Compound
D0258 | CGP37157
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| TRANSPORT OF CALCIUM | 1 μmol/L | 241 | ||||||
| ACCUMULATION OF CALCIUM | 1 μmol/L | periodically paced rat ventricular myocytes (VMs) under β-adrenergic stimulation | mitochondrial Ca2+ monitored by mitochondrial-targeted Ca2+ biosensor mtRCamp1h. | 241 | ||||
| HEART-SPECIFIC OXIDATIVE STRESS | 1 μmol/L | rat | ventricular myocytes | redox-sensitive OMM-HyPer and ERroGFP_iE biosensors | 241 | |||
| Target | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| mitochondrial Na/Ca2+ exchanger | 1 μmol/L | periodically paced rat ventricular myocytes (VMs) under β-adrenergic stimulation | mitochondrial Ca2+ monitored by mitochondrial-targeted Ca2+ biosensor mtRCamp1h. | 241 | ||||
| mitochondrial Na/Ca2+ exchanger | 1 μmol/L | inhibit | 241 | |||||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
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Warning |
Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P264, P270, P273, P301+P312, P330, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| 4,1-Benzothiazepin-2(3H)-one, 7-chloro-5-(2-chlorophenyl)-1,5-dihydro- | 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2 (3H)-one | 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one |
| 7-Chloro-5-(2-chlorophenyl)-3,5-dihydro-4,1-benzothiazepin-2-ol | 7-Chloro-5-(2-chlorophenyl)-3,5-dihydrobenzo[e][1,4]thiazepin-2(1H)-one | 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2-one |
| 75450-34-9 | AKOS024456390 | BDBM50139422 |
| BN0133 | BRD-A35623999-001-02-4 | BRD-A35623999-001-03-2 |
| BRD-A35623999-001-04-0 | BSPBio_001556 | Bio1_000408 |
| Bio1_000897 | Bio1_001386 | Bio2_000276 |
| Bio2_000756 | C-35564 | C15H11Cl2NOS |
| CC-23140 | CGP 37157 | CGP-37157 |
| CGP-37157, >=98% (HPLC), powder | CGP37157 | CHEBI:91650 |
| CHEMBL1495071 | CS-0008572 | CTK2H9014 |
| DB-055958 | DTXSID60996899 | FT-0641565 |
| HMS1361N18 | HMS1791N18 | HMS1989N18 |
| HMS3267K16 | HMS3402N18 | HMS3412I15 |
| HMS3676I15 | HSCI1_000330 | HY-15754 |
| IDI1_034026 | KBio2_000276 | KBio2_002844 |
| KBio2_005412 | KBio3_000551 | KBio3_000552 |
| KBioGR_000276 | KBioSS_000276 | NCGC00025008-02 |
| NCGC00025008-03 | Q27163475 | SCHEMBL869274 |
| SR-01000597388 | SR-01000597388-1 |