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Drug

D0412 | Ubidecarenone

Molecular Formula C59H90O4
Molecular Weight 863.3
Structure
State solid
Clearance In preclinical studies with intravenous administration of ubidecarenone, it is reported a total clearance of 1.18 ml h/kg which was indicative of a prolonged elimination.[A31415]
Volume of distribution Ubidecarenone is distributed to the various tissues of the body and it is able to enter the brain.[L1065] In preclinical studies with intravenous administration of ubidecarenone, it is reported a volume of distribution of 20.4 L/kg which reflects its ability to penetrate extensively into organs and tissues.[A31415] AS a general rule, tissues with high-energy requirements or metabolic activity tend to presents higher amounts of ubidecarenone, these organs can be heart, kidney, liver and muscle.[A31416]
Route of elimination The main elimination route of ubidecarenone is through the bile. After its oral administration, over 60% of the dose is excreted in the feces in the form of unchanged ubidecarenone and a small fraction of the metabolites.[L1065, A31416] In the urine, ubidecarenone is bound to saposin B protein and represents only 8.3% of the total administered dose.[A31416]
Protein binding In the blood, ubidecarenone is split into the various lipoprotein particles including LDL and VLDL.[L1065] The plasma concentration of ubidecarenone is highly dependent on the presence of plasma lipoproteins and about 95% of the administered form is found in the reduced form.[A31416]
Half life The pharmacokinetic properties may vary between different brands but studies have reported a half-life of ubidecarenone of 21.7 h.[A31414]
Absorption Ubidecarenone is absorbed from the small intestine into the lymphatics and then it can enter the blood. The hydrophobicity and large molecular weight limit its absorption making it very poor and variable depending on the food intake and the number of lipids presented in the food. The absorption is lower in the presence of an empty stomach and greater in presence of high lipid food diet. The daily dosage of ubidecarenone presents the reach of maximal serum concentration by reaching a plateau after three weeks.[L1065] The pharmacokinetic properties may vary between different brands but studies have reported an AUC of 11.51 mcg h/ml and a Cmax of 0.32 mcg/ml at a time of 7.9 h.[A31414]
Trade names coenzyme Q10
Description a 1,4-benzoquinone; powerful antioxidant; a component of the electron transport chain

C

C01EB09 Ubidecarenone


[C01EB] Other cardiac preparations


[C01E] OTHER CARDIAC PREPARATIONS


[C01] CARDIAC THERAPY


[C] Cardiovascular system

Toxicity Dose Time Species Model Method Action Positive criterion Reference
ANTIOXIDANT PRODUCTION 248


  • a 1,4-benzoquinone a component of the electron transport chain powerful antioxidant
    powerful antioxidant that removes free radicals, inhibits the initiation and propagation of lipid peroxidation in cellular biomembranes, and aids in the regeneration of alpha-tocopherol

    DrugBank Name Ubidecarenone
    DrugBank DB09270
    CAS Number 1339-63-5, 134887-79-9, 137234-88-9, 17745-45-8, 27696-12-4, 303-98-0
    PubChem Compound 5281915
    KEGG Compound ID C11378
    KEGG Drug D01065
    PubChem.Substance 310265165
    ChEBI 46245
    ChemSpider 4445197
    Wikipedia Coenzyme_Q10
    HET U10
    DPD 1357