Compound

D0164 | cycloheximide

Molecular Formula C15H23NO4
Molecular Weight 281.35
Structure
Description fungicide; potent, reversible and specific inhibitor of eukaryotic cytosolic translation; direct binding to the ribosome, inhibiting eEF2-mediated translocation of the nascent protein; blocking eukaryotic translational elongation

Toxicity Dose Time Species Model Method Action Positive criterion Reference
FERROPTOSIS ferroptosis weak rescue inhibitor 245

Pictogram Signal Statements Precautionary Statement Codes
Danger

H300: Fatal if swallowed [Danger Acute toxicity, oral]


H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]


H360D ***: May damage the unborn child [Danger Reproductive toxicity]


H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]


P201, P202, P264, P270, P273, P281, P301+P310, P308+P313, P321, P330, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

Aggregated GHS information provided by 222 companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]


H315 (17.12%): Causes skin irritation [Warning Skin corrosion/irritation]


H341 (99.1%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]


H360 (99.55%): May damage fertility or the unborn child [Danger Reproductive toxicity]


H411 (99.55%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P201, P202, P264, P270, P273, P280, P281, P301+P310, P302+P352, P308+P313, P321, P330, P332+P313, P362, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H300: Fatal if swallowed [Danger Acute toxicity, oral]


H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]


H360D: May damage the unborn child [Danger Reproductive toxicity]


H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]


P201, P202, P264, P270, P273, P281, P301+P310, P308+P313, P321, P330, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H300: Fatal if swallowed [Danger Acute toxicity, oral]


H315: Causes skin irritation [Warning Skin corrosion/irritation]


H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]


H360: May damage fertility or the unborn child [Danger Reproductive toxicity]


P201, P202, P264, P270, P280, P281, P301+P310, P302+P352, P305+P351+P338, P308+P313, P321, P330, P332+P313, P337+P313, P362, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • (1S-(1alpha(S*),3alpha,5beta))-4-(2-(3,5-Dimethyl-2-oxo-cyclohexyl))-2-hydroxyethyl-2,6-piperidinedione .beta.-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide 082C346
    2, 4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-, [1S-[1.alpha.(S*),3.alpha.,5.beta.]]- 2,6-Piperidinedione, 4-((2R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)- 2,6-Piperidinedione, 4-(2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-, (1S-(1alpha(S*),3alpha,5beta))-
    3-((R)-2-((1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide 3-(2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide 3-(2R)-2-((1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethylglutarimide
    3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide 4-((2R)-2-((1S,3S,5S)-(3,5-Dimethyl-2-oxocyclohexyl))-2-hydroxyethyl)piperidine-2,6-dione 4-((R)-2-((1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)piperidine-2,6-dione
    4-(2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-2,6-piperidinedione 4-[(2R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]azaperhydro ine-2,6-dione 4-[(2R)-2-[(1S,3S,5R)-3,5-dimethyl-2-oxo-cyclohexyl]-2-hydroxy-ethyl]piperidine-2,6-dione
    4-[(2R)-2-[(1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxo-cyclohexyl]-2-hydroxy-ethyl]piperidine-2,6-dione 4-[2-(3,5-Dimethyl-2-oxo-cyclohexyl)-2-hydroxyethyl]-2,6-piperidinedione
    4-[2-(3,6-piperidinedione 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione 5-21-13-00434 (Beilstein Handbook Reference)
    66-81-9 98600C0908 AB00052279_08
    ACTIDIONE AI3-15541 AKOS024282670
    AS-14624 Acti-Aid Acti-Dione
    Acti-dione BR Acti-dione PM Acti-dione TGF
    Actidion Actidione BR Actidione PM
    Actidione TGF Actidone Actispray
    Aktidion Aktidion [Czech] BDBM50080528
    BI2521 BP-12396 BPBio1_000990
    BRD-K36055864-001-05-1 BRD-K36055864-001-07-7 BRD-K36055864-001-09-3
    BRD-K36055864-001-16-8 BRN 0088868 BSPBio_000900
    BSPBio_003159 C-17728 C-9217
    C06685 C15H23NO4 CAS-66-81-9
    CBC 500046 CC-2256 CC-26065
    CCG-39902 CCRIS 937 CHEBI:27641
    CHEMBL123292 CS-4985 CX
    Caswell No. 270A Cicloheximida Cicloheximida [INN-Spanish]
    Cicloheximide Cicloheximide (INN) Cicloheximide [INN]
    Cicloheximidum Cicloheximidum [INN-Latin] Cyclohemimide
    Cyclohexamide Cycloheximid Cycloheximide (USAN)
    Cycloheximide [BSI:ISO] Cycloheximide [USAN] Cycloheximide solution, 0.1%, for microbiology
    Cycloheximide solution, Ready-Made Solution, microbial, 100 mg/mL in DMSO, 0.2 mum filtered Cycloheximide, 95% Cycloheximide, >=93.0% (HPLC)
    Cycloheximide, Antibiotic for Culture Media Use Only Cycloheximide, Biotechnology Performance Certified Cycloheximide, High Purity
    Cycloheximide, PESTANAL(R), analytical standard Cycloheximide, Streptomyces griseus Cycloheximide, from microbial, >=94% (TLC)
    D03625 DSSTox_CID_4882 DSSTox_GSID_24882
    DSSTox_RID_77565 DTXSID6024882 DivK1c_000050
    EINECS 200-636-0 EPA Pesticide Chemical Code 043401 FT 3422-2
    GNF-PF-5118 GTPL5433 Glutarimide, 3-(2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-
    HMS1570M22 HMS1921L04 HMS2092D10
    HMS2097M22 HMS3714M22 HMS500C12
    HSDB 1552 HY-12320 Hizarocin
    IDI1_000050 KBio1_000050 KBio2_001824
    KBio2_004392 KBio2_006960 KBio3_002659
    KBioGR_001408 KBioSS_001824 KUC105858N
    Kaken L918 LS-1558
    M01527 MFCD00082346 MLS001055333
    MLS002154001 NARAMYCIN A NCGC00017363-05
    NCGC00017363-06 NCGC00017363-07 NCGC00017363-08
    NCGC00017363-10 NCGC00024910-01 NCGC00024910-02
    NCGC00024910-03 NCGC00024910-04 NCGC00024910-05
    NCGC00024910-06 NCGC00169964-05 NCGC00257430-01
    NCGC00258710-01 NCI60_001540 NINDS_000050
    NM-MCD 80 NSC 185 NSC-185
    NSC-758187 NSC185 NSC758187
    Naramycin Neocycloheximide Pharmakon1600-01502112
    Prestwick0_000790 Prestwick1_000790 Prestwick2_000790
    Prestwick3_000790 Prestwick_976 Q412895
    SBB005972 SBI-0051732.P002 SC-19304
    SCHEMBL26617 SMR000686067 SPBio_000720
    SPBio_002839 SPECTRUM1502112 SR-01000597484
    SR-01000597484-1 SR-01000597484-4 SR-05000001596
    SR-05000001596-1 SR-05000001596-3 SR-05000001596-4
    ST057527 Spectrum2_000900 Spectrum3_001510
    Spectrum4_000914 Spectrum5_001635 Spectrum_001344
    TCMDC-125838 TZA Tox21_113580
    Tox21_113580_1 Tox21_201158 Tox21_303652
    U 4527 U-4527 UNII-98600C0908
    WLN: T6VMVTJ E1YQ- BL6VTJ D1 F1 YPHMISFOHDHNIV-FSZOTQKASA-N ZINC3872170
    ZX-AFC000592 Zykloheximid [1S-[1.alpha.(S*),3.alpha.,5.beta.]]-4-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-2,6-piperidinedione
    beta-(2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide cid_6197 cycloheximide
    ksc-8-190

    CAS Number 1154-57-0, 66-81-9
    PubChem Compound 6197
    KEGG Compound ID C06685
    KEGG Drug D03625
    ChEBI 27641
    ChemSpider 5962