Search References Drug Actions/Targets About Access data Feedback
Sign In
mitontu@gmail.com
2021 MitoTox | (CC BY-NC 4.0)
Drug

D0313 | Amifostine

Molecular Formula C5H15N2O3PS
Molecular Weight 214.23
Structure
State solid
Route of elimination After a 10-second bolus dose of 150 mg/m2 of ETHYOL, renal excretion of the parent drug and its two metabolites was low during the hour following drug administration, averaging 0.69%, 2.64% and 2.22% of the administered dose for the parent, thiol and disulfide, respectively.
Half life 8 minutes

V

V03AF05 Amifostine


[V03AF] Detoxifying agents for antineoplastic treatment


[V03A] ALL OTHER THERAPEUTIC PRODUCTS


[V03] ALL OTHER THERAPEUTIC PRODUCTS


[V] Various ATC structures

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory.


H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P264, P270, P301+P312, P330, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
rat LD50 intramuscular 396mg/kg (396mg/kg) Radiobiologiya. Vol. 16, Pg. 249, 1976.
man TDLo oral 11mg/kg (11mg/kg) National Technical Information Service. Vol. AD758-432,
rat LD50 intraperitoneal 418mg/kg (418mg/kg) Radiobiologiya. Vol. 16, Pg. 249, 1976.
guinea pig LD50 oral 635mg/kg (635mg/kg) National Technical Information Service. Vol. AD758-432,
monkey LD50 oral > 10gm/kg (10000mg/kg) National Technical Information Service. Vol. AD758-432,
rat LD50 oral 826mg/kg (826mg/kg) National Technical Information Service. Vol. AD758-432,
mouse LD50 oral 842mg/kg (842mg/kg) Radiobiologiya. Vol. 20, Pg. 746, 1980.
mouse LD50 intramuscular 514mg/kg (514mg/kg) Radiobiologiya. Vol. 16, Pg. 249, 1976.
mouse LD50 intraperitoneal 321mg/kg (321mg/kg) National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
guinea pig LD50 intraperitoneal 407mg/kg (407mg/kg) Radiobiologiya. Vol. 16, Pg. 249, 1976.
dog LDLo intravenous 279mg/kg (279mg/kg) Toxicologic Pathology. Vol. 13, Pg. 58, 1985.
mouse LD50 intravenous 557mg/kg (557mg/kg) National Technical Information Service. Vol. PB81-199580,

  • Body temperature increased

  • Dry mouth

  • Neoplasm malignant

  • Neutropenia

  • Non-small cell lung cancer

  • Ovarian cancer

    • ({2-[(3-aminopropyl)amino]ethyl}sulfanyl)phosphonic acid 2-((3-Aminopropyl)amino)-ethanethiol, dihydrogen phosphate ester 2-((3-Aminopropyl)amino)-ethanethiol, dihydrogen phosphate ester (9CI)
    2-(3-Aminopropyl)aminoethyl phosphorothioate 2-(3-Aminopropylamino)ethyl thiophosphate 2-(3-aminopropylamino)ethylsulfanylphosphonic acid
    2-(3-aminopropylamino)ethylsulfanylphosphonic acid,trihydrate 2-(3-azanylpropylamino)ethylsulfanylphosphonic acid 20537-88-6
    33870-EP2275420A1 33870-EP2295055A2 33870-EP2295416A2
    33870-EP2295426A1 33870-EP2295427A1 33870-EP2298748A2
    33870-EP2298764A1 33870-EP2298765A1 33870-EP2305642A2
    33870-EP2311453A1 33870-EP2311808A1 33870-EP2311829A1
    37A886 A 5922 A814662
    AB00053311-04 AB00053311-05 AB00053311_06
    AB0012846 AC-1126 AKOS015895196
    API0001443 AS-13020 AU-95722
    Acide ((amino-3 propylamino)-2 ethyl)-S-phosphorothioique Acide ((amino-3 propylamino)-2 ethyl)-S-phosphorothioique [French] Amifostina
    Amifostine Ethiofos Amifostine [USAN:INN:BAN] Amifostine,(S)
    Amifostinum Aminopropylaminoethyl thiophosphate Apaetp
    BCP08957 BIDD:GT0059 BRD-K73947551-001-01-0
    BRN 2088122 C06819 C5H15N2O3PS
    CAS-20537-88-6 CCG-35734 CCRIS 9316
    CHEBI:2636 CHEMBL1006 CS-2875
    CTK8F7705 DB01143 DSSTox_CID_2585
    DSSTox_GSID_22585 DSSTox_RID_76644 DTXSID8022585
    DivK1c_006743 EU-0100029 Ethanethiol, 2-((3-aminopropyl)amino)-, dihydrogen phosphate (ester)
    Ethanethiol, 2-[(3-aminopropyl)amino]-, 1-(dihydrogen phosphate) Ethanethiol, dihydrogen phosphate (ester) Ethanethiol, dihydrogen phosphate- (ester)
    Ethanethiol, {S-[(3-aminopropyl)amino]-,} dihydrogen phosphate- (ester) Ethiofos Ethiofos Anhydrous
    Ethyol Ethyol;WR2721 FT-0622272
    Gammaphos HMS2090I03 HMS3260E19
    HMS3713C06 HSDB 7560 HY-B0639
    ILA426L95O J-013390 J-519582
    JKOQGQFVAUAYPM-UHFFFAOYSA-N KBio1_001687 KBio2_000812
    KBio2_003380 KBio2_005948 KBioSS_000812
    KS-00001F8B LP00029 LS-108362
    Lopac-A-5922 Lopac0_000029 MLS000028473
    NCGC00015073-01 NCGC00015073-02 NCGC00015073-03
    NCGC00015073-04 NCGC00015073-05 NCGC00093549-01
    NCGC00093549-02 NCGC00260714-01 NCI60_002485
    NCIMech_000622 NSC 296961 NSC-296961
    NSC-758236 NSC296961 NSC758236
    Pharmakon1600-01503081 Phosphorothioic acid, S-(2-(3-aminopropylamino)ethyl) ester Phosphorothioic acid, S-[2-[(3-aminopropyl)amino]ethyl] ester
    Phosphorothioic acid, S-[2-[(3-aminopropyl)amino]ethyl]ester Q251698 S 8744
    S,2-(3-Aminopropylamino)ethyl-phosphorothioic acid S-(2-((3-Aminopropyl)amino)ethyl) dihydrogen phosphorothioate S-(2-((3-aminopropyl)amino)ethyl) O,O-dihydrogen phosphorothioate
    S-(2-(3-Aminopropylamino)ethyl) phosphorothioate S-2-(3-Aminopropylamino)ethyl phosphorothioic acid S-2-(3-aminopropylamino)-ethylphosphorothioic acid
    S-2-(3-aminopropylamino)ethyl O,O-dihydrogen phosphorothioate S-[2-(3-Aminopropylamino)ethyl] phosphorothioate S-[2-[(3-Aminopropyl)amino]ethyl] dihydrogen phosphorothioate
    S-omega-(3-Aminopropylamino)ethyl dihydrogen phosphorothioate S-{2-[(3-aminopropyl)amino]ethyl} dihydrogen thiophosphate SBI-0050018.P003
    SC-18798 SCHEMBL18464 SMP2_000335
    SMR000058413 SR-01000075680 SR-01000075680-1
    SR-01000075680-3 SR-01000075680-5 Sapep
    SpecPlus_000647 Spectrum5_001920 Spectrum_000332
    Tox21_110077 Tox21_110077_1 Tox21_500029
    UNII-ILA426L95O WR 2721 WR 2721C
    WR-2721 WR2721 YM 08310
    YM-08310 ZINC21992285 [2-(3-aminopropylamino)ethylthio]phosphonic acid
    amifostine {S-[2-(3-Aminopropylamino)ethyl]} phosphorothioate {S-[2-[(3-Aminopropyl)amino]ethyl]} dihydrogen phosphorothioate

    DrugBank Name Amifostine
    DrugBank DB01143
    CAS Number 112901-68-5, 20537-88-6, 63717-27-1
    PubChem Compound 2141
    KEGG Compound ID C06819
    PubChem.Substance 46505305
    ChEBI 2636
    PharmGKB PA448365
    ChemSpider 2056
    Wikipedia Amifostine
    DPD 57