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Drug

D0114 | Streptozocin

Molecular Formula C8H15N3O7
Molecular Weight 265.22
Structure
State solid
Route of elimination As much as 20% of the drug (or metabolites containing an N-nitrosourea group) is metabolized and/or excreted by the kidney.
Half life 5-15 minutes
Absorption Poor oral absorption (17-25%)

L

L01AD04 Streptozocin


[L01AD] Nitrosoureas


[L01A] ALKYLATING AGENTS


[L01] ANTINEOPLASTIC AGENTS


[L] Antineoplastic and immunomodulating agents

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 41 companies from 3 notifications to the ECHA C&L Inventory.


Reported as not meeting GHS hazard criteria by 1 of 41 companies. For more detailed information, please visit ECHA C&L website


Of the 2 notification(s) provided by 40 of 41 companies with hazard statement code(s):


H350 (100%): May cause cancer [Danger Carcinogenicity]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P201, P202, P281, P308+P313, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H301: Toxic if swallowed [Danger Acute toxicity, oral]


H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]


H351: Suspected of causing cancer [Warning Carcinogenicity]


H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]


H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]


H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]


 P201, P202, P260, P264, P270, P281, P301+P310, P307+P311, P308+P313, P314, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • 1-methyl-1-nitroso-3-((2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)urea 1-methyl-1-nitroso-3-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]urea 18883-66-4
    2-Deoxy-2[[(methylnitrosoamino)-carbonyl]amino]-D-glucopyranose 2-Desoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose 2-deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose
    2-deoxy-2-{[methyl(nitroso)carbamoyl]amino}-alpha-D-glucopyranose 24975-EP2275420A1 24975-EP2277858A1
    24975-EP2292227A2 24975-EP2295053A1 24975-EP2298767A1
    24975-EP2314574A1 27771-EP2272827A1 27771-EP2295055A2
    27771-EP2295416A2 27771-EP2295426A1 27771-EP2295427A1
    27771-EP2298748A2 27771-EP2298764A1 27771-EP2298765A1
    27771-EP2298778A1 27771-EP2305642A2 27771-EP2308833A2
    27771-EP2308861A1 27771-EP2311453A1 27771-EP2311842A2
    27771-EP2314587A1 27773-EP2277858A1 27773-EP2292227A2
    27773-EP2298767A1 27773-EP2314587A1 3-methyl-3-nitroso-1-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea
    66395-18-4 883S664 8H27GUR065
    AB00052092-03 AB00052092_04 AB00052092_05
    AB00513906 AB2000735 ACT03364
    AKOS025310730 API0015373 BCBcMAP01_000142
    BIS4356 BPBio1_000754 BSPBio_000684
    BSPBio_002734 C-16594 C07313
    C8H15N3O7 CAS-18883-66-4 CC-34553
    CCG-39870 CHEBI:9288 CHEMBL1603
    D05932 DB00428 DSSTox_CID_1282
    DSSTox_GSID_21282 DSSTox_RID_76055 DTXSID2021282
    DivK1c_000531 Epitope ID:134282 Estreptozocina
    HMS1921A07 HMS2092I09 HMS2097C06
    HMS3714C06 HMS501K13 IDI1_000531
    KBio1_000531 KBio2_001440 KBio2_004008
    KBio2_006576 KBio3_001954 KBioGR_001768
    KBioSS_001440 MFCD00006607 MLS004774123
    N-(Methylnitrosocarbamoyl)-alpha-D-glucosamine N-(Methylnitrosocarbamoyl)-|A-D-glucosamine N-D-Glucosyl-(2)-N'-nitrosomethylharnstoff
    NCGC00016738-01 NCGC00178500-01 NCGC00178500-02
    NCGC00178500-03 NCGC00178500-04 NCGC00178500-07
    NCGC00256594-01 NCGC00259408-01 NINDS_000531
    NSC-757321 NSC757321 Pharmakon1600-01500543
    Prestwick3_000732 Q257331 SBI-0051517.P003
    SCHEMBL4748 SMP1_000282 SMR001233317
    SPBio_000243 SPECTRUM1500543 SR-01000939745
    SR-01000939745-3 SR-05000001720 SR-05000001720-1
    SR-05000001720-2 STREPTOZOTOCIN SW199198-2
    Spectrum2_000062 Spectrum3_001087 Spectrum4_001244
    Spectrum5_001047 Spectrum_000960 Streptozocin (JAN/USAN/INN)
    Streptozocin, >=75% alpha-anomer basis, >=98% (HPLC), powder Streptozocin, >=98.0% (HPLC) Streptozocin, Vetec(TM) reagent grade, 98%, powder
    Streptozocine Streptozocinium Streptozocinum
    Streptozotocin Streptozotocin - Zanosar Tox21_110585
    Tox21_110585_1 Tox21_201859 Tox21_302974
    UNII-8H27GUR065 W-201687 ZINC3977737
    ZX-AFC000345 Zanosar (TN) alkylating agent
    alpha-D-Glucopyranose, 2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)- alpha-Streptozocin binds to DNA
    s1312 streptozocin streptozosin
    streptozotocin (stz)

    DrugBank Name Streptozocin
    DrugBank DB00428
    CAS Number 18883-66-4, 66395-18-4
    PubChem Compound 29327
    KEGG Compound ID C07313
    KEGG Drug D05932
    PubChem.Substance 46508872
    ChEBI 9288
    PharmGKB PA451514
    ChemSpider 27273
    TTD DAP000984
    Wikipedia Streptozocin
    DPD 8564

    1. Dykens et al. (2007)
    2. Lee et al., 2016