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Drug

D0250 | Auranofin

Molecular Formula C20H35AuO9PS
Molecular Weight 679.5
Structure
State solid
Route of elimination Approximately 60% of the absorbed gold (15% of the administered dose) from a single dose of auranofin is excreted in urine; the remainder is excreted in the feces.

M

M01CB03 Auranofin


[M01CB] Gold preparations


[M01C] SPECIFIC ANTIRHEUMATIC AGENTS


[M01] ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS


[M] Musculoskeletal system

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 44 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]


H361 (97.73%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P201, P202, P264, P270, P281, P301+P310, P308+P313, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
mouse LD50 oral 84940ug/kg (84.94mg/kg) Bollettino Chimico Farmaceutico. Vol. 128, Pg. 22, 1989.
rat LD50 intraperitoneal 25500ug/kg (25.5mg/kg) Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
rat LD50 intravenous 39mg/kg (39mg/kg) Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
rat LD50 oral 265mg/kg (265mg/kg) Veterinary Pathology. Vol. 15(Suppl,
rat LD50 subcutaneous 235mg/kg (235mg/kg) Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
dog LD50 intravenous 3200ug/kg (3.2mg/kg) Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
man TDLo oral 1200ug/kg/2W- (1.2mg/kg) gastrointestinal: ulceration or bleeding from stomach Journal of Rheumatology. Vol. 13, Pg. 228, 1986.
mouse LD50 intraperitoneal 33800ug/kg (33.8mg/kg) Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
mouse LD50 intravenous 22600ug/kg (22.6mg/kg) Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
mouse LD50 subcutaneous 53600ug/kg (53.6mg/kg) Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
women TDLo oral 5400ug/kg/10D (5.4mg/kg) Arthritis and Rheumatism. Vol. 27, Pg. 1316, 1984.

  • Arthritis

  • Psoriatic arthropathy

  • Rheumatoid arthritis

  • Synovitis

  • Abdominal pain (0.14)

  • Vomiting (0.1)

  • Anaemia

  • Dermatitis

  • Diarrhoea

  • Leukopenia

  • Protein urine present

  • Proteinuria

  • Rash

  • Stomatitis

  • Thrombocytopenia

    • (1-Thio-beta-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate (1-Thio-beta-D-glucopyranosato)(triethylphosphine)gold2,3,4,6-tetraacetate (2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosato-kappaS(1))(triethylphosphine)gold
    (2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate 2,3,4,6-Tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S (triethylphosphine)gold AURANOFIN
    Auranofina Auranofine Auranofinum
    Auroafen BDBM50153291 CHEBI:2922
    CHEMBL1366 DB00995 GTPL6306
    Ridaura SK&F-39162 SK-39162
    Triethylphosphine gold gold(+1) cation triethylphosphane

    DrugBank Name Auranofin
    DrugBank DB00995
    CAS Number 34031-32-8
    PubChem Compound 70788951
    KEGG Compound ID C06836
    KEGG Drug D00237
    PubChem.Substance 46507010
    ChEBI 2922
    PharmGKB PA448510
    ChemSpider 5293650
    BindingDB 50153291.0
    TTD DAP000757
    Wikipedia Auranofin
    DPD 1898