Compound
D0157 | Chlorpyrifos
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| LIPID PEROXIDATION | 30–50 μM | PC12 cell line | we measured the concentration malondialdehyde (MDA) to indicate formation of lipid peroxides | 242 | ||||
| MITOCHONDRIAL DYNAMICS | 30 μM | Human stem cell-derived neural progenitor cells | 247 | |||||
| FISSION | 30 μM | Human | Human induced pluripotent stem cells (iPSCs) | increase | 242 | |||
| Target | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| Mitofusin-1 | 30 μM | Human | Human induced pluripotent stem cells (iPSCs) | 242 | ||||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
  |
Danger |
H301: Toxic if swallowed [Danger Acute toxicity, oral] H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P264, P270, P273, P301+P310, P321, P330, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
Aggregated GHS information provided by 374 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral] H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P264, P270, P273, P301+P310, P321, P330, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
H301: Toxic if swallowed [Danger Acute toxicity, oral] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P264, P270, P273, P301+P310, P321, P330, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
H301: Toxic if swallowed [Danger Acute toxicity, oral] H311: Toxic in contact with skin [Danger Acute toxicity, dermal] H330: Fatal if inhaled [Danger Acute toxicity, inhalation] H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P260, P264, P270, P271, P273, P280, P284, P301+P310, P302+P352, P304+P340, P310, P312, P320, P321, P322, P330, P361, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
 |
Danger |
H301: Toxic if swallowed [Danger Acute toxicity, oral] H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure] H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] |
P260, P264, P270, P301+P310, P307+P311, P314, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | oral | 60mg/kg (60mg/kg) | Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. Vol. 13, Pg. 11, 1978. | |
| man | TDLo | oral | 300mg/kg (300mg/kg) | Archives of Toxicology. Vol. 59, Pg. 176, 1986. | |
| mammal (species unspecified) | LD50 | unreported | 163mg/kg (163mg/kg) | Journal of Agricultural and Food Chemistry. Vol. 27, Pg. 712, 1979. | |
| rat | LD50 | unreported | 150mg/kg (150mg/kg) | "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 339, 1971. | |
| mouse | LD50 | skin | 120mg/kg (120mg/kg) | Yakkyoku. Pharmacy. Vol. 38, Pg. 745, 1987. | |
| quail | LD50 | oral | 13300ug/kg (13.3mg/kg) | ASTM Special Technical Publication. Vol. (680), Pg. 157, 1979. | |
| rat | LD50 | skin | 202mg/kg (202mg/kg) | Toxicology and Applied Pharmacology. Vol. 14, Pg. 515, 1969. | |
| rabbit | LD50 | skin | 2gm/kg (2000mg/kg) | Guide to the Chemicals Used in Crop Protection. Vol. 6, Pg. 203, 1973. | |
| duck | LD50 | oral | 76mg/kg (76mg/kg) | Toxicology and Applied Pharmacology. Vol. 20, Pg. 57, 1971. | |
| guinea pig | LD50 | oral | 504mg/kg (504mg/kg) | Farm Chemicals Handbook. Vol. -, Pg. C74, 1991. | |
| rat | LD50 | oral | 82mg/kg (82mg/kg) | Toxicology and Applied Pharmacology. Vol. 14, Pg. 515, 1969. | |
| pigeon | LD50 | oral | 10mg/kg (10mg/kg) | ASTM Special Technical Publication. Vol. (680), Pg. 157, 1979. | |
| rabbit | LD50 | oral | 1gm/kg (1000mg/kg) | Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 45, 1978. | |
| guinea pig | LDLo | subcutaneous | 100mg/kg (100mg/kg) | Journal of Economic Entomology. Vol. 60, Pg. 733, 1967. | |
| bird - wild | LD50 | oral | 5mg/kg (5mg/kg) | Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972. | |
| chicken | LD50 | oral | 25400ug/kg (25.4mg/kg) | Toxicology and Applied Pharmacology. Vol. 11, Pg. 49, 1967. | |
| rat | LC50 | inhalation | > 200mg/m3/4H (200mg/m3) | Pesticide Manual. Vol. 9, Pg. 166, 1991. | |
| mouse | LD50 | intraperitoneal | 192mg/kg (192mg/kg) | Toxicology and Applied Pharmacology. Vol. 65, Pg. 144, 1982. | |
| 2-Pyridinol, 3,5,6-trichloro-, O-ester with O,O-diethyl phosphorothioate | 26848-EP2274983A1 | 26848-EP2275422A1 |
| 26848-EP2280002A1 | 26848-EP2280009A1 | 26848-EP2292608A1 |
| 26848-EP2305662A1 | 26848-EP2308857A1 | 26848-EP2308858A1 |
| 26848-EP2311816A1 | 26848-EP2311817A1 | 26848-EP2314583A1 |
| 2921-88-2 | 88579-EP2298076A1 | 88579-EP2298077A1 |
| 88579-EP2301353A1 | 88579-EP2305031A1 | 88579-EP2305034A1 |
| 88579-EP2305035A1 | 88579-EP2305662A1 | 921C882 |
| A819822 | AB00053051_06 | AC-993 |
| AI3-27311 | AKOS015891656 | BDBM74063 |
| BIDD:PXR0044 | BRD-K08303368-001-02-7 | BRD-K08303368-001-06-8 |
| BRN 1545756 | BSPBio_002437 | Bolton |
| Bonidel | Brodan | C-20634 |
| C14322 | C7H7Cl3NO3PS | C9H11Cl3NO3PS |
| CAS-2921-88-2 | CC-25729 | CCG-39144 |
| CCRIS 7144 | CHEBI:34631 | CHEMBL463210 |
| CTK8E8187 | Caswell No. 219AA | Chloropyrifos |
| Chloropyriphos | Chlorpyrifos (BAN) | Chlorpyrifos (Dursban) |
| Chlorpyrifos 10 microg/mL in Cyclohexane | Chlorpyrifos 100 microg/mL in Acetone | Chlorpyrifos 100 microg/mL in Acetonitrile |
| Chlorpyrifos 100 microg/mL in Cyclohexane | Chlorpyrifos 1000 microg/mL in Toluene | Chlorpyrifos [ANSI:BSI:ISO] |
| Chlorpyrifos [BAN] | Chlorpyrifos ethyl | Chlorpyrifos solution, 100 mug/mL in acetonitrile, PESTANAL(R), analytical standard |
| Chlorpyrifos solution, certified reference material, TraceCERT(R), 1000 mug/mL in methyl tert-butyl ether, ampule of 1 mL | Chlorpyrifos, PESTANAL(R), analytical standard | Chlorpyrifos, certified reference material, TraceCERT(R) |
| Chlorpyrifos-ethyl | Chlorpyriphos | Chlorpyriphos [ISO-French] |
| Chlorpyriphos-ethyl | Chlorpyritos | Chlorpyrofos |
| Chlorpyrophos | Clorpyrifos | Coroban |
| D07688 | DSSTox_CID_458 | DSSTox_GSID_20458 |
| DSSTox_RID_75603 | DTXSID4020458 | Danusban |
| Detmol | Detmol U.A | Detmol U.A. |
| Detmol ua | Dhanusban | Diethyl O-(3,5,6-trichloro-2-pyridyl) phosphorothioate |
| DivK1c_006614 | Dowco 179 | Durmet |
| Dursban | Dursban 10CR | Dursban 2E |
| Dursban 44 | Dursban 4E | Dursban F |
| Dursban R | Dursban, analytical standard | EINECS 220-864-4 |
| ENT 27,311 | ENT 27311 | EPA Pesticide Chemical Code 059101 |
| Empire 20 | Equity | Ethyl chlorpyriphos |
| FT-0602970 | Geodinfos | Grofo |
| HMS3039C03 | HMS3264O03 | HSDB 389 |
| InChI=1/C9H11Cl3NO3PS/c1-3-14-17(18,15-4-2)16-9-7(11)5-6(10)8(12)13-9/h5H,3-4H2,1-2H3 | J-017440 | JCS58I644W |
| KBio1_001558 | KBio2_002421 | KBio2_004989 |
| KBio2_007557 | KBio3_001937 | KBioGR_001157 |
| KBioSS_002427 | KS-5372 | Killmaster |
| LS-1137 | Lentrek | Lock-On |
| Lorsban | Lorsban 50SL | M-1133 |
| MLS001065609 | NCGC00091472-01 | NCGC00091472-02 |
| NCGC00091472-03 | NCGC00091472-04 | NCGC00091472-05 |
| NCGC00091472-06 | NCGC00091472-07 | NCGC00091472-08 |
| NCGC00091472-09 | NCGC00253974-01 | NCGC00259932-01 |
| NSC-755891 | NSC755891 | Nufos |
| O,O-DIETHYL O-3,5,6-TRICHLOROPYRIDIN-2-YL PHOSPHOROTHIOATE | O,O-Diaethyl-O-3,5,6-trichlor-2-pyridylmonothiophosphat | O,O-Diaethyl-O-3,5,6-trichlor-2-pyridylmonothiophosphat [German] |
| O,O-Diethyl O-(3,5,6-Trichloro-2-pyridyl) phosphorothioate | O,O-Diethyl O-(3,5,6-trichloro-2-pyridinyl)phosphorothioate | O,O-Diethyl O-(3,5,6-trichloro-2-pyridyl) phsophorothioate |
| O,O-Diethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate | O,O-Diethyl O-3,5,6-trichloro-2-pyridylphosphorothioate | O,O-Diethyl o-(3,5,6-trichloro-2-pyridinyl) thiophosphate # |
| O,O-Diethyl-O-(3,5,6-trichloro-2-pyridyl)phosphorothiolate | O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) phosphorothioic acid | O,O-diethyl O-(3,5,6-trichloropyridin-2-yl) phosphorothioate |
| O,O-diethyl O-(3,5,6-trichloropyridin-2-yl) thiophosphate | O799 | OMS 971 |
| OMS-0971 | Pageant | Pharmakon1600-00330058 |
| Phosphorothioic acid O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) ester | Phosphorothioic acid, O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) ester | Phosphorothioic acid, O,O-diethyl O-(3,5,6-trichloro-2-pyridyl) ester |
| Piridane | Pyrinex | Q414915 |
| Radar | Radar (fungicide) | SBI-0052543.P002 |
| SBPBAQFWLVIOKP-UHFFFAOYSA- | SBPBAQFWLVIOKP-UHFFFAOYSA-N | SC-47023 |
| SCHEMBL21680 | SMR000568474 | SPBio_001080 |
| SPECTRUM330058 | SR-01000854727 | SR-01000854727-2 |
| Silrifos | Spannit | SpecPlus_000518 |
| Spectrum2_001230 | Spectrum3_000849 | Spectrum4_000689 |
| Spectrum5_002014 | Spectrum_001897 | Stipend |
| Suscon blue | Suscon green | TR-036379 |
| Tafaban | Terial | Terial 40L |
| Tox21_202383 | Tox21_300148 | Tricel |
| Trichlorpyrphos | UNII-JCS58I644W | Warhawk |
| XRM 429 | XRM 5160 | ZINC608250 |
| Zidil | Zodiac (TN) | chlorpyrifos |
| cid_2730 | detmol u. a | diethoxy-sulfanylidene-(3,5,6-trichloropyridin-2-yl)oxy--phosphane |
| diethoxy-sulfanylidene-(3,5,6-trichloropyridin-2-yl)oxy-?^{5}-phosphane | diethoxy-sulfanylidene-(3,5,6-trichloropyridin-2-yl)oxyphosphorane | diethoxy-sulfanylidene-[(3,5,6-trichloro-2-pyridinyl)oxy]phosphorane |
| diethoxy-sulfanylidene-[3,5,6-tris(chloranyl)pyridin-2-yl]oxy-$l^{5}-phosphane | diethoxy-sulfanylidene-[3,5,6-tris(chloranyl)pyridin-2-yl]oxy--phosphane | diethoxy-thioxo-[(3,5,6-trichloro-2-pyridyl)oxy]phosphorane |
| ethyl 3,5,6-trichloropyridin-2-yl ethoxy(sulfanylidene)phosphonite | m-Chlorpyrifos | o,o-Diethyl-o-(3,5,6-trichloro-2-pyridyl)phosphorothioate |
| pridane | suSCon |
1. Meyer et al. (2017)
2. Yamada et al. (2017)
3. Zarazuela Zolkipli-Cunningham & Marni J.Falk. (2017)
4. Slotkin and Seidler, 2010