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Compound

D0423 | N-deacetyl ketoconazole

Molecular Formula C24H26Cl2N4O3
Molecular Weight 489.4
Structure

Toxicity Dose Time Species Model Method Action Positive criterion Reference
APOPTOSIS 20 μM 0.5 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
APOPTOSIS 40 μM 0.5 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
APOPTOSIS 60 μM 0.5 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
APOPTOSIS 80 μM 0.5 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
APOPTOSIS 120 μM 0.5 hours rat hepatocytes Measurement of LDH activities increase p < 0.05 8
APOPTOSIS 160 μM 0.5 hours rat hepatocytes Measurement of LDH activities increase p < 0.05 8
APOPTOSIS 20 μM 1 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
APOPTOSIS 40 μM 1 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
APOPTOSIS 60 μM 1 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
APOPTOSIS 80 μM 1 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
APOPTOSIS 120 μM 1 hours rat hepatocytes Measurement of LDH activities increase p < 0.05 8
APOPTOSIS 160 μM 1 hours rat hepatocytes Measurement of LDH activities increase p < 0.05 8
APOPTOSIS 20 μM 2 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
APOPTOSIS 40 μM 2 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
APOPTOSIS 60 μM 2 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
APOPTOSIS 80 μM 2 hours rat hepatocytes Measurement of LDH activities increase p < 0.05 8
APOPTOSIS 120 μM 2 hours rat hepatocytes Measurement of LDH activities increase p < 0.05 8
APOPTOSIS 160 μM 2 hours rat hepatocytes Measurement of LDH activities increase p < 0.05 8
APOPTOSIS 20 μM 4 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
APOPTOSIS 40 μM 4 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
APOPTOSIS 60 μM 4 hours rat hepatocytes Measurement of LDH activities increase p < 0.05 8
APOPTOSIS 80 μM 4 hours rat hepatocytes Measurement of LDH activities increase p < 0.05 8
APOPTOSIS 120 μM 4 hours rat hepatocytes Measurement of LDH activities increase p < 0.05 8
APOPTOSIS 160 μM 4 hours rat hepatocytes Measurement of LDH activities increase p < 0.05 8
APOPTOSIS 120 μM 0.5 hours rat hepatocytes Measurement of LDH activities; co-treatment of 250 μM n-Octylamine increase p < 0.05 8
APOPTOSIS 120 μM 0.5 hours rat hepatocytes Measurement of LDH activities; co-treatment of 100 μM Methimazole affect p < 0.05 8
APOPTOSIS 120 μM 1 hours rat hepatocytes Measurement of LDH activities; co-treatment of 250 μM n-Octylamine increase p < 0.05 8
APOPTOSIS 120 μM 1 hours rat hepatocytes Measurement of LDH activities; co-treatment of 100 μM Methimazole affect p < 0.05 8
APOPTOSIS 160 μM 1 hours rat hepatocytes Measurement of LDH activities; co-treatment of 250 μM n-Octylamine increase p < 0.05 8
APOPTOSIS 160 μM 1 hours rat hepatocytes Measurement of LDH activities; co-treatment of 100 μM Methimazole affect p < 0.05 8

Target Dose Time Species Model Method Action Positive criterion Reference
Lactate dehydrogenase 20 μM 0.5 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
Lactate dehydrogenase 40 μM 0.5 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
Lactate dehydrogenase 60 μM 0.5 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
Lactate dehydrogenase 80 μM 0.5 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
Lactate dehydrogenase 120 μM 0.5 hours rat hepatocytes Measurement of LDH activities leakage p < 0.05 8
Lactate dehydrogenase 160 μM 0.5 hours rat hepatocytes Measurement of LDH activities leakage p < 0.05 8
Lactate dehydrogenase 20 μM 1 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
Lactate dehydrogenase 40 μM 1 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
Lactate dehydrogenase 60 μM 1 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
Lactate dehydrogenase 80 μM 1 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
Lactate dehydrogenase 120 μM 1 hours rat hepatocytes Measurement of LDH activities leakage p < 0.05 8
Lactate dehydrogenase 160 μM 1 hours rat hepatocytes Measurement of LDH activities leakage p < 0.05 8
Lactate dehydrogenase 20 μM 2 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
Lactate dehydrogenase 40 μM 2 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
Lactate dehydrogenase 60 μM 2 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
Lactate dehydrogenase 80 μM 2 hours rat hepatocytes Measurement of LDH activities leakage p < 0.05 8
Lactate dehydrogenase 120 μM 2 hours rat hepatocytes Measurement of LDH activities leakage p < 0.05 8
Lactate dehydrogenase 160 μM 2 hours rat hepatocytes Measurement of LDH activities leakage p < 0.05 8
Lactate dehydrogenase 20 μM 4 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
Lactate dehydrogenase 40 μM 4 hours rat hepatocytes Measurement of LDH activities Negative p < 0.05 8
Lactate dehydrogenase 60 μM 4 hours rat hepatocytes Measurement of LDH activities leakage p < 0.05 8
Lactate dehydrogenase 80 μM 4 hours rat hepatocytes Measurement of LDH activities leakage p < 0.05 8
Lactate dehydrogenase 120 μM 4 hours rat hepatocytes Measurement of LDH activities leakage p < 0.05 8
Lactate dehydrogenase 160 μM 4 hours rat hepatocytes Measurement of LDH activities leakage p < 0.05 8
Lactate dehydrogenase 120 μM 0.5 hours rat hepatocytes Measurement of LDH activities; co-treatment of 250 μM n-Octylamine leakage p < 0.05 8
Lactate dehydrogenase 120 μM 0.5 hours rat hepatocytes Measurement of LDH activities; co-treatment of 100 μM Methimazole not specified p < 0.05 8
Lactate dehydrogenase 120 μM 1 hours rat hepatocytes Measurement of LDH activities; co-treatment of 250 μM n-Octylamine leakage p < 0.05 8
Lactate dehydrogenase 120 μM 1 hours rat hepatocytes Measurement of LDH activities; co-treatment of 100 μM Methimazole not specified p < 0.05 8
Lactate dehydrogenase 160 μM 1 hours rat hepatocytes Measurement of LDH activities; co-treatment of 250 μM n-Octylamine leakage p < 0.05 8
Lactate dehydrogenase 160 μM 1 hours rat hepatocytes Measurement of LDH activities; co-treatment of 100 μM Methimazole not specified p < 0.05 8

Pictogram Signal Statements Precautionary Statement Codes
Danger

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.


H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]


H341 (100%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]


H411 (100%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]


 P201, P202, P264, P270, P273, P281, P301+P310, P308+P313, P321, P330, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • 1-(4-((2-((1H-Imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine 4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine 67914-61-8
    89929-33-9 Deacetyl Ketoconazole SCHEMBL10567541

    CAS Number 67914-61-8, 89929-33-9
    PubChem Compound 10480684
    ChemSpider 8656091/10242066