Drug
D0290 | Oxfenicine
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| FATTY ACID METABOLISM | 1.5 to 4.5mM | 24hr | T47D cells | quantifies the conversion of [9,10-3H(N)]-palmitic acid to 3H2O with diffusion | inhibition | Student’s two-tail t-test, where p < 0.05 | 273 | |
| MITOCHONDRIAL FATTY ACID BETA OXIDATION | >100/>100 | human/rat | hepatocytes | Fatty acid oxidation (FAO) was determined by measuring 14CO2 release from 14C-labeled palmitate | inhibition | IC50 (μM) | 333 | |
| SYNTHESIS OF KETONE BODY | >100 | Wistar rat | hepatocytes | ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) | inhibition | IC50 (μM) | 333 | |
| Target | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| Carnitine O-palmitoyltransferase 1, liver isoform, CPT1-L, EC 2.3.1.21 | >100/− | human/rat | recombinant Pichia pastoris Membrane Preparations | spectrophotometric assay with DTNB | Negative | IC50 (μM) | 333 | |
| Carnitine O-palmitoyltransferase 1, muscle isoform | >100 | human/rat | recombinant Pichia pastoris Membrane Preparations | spectrophotometric assay with DTNB | Negative | IC50 (μM) | 333 | |
| Carnitine O-palmitoyltransferase 2, mitochondrial, EC 2.3.1.21 | >100/− | human/rat | recombinant Pichia pastoris Membrane Preparations | spectrophotometric assay with DTNB | Negative | IC50 (μM) | 333 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
 |
Warning |
Aggregated GHS information provided by 40 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H302 (97.5%): Harmful if swallowed [Warning Acute toxicity, oral] H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (97.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| (2S)-2-amino-2-(4-hydroxyphenyl)acetic acid | (2S)-2-azanyl-2-(4-hydroxyphenyl)ethanoic acid | (2S)-amino(4-hydroxyphenyl)ethanoic acid |
| (2s)-Amino(4-Hydroxyphenyl)Acetic Acid | (S)-(+)-2-Amino-2-(4-hydroxyphenyl)acetic Acid | (S)-2-AMINO-2-(4-HYDROXYPHENYL)ACETIC ACID |
| (S)-2-Amino-2-(4-hydroxyphenyl)essigsaeure | (S)-4-hydroxyphenylglycine | (S)-Amino-(4-hydroxyphenyl)acetic acid |
| (S)-alpha-Amino-4-hydroxybenzeneacetic acid | (s)-(4-hydroxyphenyl)glycine | 32462-30-9 |
| 4-Hydroxy-L-(+)-2-phenylglycine | 4-Hydroxy-L-phenylglycine | 4-Hydroxy-L-phenylglycine, >=99.0% (NT) |
| 4-Hydroxyphenylglycine | 9YH0WH2Z02 | A821286 |
| AC-24628 | ACT05092 | AKOS016842371 |
| ANW-48447 | BDBM50403035 | BR-28583 |
| Benzeneacetic acid, a-amino-4-hydroxy-, (aS)- | Benzeneacetic acid, alpha-amino-4-hydroxy-, (S)- | Benzeneacetic acid, alpha-amino-4-hydroxy-, (alphaS)- |
| C12323 | CAS-32462-30-9 | CHEBI:31755 |
| CHEMBL1232077 | CS-W018812 | CTK4G8744 |
| D05292 | DB04291 | DS-11081 |
| DSSTox_CID_26403 | DSSTox_GSID_46403 | DSSTox_RID_81583 |
| DTXSID3046403 | EINECS 251-061-7 | FT-0630187 |
| H-Phg(4-OH)-OH | HY-W018026 | J-018746 |
| KS-00000MKP | L-(+)-2-(4-Hydroxyphenyl)glycine | L-(+)-A-4-HYDROXYPHENYLGLYCINE |
| L-2-(4-Hydroxyphenyl)glycine | L-2-(p-Hydroxyphenyl)glycine | L-4-Hydroxyphenylglycine |
| L-P-HYDROXYPHENYGLYCINE | LJCWONGJFPCTTL-ZETCQYMHSA-N | NCGC00164509-01 |
| NCGC00344518-01 | OXFENICINE | Oxfenicina |
| Oxfenicina [INN-Spanish] | Oxfenicine (USAN/INN) | Oxfenicine [USAN:INN:BAN] |
| Oxfenicinum | Oxfenicinum [INN-Latin] | PubChem13975 |
| Q27095113 | S-1484 | SC-20695 |
| SCHEMBL122315 | ST2408292 | TC-137192 |
| Tox21_112144 | Tox21_112144_1 | UK 25842 |
| UK-25,842 | UK-25842 | UNII-7UYG7X0F53 component LJCWONGJFPCTTL-ZETCQYMHSA-N |
| UNII-9YH0WH2Z02 | W5427 | ZINC6667724 |
| bmse000629 | p-Hydroxy-L-phenylglycine |