MITOTOX

Compound

D0205 | MPTP

Properties

Molecular Formula	C12H15N
Molecular Weight	173.25
Structure
Description	prodrug to the neurotoxin MPP+

Therapeutic Classification Source: DrugBank

Targets

Target	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
NADH:ubiquinone reductase								185

GHS Hazard Tables Source: PubChem

Pictogram	Signal	Statements	Precautionary Statement Codes
	Danger	Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral] H370 (97.44%): Causes damage to organs [Danger Specific target organ toxicity, single exposure] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.	P260, P264, P270, P301+P310, P307+P311, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Pictogram

Signal

Statements

Precautionary Statement Codes

Danger

Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

H370 (97.44%): Causes damage to organs [Danger Specific target organ toxicity, single exposure]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

P260, P264, P270, P301+P310, P307+P311, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Indications Source: SIDER

Synonyms Source: PubChem

1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridine	1-METHYL-4-PHENYL-PIPERIDINE-3-EN	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, 97%	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, free base	1-Methyl-4-phenyl-1,2,3,6-tetrahydroxpyridine
1-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine	1-methyl-4-phenyl-1,2,3,6-tetrahydro pyridine	1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine
1-methyl-4-phenyl-3,6-dihydro-2H-pyridine	28289-54-5	4CH-024688
9P21XSP91P	A819403	AB0076709
ACM28289545	AK116498	AKOS003657026
AS-38061	BDBM50003599	BRN 0133712
C-30529	C04599	CCRIS 2186
CHEBI:17963	CHEMBL24172	CTK4G1161
DB-047370	DTXSID8040933	EINECS 248-939-7
FCH1113171	FT-0638772	HSDB 6942
J-017031	LS-132033	MCULE-2830400928
MPTP	N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	N-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine
NSC 139654	NSC-139654	NSC139654
PLRACCBDVIHHLZ-UHFFFAOYSA-N	PYRIDINE, 1,2,3,6-TETRAHYDRO-1-METHYL-4-PHENYL-	Pyridine,1,2,3,6-tetrahydro-1-methyl-4-phenyl-
Q239816	QC-3853	SCHEMBL50923
ST24038114	ST45026142	STK191942
UNII-9P21XSP91P	X-2265	ZINC968184

External IDs

CAS Number	28289-54-5
PubChem Compound	1388
KEGG Compound ID	C04599
ChEBI	17963
ChemSpider	1346
Wikipedia	MPTP

References

1. Dykens et al. (2014)

2. Chan et al. (2005)

3. Mandavilli et al 2000, Yamaguchi et al., 2006