D0375 | Nigericin
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| TRANSPORT OF PROTONS BUT NOT CHARGE (K+) | affect | 201 | ||||||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
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Danger |
Aggregated GHS information provided by 272 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral] H315 (99.63%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (99.63%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (99.63%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 48mg/kg (48mg/kg) | Journal of Antibiotics. Vol. 30, Pg. 77-5, 1977. | |
| (2R)-2-((3S)-6-{[2-((5S)-5-{(3S)-5-[(3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethylperhydro-2H-pyran-2-yl]-3-methyloxolan-2-yl}-5-methyloxolan-2-yl)(2S,4R,9R,10R)-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]dec-7-yl]methyl}-3-methylperhydro-2H-pyran-2-yl)propanoic acid | (2R)-2-[(2R,3S,6R)-6-[[(1R,3S,5R,6R,7R,9R)-3-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-tetrahydropyran-2-yl]-3-methyl-tetrahydrofuran-2-yl]-5-methyl-tetrahydrofuran-2-yl]-7-methoxy-1,3,6-trimethyl-4,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyl-tetrahydropyran-2-yl]propanoic acid | (2R)-2-[(2R,3S,6R)-6-{[(2S,4R,5R,7R,9R,10R)-2-{(2S,2'R,3'S,5R,5'R)-5'-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl]-2,3'-dimethyloctahydro-2,2'-bifuran-5-yl}-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]dec-7-yl]methyl}-3-methyltetrahydro-2H-pyran-2-yl]propanoic acid |
| 28380-24-7 | 28643-80-3 | Antibiotic K 178 |
| Antibiotic X-464 | Azalomycin M | BRN 1696755 |
| BSPBio_001599 | C11609 | C40H68O11 |
| CHEBI:7569 | CHEMBL405862 | CS-0091495 |
| DTXSID9041079 | Epinigericin | HMS1791P21 |
| HMS1989P21 | HMS3402P21 | HY-127019 |
| Helix C | Helixin C | LS-96660 |
| NCGC00163412-02 | NSC292567 | Pandavir |
| Polyetherin A | Q7033077 | RRU6GY95IS |
| SCHEMBL149611 | SR-05000002332 | SR-05000002332-2 |
| UNII-RRU6GY95IS | UNII-VZ2M4595UZ component DANUORFCFTYTSZ-SJSJOXFOSA-N | X-464 |
| ZINC85552063 | nigericin |