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Drug

D0110 | Salsalate

Molecular Formula C14H10O5
Molecular Weight 258.23
Structure
State solid
Protein binding Salicylate: 90-95% bound at plasma salicylate concentrations <100 mcg/mL; 70-85% bound at concentrations of 100-400 mcg/mL; 25-60% bound at concentrations >400 mcg/mL.
Half life The parent compound has an elimination half-life of about 1 hour. Salicylic acid (the active metabolite) biotransformation is saturated at anti-inflammatory doses of salsalate. Such capacity limited biotransformation results in an increase in the half-life of salicylic acid from 3.5 to 16 or more hours.
Absorption Salsalate is insoluble in acid gastric fluids (< 0.1 mg/ml at pH 1.0), but readily soluble in the small intestine where it is partially hydrolyzed to two molecules of salicylic acid. A significant portion of the parent compound is absorbed unchanged. The amount of salicylic acid available from salsalate is about 15% less than from aspirin, when the two drugs are administered on a salicylic acid molar equivalent basis (3.6 g salsalate/5 g aspirin). Food slows the absorption of all salicylates including salsalate.

N

N02BA06 Salsalate


[N02BA] Salicylic acid and derivatives


[N02B] OTHER ANALGESICS AND ANTIPYRETICS


[N02] ANALGESICS


[N] Nervous system

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 45 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H302 (88.89%): Harmful if swallowed [Warning Acute toxicity, oral]


H315 (11.11%): Causes skin irritation [Warning Skin corrosion/irritation]


H319 (11.11%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H400 (84.44%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P264, P270, P273, P280, P301+P312, P302+P352, P305+P351+P338, P321, P330, P332+P313, P337+P313, P362, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

  • Arthritis

  • Osteoarthritis

  • Rheumatic disorder

  • Rheumatoid arthritis

    • 2-((2-Hydroxybenzoyl)oxy)benzoic acid 2-(2-hydroxybenzoyl)oxybenzoic acid 2-(2-hydroxybenzoyloxy)benzoic acid
    2-(2-hydroxyphenylcarbonyloxy)benzoic acid 2-Carboxyphenyl salicylate 2-Carboxyphenyl salicylate, AldrichCPR
    2-Hydroxybenzoic Acid 2-Carboxyphenyl Ester 2-Hydroxybenzoic Acid 2-Carboxyphenyl Ester 2-Hydroxybenzoic acid 2-carboxyphenyl ester
    2-Salicyloyloxybenzoic Acid 2-Salicylsalicylic acid 2-[(2-Hydroxybenzoyl)oxy]benzoic Acid (Salicylsalicylic Acid)
    2-[(2-Hydroxybenzoyl)oxy]benzoic acid # 2-[(2-hydroxyphenyl)carbonyloxy]benzoic acid 2-{[(2-hydroxyphenyl)carbonyl]oxy}benzoic acid
    552-94-3 AB01563259_01 AB01563259_02
    AC-18298 ACMC-209lm5 AK114551
    AKOS003368478 ANW-32283 API0002421
    AS-12645 AX8015186 Aspirin Impurity E
    BDBM85244 BRN 2590908 BSPBio_001665
    Benzoic acid, 2-carboxyphenyl ester Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester C-16063
    CAS-552-94-3 CAS_552-94-3 CC-09787
    CCG-39652 CHEBI:9014 CHEMBL154111
    CS-4891 Certified Reference Material D00428
    DB-020760 DB01399 DSSTox_CID_3572
    DSSTox_GSID_23572 DSSTox_RID_77088 DTXSID1023572
    Diacesal Diplosal Disalcid
    Disalcid (TN) Disalgesic Disalicylic acid
    Disalicylic acid; Disalicylsaeure Disalyl
    EINECS 209-027-4 FT-0632376 GL4615
    HMS2091A05 HMS3652P07 HY-B1245
    KBio2_002563 KBio2_005131 KBio2_007699
    KBio3_001165 KBioGR_001500 KBioSS_002572
    KS-00000WSM LS-37546 MCULE-7200376848
    MFCD00020252 Mono-gesic NCGC00096014-01
    NCGC00096014-02 NCGC00096014-03 NSC 49171
    NSC-49171 NSC-755823 NSC49171
    NSC755823 NSC_5161 Nobacid
    O-Salicylcylsalicylsaeure O-Salicyloylsalicylic Acid Pharmakon1600-00200331
    Q-100630 Q1320691 S0129
    SBB003097 SBI-0206687.P002 SCHEMBL15562
    SPBio_000845 SPECTRUM200331 SR-05000001536
    SR-05000001536-1 ST083489 ST24027407
    SW219189-1 Sal Ester Sal Salflex
    Salical Salicylic Acid 2-Carboxyphenyl Ester Salicylic Acid Salicylate
    Salicylic acid bimolecular ester Salicylic acid, bimolecular ester Salicylic acid, salicylate
    Salicyloxysalicylic acid Salicyloylsalicylic acid Salicylsalicylic Acid (2-[(2-Hydroxybenzoyl)oxy]benzoic Acid)
    Salicylsalicylic acid Salicylsalicylic acid, 98% Salicylsalicylic acid;Disalicylic acid
    Salina Saloxium Salsalate
    Salsalate (Aspirin Impurity E), Pharmaceutical Secondary Standard Salsalate (USP/INN) Salsalate [USAN:INN:BAN]
    Salsalate [USAN:USP:INN:BAN] Salsalate, >=98% (HPLC) Salsalate, United States Pharmacopeia (USP) Reference Standard
    Salsalato Salsalato [INN-Spanish] Salsalatum
    Salsalatum [INN-Latin] Salysal Sasapirin
    Sasapyrin Sasapyrine (JAN) Sasapyrinum
    Spectrum2_000693 Spectrum3_000173 Spectrum4_000940
    Spectrum5_000670 Spectrum_001998 TC-121028
    Tox21_111548 Tox21_111548_1 UNII-V9MO595C9I
    V9MO595C9I WVYADZUPLLSGPU-UHFFFAOYSA-N ZINC2062
    o-Salicylsalicylic acid s4188 sasapyrine

    DrugBank Name Salsalate
    DrugBank DB01399
    CAS Number 552-94-3, 5690-13-1
    PubChem Compound 5161
    KEGG Drug D00428
    PubChem.Substance 46506882
    ChEBI 9014
    PharmGKB PA164745462
    ChemSpider 4977
    BindingDB 85244.0
    TTD DAP000734
    Wikipedia Salsalate
    DPD 11931

    1. Dykens et al. (2007)