3S CC-29459 CHEBI:5856
    CHEMBL533 D08060 DB00308
    DTXSID20861271 FT-0631106 GTPL7200
    HMS3741K11 Ibutilid Ibutilida
    Ibutilida [INN-Spanish] Ibutilide Ibutilide (INN)
    Ibutilide [BAN:INN] Ibutilide [INN:BAN] Ibutilidum
    Ibutilidum [INN-Latin] LS-90123 MCULE-5393489002
    Methanesulfonamide, N-[4-[4-(ethylheptylamino)-1-hydroxybutyl]phenyl]- N-(4-(4-(ethyl(heptyl)amino)-1-hydroxybutyl)phenyl)methanesulfonamide N-[4-[4-(ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide
    N-{4-[4-(Ethyl-heptyl-amino)-1-hydroxy-butyl]-phenyl}-methanesulfonamide Q3791612 SCHEMBL3719856
    ibutilide, (+-)-isomer n-(4-{4-[ethyl(heptyl)amino]-1-hydroxybutyl}phenyl)methanesulfonamide

    DrugBank Name Ibutilide
    DrugBank DB00308
    CAS Number 100632-81-3, 122647-31-8, 122647-32-9, 130350-52-6, 136591-58-7
    PubChem Compound 60753
    KEGG Compound ID C07753
    KEGG Drug D00648
    PubChem.Substance 46507904
    ChEBI 5856
    PharmGKB PA449958
    ChemSpider 54755
    BindingDB 50131432.0
    TTD DAP000279
    Wikipedia Ibutilide
    DPD 12005

    1. Dykens et al. (2007)