Drug

D0315 | Anthralin

Molecular Formula C14H10O3
Molecular Weight 226.23
Structure
State solid
Absorption Anthralin penetrates damaged skin and psoriatic lesions faster and to a greater extent than normal skin, likely due to increased vascularity of psoriatic lesions [L1932].

D

D05AC51 Dithranol, combinations


[D05AC] Antracen derivatives


[D05A] ANTIPSORIATICS FOR TOPICAL USE


[D05] ANTIPSORIATICS


[D] Dermatological drugs


D05AC01 Dithranol


[D05AC] Antracen derivatives


[D05A] ANTIPSORIATICS FOR TOPICAL USE


[D05] ANTIPSORIATICS


[D] Dermatological drugs


Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 58 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H315 (98.28%): Causes skin irritation [Warning Skin corrosion/irritation]


H319 (98.28%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H335 (96.55%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
rat LD50 intraperitoneal 3mg/kg (3mg/kg) Developments in Biochemistry. Vol. 23, Pg. 759, 1982.
mouse LD50 oral 1542mg/kg (1542mg/kg) Archives of Toxicology. Vol. 59, Pg. 180, 1986.
rat LD50 oral 3216mg/kg (3216mg/kg) Archives of Toxicology. Vol. 59, Pg. 180, 1986.
mouse LD50 intraperitoneal > 1600mg/kg (1600mg/kg) JNCI, Journal of the National Cancer Institute. Vol. 62, Pg. 911, 1979.


  • 1,8,9-Trihydroxyanthracene, 97% 1,8-DIHYDROXY-9(10H)-ANTHRACENONE 1,8-Dihydroxy-9(10H)-anthracenone #
    1,8-Dihydroxy-9(10H)-anthracenone;Anthralin 1,8-Dihydroxy-9-anthrone 1,8-Dihydroxyanthracen-9(10H)-one
    1,8-Dihydroxyanthrone 1,8-dihydroxy-10-hydroanthracen-9-one 1,8-dihydroxy-10H-anthracen-9-one
    1,8-dihydroxy-9,10-dihydroanthracen-9-one 1,8-dihydroxy-9-(10H)anthracenone 1,8-dihydroxy-9-anthrane
    1143-38-0 4-06-00-07602 (Beilstein Handbook Reference) 9(10H)-Anthracenone, 1,8-dihydroxy-
    9(10H)-Anthracenone, 1,8-dihydroxy- (9CI) 9(10H)-Anthracenone,8-dihydroxy- AB00051916_07
    AB0105711 AC-14842 AK481321
    AKOS015914122 ANTHRADERM (TN) API0002431
    Anthra-Derm Anthralin (Dithranol) Anthralin (Dithranol), Pharmaceutical Secondary Standard
    Anthralin (USP) Anthralin [USP] Anthralin, Dithranol
    Anthralin, United States Pharmacopeia (USP) Reference Standard Anthraline Anthrone, 1,8-dihydroxy-
    Anthrone,8-dihydroxy- BDBM50041802 BRN 2054360
    BSPBio_001868 Batridol C06831
    CAS-1143-38-0 CCG-38920 CCRIS 628
    CHEBI:37510 CHEMBL46469 CS-2980
    CTK8A0163 Certified Reference Material Chrysodermol
    Cignolin Cigthranol D00233
    DB-060606 DB11157 DSSTox_CID_4538
    DSSTox_GSID_24538 DSSTox_RID_77448 DTXSID7024538
    Dithranol Dithranol (INN) Dithranol ,(S)
    Dithranol [INN] Dithranol, >=90% (HPLC) Dithranol, European Pharmacopoeia (EP) Reference Standard
    Dithranolum Dithranolum [INN-Latin] DivK1c_000021
    DrithoCreme Drithoscalp EINECS 214-538-0
    Epitope ID:114081 FT-0625372 HMS1920E07
    HMS2091K07 HMS2271B09 HMS3715H19
    HMS500B03 HY-B0738 IDI1_000021
    InChI=1/C14H10O3/c15-10-5-1-3-8-7-9-4-2-6-11(16)13(9)14(17)12(8)10/h1-6,15-16H,7H2 K-1044 KBio1_000021
    KBio2_000436 KBio2_003004 KBio2_005572
    KBio3_001368 KBioGR_000622 KBioSS_000436
    KS-5183 LS-570 MCULE-8492759735
    MFCD00001250 MFCD00053409 MLS001332632
    MLS002415712 NCGC00091330-01 NCGC00091330-02
    NCGC00091330-03 NCGC00091330-04 NCGC00091330-05
    NCGC00091330-07 NCGC00253941-01 NCGC00259400-01
    NCI60_004019 NINDS_000021 NSC 43970
    NSC 629313 NSC-43970 NSC-629313
    NSC-755873 NSC43970 NSC629313
    NSC755873 NUZWLKWWNNJHPT-UHFFFAOYSA- NUZWLKWWNNJHPT-UHFFFAOYSA-N
    Pharmakon1600-01500127 Prestwick_528 Psodadrate
    Psoriacid-Stift Q419397 SBI-0051286.P003
    SC-19051 SCHEMBL3197 SPBio_000122
    SPECTRUM1500127 SR-05000002011 SR-05000002011-1
    SR-05000002011-2 ST50825759 Spectrum2_000111
    Spectrum3_000304 Spectrum4_000151 Spectrum5_000820
    Spectrum_000056 Tox21_111115 Tox21_111115_1
    Tox21_201851 Tox21_300290 U8CJK0JH5M
    UNII-U8CJK0JH5M W-108602 ZINC1322
    Zithranol-RR anthralin cid_2202
    cignoline

    DrugBank Name Anthralin
    DrugBank DB11157
    CAS Number 1143-38-0, 480-22-8
    PubChem Compound 2202
    KEGG Compound ID C06831
    KEGG Drug D00233
    PubChem.Substance 347827926
    ChEBI 37510
    ChemSpider 2117
    BindingDB 50041802.0
    Wikipedia Dithranol
    DPD 9362