Drug

D0103 | Procaine

Molecular Formula C13H20N2O2
Molecular Weight 236.31
Structure
State solid
Route of elimination With normal kidney function, the drug is excreted rapidly by tubular excretion.
Half life 7.7 minutes

S

N

C

S01HA05 Procaine


[S01HA] Local anesthetics


[S01H] LOCAL ANESTHETICS


[S01] OPHTHALMOLOGICALS


[S] Sensory organs


N01BA52 Procaine, combinations


[N01BA] Esters of aminobenzoic acid


[N01B] ANESTHETICS, LOCAL


[N01] ANESTHETICS


[N] Nervous system


N01BA02 Procaine


[N01BA] Esters of aminobenzoic acid


[N01B] ANESTHETICS, LOCAL


[N01] ANESTHETICS


[N] Nervous system


C05AD05 Procaine


[C05AD] Local anesthetics


[C05A] AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE


[C05] VASOPROTECTIVES


[C] Cardiovascular system


Pictogram Signal Statements Precautionary Statement Codes
Warning

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.


H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]


P264, P270, P301+P312, P330, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
rat LD50 intramuscular > 2gm/kg (2000mg/kg) Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
mouse LD50 intramuscular > 2gm/kg (2000mg/kg) Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
rat LD50 intraperitoneal 420mg/kg (420mg/kg) Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
mouse LD50 oral > 2gm/kg (2000mg/kg) Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
guinea pig LD50 intramuscular 1194mg/kg (1194mg/kg) Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
rat LD50 oral > 2gm/kg (2000mg/kg) Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
mouse LD50 intraperitoneal 371mg/kg (371mg/kg) Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
guinea pig LD50 intraperitoneal 518mg/kg (518mg/kg) Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
mouse LDLo subcutaneous 4gm/kg (4000mg/kg) Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 55, Pg. 23, 1959.


  • .beta.-(Diethylamino)ethyl 4-aminobenzoate .beta.-(Diethylamino)ethyl p-aminobenzoate .beta.-Diethylaminoethyl 4-aminobenzoate
    2-(Diethylamino)ethyl 4-aminobenzoate 2-(Diethylamino)ethyl p-aminobenzoate 2-(Diethylamino)ethyl-4-aminobenzoate
    2-(N,N-diethylamino)ethyl 4-amino-benzoate 2-(diethylamino)ethyl 4-aminobenzoate;hydrochloride 2-(diethylamino)ethyl 4-azanylbenzoate
    2-(diethylamino)ethyl 4-azanylbenzoate;hydrochloride 2-Diethylaminoethyl 4-aminobenzoate 2-Diethylaminoethyl p-aminobenzoate
    2-Diethylaminoethylester kyseliny p-aminobenzoove 2-Diethylaminoethylester kyseliny p-aminobenzoove [Czech] 4-14-00-01138 (Beilstein Handbook Reference)
    4-Amino-benzoic acid 2-diethylamino-ethyl ester 4-Amino-benzoic acid-beta-diethylaminoethylester 4-Aminobenzoesaeure-beta-diethylaminoethylester
    4-Aminobenzoic acid 2-diethylaminoethyl ester 4-Aminobenzoic acid diethylaminoethyl ester 4-amino-benzoic acid2-diethylamino-ethyl ester
    4-aminobenzoic acid 2-(diethylamino)ethyl ester 4-aminobenzoic acid 2-(diethylamino)ethyl ester;hydrochloride 4Z8Y51M438
    59-46-1 A16131 A19427
    A832329 AB00053531 AB00053531-09
    AB00053531_11 AB00053531_12 AB0031355
    AE-641/00560024 AK-50386 AKOS000115407
    API0007241 ARONIS24492 AX8149095
    Allocaine (Salt/Mix) Aminocaine (Salt/Mix) Anticort (TM)
    Anuject BBC/658 BBL005106
    BDBM64452 BENZOIC ACID,4-AMINO,2-DIETHYLAMINOETHYL ESTER PROCAIN BASE BPBio1_000179
    BR-50386 BRD-K24616672-003-05-2 BRD-K24616672-003-10-2
    BRN 0913480 BSPBio_000161 BSPBio_002231
    Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester Benzoic acid, p-amino-, 2-(diethylamino)ethyl ester Benzoic acid,4-amino-,2-(diethylamino)ethyl ester
    C07375 CAS-51-05-8 CCG-205046
    CHEBI:8430 CHEMBL569 CS-2647
    CTK6E8435 D08422 DB00721
    DS-1216 DTXSID7045021 Diethylaminoethyl p-aminobenzoate
    DivK1c_000120 Duracaine EBD36851
    EINECS 200-426-9 EN300-33930 Epitope ID:115010
    FT-0654843 Factor H3 GTPL4291
    Gerokit Gerovital Gerovital H-3
    Gerovital H3 (Salt/Mix) HSDB 3388 HTS001398
    HY-B0546 IDI1_000120 InChI=1/C13H20N2O2/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H
    Jenacain Jenacaine KBio1_000120
    KBio2_001318 KBio2_003886 KBio2_006454
    KBio3_001731 KBioGR_000975 KBioSS_001318
    KS-00000GZ6 LS-35778 Lopac-P-9879
    Lopac0_000966 M-7441 MCULE-8861116126
    MFDFERRIHVXMIY-UHFFFAOYSA-N MLS001304095 NCGC00015864-01
    NCGC00015864-02 NCGC00015864-03 NCGC00015864-04
    NCGC00162298-01 NINDS_000120 NSC 169497
    NSC-169497 NSC169497 Neocaine (Salt/Mix)
    Neotonocaine (Salt/Mix) Nissocaine Norocaine
    Novocain Novocain (Salt/Mix) Novocaine
    Novocaine (Salt/Mix) P1961 Prestwick0_000041
    Prestwick1_000041 Prestwick2_000041 Prestwick3_000041
    Procain Procaina Procaina [INN-Spanish]
    Procaine (INN) Procaine [INN:BAN] Procaine, base
    Procainum Procainum [INN-Latin] Q423741
    SAMPL3, G2 SBB066226 SBI-0050939.P004
    SC-54112 SCHEMBL3524 SMR000718771
    SP-01 SP-01A SP01
    SP01A SPBio_001331 SPBio_002082
    ST024758 ST24031565 STK177303
    Scurocaine (Salt/Mix) Sevicaine (Salt/Mix) Solution of novocain (TN)
    Spectrum2_001296 Spectrum3_000556 Spectrum4_000488
    Spectrum5_001186 Spectrum_000838 Spinocaine
    Stoff H3 TR-018212 TR-020622
    UNII-4Z8Y51M438 Vitamin H3 WLN: ZR DVO2N2&2
    X4422 ZINC1530757 ZX-AS004859
    ZX-AT008592 aminocaine;anadolor beta-(Diethylamino)ethyl 4-aminobenzoate
    beta-(Diethylamino)ethyl p-aminobenzoate beta-Diethylaminoethyl 4-aminobenzoate cid_5795
    novocaine; p-Aminobenzoic acid 2-diethylaminoethyl ester p-Aminobenzoic acid, 2-(diethylamino)ethyl ester
    p-Aminobenzoyldiethylaminoethanol procaine s4668

    DrugBank Name Procaine
    DrugBank DB00721
    CAS Number 1110-47-0, 51-05-8, 59-46-1
    PubChem Compound 4914
    KEGG Compound ID C07375
    KEGG Drug D08422
    PubChem.Substance 46507724
    ChEBI 8430
    PharmGKB PA451110
    ChemSpider 4745
    BindingDB 64452.0
    TTD DAP000296
    Wikipedia Procaine
    DPD 8836

    1. Chan et al. (2005)