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Drug

D0193 | MDMA

Molecular Formula C11H15NO2
Molecular Weight 193.24
Structure
State solid
Route of elimination renal
Half life 6–10 (though duration of effects is typically actually 3–5 hours)
Trade names ecstasy; Molly
Description psychoactive drug; increasing the activity of the neurotransmitters serotonin, dopamine and noradrenaline

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MITOCHONDRIAL DYNAMICS 20 μM MDMA mixture for 24 hrs Mouse primary hippocampal neurons 247

Pictogram Signal Statements Precautionary Statement Codes
Danger

H301: Toxic if swallowed [Danger Acute toxicity, oral]


H315: Causes skin irritation [Warning Skin corrosion/irritation]


H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


 P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
dog LD50 intravenous 14mg/kg (14mg/kg) Toxicology and Applied Pharmacology. Vol. 25, Pg. 299, 1973.
rat LD50 intraperitoneal 49mg/kg (49mg/kg) Toxicology and Applied Pharmacology. Vol. 25, Pg. 299, 1973.
monkey LD50 intravenous 22mg/kg (22mg/kg) Toxicology and Applied Pharmacology. Vol. 25, Pg. 299, 1973.
guinea pig LD50 intraperitoneal 98mg/kg (98mg/kg) Toxicology and Applied Pharmacology. Vol. 25, Pg. 299, 1973.
mouse LD50 intraperitoneal 97mg/kg (97mg/kg) Toxicology and Applied Pharmacology. Vol. 25, Pg. 299, 1973.


  • (+-)-(3,4-Methylenedioxy)methamphetamine (+-)-N-Methyl-1-(3,4-methylenedioxyphenyl)-2-aminopropane (+-)-N-Methyl-3,4-(methylenedioxy)amphetamine
    (+/-)-(3,4-Methylenedioxy)methamphetamine (+/-)-3,4-METHYLENEDIOXYMETHAMPHETAMINE (+/-)-MDMA solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material
    (RS)-3,4-(methylenedioxy)methamphetamine 1,3-Benzodioxole-5-ethanamine, N,alpha-dimethyl- 1,3-Benzodioxole-5-ethanamine,N,a-dimethyl-
    1-(1,3-Benzodioxol-5-yl)-N-methyl-2-propanamine 1-(1,3-benzodioxol-5-yl)-N-methylpropan-2-amine 3,4-MDMA
    3,4-Methylenedioxy-N,alpha-dimethyl-beta-phenylethylamine 3,4-Methylenedioxy-N-methylamphetamine (MDMA) 3,4-methylenedioxymethamphetamine
    3,4-methylenedioxymethylamphetamine 42542-10-9 54946-52-0
    69610-10-2 AKOS006283463 BDBM50010588
    C07577 CCRIS 9277 CHEBI:1391
    CHEMBL43048 CTK5D0599 D11172
    DB01454 DEA No. 7405 DL-(3,4-Methylenedioxy)methamphetamine
    DTXSID90860791 DivK1c_000962 Ecstasy
    Ecstasy (Drug) Epitope ID:178091 FT-0693477
    GTPL4574 HSDB 6929 IDI1_000962
    KBio1_000962 KE1SEN21RM LS-34695
    LS-34696 MDMA MDMA (unspecified)
    Mandy [Street Name] Methylenedioxy Methamphetamine Methylenedioxymethamphetamine
    Midomafetamine Midomafetamine (USAN/INN) Midomafetamine [USAN]
    N,alpha-Dimethyl-1,3-benzodioxole-5-ethanamine N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE NCGC00168266-01
    NCGC00168266-02 NINDS_000962 PDSP1_001522
    PDSP2_001506 Phenethylamine, N,alpha-dimethyl-3,4-methylenedioxy- Q69488
    SCHEMBL44210 SHXWCVYOXRDMCX-UHFFFAOYSA-N UNII-KE1SEN21RM
    XTC XTC [Street Name] [1-(2H-1,3-benzodioxol-5-yl)propan-2-yl](methyl)amine
    rac-3,4-Methylenedioxymethamphetamine rac-MDMA (rac-3,4-Methylenedioxymethamphetamine) 1.0 mg/ml in Methanol

    DrugBank Name Midomafetamine
    DrugBank DB01454
    CAS Number 115654-61-0, 136765-43-0, 42542-10-9, 54946-52-0, 69610-10-2, 92279-84-0
    PubChem Compound 1615
    KEGG Compound ID C07577
    PubChem.Substance 46506404
    ChEBI 1391
    PharmGKB PA131887008
    ChemSpider 1556
    BindingDB 50010588.0
    Wikipedia MDMA

    1. Meyer et al. (2017)
    2. Barbosa et al. (2014)