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Drug

D0117 | Telbivudine

Molecular Formula C10H14N2O5
Molecular Weight 242.23
Structure
State solid
Clearance * 7.6 +/- 2.9 L/h [Normal renal function (Clcr>80 mL/min)] * 5.0 +/- 1.2 L/h [Mild renal function impairement (Clcr=50-80 mL/min)] * 2.6 +/- 1.2 L/h [Moderate renal function impairement (Clcr=30-49 mL/min)] * 0.7 +/- 0.4 L/h [Severe renal function impairement (Clcr<30 mL/min)]
Route of elimination Telbivudine is eliminated primarily by urinary excretion of unchanged drug.
Protein binding In vitro binding of telbivudine to human plasma proteins is low (3.3%).
Half life Approximately 15 hours.
Absorption Absorbed following oral administration. Telbivudine absorption and exposure were unaffected when a single 600–mg dose was administered with a high–fat (~55 g), high–calorie (~950 kcal) meal.

J

J05AF11 Telbivudine


[J05AF] Nucleoside and nucleotide reverse transcriptase inhibitors


[J05A] DIRECT ACTING ANTIVIRALS


[J05] ANTIVIRALS FOR SYSTEMIC USE


[J] Antiinfectives for systemic use

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory.


Reported as not meeting GHS hazard criteria by 1 of 39 companies. For more detailed information, please visit ECHA C&L website


Of the 1 notification(s) provided by 38 of 39 companies with hazard statement code(s):


H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P264, P270, P301+P312, P330, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • 1-((2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 1-((2S,4S,5S)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 1-(2-Deoxy-beta-L-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-Pyrimidinedione
    1-(2-Deoxy-beta-L-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione 1-(2-Deoxy-beta-L-erythropentafuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione 1-(2-deoxy-beta-L-ribofuranosyl)-5-methyluracil
    1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione 1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione 1-[(2s,4r,5s)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione
    2'-Deoxy-L-thymidine 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-b-L-erythro-pentofuranosyl)-5-methyl- 2-Deoxy-L-thymidine
    26879-47-0 2OC4HKD3SF 3424-98-4
    5-methyl-l-uridine AB01274717-01 AB01274717_02
    AB2000195 AC-5632 AKOS025117349
    API0025947 AS-35209 BDBM50088372
    BRD-K15976406-001-01-7 CHEBI:63624 CHEMBL374731
    CS-1934 CT-990 D06675
    DB01265 DTXSID30187813 Epavudine
    Epavudine;L-Thymidine;NV 02B GC4386 HY-B0017
    IQFYYKKMVGJFEH-CSMHCCOUSA-N L-Deoxythymidine L-Thymidine
    L-dT LDT-600 LDT600
    LLT LS-186402 LS-187347
    LdT MFCD02683612 NB 02B
    NCGC00346560-01 NV 02B NV-02B
    Q413621 SB20806 SCHEMBL124279
    SW220236-1 Sebivo Sebivo;Tyzeka
    Telbivudin Telbivudine Telbivudine (Sebivo, Tyzeka)
    Telbivudine (USAN/INN) Telbivudine [USAN:INN:BAN] Telbivudine [USAN]
    Telbivudine(Tyzeka, Sebivo) Telbivudine, >=98% (HPLC) Thymine, 1-(2-deoxy-.beta.-L-erythro-pentofuranosyl)-
    Thymine, 1-(2-deoxy-beta-L-erythro-pentofuranosyl)- Tyzeka Tyzeka (TN)
    UNII-2OC4HKD3SF Z2574360267 ZINC2159
    b-L-2'-deoxy-thymidine beta-L-2'-Deoxythymidine beta-L-Thymidine
    s1651

    DrugBank Name Telbivudine
    DrugBank DB01265
    CAS Number 26879-47-0, 3424-98-4, 50-89-5
    PubChem Compound 159269
    KEGG Drug D06675
    PubChem.Substance 46508706
    ChEBI 63624
    PharmGKB PA164760861
    ChemSpider 140081
    BindingDB 50088372.0
    TTD DAP000698
    Wikipedia Telbivudine
    HET LLT
    DPD 20037

    1. Dykens et al. (2007)
    2. Szymanski et al., 2015