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Drug

D0123 | Tolmetin

Molecular Formula C15H15NO3
Molecular Weight 257.28
Structure
State solid
Half life Biphasic elimination from the plasma consisting of a rapid phase with a half-life of one to 2 hours followed by a slower phase with a half-life of about 5 hours.
Absorption Rapidly and almost completely absorbed with peak plasma levels being reached within 30-60 minutes after an oral therapeutic dose.

M

M02AA21 Tolmetin


[M02AA] Antiinflammatory preparations, non-steroids for topical use


[M02A] TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN


[M02] TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN


[M] Musculoskeletal system

M01AB03 Tolmetin


[M01AB] Acetic acid derivatives and related substances


[M01A] ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS


[M01] ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS


[M] Musculoskeletal system

Pictogram Signal Statements Precautionary Statement Codes
Warning

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.


H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]


H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]


H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


 P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
mouse LD50 unreported 1107mg/kg (1107mg/kg) Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 19, Pg. 460, 1984.
mammal (species unspecified) LD50 oral 300mg/kg (300mg/kg) Indian Journal of Medical Research. Vol. 81, Pg. 621, 1985.
rat LD50 oral 293mg/kg (293mg/kg) gastrointestinal: ulceration or bleeding from stomach Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1526, 1975.
mouse LD50 intraperitoneal 600mg/kg (600mg/kg) Farmaco, Edizione Scientifica. Vol. 38, Pg. 90, 1983.
rat LD50 rectal 744mg/kg (744mg/kg) Archivos de Farmacologia y Toxicologia. Vol. 5, Pg. 257, 1979.
mouse LD50 intravenous 680mg/kg (680mg/kg) Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 45, 1977.
mouse LD50 oral 914mg/kg (914mg/kg) Farmaco, Edizione Scientifica. Vol. 38, Pg. 90, 1983.

  • Arthritis

  • Juvenile idiopathic arthritis

  • Osteoarthritis

  • Peptic ulcer

  • Rheumatoid arthritis

  • Ulcer

  • Nausea (0.11)

    • 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid 1-Methyl-5-(4-methylbenzoyl)-pyrrole-2-acetic acid 1-Methyl-5-(4-methylbenzoyl)pyrrole-2-acetic acid
    1-Methyl-5-p-toluoyl-pyrrole-2-acetic acid 1-Methyl-5-p-toluoylpyrrole-2-acetic acid 1-methyl- 5-(p-toluoyl)pyrrole-2-acetic acid
    171T233 1H-Pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)- 1H-Pyrrole-2-aceticacid, 1-methyl-5-(4-methylbenzoyl)-
    2-(1-METHYL-5-(4-METHYLBENZOYL)-1H-PYRROL-2-YL)ACETIC ACID 2-[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetic acid 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetic acid
    2-[1-methyl-5-(4-methylphenyl)carbonyl-pyrrol-2-yl]ethanoic acid 2-[1-methyl-5-[(4-methylphenyl)-oxomethyl]-2-pyrrolyl]acetic acid 2-{1-methyl-5-[(4-methylphenyl)carbonyl]-1H-pyrrol-2-yl}acetic acid
    26171-23-3 4CH-007739 5-(p-Toluoyl)-1-methylpyrrole-2-acetic acid
    5-22-06-00392 (Beilstein Handbook Reference) A818238 AB0023814
    ACM26171233 AK-34409 AKOS015850645
    ANW-52106 API0009078 AX8154345
    Acido 1-metil-5-(p-tolnil)-pirrol-2-acetico Acido 1-metil-5-(p-tolnil)-pirrol-2-acetico [Spanish] BCP09085
    BDBM50295287 BIDD:GT0468 BPBio1_000959
    BR-34409 BRD-K82562631-236-02-0 BRD-K82562631-325-03-9
    BRN 0485305 BSPBio_000871 BSPBio_002106
    C07149 CHEBI:71941 CHEMBL1020
    CS-W008734 CTK1A2122 D02355
    D8K2JPN18B DB00500 DTXSID2043951
    DivK1c_000213 EINECS 247-497-2 FT-0649942
    GS-6529 GTPL7311 HMS2090D06
    HSDB 3403 IDI1_000213 J-504975
    KBio1_000213 KBio2_001415 KBio2_003983
    KBio2_006551 KBio3_001606 KBioGR_000797
    KBioSS_001415 KS-00000H6J LS-136618
    MCN 2559 McN-2559 McN-2559-21-98
    NINDS_000213 Oprea1_869397 Prestwick0_000856
    Prestwick1_000856 Prestwick2_000856 Prestwick3_000856
    PubChem15045 Pyrrole-2-acetic acid, 1-methyl-5-p-toluoyl- Q3992411
    S-3564 SBI-0051537.P002 SCHEMBL3150
    SPBio_000990 SPBio_002792 ST24027131
    Spectrum2_001205 Spectrum3_000603 Spectrum4_000359
    Spectrum5_001194 Spectrum_000935 TLT
    TR-011846 Tolectin Tolmetin (USAN/INN)
    Tolmetin Sodium, Dihydrate Tolmetin [USAN:BAN:INN] Tolmetin [USAN:INN:BAN]
    Tolmetina Tolmetina [DCIT] Tolmetine
    Tolmetine [INN-French] Tolmetino Tolmetino [INN-Spanish]
    Tolmetinum Tolmetinum [INN-Latin] UNII-D8K2JPN18B
    UPSPUYADGBWSHF-UHFFFAOYSA-N W4953 ZINC2191
    [1-Methyl-5-(4-methyl-benzoyl)-1H-pyrrol-2-yl]-acetic acid [1-Methyl-5-(4-methyl-benzoyl)-1H-pyrrol-2-yl]-acetic acid(tolmetin) [1-Methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetic acid
    [1-Methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetic acid # tolmetin

    DrugBank Name Tolmetin
    DrugBank DB00500
    CAS Number 1184998-16-0, 26171-23-3
    PubChem Compound 5509
    KEGG Compound ID C07149
    KEGG Drug D02355
    PubChem.Substance 46507060
    ChEBI 71941
    PharmGKB PA451721
    ChemSpider 5308
    BindingDB 50295287.0
    TTD DAP000777
    Wikipedia Tolmetin
    HET TLT
    DPD 11239

    1. Dykens et al. (2007)