MITOTOX

Drug

D0454 | nitrofurazone

Properties

Molecular Formula	C6H6N4O4
Molecular Weight	198.14
Structure
State	solid
Half life	5 hours
Absorption	Well absorbed.
Trade names	Aldomycin, Amifur, Chemfuran, Coxistat, Furacin, Furan-2, Furacinetten, Furaplast, Furazol W, Furesol Furracoccid, Mammex, Nefco, Nifuzon, Nitrofural, Vabrocid
Description	antimicrobial; nitrofuran class; topical anti-infective agent effective against gram-negative and gram-positive bacteria

Therapeutic Classification Source: DrugBank

S02AA02 Nitrofural

[S02AA] Antiinfectives

[S02A] ANTIINFECTIVES

[S02] OTOLOGICALS

[S] Sensory organs

S01AX04 Nitrofural

[S01AX] Other antiinfectives

[S01A] ANTIINFECTIVES

[S01] OPHTHALMOLOGICALS

[S] Sensory organs

P01CC02 Nitrofural

[P01CC] Nitrofuran derivatives

[P01C] AGENTS AGAINST LEISHMANIASIS AND TRYPANOSOMIASIS

[P01] ANTIPROTOZOALS

[P] Antiparasitic products, insecticides and repellents

D09AA03 Nitrofural

[D09AA] Medicated dressings with antiinfectives

[D09A] MEDICATED DRESSINGS

[D09] MEDICATED DRESSINGS

[D] Dermatological drugs

D08AF01 Nitrofural

[D08AF] Nitrofuran derivatives

[D08A] ANTISEPTICS AND DISINFECTANTS

[D08] ANTISEPTICS AND DISINFECTANTS

[D] Dermatological drugs

B05CA03 Nitrofural

[B05CA] Antiinfectives

[B05C] IRRIGATING SOLUTIONS

[B05] BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS

[B] Blood and blood forming organs

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Species	Model	Method	Action	Positive criterion	Reference
STATE 3 RESPIRATION	1mM	mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake	decrease	p < 0.05; 64% inhibition	13
STATE 3 RESPIRATION	1mM	mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake	Negative	p < 0.05	13
STATE 3 RESPIRATION	1mM	mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake	decrease	p < 0.05; 63% inhibition	13
STATE 3 RESPIRATION	5μM	mouse; C57B/6J	mitoplasts	Measurement of oxygen uptake	decrease	p < 0.05	13
STATE 4 RESPIRATION	5μM	mouse; C57B/6J	mitoplasts	Measurement of oxygen uptake	decrease	p < 0.05	13
DNP-UNCOUPLED RESPIRATION	1mM	mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake	decrease	p < 0.05	13
DNP-UNCOUPLED RESPIRATION	1mM	mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake	Negative	p < 0.05	13
DNP-UNCOUPLED RESPIRATION	1mM	mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake	decrease	p < 0.05	13

GHS Hazard Tables Source: PubChem

Pictogram	Signal	Statements	Precautionary Statement Codes
	Danger	Aggregated GHS information provided by 100 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. Reported as not meeting GHS hazard criteria by 52 of 100 companies. For more detailed information, please visit ECHA C&L website Of the 7 notification(s) provided by 48 of 100 companies with hazard statement code(s): H301 (10.42%): Toxic if swallowed [Danger Acute toxicity, oral] H302 (89.58%): Harmful if swallowed [Warning Acute toxicity, oral] H317 (87.5%): May cause an allergic skin reaction [Warning Sensitization, Skin] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.	P261, P264, P270, P272, P280, P301+P310, P301+P312, P302+P352, P321, P330, P333+P313, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Pictogram

Signal

Statements

Precautionary Statement Codes

Danger

Aggregated GHS information provided by 100 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria by 52 of 100 companies. For more detailed information, please visit ECHA C&L website

Of the 7 notification(s) provided by 48 of 100 companies with hazard statement code(s):

H301 (10.42%): Toxic if swallowed [Danger Acute toxicity, oral]

H302 (89.58%): Harmful if swallowed [Warning Acute toxicity, oral]

H317 (87.5%): May cause an allergic skin reaction [Warning Sensitization, Skin]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

P261, P264, P270, P272, P280, P301+P310, P301+P312, P302+P352, P321, P330, P333+P313, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Indications Source: SIDER

Synonyms Source: PubChem

(2E)-2-[(5-nitrofuran-2-yl)methylidene]hydrazinecarboxamide	(5-Nitro-2-furfurylidenamino)urea	(5-Nitro-2-furfurylideneamino)urea
(E)-2-((5-nitrofuran-2-yl)methylene)hydrazine-1-carboxamide	1-(5-Nitro-2-furfurylidene)semicarbazide	1-(5-Nitrofurfurylidene)semicarbazide
2((5-Nitro-2-furanyl)methylene)hydrazinecarboxamide	2-((5-Nitro-2-furanyl)methylene)hydrazinecarboxamide	2-Furaldehyde, 5-nitro-, semicarbazone
2-Furancarboxaldehyde, 5-nitro-, semicarbazone	2-Furancarboxaldehyde, semicarbazone	2-[(5-Nitro-2-furanyl)methylene]hydrazinecarboxamide
2-[(5-nitro-2-furyl)methylene]hydrazinecarboxamide	5-Nitro-2-furaldehyde semicarbazone	5-Nitro-2-furaldehyde semicarbazone, >=97.0% (HPLC)
5-Nitro-2-furaldehyde, semicarbazone	5-Nitro-2-furancarboxaldehyde semicarbazone	5-Nitro-2-furfural semicarbazone
5-Nitro-2-furfuraldehyde semicarbazone	5-Nitrofuraldehyde semicarbazide	5-Nitrofuran-2-aldehyde semicarbazone
5-Nitrofurazone	5-Nitrofurfural semicarbazone	5-nitrofuran-2-carbaldehyde semicarbazone
59-87-0	6-Nitrofuraldehyde semicarbazide	AB00373885
AB00373885-04	AB00373885_05	AB00373885_06
AB2000189	AC-10331	AI3-17333
AKOS000304771	ARONIS24564	Actin-N
Acutol	Aldomycin	Alfucin
Amifur	BDBM50420350	BPBio1_000423
BRD-K79092138-001-05-2	BRD-K79092138-001-06-0	BRN 0086403
BSPBio_000383	BSPBio_002075	Babrocid
Becafurazone	Biofuracina	Biofurea
C08042	CAS-59-87-0	CCG-39642
CCRIS 1195	CHEBI:44368	CHEMBL869
CS-2174	Certified Reference Material;	Chemofuran
Chixin	Cocafurin	Coxistat
D00862	DB00336	DSSTox_CID_944
DSSTox_GSID_20944	DSSTox_RID_75881	Dermofural
Dymazone	Dynazone	EINECS 200-443-1
Eldezol	Eldezol F-6	Fedacin
Flavazone	Fracine	Fura-septin
Furacilin	Furacilinum	Furacillin
Furacin	Furacin (TN)	Furacin-E
Furacin-Hc	Furacine	Furacinetten
Furacoccid	Furacort	Furacycline
Furaderm	Furagent	Furalcyn
Furaldon	Furalone	Furametral
Furan-Ofteno	Furaplast	Furaseptyl
Furaskin	Furatsilin	Furaziline
Furazin	Furazina	Furazol W
Furazone	Furazyme	Furesol
Furfurin	Furosem	Fuvacillin
H823	HMS1569D05	HMS1920B04
HMS2091J04	HMS2096D05	HMS3713D05
HMS502G20	HSDB 3136	HY-B0226
Hemofuran	Hydrazinecarboxamide, 2-((5-nitro-2-furanyl)methylene)-	Hydrazinecarboxamide, 2-[(5-nitro-2-furanyl)methylene]-
IAIWVQXQOWNYOU-FPYGCLRLSA-N	IDI1_000778	Ibiofural
LS41202	MCULE-5485227436	MFCD00003225
MLS002153843	Mammex	Mastofuran
Monafuracin	Monafuracis	Monofuracin
N-[(1E)-2-(5-nitro(2-furyl))-1-azavinyl]aminoamide	N0200	NCGC00090686-01
NCGC00090686-02	NCGC00090686-03	NCGC00090686-04
NCGC00090686-05	NCGC00090686-06	NCGC00090686-07
NCGC00090686-08	NCGC00090686-11	NCGC00260533-01
NCI-C56064	NF-7	NFS
NFZ	NSC 1602	NSC 2100
NSC-1602	NSC-2100	NSC-757244
NSC1602	NSC2100	NSC757244
Nefco	Nfz mix	Nifucin
Nifurid	Nifuzon	Nitrofural
Nitrofural (INN)	Nitrofural [INN]	Nitrofural for peak identification, European Pharmacopoeia (EP) Reference Standard
Nitrofural, European Pharmacopoeia (EP) Reference Standard	Nitrofural;Furacilin;ACTIN-N;Otofuran	Nitrofuraldehyde semicarbazone
Nitrofuralum	Nitrofuralum [INN-Latin]	Nitrofuran (bactericide)
Nitrofurane	Nitrofurazan	Nitrofurazone (Nitrofural)
Nitrofurazone (USP)	Nitrofurazone [USP:INN:BAN]	Nitrofurazone solution, 100 mug/mL in acetonitrile, VETRANAL(TM), analytical standard
Nitrofurazone, Pharmaceutical Secondary Standard	Nitrofurazone, United States Pharmacopeia (USP) Reference Standard	Nitrofurazonum
Nitrofurol	Nitrozone	Otofural
Otofuran	Pharmakon1600-01500434	Prestwick2_000492
Prestwick3_000492	Prestwick_806	PubChem7175
Q-201480	RTR-032588	Rivafurazon
Rivopon-5	SBB028409	SBI-0051458.P003
SC-05628	SCHEMBL25416	SCHEMBL25417
SMR000059012	SPECTRUM1500434	SR-05000002027
SR-05000002027-1	SR-05000002027-3	ST4012758
STK741625	Sanfuran	Semikarbazon 5-nitrofurfuralu
Semikarbazon 5-nitrofurfuralu [Polish]	Semioxamazide, 1-(5-nitrofurfurylidene)-	Spectrum5_001160
Spray-Dermis	Spray-Foral	Structure of 5-nitro-2-furaldehyde-semicarbazone
TR-032588	Tox21_110997	Tox21_110997_1
Tox21_202988	Tox21_400035	U-6421
UNII-X8XI70B5Z6	Usaf ea-4	Vabrocid
Vadrocid	Veterinary nitrofurazone	WLN: T5OJ BNW E1UNMVZ
X8XI70B5Z6	Yatrocin	ZINC4802968
[(E)-(5-nitro-2-furyl)methyleneamino]urea	[(E)-(5-nitrofuran-2-yl)methylideneamino]urea	[(E)-[(5-nitrofuran-2-yl)methylidene]amino]urea
component of Furacort	component of Furadex	component of Furadex (Salt/Mix)
component of Furea	component of Furea (Salt/Mix)	nitrofurazone
s1644

External IDs

DrugBank Name	Nitrofural
DrugBank	DB00336
CAS Number	112574-44-4, 59-87-0, 6159-33-7
PubChem Compound	5447130
KEGG Compound ID	C08042
KEGG Drug	D00862
ChEBI	44368