Drug

D0301 | Trifluoperazine

Molecular Formula C21H24F3N3S
Molecular Weight 407.5
Structure
State solid
Half life 10-20 hours

N

N05AB06 Trifluoperazine


[N05AB] Phenothiazines with piperazine structure


[N05A] ANTIPSYCHOTICS


[N05] PSYCHOLEPTICS


[N] Nervous system


Toxicity Dose Time Species Model Method Action Positive criterion Reference
UNCOUPLING rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay increase 53

Organism Test type Route Dose (normalized dose) Effect Source
mouse LD50 intravenous 29mg/kg (29mg/kg) Psychopharmacology Service Center, Bulletin. Vol. 2, Pg. 17, 1963.
mouse LD50 oral 1350mg/kg (1350mg/kg) Psychopharmacology Service Center, Bulletin. Vol. 2, Pg. 17, 1963.
mouse LD50 intraperitoneal 120mg/kg (120mg/kg) Neuropharmacology. Vol. 9, Pg. 235, 1970.

  • Aggression

  • Agitated depression

  • Agitation

  • Alcohol abuse

  • Alcoholism

  • Anxiety

  • Bipolar disorder

  • Bipolar I disorder

  • Brain injury

  • Catatonia

  • Delusion

  • Electroencephalogram abnormal

  • Generalised anxiety disorder

  • Hallucination

  • Mental retardation

  • Mitral valve incompetence

  • Neurosis

  • Psychotic disorder

  • Schizophrenia

  • Schizophrenia, paranoid type

  • Senile psychosis

  • Tardive dyskinesia

  • Tension

  • Tremor

  • 10-(.gamma.-(N'-Methylpiperazino)propyl)-2-trifluoromethylphenothiozine 10-(3-(4-Methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)phenothiazine 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-10H-phenothiazine
    10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-phenothiazine 10-(3-(4-methylpiperazin-1-yl)propyl)-2-(trifluoromethyl)-10H-phenothiazine 10-(gamma-(N'-Methylpiperazino)propyl)-2-trifluoromethylphenothiazine
    10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE 10-[3-(4-Methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine 10-[3-(4-Methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine #
    10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine
    10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine dihydrochloride 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride 10-[3-(4-methylpiperazino)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride
    10H-Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)- 10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)- 117-89-5
    2-Trifluoromethyl-10-(3'-(1-methyl-4-piperazinyl)propyl)phenothiazine 2-Trifluoromethyl-10-[3'-(1-methyl-4-piperazinyl)propyl]phenothiazine 214IZI85K3
    5858-EP2302003A1 5858-EP2309505A1 605-75-4
    AB00053558 AB00053558-27 AB00053558_28
    AB00053558_29 AKOS001487920 AX8155275
    Apo-trifluoperazine (TN) BDBM79181 BIDD:PXR0132
    BPBio1_000338 BPBio1_001345 BRD-K89732114-001-02-6
    BRD-K89732114-001-03-4 BRD-K89732114-001-05-9 BRD-K89732114-300-05-5
    BRD-K89732114-300-07-1 BSPBio_000306 BSPBio_001190
    BSPBio_002928 Bio1_000458 Bio1_000947
    Bio1_001436 Bio2_000435 Bio2_000915
    Biomol-NT_000060 C07168 C21H24F3N3S
    CAS-440-17-5 CCG-37306 CCRIS 6994
    CHEBI:45951 CHEMBL422 Calmazine
    D08636 DB00831 DTXSID1046928
    DivK1c_000843 EINECS 204-219-4 FT-0650159
    Fluoperazine Fluoperazine (Salt/Mix) Flurazine
    GTPL214 HMS1362L11 HMS1792L11
    HMS1990L11 HMS2089J11 HMS3429O07
    HSDB 3195 IDI1_000843 IDI1_002190
    Jatroneural (Salt/Mix) KBio1_000843 KBio2_000530
    KBio2_001148 KBio2_002431 KBio2_003098
    KBio2_003716 KBio2_004999 KBio2_005666
    KBio2_006284 KBio2_007567 KBio3_000959
    KBio3_000960 KBio3_002148 KBio3_002910
    KBioGR_000530 KBioGR_000835 KBioGR_002431
    KBioSS_000530 KBioSS_001148 KBioSS_002437
    KSC-210-031 KUC109776N L001075
    LS-105595 Lopac-T-8516 Lopac0_001232
    M989 MCULE-3726407978 MLS001146870
    MLS002702821 MLS006011857 MRF-0000088
    NCGC00013226 NCGC00013226-02 NCGC00013226-03
    NCGC00013226-04 NCGC00013226-05 NCGC00013226-06
    NCGC00013226-07 NCGC00013226-08 NCGC00013226-09
    NCGC00013226-10 NCGC00013226-11 NCGC00013226-12
    NCGC00013226-13 NCGC00013226-15 NCGC00024251-03
    NCGC00024251-04 NCGC00024251-05 NCGC00024251-06
    NCGC00024251-07 NCI17474 NCI60_001427
    NCI60_004087 NCIStruc1_001127 NCIStruc2_001093
    NINDS_000843 NSC 17474 NSC 46061
    NSC-17474 NSC17474 PDSP1_001300
    PDSP2_001284 Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)- Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-
    Prestwick0_000313 Prestwick1_000313 Prestwick2_000313
    Prestwick3_000313 Q1752915 QTL1_000085
    RP 7623 SBI-0051199.P003 SC-95890
    SCHEMBL24866 SKF 5019 SMR001566649
    SPBio_000755 SPBio_002525 SR-01000003020-6
    STK182873 Spectrum2_000828 Spectrum3_001374
    Spectrum4_000368 Spectrum5_001553 Spectrum_000668
    Stelazine Stelazine (*Dihydrochloride*) Stelazine (Salt/Mix)
    Synklor (Salt/Mix) TFP Terfluzine (Salt/Mix)
    Trifluoperazin Trifluoperazin HCl Trifluoperazina
    Trifluoperazina [INN-Spanish] Trifluoperazina [Italian] Trifluoperazine (INN)
    Trifluoperazine [INN:BAN] Trifluoperazine hydrochloride Trifluoperazinum
    Trifluoperazinum [INN-Latin] Trifluoromethyl-10-(3'-(1-methyl-4-piperazinyl)propyl)phenothiazine Trifluoromethylperazine
    Trifluoroperazine Trifluperazine Triflurin
    Trifluroperizine Triftazin (Salt/Mix) Triftazine (Salt/Mix)
    Triperazine Tripfluoperazine Hydrochloride Triphthasine
    Triphthazine (Salt/Mix) UNII-214IZI85K3 ZEWQUBUPAILYHI-UHFFFAOYSA-N
    ZINC19418959 cMAP_000048 cid_2913535
    cid_5566 trifluoperazine

    DrugBank Name Trifluoperazine
    DrugBank DB00831
    CAS Number 117-89-5, 440-17-5
    PubChem Compound 5566
    KEGG Compound ID C07168
    KEGG Drug D08636
    PubChem.Substance 46507961
    ChEBI 45951
    PharmGKB PA451771
    ChemSpider 5365
    BindingDB 79181.0
    TTD DAP000034
    Wikipedia Trifluoperazine
    HET TFP
    DPD 7996|7997