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Drug

D0278 | Meclizine

Molecular Formula C25H27ClN2
Molecular Weight 390.9
Structure
State solid
Clearance There is limited data on the clearance of meclizine.
Volume of distribution The volume of distribution of meclizine in humans has not been fully studied. It is proposed that meclizine may be excreted into breast milk.[L6760]
Route of elimination Meclizine is excreted in the urine as metabolites and in the feces as unchanged drug.[L6760]
Protein binding There is limited data on the protein binding profile of meclizine.
Half life Meclizine has a plasma elimination half-life of about 5-6 hours in humans.[L6772]
Absorption Most histamine H1 antagonists are reported to be readily absorbed following oral administration.[L6760] Upon oral administration, the time to reach peak plasma concentrations (Cmax) of meclizine is about 3 hours post-dose, with the value ranging from 1.5 to 6 hours.[L6772]

R

R06AE55 Meclozine, combinations


[R06AE] Piperazine derivatives


[R06A] ANTIHISTAMINES FOR SYSTEMIC USE


[R06] ANTIHISTAMINES FOR SYSTEMIC USE


[R] Respiratory system

R06AE05 Meclozine


[R06AE] Piperazine derivatives


[R06A] ANTIHISTAMINES FOR SYSTEMIC USE


[R06] ANTIHISTAMINES FOR SYSTEMIC USE


[R] Respiratory system

Organism Test type Route Dose (normalized dose) Effect Source
rat LD50 oral 1750mg/kg (1750mg/kg) Proceedings of the European Society for the Study of Drug Toxicity. Vol. 9, Pg. 134, 1968.
mouse LD50 intramuscular 625mg/kg (625mg/kg) Compilation of LD50 Values of New Drugs.
mouse LD50 oral 1650mg/kg (1650mg/kg) Compilation of LD50 Values of New Drugs.


  • (+-)-Meclizine (.+/-.)-Meclizine 1-((4-Chlorophenyl)(phenyl)methyl)-4-(3-methylbenzyl)piperazine
    1-((4-Chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)piperazine 1-(p-Chloro-.alpha.-phenylbenzyl)-4-(m-methylbenzyl)piperazine 1-(p-Chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)piperazine
    1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)diethylenediamine 1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)piperazine 1-[(4-Chlorophenyl)(phenyl)methyl]-4-(3-methylbenzyl)piperazine
    1-[(4-Chlorophenyl)(phenyl)methyl]-4-(3-methylbenzyl)piperazine # 1-[(4-chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine 1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine
    1-p-Chlorobenzhydryl-4-m-methylbenzylpiperazine 189298-48-4 569-65-3
    AB00053493 AB00053493_14 AB00053493_15
    AB1009566 AKOS015951354 Ancolan
    Ancolon Antivert BCP28339
    BDBM81467 BPBio1_000588 BRD-A50311610-300-05-4
    BRD-A50311610-300-06-2 BRN 0332002 BSPBio_000534
    BSPBio_001949 Bonadettes Bonadoxin (Salt/Mix)
    Bonamine (Salt/Mix) Bonine C07116
    CAS_569-65-3 CHEBI:6709 CHEMBL1623
    CTK6G9296 Calmonal Chiclida
    D08163 DB00737 DTXSID0023242
    Diadril (Salt/Mix) DivK1c_000407 Dramamine II
    EINECS 209-323-3 EN300-58334 FT-0659103
    GTPL2757 HSDB 3113 Histamethine
    Histamethizine Histametizine Histametizyn
    Histametizyne IDI1_000407 Itinerol
    KBio1_000407 KBio2_001371 KBio2_003939
    KBio2_006507 KBio3_001449 KBioGR_000473
    KBioSS_001371 L001136 LS-111206
    MCULE-7463916552 Marex Meclizine [INN:BAN]
    Meclizine hydrochloride Meclizine;Meclozine Meclozin
    Meclozina Meclozina [INN-Spanish] Meclozine
    Meclozine (BAN) Meclozine [INN] Meclozinum
    Meclozinum [INN-Latin] Monamine NCGC00018296-02
    NCGC00018296-04 NCGC00018296-08 NINDS_000407
    NSC 169189 NSC-169189 NSC169189
    NSC_4034 Navicalm Neo-istafene
    Neo-suprimal Neo-suprimel Nevidoxine (TN)
    OCJYIGYOJCODJL-UHFFFAOYSA-N Parachloramine Parachloramine
    Peremesin Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)- Piperazine, 1-(p-chloro-.alpha.-phenylbenzyl)-4-(m-methylbenzyl)-
    Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)- Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]- Postafene
    Prestwick0_000457 Prestwick1_000457 Prestwick2_000457
    Prestwick3_000457 Q386441 Ravelon
    Ru-Vert-M SBI-0051433.P003 SC-51103
    SCHEMBL4649 SPBio_000100 SPBio_002473
    Sabari Sea-Legs Siguran
    Spectrum2_000110 Spectrum3_000485 Spectrum4_000037
    Spectrum5_000919 Spectrum_000891 Subari
    Suprimal Travelon U. C. B. 5062
    U.C.B. 5062 UCB 170 UCB 5052
    UCB 5062 Vertizine (Salt/Mix) Vomisseis
    Vomissels WLN: T6N DNTJ AYR&R DG& D1R C1 Z53003552
    meclizine

    DrugBank Name Meclizine
    DrugBank DB00737
    CAS Number 1104-22-9, 189298-48-4, 31884-77-2, 569-65-3
    PubChem Compound 4034
    KEGG Compound ID C07116
    KEGG Drug D08163
    PubChem.Substance 46507782
    ChEBI 6709
    PharmGKB PA450338
    ChemSpider 3894
    BindingDB 81467.0
    TTD DAP000795
    Wikipedia Meclizine
    DPD 6316