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Drug

D0285 | Acetylcysteine

Molecular Formula C5H9NO3S
Molecular Weight 163.2
Structure
State solid
Protein binding 0.83
Half life 5.6 hours (adults), 11 hours (neonates)
Absorption Bioavailability is 6–10% following oral administration and less than 3% following topical administration.
Trade names Acetadote, Fluimucil, Mucomyst
Description treat paracetamol (acetaminophen) overdose; promotes the re-synthesis of GSH; a precursor of glutathione; thiol-containing antioxidant; modulator of the intracellular redox state.

S

V

R

V03AB23 Acetylcysteine


[V03AB] Antidotes


[V03A] ALL OTHER THERAPEUTIC PRODUCTS


[V03] ALL OTHER THERAPEUTIC PRODUCTS


[V] Various ATC structures

S01XA08 Acetylcysteine


[S01XA] Other ophthalmologicals


[S01X] OTHER OPHTHALMOLOGICALS


[S01] OPHTHALMOLOGICALS


[S] Sensory organs

R05CB01 Acetylcysteine


[R05CB] Mucolytics


[R05C] EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS


[R05] COUGH AND COLD PREPARATIONS


[R] Respiratory system

Toxicity Dose Time Species Model Method Action Positive criterion Reference
RSS PRODUCTION rho-GFP (Redox-sensitive GFP) 244

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 51 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


Reported as not meeting GHS hazard criteria by 26 of 51 companies. For more detailed information, please visit ECHA C&L website


Of the 7 notification(s) provided by 25 of 51 companies with hazard statement code(s):


H315 (64%): Causes skin irritation [Warning Skin corrosion/irritation]


H319 (96%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H335 (60%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
mouse LD50 oral 4400mg/kg (4400mg/kg) European Patent Application. Vol. #0192191,
mouse LD50 intraperitoneal 400mg/kg (400mg/kg) National Technical Information Service. Vol. AD691-490,
dog LD50 intravenous 700mg/kg (700mg/kg) Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 479, 1979.
dog LD50 oral > 1gm/kg (1000mg/kg) Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 479, 1979.
dog LD50 intraperitoneal 700mg/kg (700mg/kg) Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 479, 1979.
mouse LD50 intravenous 3800mg/kg (3800mg/kg) Journal of Medicinal Chemistry. Vol. 10, Pg. 1172, 1967.
rat LD50 oral 5050mg/kg (5050mg/kg) Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
child TDLo multiple routes 8480mg/kg/3D- (8480mg/kg) liver: liver function tests impaired Pediatrics. Vol. 79, Pg. 281, 1987.
rat LD50 intravenous 1140mg/kg (1140mg/kg) gastrointestinal: other changes European Journal of Respiratory Diseases. Vol. 61(Suppl,


  • (2R)-2-(acetylamino)-3-mercaptopropanoic acid (2R)-2-(acetylamino)-3-sulfanylpropanoic acid (2R)-2-Acetamido-3-sulfanyl-propanoic acid
    (2R)-2-acetamido-3-sulfanylpropanoic acid (2R)-2-acetylamino-3-mercapto-propionic acid (2R)-2-acetylamino-3-sulfanylpropanoic acid
    (R)-2-Acetamido-3-mercaptopropanoic acid (R)-2-acetylamino-3-mercaptopropanoic acid (R)-mercapturic acid
    (S)-2-Acetamido-3-mercaptopropanoic acid 16A911 2-Acetylamino-3-mercapto-propionate
    2-Acetylamino-3-mercapto-propionic acid 616-91-1 66233-EP2298305A1
    66233-EP2308851A1 A 7250 A-1100
    A0905 AB0013800 AB00382974-12
    AB00382974_13 AB1002786 AC-16071
    AC-24117 AKOS015841009 AM20100502
    ANTIOXIDANT MODEL (TRAMP) -N-ACETYLCYSTEINE ANW-33915 Ac-Cys-OH
    AcCys Acetadote Acetein
    Acetilcisteina Acetilcisteina [INN-Spanish] Acetyl Cysteine,(S)
    Acetyl-L-cysteine Acetylcysteine (JP17/USP/INN) Acetylcysteine [USAN:INN:BAN]
    Acetylcysteine [USAN:USP:INN:BAN:JAN] Acetylcysteine, British Pharmacopoeia (BP) Reference Standard Acetylcysteine, European Pharmacopoeia (EP) Reference Standard
    Acetylcysteine, United States Pharmacopeia (USP) Reference Standard Acetylcysteinum Acetylcysteinum [INN-Latin]
    Airbron BDBM50420190 BP-12854
    BR-46577 BRD-K59058747-001-20-9 BSPBio_001794
    Broncholysin Brunac C06809
    CABC898A-E48B-4E13-9F72-98D0609A1854 CAS-616-91-1 CCG-204176
    CCRIS 3764 CHEBI:28939 CHEMBL600
    CS-2160 CTK2F2887 Certified Reference Material
    Cetylev Cysteine, N-acetyl-, L- D00221
    DB-038288 DB06151 DSSTox_CID_21
    DSSTox_GSID_20021 DSSTox_RID_75324 DTXSID5020021
    EINECS 210-498-3 EN300-72028 EU-0100081
    Exomuc F1905-7178 FT-0629832
    Fabrol Fluatox Fluimicil Infantil
    Fluimucetin Fluimucil Flumil
    Flumucetin Fluprowit GS-3121
    HMS2234J22 HMS3260A04 HMS3655G11
    HMS3715D03 HSDB 3003 HY-B0215
    I630 Ilube Inspir
    J-507685 KBio3_001294 KBioGR_000554
    KS-0000026W KSC352Q8P L-.alpha.-Acetamido-.beta.-mercaptopropionic acid
    L-Acetylcysteine L-Cysteine, N-acetyl- L-Cysteine, N-acetyl- & Tumor necrosis factor
    L-alpha-Acetamido-beta-mercaptopropionic acid LNAC LNAC
    LP00081 LS-2165 Lopac0_000081
    Lysomucil MFCD00004880 MLS000028419
    MLS001076125 MLS006011563 MUCOMYST (TN)
    MUCOSIL-10 MUCOSIL-20 Mercapturic acid
    Mercapturic acid, (R)- Muco sanigen Mucocedyl
    Mucofilin Mucolator Mucolyticum
    Mucolyticum Lappe Mucolyticum-Lappe Mucolytikum Lappe
    Mucomyst Mucosil Mucosolvin
    Mucret N-Acety-L-Cysteine N-Acetyl cysteine
    N-Acetyl-3-mercaptoalanine N-Acetyl-L-(+)-cysteine N-Acetyl-L-cysteine
    N-Acetyl-L-cysteine & Tumor necrosis factor (TNF) N-Acetyl-L-cysteine hydrochloride N-Acetyl-L-cysteine, 98%
    N-Acetyl-L-cysteine, BioXtra, >=99% (TLC) N-Acetyl-L-cysteine, PharmaGrade, Ajinomoto, Manufactured under appropriate GMP controls for pharma or biopharmaceutical production, suitable for cell culture N-Acetyl-L-cysteine, Pharmaceutical Secondary Standard
    N-Acetyl-L-cysteine, SAJ special grade, 98.0-102.0% N-Acetyl-L-cysteine, Sigma Grade, >=99% (TLC), powder N-Acetyl-L-cysteine, Vetec(TM) reagent grade, 98%
    N-Acetyl-L-cysteine, cell culture tested, BioReagent N-Acetyl-cysteine N-Acetylcysteine
    N-acetyl-(R)-cysteine N-acetyl-L-cystein N-acetyl-l-cys
    N-acetylcystein N-alpha-Acetyl-L-cysteine NAC
    NAC & TNF NAC,L-alpha-Acetamido-beta-mercaptopropionic acid NAC-TB
    NCGC00015086-04 NCGC00022304-03 NCGC00022304-04
    NCGC00022304-05 NCGC00022304-06 NCGC00022304-07
    NCGC00022304-08 NCGC00258631-01 NCGC00260766-01
    NSC 111180 NSC-111180 NSC111180
    Naxid (Salt/Mix) Neo-fluimucil Opera_ID_452
    PWKSKIMOESPYIA-BYPYZUCNSA-N Parvolex PubChem12963
    Q375613 RK-0202 RTC-066653
    Respaire SC-09436 SC2
    SCHEMBL5292 SMR000058377 SPBio_000012
    SR-01000075439 SR-01000075439-1 SR-01000075439-3
    SR-01000075439-5 ST2408139 ST50824849
    SW199597-2 Sodium 2-acetamido-3-mercaptopropionate Spectrum2_000086
    Spectrum3_000287 Spectrum4_000137 Spectrum5_000764
    Syntemucol TC-066653 Tixair
    Tox21_110877 Tox21_110877_1 Tox21_201078
    Tox21_500081 UNII-2SPH1IMO2V component PWKSKIMOESPYIA-BYPYZUCNSA-N UNII-WYQ7N0BPYC
    WYQ7N0BPYC ZINC3589203 acetyl cysteine
    acetylcysteine acetylcysteine (n-acetyl-l-cysteine) component of Naxid
    cysteine, N-acetyl- mercapturic acid s1623

    DrugBank Name Acetylcysteine
    DrugBank DB06151
    CAS Number 18829-79-3, 19542-74-6, 38520-57-9, 616-91-1, 7218-04-4
    PubChem Compound 12035
    KEGG Compound ID C06809
    KEGG Drug D00221
    PubChem.Substance 99443235
    ChEBI 28939
    PharmGKB PA448033
    ChemSpider 11540
    BindingDB 50420190.0
    TTD DNC000981
    Wikipedia Acetylcysteine
    HET SC2
    DPD 10303