Drug

D0203 | MPP

Molecular Formula C10H15O3PS2
Molecular Weight 278.3
Structure
Description positively charged organic molecule; neurotoxin; inhibiting Complex I

Toxicity Dose Time Species Model Method Action Positive criterion Reference
GLUCOSE GALACTOSE IC50 RATIO 30 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay EC25(NA) [Glc/Gal] 326

Target Dose Time Species Model Method Action Positive criterion Reference
NADH:ubiquinone reductase 30 LUHMES (Lund human mesencephalic) cells Glc–Gal–NeuriTox assay EC25(NA) [Glc/Gal] 326

Pictogram Signal Statements Precautionary Statement Codes
Danger

H302: Harmful if swallowed [Warning Acute toxicity, oral]


H312: Harmful in contact with skin [Warning Acute toxicity, dermal]


H331: Toxic if inhaled [Danger Acute toxicity, inhalation]


H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]


H372 **: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]


H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


P201, P202, P260, P261, P264, P270, P271, P273, P280, P281, P301+P312, P302+P352, P304+P340, P308+P313, P311, P312, P314, P321, P322, P330, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

Aggregated GHS information provided by 206 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H302 (97.57%): Harmful if swallowed [Warning Acute toxicity, oral]


H312 (97.57%): Harmful in contact with skin [Warning Acute toxicity, dermal]


H331 (99.51%): Toxic if inhaled [Danger Acute toxicity, inhalation]


H341 (100%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]


H372 (100%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]


H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P201, P202, P260, P261, P264, P270, P271, P273, P280, P281, P301+P312, P302+P352, P304+P340, P308+P313, P311, P312, P314, P321, P322, P330, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H302: Harmful if swallowed [Warning Acute toxicity, oral]


H312: Harmful in contact with skin [Warning Acute toxicity, dermal]


H331: Toxic if inhaled [Danger Acute toxicity, inhalation]


H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]


H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]


H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


P201, P202, P260, P261, P264, P270, P271, P273, P280, P281, P301+P312, P302+P352, P304+P340, P308+P313, P311, P312, P314, P321, P322, P330, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H302: Harmful if swallowed [Warning Acute toxicity, oral]


H312: Harmful in contact with skin [Warning Acute toxicity, dermal]


H331: Toxic if inhaled [Danger Acute toxicity, inhalation]


H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]


H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]


H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]


P201, P202, P260, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P340, P307+P311, P308+P313, P311, P312, P314, P321, P322, P330, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • 4-Meth ylmercapto-3-methylphenyl dimethyl thiophosphate 4-Methylmercapto-3-methylphenyl dimethyl thiophosphate 55-38-9
    AB00053057_04 AC-16722 ACN-048892
    AI3-25540 AKOS015889922 B 29493
    BAY 29493 BIDD:ER0528 BL0L45OVKT
    BRD-K67217586-001-02-3 BRD-K67217586-001-04-9 BRN 1974129
    BSPBio_002469 BX-2 Bay-Bassa
    Baycid Bayer 29493 Bayer 9007
    Bayer S-1752 Baytex C-17512
    C10H15O3PS2 C14420 CAS-55-38-9
    CC-28403 CCG-39101 CCRIS 310
    CHEBI:34761 CHEMBL1604375 Caswell No. 456F
    Cresol, 4-(methylthio)-, O-ester with O,O-d imethyl phosphorothioate Cresol, 4-(methylthio)-, O-ester with O,O-dimethyl phosphorothioate D07950
    DSSTox_CID_620 DSSTox_GSID_20620 DSSTox_RID_75695
    DTXSID8020620 Dimethyl (3-methyl-4-(methylthio)phenyl) phosphorothionate Dimethyl O-((4-me thylmercapto)-3-methylphenyl)thionophosphate
    Dimethyl O-((4-methylmercapto)-3-methylphenyl)thionophosphate Dimethyl O-(3-methyl-4-(methylthio)phenyl) thiophosphate Dimethyl O-(4-(methylthio)-m-tolyl) phosphorothioate
    Dimethyl methylthiotolyl phosphorothioat e Dimethyl methylthiotolyl phosphorothioate DivK1c_006646
    EINECS 200-231-9 ENT 25,540 ENT 25540
    EPA Pesticide Chemical Code 053301 Entex FT-0603232
    Fenthion (BAN) Fenthion (MPP) Fenthion 10 microg/mL in Cyclohexane
    Fenthion 4E Fenthion [BAN] Fenthion [BSI:ISO]
    Fenthion [INN:BAN] Fenthion, PESTANAL(R), analytical standard Fenthion, analytical standard
    Fenthion-methyl Fenthione Figuron
    HMS3091A22 HMS3264I08 HSDB 1403
    InChI=1/C10H15O3PS2/c1-8-7-9(5-6-10(8)16-4)13-14(15,11-2)12-3/h5-7H,1-4H3 KBio1_001590 KBio2_002454
    KBio2_005022 KBio2_007590 KBio3_001969
    KBioGR_001189 KBioSS_002461 LS-1355
    Lebaycid Lebaycid(R) Lebayeid
    MLS002695988 MPP (Pestiide) MPP (pesticide)
    Mercaptophos Mosquitocide 700 NCGC00091635-01
    NCGC00091635-02 NCGC00091635-03 NCGC00091635-04
    NCGC00091635-05 NCGC00091635-06 NCGC00091635-07
    NCGC00091635-08 NCGC00091635-09 NCGC00254566-01
    NCGC00259144-01 NCI-C08651 NSC-755881
    NSC755881 O,O-Dimethyl O-(3-methyl-4-(methylthio)phenyl)phosphorothioate O,O-Dimethyl O-(3-methyl-4-methylmercaptophenyl)phosphorothioate
    O,O-Dimethyl O-(3-methyl-4-methylthio-fenyl)-monothiofosfaat O,O-Dimethyl O-(3-methyl-4-methylthio-fenyl)-monothiofosfaat [Dutch] O,O-Dimethyl O-(4-(methylthio)-m-tolyl) phosphorothioate
    O,O-Dimethyl O-(4-methylmercapto-3-methylphenyl) thionophosphate O,O-Dimethyl O-(4-methylthio-3-methylphenyl) phosphorothioate O,O-Dimethyl O-(4-methylthio-3-methylphenyl) thiophosphate
    O,O-Dimethyl O-3-methyl-4-methylthiophenyl phosphorothioate O,O-Dimethyl O-4-(methylmercapto)-3-methylphenyl phosphorothioate O,O-Dimethyl O-4-methylthio-m-tolyl phosphorothioate
    O,O-Dimethyl O-[(3-methyl-4-methylthio)phenyl] phosphorothioate, 9CI O,O-Dimethyl O-[3-methyl-4-(methylsulfanyl)phenyl] thiophosphate # O,O-Dimethyl-O-(3-methyl-4-methylmercaptophenyl)phosphorothioate
    O,O-Dimethyl-O-(3-methyl-4-methylthio-fenyl)-monothiofosfaat O,O-Dimethyl-O-(3-methyl-4-methylthio-fenyl)-monothiofosfaat [Dutch] O,O-Dimethyl-O-(3-methyl-4-methylthio-phenyl)-thionophosphat
    O,O-Dimethyl-O-(3-methyl-4-methylthio-phenyl)-thionophosphat [German] O,O-Dimethyl-O-(3-methyl-4-methylthio-phenyl)-thionophosphate O,O-Dimethyl-O-(3-methyl-4-methylthiophenyl)-monothiophosphat
    O,O-Dimethyl-O-(3-methyl-4-methylthiophenyl)-monothiophosphat [German] O,O-Dimethyl-O-(3-methyl-4-methylthiophenyl)-monothiophosphate O,O-Dimethyl-O-4-(methylmercapto)-3-methylphenyl phosphorothioate
    O,O-Dimethyl-O-4-(methylmercapto)-3-methylphenyl thiophosphate O,O-Dimetil-O-(3-metil-4-metiltio-fenil)-monotiofosfato O,O-Dimetil-O-(3-metil-4-metiltio-fenil)-monotiofosfato [Italian]
    O,O-dimethyl O-(3-methyl-4-methylthiophenyl) thiophosphate O,O-dimethyl O-3-methyl-4-(methylthio)phenyl phosphorothioate O,O-dimethyl O-4-(methylmercapto)-3-methylphenyl phosphorothio ate
    O,O-dimethyl O-[3-methyl-4-(methylsulfanyl)phenyl] phosphorothioate O,O-dimethyl O-[3-methyl-4-(methylthio)phenyl] thiophosphate O,O-dimethyl-O-[4-(methylthio)-m-tolyl] phosphorothioate
    OMS 2 PNVJTZOFSHSLTO-UHFFFAOYSA- PNVJTZOFSHSLTO-UHFFFAOYSA-N
    Pharmakon1600-00330064 Phenthion Phosphorothioic acid O,O-dimethyl O-[3-methyl-4-(methylthio)phenyl]ester
    Phosphorothioic acid, O,O-dimethyl O-(3-methyl-4-(methylthio)phenyl) ester Phosphorothioic acid, O,O-dimethyl O-(4-(methylthio)-m-tolyl) ester Phosphorothioic acid, O,O-dimethyl O-[3-methyl-4-(methylthio)phenyl] ester
    Phosphorothioic acid, O,O-dimethyl O-[4-(methylthio)-m-tolyl] ester Pro-Spot Q418354
    Quel etox Queletox Rid-a-Bird
    S 1752 SBI-0052549.P002 SCHEMBL26907
    SMR000777965 SPBio_001102 SPECTRUM330064
    SR-01000872733 SR-01000872733-1 SpecPlus_000550
    Spectrum2_001231 Spectrum3_000855 Spectrum4_000695
    Spectrum5_002028 Spectrum_001919 Spotten
    Spotton Sulfidophos Talodex
    Thiophosphate de O,O-dimethyle et de O-(3-methyl-4-methylthiophenyle) Thiophosphate de O,O-dimethyle et de O-(3-methyl-4-methylthiophenyle) [French] Tiguvon
    Tiguvon (TN) Tox21_111157 Tox21_111157_1
    Tox21_201595 Tox21_300658 UNII-BL0L45OVKT
    ZINC1443 dimethoxy-(3-methyl-4-methylsulfanylphenoxy)-sulfanylidene-?^{5}-phosphane dimethoxy-(3-methyl-4-methylsulfanylphenoxy)-sulfanylidenephosphorane
    fenthion m-Cresol, 4-(methylthio)-, O-ester with O,O-dimethyl phosphorothioate methyl 3-methyl-4-(methylsulfanyl)phenyl methoxy(sulfanylidene)phosphonite
    o,o-Dimethyl o-[3-methyl-4-(methylsulfanyl)phenyl] thiophosphate o,o-Dimethyl o-[3-methyl-4-(methylthio)phenyl]phosphorothioate phosphorothioic acid O,O-dimethyl O-(4-methylthio)-m-tolyl ester

    DrugBank Name Fenthion
    DrugBank DB11412
    CAS Number 55-38-9
    PubChem Compound 3346
    KEGG Compound ID C14420
    KEGG Drug D07950
    ChEBI 34761
    ChemSpider 3229
    Wikipedia Fenthion

    1. Zarazuela Zolkipli-Cunningham & Marni J.Falk. (2017)
    2. Meyer et al. (2013)