Compound

D0157 | Chlorpyrifos

Molecular Formula C9H11Cl3NO3PS
Molecular Weight 350.6
Structure
Description organophosphate pesticide; It acts on the nervous systems of insects by inhibiting the acetylcholinesterase enzyme.

Toxicity Dose Time Species Model Method Action Positive criterion Reference
LIPID PEROXIDATION 30–50 μM PC12 cell line we measured the concentration malondialdehyde (MDA) to indicate formation of lipid peroxides 242
MITOCHONDRIAL DYNAMICS 30 μM Human stem cell-derived neural progenitor cells 247
FISSION 30 μM Human Human induced pluripotent stem cells (iPSCs) increase 242

Target Dose Time Species Model Method Action Positive criterion Reference
Mitofusin-1 30 μM Human Human induced pluripotent stem cells (iPSCs) 242

Pictogram Signal Statements Precautionary Statement Codes
Danger

H301: Toxic if swallowed [Danger Acute toxicity, oral]


H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


P264, P270, P273, P301+P310, P321, P330, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

Aggregated GHS information provided by 374 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]


H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P264, P270, P273, P301+P310, P321, P330, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H301: Toxic if swallowed [Danger Acute toxicity, oral]


H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


P264, P270, P273, P301+P310, P321, P330, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H301: Toxic if swallowed [Danger Acute toxicity, oral]


H311: Toxic in contact with skin [Danger Acute toxicity, dermal]


H330: Fatal if inhaled [Danger Acute toxicity, inhalation]


H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


P260, P264, P270, P271, P273, P280, P284, P301+P310, P302+P352, P304+P340, P310, P312, P320, P321, P322, P330, P361, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H301: Toxic if swallowed [Danger Acute toxicity, oral]


H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]


H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]


H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]


P260, P264, P270, P301+P310, P307+P311, P314, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
mouse LD50 oral 60mg/kg (60mg/kg) Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. Vol. 13, Pg. 11, 1978.
man TDLo oral 300mg/kg (300mg/kg) Archives of Toxicology. Vol. 59, Pg. 176, 1986.
mammal (species unspecified) LD50 unreported 163mg/kg (163mg/kg) Journal of Agricultural and Food Chemistry. Vol. 27, Pg. 712, 1979.
rat LD50 unreported 150mg/kg (150mg/kg) "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 339, 1971.
mouse LD50 skin 120mg/kg (120mg/kg) Yakkyoku. Pharmacy. Vol. 38, Pg. 745, 1987.
quail LD50 oral 13300ug/kg (13.3mg/kg) ASTM Special Technical Publication. Vol. (680), Pg. 157, 1979.
rat LD50 skin 202mg/kg (202mg/kg) Toxicology and Applied Pharmacology. Vol. 14, Pg. 515, 1969.
rabbit LD50 skin 2gm/kg (2000mg/kg) Guide to the Chemicals Used in Crop Protection. Vol. 6, Pg. 203, 1973.
duck LD50 oral 76mg/kg (76mg/kg) Toxicology and Applied Pharmacology. Vol. 20, Pg. 57, 1971.
guinea pig LD50 oral 504mg/kg (504mg/kg) Farm Chemicals Handbook. Vol. -, Pg. C74, 1991.
rat LD50 oral 82mg/kg (82mg/kg) Toxicology and Applied Pharmacology. Vol. 14, Pg. 515, 1969.
pigeon LD50 oral 10mg/kg (10mg/kg) ASTM Special Technical Publication. Vol. (680), Pg. 157, 1979.
rabbit LD50 oral 1gm/kg (1000mg/kg) Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 45, 1978.
guinea pig LDLo subcutaneous 100mg/kg (100mg/kg) Journal of Economic Entomology. Vol. 60, Pg. 733, 1967.
bird - wild LD50 oral 5mg/kg (5mg/kg) Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
chicken LD50 oral 25400ug/kg (25.4mg/kg) Toxicology and Applied Pharmacology. Vol. 11, Pg. 49, 1967.
rat LC50 inhalation > 200mg/m3/4H (200mg/m3) Pesticide Manual. Vol. 9, Pg. 166, 1991.
mouse LD50 intraperitoneal 192mg/kg (192mg/kg) Toxicology and Applied Pharmacology. Vol. 65, Pg. 144, 1982.


  • 2-Pyridinol, 3,5,6-trichloro-, O-ester with O,O-diethyl phosphorothioate 26848-EP2274983A1 26848-EP2275422A1
    26848-EP2280002A1 26848-EP2280009A1 26848-EP2292608A1
    26848-EP2305662A1 26848-EP2308857A1 26848-EP2308858A1
    26848-EP2311816A1 26848-EP2311817A1 26848-EP2314583A1
    2921-88-2 88579-EP2298076A1 88579-EP2298077A1
    88579-EP2301353A1 88579-EP2305031A1 88579-EP2305034A1
    88579-EP2305035A1 88579-EP2305662A1 921C882
    A819822 AB00053051_06 AC-993
    AI3-27311 AKOS015891656 BDBM74063
    BIDD:PXR0044 BRD-K08303368-001-02-7 BRD-K08303368-001-06-8
    BRN 1545756 BSPBio_002437 Bolton
    Bonidel Brodan C-20634
    C14322 C7H7Cl3NO3PS C9H11Cl3NO3PS
    CAS-2921-88-2 CC-25729 CCG-39144
    CCRIS 7144 CHEBI:34631 CHEMBL463210
    CTK8E8187 Caswell No. 219AA Chloropyrifos
    Chloropyriphos Chlorpyrifos (BAN) Chlorpyrifos (Dursban)
    Chlorpyrifos 10 microg/mL in Cyclohexane Chlorpyrifos 100 microg/mL in Acetone Chlorpyrifos 100 microg/mL in Acetonitrile
    Chlorpyrifos 100 microg/mL in Cyclohexane Chlorpyrifos 1000 microg/mL in Toluene Chlorpyrifos [ANSI:BSI:ISO]
    Chlorpyrifos [BAN] Chlorpyrifos ethyl Chlorpyrifos solution, 100 mug/mL in acetonitrile, PESTANAL(R), analytical standard
    Chlorpyrifos solution, certified reference material, TraceCERT(R), 1000 mug/mL in methyl tert-butyl ether, ampule of 1 mL Chlorpyrifos, PESTANAL(R), analytical standard Chlorpyrifos, certified reference material, TraceCERT(R)
    Chlorpyrifos-ethyl Chlorpyriphos Chlorpyriphos [ISO-French]
    Chlorpyriphos-ethyl Chlorpyritos Chlorpyrofos
    Chlorpyrophos Clorpyrifos Coroban
    D07688 DSSTox_CID_458 DSSTox_GSID_20458
    DSSTox_RID_75603 DTXSID4020458 Danusban
    Detmol Detmol U.A Detmol U.A.
    Detmol ua Dhanusban Diethyl O-(3,5,6-trichloro-2-pyridyl) phosphorothioate
    DivK1c_006614 Dowco 179 Durmet
    Dursban Dursban 10CR Dursban 2E
    Dursban 44 Dursban 4E Dursban F
    Dursban R Dursban, analytical standard EINECS 220-864-4
    ENT 27,311 ENT 27311 EPA Pesticide Chemical Code 059101
    Empire 20 Equity Ethyl chlorpyriphos
    FT-0602970 Geodinfos Grofo
    HMS3039C03 HMS3264O03 HSDB 389
    InChI=1/C9H11Cl3NO3PS/c1-3-14-17(18,15-4-2)16-9-7(11)5-6(10)8(12)13-9/h5H,3-4H2,1-2H3 J-017440 JCS58I644W
    KBio1_001558 KBio2_002421 KBio2_004989
    KBio2_007557 KBio3_001937 KBioGR_001157
    KBioSS_002427 KS-5372 Killmaster
    LS-1137 Lentrek Lock-On
    Lorsban Lorsban 50SL M-1133
    MLS001065609 NCGC00091472-01 NCGC00091472-02
    NCGC00091472-03 NCGC00091472-04 NCGC00091472-05
    NCGC00091472-06 NCGC00091472-07 NCGC00091472-08
    NCGC00091472-09 NCGC00253974-01 NCGC00259932-01
    NSC-755891 NSC755891 Nufos
    O,O-DIETHYL O-3,5,6-TRICHLOROPYRIDIN-2-YL PHOSPHOROTHIOATE O,O-Diaethyl-O-3,5,6-trichlor-2-pyridylmonothiophosphat O,O-Diaethyl-O-3,5,6-trichlor-2-pyridylmonothiophosphat [German]
    O,O-Diethyl O-(3,5,6-Trichloro-2-pyridyl) phosphorothioate O,O-Diethyl O-(3,5,6-trichloro-2-pyridinyl)phosphorothioate O,O-Diethyl O-(3,5,6-trichloro-2-pyridyl) phsophorothioate
    O,O-Diethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate O,O-Diethyl O-3,5,6-trichloro-2-pyridylphosphorothioate O,O-Diethyl o-(3,5,6-trichloro-2-pyridinyl) thiophosphate #
    O,O-Diethyl-O-(3,5,6-trichloro-2-pyridyl)phosphorothiolate O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) phosphorothioic acid O,O-diethyl O-(3,5,6-trichloropyridin-2-yl) phosphorothioate
    O,O-diethyl O-(3,5,6-trichloropyridin-2-yl) thiophosphate O799 OMS 971
    OMS-0971 Pageant Pharmakon1600-00330058
    Phosphorothioic acid O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) ester Phosphorothioic acid, O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) ester Phosphorothioic acid, O,O-diethyl O-(3,5,6-trichloro-2-pyridyl) ester
    Piridane Pyrinex Q414915
    Radar Radar (fungicide) SBI-0052543.P002
    SBPBAQFWLVIOKP-UHFFFAOYSA- SBPBAQFWLVIOKP-UHFFFAOYSA-N SC-47023
    SCHEMBL21680 SMR000568474 SPBio_001080
    SPECTRUM330058 SR-01000854727 SR-01000854727-2
    Silrifos Spannit SpecPlus_000518
    Spectrum2_001230 Spectrum3_000849 Spectrum4_000689
    Spectrum5_002014 Spectrum_001897 Stipend
    Suscon blue Suscon green TR-036379
    Tafaban Terial Terial 40L
    Tox21_202383 Tox21_300148 Tricel
    Trichlorpyrphos UNII-JCS58I644W Warhawk
    XRM 429 XRM 5160 ZINC608250
    Zidil Zodiac (TN) chlorpyrifos
    cid_2730 detmol u. a diethoxy-sulfanylidene-(3,5,6-trichloropyridin-2-yl)oxy--phosphane
    diethoxy-sulfanylidene-(3,5,6-trichloropyridin-2-yl)oxy-?^{5}-phosphane diethoxy-sulfanylidene-(3,5,6-trichloropyridin-2-yl)oxyphosphorane diethoxy-sulfanylidene-[(3,5,6-trichloro-2-pyridinyl)oxy]phosphorane
    diethoxy-sulfanylidene-[3,5,6-tris(chloranyl)pyridin-2-yl]oxy-$l^{5}-phosphane diethoxy-sulfanylidene-[3,5,6-tris(chloranyl)pyridin-2-yl]oxy--phosphane diethoxy-thioxo-[(3,5,6-trichloro-2-pyridyl)oxy]phosphorane
    ethyl 3,5,6-trichloropyridin-2-yl ethoxy(sulfanylidene)phosphonite m-Chlorpyrifos o,o-Diethyl-o-(3,5,6-trichloro-2-pyridyl)phosphorothioate
    pridane suSCon

    CAS Number 2921-88-2, 5598-13-0
    PubChem Compound 2730
    KEGG Compound ID C14322
    KEGG Drug D07688
    ChEBI 34631
    ChemSpider 2629
    Wikipedia Chlorpyrifos

    1. Meyer et al. (2017)
    2. Yamada et al. (2017)
    3. Zarazuela Zolkipli-Cunningham & Marni J.Falk. (2017)
    4. Slotkin and Seidler, 2010