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Drug

D0324 | Beta carotene

Molecular Formula C40H56
Molecular Weight 536.9
Structure
State solid
Clearance The clearance rate of beta-carotene administered orally is 0.68 nmol/L each hour.[A32488]
Volume of distribution No pharmacokinetic studies have been performed regarding the volume of distribution of beta-carotene.
Route of elimination The unabsorbed carotene is excreted in feces.[L2202] It is also excreted in feces and urine as metabolites.[L2214] The consumption of dietary fiber can increase the fecal excretion of fats and other fat-soluble compounds such as beta-carotene.[L2226]
Protein binding Beta-carotene is thought to be highly bound to plasma proteins. It is registered to be retained by the chylomicron and transported in VLDL. After absorption, beta-carotene is rapidly transformed to retinol which is highly bound to a high number of plasma proteins.[T164]
Half life The apparent half-life of beta-carotene is of 6-11 days after initial administration.[A32487]
Absorption After administration of beta-carotene, some of the administered dose is absorbed into the circulatory system unchanged and stored in the fat tissue. The coadministration of beta-carotene and a high-fat content diet is correlated to a better absorption of beta-carotene. The absorption is also dependent on the isomeric form of the molecule where the cis conformation seems to present a higher bioavailability. The absorption of beta-carotene is thought to be performed in 6-7 hours.[L2202] The reported AUC of beta-carotene when administered orally from 0 to 440 hours after initial administration was reported to be 26.3 mcg.h/L. The maximal concentration of beta-carotene is attained in a dual pharmacokinetic profile after 6 hours and again after 32 hours with a concentration of 0.58 micromol/L.[A32488]

D

A

D02BB01 Betacarotene


[D02BB] Protectives against UV-radiation for systemic use


[D02B] PROTECTIVES AGAINST UV-RADIATION


[D02] EMOLLIENTS AND PROTECTIVES


[D] Dermatological drugs

A11CA02 Betacarotene


[A11CA] Vitamin A, plain


[A11C] VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO


[A11] VITAMINS


[A] Alimentary tract and metabolism

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 339 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


Reported as not meeting GHS hazard criteria by 287 of 339 companies. For more detailed information, please visit ECHA C&L website


Of the 6 notification(s) provided by 52 of 339 companies with hazard statement code(s):


H315 (46.15%): Causes skin irritation [Warning Skin corrosion/irritation]


H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H412 (46.15%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P264, P273, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • (1E,3E,5E,7E,9E,11E,13E,15E,17E)-1,18-bis(2,6,6-trimethylcyclohex-1-enyl)-3,7, 12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaene (9Z,13Z)-beta-Carotene (all-E)-1,1'-(3,7,12,16-Tetramethyl-1,3,5, 7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis[2,6, 6-trimethylcyclohexene]
    (all-E)-1,1'-(3,7,12,16-Tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis(2,6,6-trimethylcyclohexene) .beta. Carotene .beta., .beta.-Carotene
    .beta.,.beta.-Carotene .beta.,.beta.-Carotene, neo B .beta.-Carotene
    .beta.-Carotene, all-trans- 01YAE03M7J 1,1'-(3,7,12,16-Tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis(2,6,6-trimethylcyclohexene
    1,1'-(3,7,12,16-Tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis(2,6,6-trimethylcyclohexene), (all E)- 1,1'-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaene-1,18-diyl]bis(2,6,6-trimethylcyclohexene) 1,18-Bis(2,6,6-trimethyl-1-cyclohexenyl)-3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonene
    1,3,3-trimethyl-2-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyl-18-(2,6,6-trimethylcyclohexen-1-yl)octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]cyclohexene 117179-EP2292227A2 117179-EP2298776A1
    2,2'-((1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaene-1,18-diyl)bis(1,3,3-trimethylcyclohex-1-ene) 3046-EP2298772A1 3046-EP2308839A1
    7235-40-7 89648336-F9B2-44A0-9BF8-62E73369CB9B AB00051925_06
    AB00051925_07 AB2000280 AC-1869
    AKOS015896682 AS-13354 BDBM54988
    BIDD:PXR0110 BSPBio_003404 Beta Carotene Natural
    Beta Carotene, United States Pharmacopeia (USP) Reference Standard Beta carotene [USAN:USP] BetaVit
    Betacarotene Betacarotene (INN) Betacarotene [INN]
    Betacaroteno Betacaroteno [INN-Spanish] Betacaroteno [Spanish]
    Betacarotenum Betacarotenum [INN-Latin] Betacarotenum [Latin]
    C-23129 C.I. 75130 C.I. Food Orange 5
    C02094 C39H54 CAS-7235-40-7
    CC0205 CCG-36062 CCRIS 3245
    CHEBI:17579 CHEMBL1293 CI 40800
    CI 75130 CS-2262 Carotaben
    Carotene, .beta. Carotene, Provitamin A Certified Reference Material
    Cyclohexene, 1,1'-(3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis(2,6,6-trimethyl-, (all-E)- Cyclohexene, 1,1'-(3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis[2,6,6-trimethyl-, (all-E)- D03101
    DB06755 DSSTox_CID_253 DSSTox_GSID_20253
    DSSTox_RID_75466 DTXSID3020253 Diet,beta-carotene supplementation
    E160A EC 230-636-6 EINECS 230-636-6
    Food orange 5 H982 HMS2091M17
    HMS501A12 HSDB 3264 HY-N0411
    I(2)-Carotene IDI1_000330 J10299
    KPMK Karotin Karotin [Czech]
    LMPR01070001 LS-1621 Lucaratin
    MLS001066383 N1547 NCGC00096081-01
    NCGC00096081-02 NSC 62794 NSC-755910
    NSC62794 NSC755910 Natural Yellow 26
    OENHQHLEOONYIE-JLTXGRSLSA-N Pharmakon1600-01500143 Provatene
    Provitamin A Q-200706 Q306135
    SBI-0051295.P003 SC-19470 SDCCGMLS-0066579.P001
    SMR000112037 SR-01000763803 SR-01000763803-2
    SR-01000763803-3 SR-01000763803-4 ST097774
    SW220035-1 Serlabo Solate
    Solatene Solatene (TN) Solatene (caps)
    Spectrum5_000505 Tox21_111557 UNII-01YAE03M7J
    UNII-N53I4V2IA6 component OENHQHLEOONYIE-JLTXGRSLSA-N Vetoron ZINC6845076
    Zlut prirodni 26 Zlut prirodni 26 [Czech] all trans beta-Carotene
    all-E-.beta.-Carotene all-trans-.beta.-Carotene all-trans-beta-Carotene
    b,b-Carotene b-Carotene beta -carotene
    beta Carotene beta Carotene (USP) beta carotene [USAN]
    beta,beta-Carotene beta-Carotene, >=97.0% (UV) beta-Carotene, Pharmaceutical Secondary Standard
    beta-Carotene, Type I, synthetic, >=93% (UV), powder beta-Carotene, Type II, synthetic, >=95% (HPLC), crystalline beta-Carotene, Vetec(TM) reagent grade, >=93%
    beta-Carotene, all-trans- beta-Carotin beta-Carotine
    beta-Karotin beta-carotene beta;-Carotene
    bmse000832 cid_5280489 s1767
    trans-.beta.-Carotene trans-B-Carotene trans-beta-Carotene

    DrugBank Name Beta carotene
    DrugBank DB06755
    CAS Number 116-32-5, 31797-85-0, 7235-40-7, 75097-32-4
    PubChem Compound 5280489
    KEGG Compound ID C02094
    KEGG Drug D03101
    PubChem.Substance 347827791
    ChEBI 17579
    ChemSpider 4444129
    BindingDB 54988.0
    Wikipedia Beta_carotene
    HET BCR
    DPD 11079|704