Drug
D0209 | Nitrogen Mustard
L
L01AA05 Chlormethine
[L01AA] Nitrogen mustard analogues
[L01A] ALKYLATING AGENTS
[L01] ANTINEOPLASTIC AGENTS
[L] Antineoplastic and immunomodulating agents
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
   |
Danger |
H300: Fatal if swallowed [Danger Acute toxicity, oral] H310: Fatal in contact with skin [Danger Acute toxicity, dermal] H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] H318: Causes serious eye damage [Danger Serious eye damage/eye irritation] H330: Fatal if inhaled [Danger Acute toxicity, inhalation] H340: May cause genetic defects [Danger Germ cell mutagenicity] H350: May cause cancer [Danger Carcinogenicity] H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure] |
P201, P202, P260, P262, P264, P270, P271, P280, P281, P284, P301+P310, P301+P330+P331, P302+P350, P303+P361+P353, P304+P340, P305+P351+P338, P308+P313, P309+P311, P310, P320, P321, P322, P330, P361, P363, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | skin | 29mg/kg (29mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 224, 1947. | |
| mouse | LD50 | subcutaneous | 2600ug/kg (2.6mg/kg) | National Technical Information Service. Vol. PB158-507, | |
| rabbit | LD50 | oral | 5mg/kg (5mg/kg) | National Technical Information Service. Vol. PB158-507, | |
| rabbit | LD50 | subcutaneous | 3mg/kg (3mg/kg) | National Technical Information Service. Vol. PB158-507, | |
| monkey | LDLo | skin | 50mg/kg (50mg/kg) | National Technical Information Service. Vol. PB158-507, | |
| rat | LD50 | skin | 12mg/kg (12mg/kg) | Fundamental and Applied Toxicology. Vol. 5, Pg. S160, 1985. | |
| guinea pig | LD50 | oral | 12mg/kg (12mg/kg) | National Technical Information Service. Vol. PB158-507, | |
| rabbit | LD50 | intravenous | 1600ug/kg (1.6mg/kg) | National Technical Information Service. Vol. PB158-507, | |
| rat | LD50 | oral | 10mg/kg (10mg/kg) | National Technical Information Service. Vol. PB158-507, | |
| domestic animals - goat/sheep | LD50 | skin | 20mg/kg (20mg/kg) | National Technical Information Service. Vol. PB158-507, | |
| rat | LD50 | unreported | 1700ug/kg (1.7mg/kg) | Pharmaceutical Bulletin. Vol. 1, Pg. 297, 1953. | |
| guinea pig | LD50 | subcutaneous | 2mg/kg (2mg/kg) | lungs, thorax, or respiration: acute pulmonary edema | National Technical Information Service. Vol. PB158-507, |
| rat | LD50 | intravenous | 1100ug/kg (1.1mg/kg) | National Technical Information Service. Vol. PB158-507, | |
| rat | LD50 | intraperitoneal | 860ug/kg (0.86mg/kg) | Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 1, Pg. 154, 1968. | |
| rat | LD50 | subcutaneous | 1200ug/kg (1.2mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 83, Pg. 376, 1953. | |
| cat | LCLo | inhalation | 290mg/m3/10M (290mg/m3) | National Defense Research Committee, Office of Scientific Research and Development, Progress Report.Vol. NDCrc-132, Pg. APR1942, | |
| mouse | LD50 | oral | 10mg/kg (10mg/kg) | National Technical Information Service. Vol. PB158-507, | |
| rat | LD50 | intracrebral | 125ug/kg (0.125mg/kg) | Journal of Pharmacy and Pharmacology. Vol. 18, Pg. 760, 1966. | |
| chicken | LD50 | intravenous | 10mg/kg (10mg/kg) | National Technical Information Service. Vol. PB158-507, | |
| domestic animals - goat/sheep | LDLo | oral | 100mg/kg (100mg/kg) | National Technical Information Service. Vol. PB158-507, | |
| mouse | LD50 | intraperitoneal | 2400ug/kg (2.4mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 1921, 1972. | |
| dog | LD65 | intravenous | 1mg/kg (1mg/kg) | National Technical Information Service. Vol. PB158-507, | |
| mouse | LD50 | intravenous | 2mg/kg (2mg/kg) | National Technical Information Service. Vol. PB158-507, | |
| rabbit | LD50 | skin | 12mg/kg (12mg/kg) | National Technical Information Service. Vol. PB158-507, | |
| pigeon | LDLo | intravenous | 15mg/kg (15mg/kg) | National Technical Information Service. Vol. PB158-507, | |
| .Beta.,.beta.'-Dichlorodiethyl-N-methylamine | 055M867 | 1, 5-Dichloro-3-methyl-3-azapentane hydrochloride |
| 13159-EP2277876A1 | 13159-EP2292614A1 | 13159-EP2295426A1 |
| 13159-EP2295427A1 | 13159-EP2308833A2 | 13159-EP2308861A1 |
| 13159-EP2311825A1 | 13159-EP2311842A2 | 13159-EP2316834A1 |
| 13159-EP2374454A1 | 2,2'-Dichloro-N-methyldiethylamine | 2,2'-Dichlorodiethyl-methylamine |
| 2-Chloro-N-(2-chloroethyl)-N-methylethanamine | 2-chloro-N-(2-chloroethyl)-N-methyl-ethanamine | 49304-EP2272827A1 |
| 49304-EP2311840A1 | 50D9XSG0VR | 51-75-2 |
| A8064 | AB00052033-04 | AB00052033_05 |
| AKOS006229862 | Antimit | BDBM200297 |
| BRD-K12829205-001-03-0 | BRN 0605323 | BSPBio_001947 |
| Bis(.beta.-chloroethyl)methylamine | Bis(2-chloroethyl)methylamine | Bis(b-chloroethyl)methylamine |
| Bis(beta-chloroethyl) methylamine | Bis(beta-chloroethyl)methylamine | Bis-(2-chloroethyl)methylamine |
| C07115 | C5H11Cl2N | CCG-39885 |
| CCRIS 447 | CHEBI:28925 | CHEMBL427 |
| Carolysine | Caryolysin (Salt/Mix) | Caryolysine |
| Caryolysine (Salt/Mix) | Chloramine (the nitrogen mustard) | Chlorethazine |
| Chlormethine | Chlormethine (INN) | Chlormethine [INN:BAN] |
| Chlormethinehydrochloride | Chlormethinum [INN-Latin] | Cloramin |
| Clormetina | Clormetina [INN-Spanish] | D07671 |
| DB00888 | DTXSID2020975 | Di(2-chloroethyl)methylamine |
| Dichlor amine | Dichloren (Salt/Mix) | Diethylamine, 2,2'-dichloro-N-methyl- |
| DivK1c_000759 | EINECS 200-120-5 | ENT-25294 |
| Embechine | Embichin | Embichin (Salt/Mix) |
| Epitope ID:116224 | Eraso (Salt/Mix) | Ethanamine, 2-chloro-N-(2-chloroethyl)-N-methyl- |
| GTPL7218 | HAWPXGHAZFHHAD-UHFFFAOYSA-N | HMS1920J15 |
| HMS2091B04 | HMS502F21 | HN-2 |
| HN2 | HSDB 5083 | Hn2 (amine) |
| IDI1_000759 | KBio1_000759 | KBio2_001369 |
| KBio2_003937 | KBio2_006505 | KBio3_001447 |
| KBioGR_001448 | KBioSS_001369 | LS-7559 |
| Ledaga | MBA | MCULE-6341452542 |
| Me chloroethamine | Mebichloramine | Mechlorethanamine |
| Mechloroethamine | Mecloretamina | Mecloretamina [Italian] |
| Methyl-bis(2-chloroethyl)amine | Methylbis(.beta.-chloroethyl)amine | Methylbis(2-chloroethyl)amine |
| Methylbis(beta-chloroethyl)amine | Methylchlorethamine | Methyldi(2-chloroethyl)amine |
| Mitoxine (*Hydrochloride*) | Mustargen | Mustine |
| Mustine note | N,N-Bis(2-chloroethyl)-N-methylamine | N,N-Bis(2-chloroethyl)-N-methylamine # |
| N,N-Bis(2-chloroethyl)methylamine | N,N-Di(chloroethyl)methylamine | N-Lost |
| N-METHYL-DI(2-CHLORO)-ETHYLAMINE | N-Methyl lost | N-Methyl-2,2'-dichlorodiethylamine |
| N-Methyl-bis(.beta.-chloroethyl)amine | N-Methyl-bis(2-chloroethyl)amine | N-Methyl-bis(beta-chloroethyl)amine |
| N-Methyl-bis-chloraethylamin | N-Methyl-bis-chloraethylamin [German] | N-Methyl-lost |
| N-Methyl-lost [German] | N-methylbis(2-chloroethyl)amine | N-methyldi-(2-chloroethyl)amine |
| NCGC00091835-02 | NCGC00091835-03 | NCGC00091835-04 |
| NCGC00091835-05 | NCGC00091835-06 | NCGC00091835-07 |
| NCGC00091835-08 | NCGC00091835-09 | NCI60_041682 |
| NINDS_000759 | NSC 762 | NSC-757087 |
| NSC-762 | NSC757087 | Nitol (*Hydrochloride*) |
| Nitol (Salt/Mix) | Nitrogen mustard | Nitrogen mustard (HN-2) |
| Nitrogranulogen | Pharmakon1600-01500375 | Q418011 |
| SBI-0051432.P003 | SCHEMBL3861 | SPBio_000496 |
| SPECTRUM1500375 | SR-05000001664 | SR-05000001664-1 |
| STL484282 | Spectrum2_000448 | Spectrum3_000484 |
| Spectrum4_000924 | Spectrum5_001702 | Spectrum_000889 |
| Stickstofflost (*Hydrochloride*) | Stickstofflost (ebewe) | T 1024 |
| T-1024 | TL 146 | U601 |
| UNII-50D9XSG0VR | Valchlor | ZINC2539484 |
| beta,beta'-Dichlorodiethyl-N-methylamine | bis(2-chloro-ethyl)-methyl-amine | bis(2-chloroethyl)(methyl)amine |
| bis(chloroethyl)methylamine | bis-(2-chloro-ethyl)-methyl-amine | bis-(2-chloro-ethyl)-methylamine |
| cid_4033 | mechlorethamine |
| DrugBank Name | Mechlorethamine |
| DrugBank | DB00888 |
| CAS Number | 51-75-2, 55-86-7 |
| PubChem Compound | 4033 |
| KEGG Compound ID | C07115 |
| KEGG Drug | D07671 |
| PubChem.Substance | 46505784 |
| ChEBI | 28925 |
| PharmGKB | PA450336 |
| ChemSpider | 3893 |
| BindingDB | 200297.0 |
| Wikipedia | Mechlorethamine |
1. LeDoux et al. 1992