Search References Drug Actions/Targets About Access data Feedback
Sign In
mitontu@gmail.com
2021 MitoTox | (CC BY-NC 4.0)
Drug

D0329 | Ciclopirox

Molecular Formula C12H17NO2
Molecular Weight 207.27
Structure
State solid
Route of elimination Most of the compound is excreted either unchanged or as glucuronide. After oral administration of 10 mg of radiolabeled drug (14C-ciclopirox) to healthy volunteers, approximately 96% of the radioactivity was excreted renally within 12 hours of administration. Ninety-four percent of the renally excreted radioactivity was in the form of glucuronides.
Protein binding Protein binding is 94-97% following topical administration.
Half life 1.7 hours for 1% topical solution.
Absorption Rapidly absorbed after oral administration. Mean absorption of ciclopirox after application to nails of all twenty digits and adjacent 5 millimeters of skin once daily for 6 months in patients with dermatophytic onychomycoses was less than 5% of the applied dose. Ciclopirox olamine also penetrates into hair and through the epidermis and hair follicles into sebaceous glands and dermis.
Description a synthetic antifungal agent for topical dermatologic treatment

G

D

G01AX12 Ciclopirox


[G01AX] Other antiinfectives and antiseptics


[G01A] ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS


[G01] GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS


[G] Genitourinary system and reproductive hormones

D01AE14 Ciclopirox


[D01AE] Other antifungals for topical use


[D01A] ANTIFUNGALS FOR TOPICAL USE


[D01] ANTIFUNGALS FOR DERMATOLOGICAL USE


[D] Dermatological drugs

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 213 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


Reported as not meeting GHS hazard criteria by 1 of 213 companies. For more detailed information, please visit ECHA C&L website


Of the 6 notification(s) provided by 212 of 213 companies with hazard statement code(s):


H302 (98.11%): Harmful if swallowed [Warning Acute toxicity, oral]


H312 (97.17%): Harmful in contact with skin [Warning Acute toxicity, dermal]


H319 (99.06%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H332 (97.17%): Harmful if inhaled [Warning Acute toxicity, inhalation]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P322, P330, P337+P313, P363, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

  • Body tinea

  • Candida infection

  • Dandruff

  • Diabetes mellitus

  • Diabetic neuropathy

  • Epilepsy

  • Fungal infection

  • Fungal skin infection

  • Herpes simplex

  • Herpes zoster

  • Hypersensitivity

  • Infection

  • Nail disorder

  • Onychomycosis

  • Pityriasis

  • Skin candida

  • Tinea cruris

  • Tinea infection

  • Tinea pedis

    • (6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone) 1-hydroxy-4-methyl-6-cyclohexyl-2-pyridone 19W019ZDRJ
    2(1H)-Pyridinone, 6-cyclohexyl-1-hydroxy-4-methyl- 2(1H)-Pyridone, 6-cyclohexyl-1-hydroxy-4-methyl- 2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methyl-2-pyridinone
    2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methyl-2-pyridone 2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one 2-azanylethanol;6-cyclohexyl-4-methyl-1-oxidanyl-pyridin-2-one
    29342-05-0 342C050 6-CYCLOHEXYL-1-HYDROXY-4-METHYL-1H-PYRIDIN-2-ONE
    6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone # 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone
    6-Cyclohexyl-1-hydroxy-4-methyl-2-(1H)-pyridone 6-cyclohexyl-1-hydroxy-4-methyl-1,2-dihydropyridin-2-one 6-cyclohexyl-1-hydroxy-4-methyl-2(1 H )-pyridinone
    6-cyclohexyl-1-hydroxy-4-methyl-2-pyridinone 6-cyclohexyl-1-hydroxy-4-methyl-pyridin-2-one 6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one
    6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one 6-cyclohexyl-4-methyl-1-oxidanyl-pyridin-2-one A819878
    AB00053438_09 AB00053438_10 AB00053438_11
    AB0011605 AB06517 AB2000628
    AC-24195 AK544043 AKOS015895717
    BCP28530 BDBM66087 BG0571
    BIDD:GT0080 BPBio1_000641 BRD-K13044802-213-04-1
    BRD-K13044802-213-09-0 BSPBio_000581 BSPBio_002041
    Batrafen C-10474 CC-25776
    CHEBI:453011 CHEMBL1413 CICLOPIROX
    CNL8 CS-2561 CTK4G3143
    Ciclopirox (Penlac) Ciclopirox (USP/INN) Ciclopirox Olamin
    Ciclopirox [USAN:BAN:INN] Ciclopirox [USAN:USP:INN:BAN] Ciclopirox gel
    Ciclopirox, >=98% (HPLC) Ciclopirox, European Pharmacopoeia (EP) Reference Standard Ciclopirox, United States Pharmacopeia (USP) Reference Standard
    Ciclopirox-Olamin Ciclopirox-Penlac Ciclopiroxum
    Ciclopiroxum [INN-Latin] D03488 DB-047566
    DB01188 DTXSID9048564 Dafnegin-CSC
    EINECS 249-577-2 FT-0602961 HMS3656I12
    HOE 296 HOE 296b HOE-296;Ciclopiroxum
    HOE-296b HOE296b HY-B0450
    KBio3_001261 KBioGR_000816 KS-00000L3N
    KS-5085 KSC563C4H LS-174247
    Loprox Loprox (TN) Loprox Gel
    Loprox cream Loprox;Mycoster;Stieprox;HOE 296b;Penlac MLS002153867
    NCGC00017112-04 NCGC00017112-05 NCGC00017112-06
    NCGC00017112-08 NCGC00017112-11 NCGC00178850-01
    NCGC00178850-02 Penlac Penlac
    Penlac (TN) Prestwick0_000541 Prestwick1_000541
    Prestwick2_000541 Prestwick3_000541 Q419468
    SBI-0206690.P002 SC-17361 SCHEMBL34424
    SCKYRAXSEDYPSA-UHFFFAOYSA-N SMR001233223 SPBio_000252
    SPBio_002502 SR-05000001589-5 SW196923-5
    Spectrum2_000146 Spectrum3_000351 Spectrum4_000288
    Spectrum5_000747 Stieprox Terit
    UNII-19W019ZDRJ W-106995 ZINC1145
    cid_38911 cyclopirox cyclopyroxolamine
    s2528

    DrugBank Name Ciclopirox
    DrugBank DB01188
    CAS Number 29342-05-0
    PubChem Compound 2749
    KEGG Drug D03488
    PubChem.Substance 46506333
    ChEBI 453011
    PharmGKB PA164747060
    ChemSpider 2647
    BindingDB 66087.0
    TTD DAP000466
    Wikipedia Ciclopirox
    HET B4O
    DPD 1913|12378