Compound

D0226 | Perfluorooctanoic acid

Molecular Formula C8HF15O2
Molecular Weight 414.07
Structure
Description a perfluorinated carboxylic acid; industrial surfactant

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MITOCHONDRIAL DYNAMICS In utero exposure (GD 1–17) to 1 mg/kg bodyweight dam Post-natal day 91 mouse livers 247

Pictogram Signal Statements Precautionary Statement Codes
Danger

H302: Harmful if swallowed [Warning Acute toxicity, oral]


H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]


H332: Harmful if inhaled [Warning Acute toxicity, inhalation]


H351: Suspected of causing cancer [Warning Carcinogenicity]


H360D: May damage the unborn child [Danger Reproductive toxicity]


H362: May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]


H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]


P201, P202, P260, P261, P263, P264, P270, P271, P280, P281, P301+P312, P304+P312, P304+P340, P305+P351+P338, P308+P313, P310, P312, P314, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

Aggregated GHS information provided by 153 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H302 (94.77%): Harmful if swallowed [Warning Acute toxicity, oral]


H314 (35.95%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]


H318 (68.63%): Causes serious eye damage [Danger Serious eye damage/eye irritation]


H332 (64.05%): Harmful if inhaled [Warning Acute toxicity, inhalation]


H351 (64.05%): Suspected of causing cancer [Warning Carcinogenicity]


H360 (64.05%): May damage fertility or the unborn child [Danger Reproductive toxicity]


H362 (64.05%): May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]


H372 (64.05%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P201, P202, P260, P261, P263, P264, P270, P271, P280, P281, P301+P312, P301+P330+P331, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P308+P313, P310, P312, P314, P321, P330, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Warning

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.


H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]


H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H301: Toxic if swallowed [Danger Acute toxicity, oral]


H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H331: Toxic if inhaled [Danger Acute toxicity, inhalation]


H351: Suspected of causing cancer [Warning Carcinogenicity]


H360D: May damage the unborn child [Danger Reproductive toxicity]


H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]


P201, P202, P260, P261, P264, P270, P271, P280, P281, P301+P310, P304+P340, P305+P351+P338, P308+P313, P311, P314, P321, P330, P337+P313, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H302: Harmful if swallowed [Warning Acute toxicity, oral]


H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]


H332: Harmful if inhaled [Warning Acute toxicity, inhalation]


H351: Suspected of causing cancer [Warning Carcinogenicity]


H360: May damage fertility or the unborn child [Danger Reproductive toxicity]


H362: May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]


H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]


P201, P202, P260, P261, P263, P264, P270, P271, P280, P281, P301+P312, P304+P312, P304+P340, P305+P351+P338, P308+P313, P310, P312, P314, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

H360: May damage fertility or the unborn child [Danger Reproductive toxicity]


H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]


P201, P202, P260, P264, P270, P281, P308+P313, P314, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Pentadecafluoro-Octanoic Acid 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Pentadecafluorooctanoic acid 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Pentadecafluorooctanoic acid #
    335-67-1 335-93-3 8PF
    947VD76D3L 97812-EP2305685A1 97812-EP2305686A1
    ACMC-1CN9C AI3-19341 AK161799
    AKOS005259894 AS-15245 BRN 1809678
    C7F15COOH C8HF15O2 CAS-335-67-1
    CCRIS 4386 CHEBI:35549 CHEMBL172988
    CS-B0915 CTK1C2449 DB-048447
    DSSTox_CID_11865 DSSTox_GSID_31865 DSSTox_RID_78895
    DTXSID8031865 EINECS 206-397-9 FT-0631976
    Fluorad FC-26 (Salt/Mix) HSDB 7137 Hexanoyl fluoride, 3,3,4,4,5,5,6,6,6-nonafluoro-2-oxo-
    Hexanoyl fluoride,3,4,4,5,5,6,6,6-nonafluoro-2-oxo- IPC-PFFA-8 IPC-PFFA-8 HG
    K-7733 KS-00000VX0 LS-1215
    LS40741 MCULE-1103416295 MFCD00004174
    NCGC00164448-01 NCGC00164448-02 NCGC00164448-03
    NCGC00254596-01 NSC 95114 NSC-95114
    NSC95114 O617 Octanoic acid, 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluoro-
    Octanoic acid, pentadecafluoro- P0764 PERFLUOROOCTANOIC ACID
    PFOA Pentadecafluoro-1-octanoic acid Pentadecafluoro-n-octanoic acid
    Pentadecafluorooctanoic Acid High Grade Pentadecafluorooctanoic acid Pentadecafluorooctanoic acid solution, 100 mug/mL in methanol, analytical standard
    Pentadecafluorooctanoic acid, 96% Pentadecafluorooctanoic acid, analytical grade Pentadecafluorooctanoic acid, analytical standard
    Pentadecafluorooctanoicacid Perfluoro-n-octanoic acid Perfluorocaprylic acid
    Perfluoroctanoic acid Perfluoroheptanecarboxylic acid Perfluorooctanoic Acid High Grade
    Perfluorooctanoic acid 100 microg/mL in Acetonitrile Perfluorooctanoic acid, 96% Q418348
    RTR-014034 SC-13661 SCHEMBL22556
    SNGREZUHAYWORS-UHFFFAOYSA-N ST24038407 TR-014034
    TRA0098108 Tox21_300688 UNII-947VD76D3L
    W-106771 Z1270326259 ZINC6844606
    n-perfluorooctanoic acid perfluorooctylcarboxylic acid

    CAS Number 2395-00-8, 301305-73-7, 335-67-1, 335-93-3, 3825-26-1, 864071-08-9
    PubChem Compound 9554
    ChEBI 35549
    ChemSpider 9180
    Wikipedia Perfluorooctanoic acid

    1. Meyer et al. (2017)
    2. Quist et al. (2015)