Drug

D0093 | Oxaprozin

Molecular Formula C18H15NO3
Molecular Weight 293.3
Structure
State solid
Volume of distribution * 11 to 17 L/70 kg
Route of elimination Oxaprozin is expected to be excreted in human milk based on its physical-chemical properties; however, the amount of oxaprozin excreted in breast milk has not been evaluated. Approximately 95% of oxaprozin is metabolized by the liver. Approximately 5% of the oxaprozin dose is excreted unchanged in the urine. Sixty-five percent (65%) of the dose is excreted in the urine and 35% in the feces as metabolite. Biliary excretion of unchanged oxaprozin is a minor pathway. Several oxaprozin metabolites have been identified in human urine or feces.
Protein binding >99.5% bound to albumin
Half life 54.9 hours
Absorption Oxaprozin is 95% absorbed after oral administration. Food may reduce the rate of absorption of oxaprozin, but the extent of absorption is unchanged. Antacids do not significantly affect the extent and rate of oxaprozin absorption.

M

M01AE12 Oxaprozin


[M01AE] Propionic acid derivatives


[M01A] ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS


[M01] ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS


[M] Musculoskeletal system


Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 3 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H302 (33.33%): Harmful if swallowed [Warning Acute toxicity, oral]


H315 (33.33%): Causes skin irritation [Warning Skin corrosion/irritation]


H319 (33.33%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H411 (33.33%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]


H412 (33.33%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P264, P270, P273, P280, P301+P312, P302+P352, P305+P351+P338, P321, P330, P332+P313, P337+P313, P362, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

  • Arthritis

  • Juvenile idiopathic arthritis

  • Osteoarthritis

  • Rheumatoid arthritis

  • .beta.-(4,5-Diphenyloxazol-2-yl)propionic acid 2-OXAZOLEPROPIONIC ACID, 4,5-DIPHENYL- 2-Oxazolepropanoic acid, 4,5-diphenyl-
    2-Oxazolepropanoic acid,5-diphenyl- 2-Oxazolepropionic acid,5-diphenyl- 21256-18-8
    256O188 3-(4, 5-Diphenyl-2-oxazolyl)propenoic acid 3-(4,5-Diphenyl-1,3-oxazol-2-yl)propanoic acid
    3-(4,5-Diphenyl-1,3-oxazol-2-yl)propanoic acid # 3-(4,5-Diphenyl-2-oxazolyl)propanoic acid 3-(4,5-Diphenyl-2-oxazolyl)propenoic acid
    3-(4,5-Diphenyl-2-oxazolyl)propionic acid 3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid 3-(4,5-Diphenyloxazol-2-yl)propanoic acid
    3-(diphenyl-1,3-oxazol-2-yl)propanoic acid 4, 5-Diphenyl-2-oxazolepropionic acid 4,5-Diphenyl-2-oxazolepropanoic acid
    4,5-Diphenyl-2-oxazolepropionic acid 4,5-Diphenyloxazole-2-propionic acid 4,5-diphenyloxazole-2-propanoic acid
    4.5-Diphenyl-2-oxazolepropanoic acid|||Daypro A815225 AB0011812
    AB00514024 AB00514024_08 AB00514024_09
    AC-26512 AK-84489 AKOS000206807
    ANW-63377 Actirin Alvo
    B1804 BCP28431 BDBM50002861
    BIDD:GT0438 BIDD:PXR0149 BPBio1_001122
    BRD-K25394294-001-05-7 BRD-K25394294-001-08-1 BRN 1083168
    BSPBio_001020 BSPBio_002696 C07356
    C18H15NO3 CAS-21256-18-8 CCG-36508
    CHEBI:7822 CHEMBL1071 CPD000058286
    CS-7975 CTK7J3117 D00463
    DB00991 DSSTox_CID_25118 DSSTox_GSID_45118
    DSSTox_RID_80684 DTXSID1045118 Danoprox
    Daypro Daypro (TN) Dayrun
    Deflam Durapro Duraprost
    EINECS 244-296-1 EN300-25629 EU-0100944
    FT-0638104 GTPL7252 HMS1571C22
    HMS1922P17 HMS2051L15 HMS2093O08
    HMS2098C22 HMS3262N10 HMS3393L15
    HMS3652H17 HMS3715C22 HMS566H22
    HSDB 7586 HY-B0808 J-013955
    J10396 K-6109 KBio3_001916
    KBioGR_001722 KS-00000ULR KS-5196
    LP00944 LS-100216 Lopac-O-9637
    Lopac0_000944 MCULE-7099031811 MFCD00215977
    MHJ80W9LRB MLS000759535 MLS001424072
    Maybridge1_008800 NC00214 NCGC00014711
    NCGC00014711-01 NCGC00014711-02 NCGC00014711-03
    NCGC00014711-04 NCGC00014711-05 NCGC00014711-06
    NCGC00014711-07 NCGC00014711-08 NCGC00014711-09
    NCGC00014711-10 NCGC00014711-11 NCGC00014711-14
    NCGC00014711-15 NCGC00094249-01 NCGC00094249-02
    NCGC00094249-03 NCGC00094249-04 NCGC00094249-05
    NCGC00094249-06 NCGC00094249-07 NCGC00261629-01
    NCI310839 NCI60_002681 NCIStruc1_000799
    NCIStruc2_000787 NSC 310839 NSC-310839
    NSC-758949 NSC310839 NSC758949
    O 9637 O0377 OFPXSFXSNFPTHF-UHFFFAOYSA-N
    Oprea1_509470 Oxapro Oxaprozi
    Oxaprozin (JP17/USAN/INN) Oxaprozin [USAN:BAN:INN:JAN] Oxaprozin [USAN:USP:INN:BAN:JAN]
    Oxaprozin, United States Pharmacopeia (USP) Reference Standard Oxaprozin, solid Oxaprozin,(S)
    Oxaprozina Oxaprozina [INN-Spanish] Oxaprozine
    Oxaprozine [INN-French] Oxaprozinum Oxaprozinum [INN-Latin]
    Oxaprozinum;Wy21743 Pharmakon1600-01505267 Prestwick0_001060
    Prestwick1_001060 Prestwick2_001060 Prestwick3_001060
    Q1749609 SAM001246770 SBB053166
    SBI-0050918.P002 SC-13926 SCHEMBL3286
    SMR000058286 SPBio_001652 SPBio_002940
    SPECTRUM1505267 SR-01000076053 SR-01000076053-1
    SR-01000076053-3 SR-01000076053-7 SR-01000076053-9
    ST50949623 SW197319-4 Spectrum2_001696
    Spectrum3_001078 Spectrum4_001231 TC-152122
    Tox21_110059 Tox21_110059_1 Tox21_500944
    UNII-MHJ80W9LRB Voir WY 21743
    WY-21,743 WY-21743 Walix
    Wy21743 Xopane Z217102860
    ZINC49643479 beta-(4,5-Diphenyloxazol-2-yl)propionic acid oxaprosin
    oxaprozin s4230

    DrugBank Name Oxaprozin
    DrugBank DB00991
    CAS Number 174064-08-5, 21256-18-8
    PubChem Compound 4614
    KEGG Compound ID C07356
    KEGG Drug D00463
    PubChem.Substance 46506429
    ChEBI 7822
    PharmGKB PA450730
    ChemSpider 4453
    BindingDB 50002861.0
    TTD DAP000622
    Wikipedia Oxaprozin
    DPD 1863

    1. Dykens et al. (2007)