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Drug

D0104 | Propofol

Molecular Formula C12H18O
Molecular Weight 178.27
Structure
State liquid
Clearance * 23 - 50 mL/kg/min * 1.6 - 3.4 L/min [70 Kg adults]
Volume of distribution * 60 L/kg [healthy adults]
Route of elimination It is chiefly eliminated by hepatic conjugation to inactive metabolites which are excreted by the kidney.
Protein binding 95 to 99%, primarily to serum albumin and hemoglobin
Half life Initial distribution phase t<sub>1/2&alpha;</sub>=1.8-9.5 minutes. Second redistirubtion phase t<sub>1/2&beta;</sub>=21-70 minutes. Terminal elimination phase t<sub>1/2&gamma;</sub>=1.5-31 hours.
Absorption Rapid - time to onset of unconsciousness is 15-30 seconds, due to rapid distribution from plasma to the CNS. Distribution is so rapid that peak plasma concentrations cannot be readily measured. Duration of action is 5-10 minutes.
Trade names Diprivan
Description General anesthetics

N

N01AX10 Propofol


[N01AX] Other general anesthetics


[N01A] ANESTHETICS, GENERAL


[N01] ANESTHETICS


[N] Nervous system

Toxicity Dose Time Species Model Method Action Positive criterion Reference
ELECTROPHORETIC UNCOUPLING 278
FATTY ACID METABOLISM 197
ROS PRODUCTION increase 197

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 1491 companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]


H315 (97.52%): Causes skin irritation [Warning Skin corrosion/irritation]


H319 (97.52%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H335 (95.51%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • 2, 6-Diisopropylphenol 2,6 Diisopropylphenol 2,6-Bis(1-methylethyl)phenol
    2,6-DIISOPROPYLPHENOL 2,6-DIISOPROPYLPHENOL 2,6-Diisopropyl phenol
    2,6-Diisopropylphenol, 97% 2,6-Diisopropylphenol, >=97% 2,6-Diisopropylphenol, analytical standard
    2,6-bis(Isopropyl)phenol 2,6-bis(methylethyl)phenol 2,6-bis(propan-2-yl)phenol
    2,6-di isopropyl phenol 2,6-di(propan-2-yl)phenol 2,6-diisopropyl-phenol
    2078-54-8 3f33 3p50
    4-06-00-03435 (Beilstein Handbook Reference) A814898 AB00513968
    AB00513968-07 AB00513968_08 AC-2038
    ACMC-1CPLW AI3-26295 AKOS009159417
    AM90311 ANW-24224 AS-13299
    Ampofol Aquafo Aquafol
    BCP02920 BCP0726000298 BDBM50058046
    BIDD:GT0436 BPBio1_000950 BPBio1_000969
    BRD-K82255054-001-03-5 BRD-K82255054-001-08-4 BRN 1866484
    BSPBio_000862 Biomol-NT_000248 C07523
    C12H18O CAS-2078-54-8 CCG-204529
    CCRIS 9000 CHEBI:44915 CHEMBL526
    CP0141 CPD000059151 CS-W020057
    CTK3J0557 Certified Reference Material D00549
    D0617 D126608 DB00818
    DDS-04F DSSTox_CID_3523 DSSTox_GSID_23523
    DSSTox_RID_77063 DTXSID6023523 Diisopropylphenol
    Diisopropylphenol (Related) Dipravan Diprifusor
    Diprivan Diprivan (TN) Diprivan 10
    Diprivan Injectable emulsion Diprofol Disoprivan
    Disoprofol EINECS 218-206-6 EU-0100437
    FT-0610672 Fresofol GTPL5464
    H835 HMS1570L04 HMS2089O21
    HMS2094E17 HMS2097L04 HMS2231E16
    HMS3259E03 HMS3261G16 HMS3369I16
    HMS3714L04 HSDB 7123 ICI 35,868
    ICI 35868 ICI-35,868 ICI-35868
    InChI=1/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H Ivofol KS-00000MQ0
    KSC490K5P LP00437 LS-996
    Lopac-D126608 Lopac0_000437 MCULE-1903292305
    MFCD00008885 MFCD00008885 (98%) MLS-0318084
    MLS-0318084.P017 MLS001066348 MLS001335999
    MLS002454360 NC00449 NCGC00015389-01
    NCGC00015389-02 NCGC00015389-03 NCGC00015389-04
    NCGC00015389-05 NCGC00015389-06 NCGC00015389-07
    NCGC00015389-08 NCGC00015389-09 NCGC00015389-10
    NCGC00015389-11 NCGC00015389-14 NCGC00091538-01
    NCGC00091538-02 NCGC00091538-03 NCGC00091538-04
    NCGC00091538-05 NCGC00091538-06 NCGC00257228-01
    NCGC00260670-01 NCGC00261122-01 NSC 5105
    NSC-5105 NSC-758909 NSC5105
    NSC758909 OLBCVFGFOZPWHH-UHFFFAOYSA-N PROPOFOL
    Pharmakon1600-01505022 Phenol, 2, 6-bis(1-methylethyl)- Phenol, 2,6-bis(1-methylethyl)-
    Phenol, 2,6-diisopropyl- Phenol,6-bis(1-methylethyl)- Phenol,6-diisopropyl-
    Pofol Prestwick0_000931 Prestwick1_000931
    Prestwick2_000931 Prestwick3_000931 Propofol (Diprivan)
    Propofol (JAN/USAN/INN) Propofol 1.0 mg/ml in Methanol Propofol IDD-D
    Propofol [USAN:INN:BAN] Propofol [USAN:USP:INN:BAN] Propofol for peak identification, European Pharmacopoeia (EP) Reference Standard
    Propofol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material Propofol, British Pharmacopoeia (BP) Reference Standard Propofol, European Pharmacopoeia (EP) Reference Standard
    Propofol, Pharmaceutical Secondary Standard Propofol, United States Pharmacopeia (USP) Reference Standard Propofol-Lipuro
    Propofolum Propofolum [Latin] Propovan
    Propoven Q-201631 Q422740
    RTR-009757 Rapinovet Recofol
    SAM002264610 SC-18796 SCHEMBL36245
    SMR000059151 SPBio_003031 SPECTRUM1505022
    SR-01000075468 SR-01000075468-1 SR-01000075468-4
    SR-01000075468-6 ST2415947 ST50405911
    SY013479 TR-009757 TRA0038441
    Tox21_110134 Tox21_110134_1 Tox21_201371
    Tox21_303225 Tox21_500437 UNII-YI7VU623SF
    VZ22957 YI7VU623SF Z1245735300
    ZD-0859 ZINC968303 ghl.PD_Mitscher_leg0.558
    propofol

    DrugBank Name Propofol
    DrugBank DB00818
    CAS Number 113981-41-2, 2078-54-8
    PubChem Compound 4943
    KEGG Compound ID C07523
    KEGG Drug D00549
    PubChem.Substance 46504991
    ChEBI 44915
    PharmGKB PA451141
    ChemSpider 4774
    BindingDB 50058046.0
    TTD DAP000662
    Wikipedia Propofol
    HET PFL
    DPD 8209

    1. Chan et al. (2005)
    2. Vuda et al. (2016)