Search References Drug Actions/Targets About Access data Feedback
Sign In
mitontu@gmail.com
2021 MitoTox | (CC BY-NC 4.0)
Drug

D0495 | tolterodine

Molecular Formula C22H31NO
Molecular Weight 325.5
Structure
State solid
Volume of distribution * 113 ± 26.7 L
Route of elimination Following administration of a 5-mg oral dose of 14C-tolterodine solution to healthy volunteers, 77% of radioactivity was recovered in urine and 17% was recovered in feces in 7 days.
Protein binding Approximately 96.3%.
Half life 1.9-3.7 hours

G

G04BD07 Tolterodine


[G04BD] Drugs for urinary frequency and incontinence


[G04B] UROLOGICALS


[G04] UROLOGICALS


[G] Genitourinary system and reproductive hormones

Toxicity Dose Time Species Model Method Action Positive criterion Reference
UNCOUPLING rat isolated liver mitochondria measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay increase 53

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 112 companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H301 (67.86%): Toxic if swallowed [Danger Acute toxicity, oral]


H302 (34.82%): Harmful if swallowed [Warning Acute toxicity, oral]


H361 (99.11%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]


H411 (26.79%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P201, P202, P264, P270, P273, P281, P301+P310, P301+P312, P308+P313, P321, P330, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)
Danger

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.


H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]


H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]


 P201, P202, P264, P270, P281, P301+P310, P308+P313, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • (+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl)-p-cresol (+)-(R)-3-(2-hydroxy-5-methylphenyl)-N,N-diisopropyl-3-phenylpropylamine (+)-Tolterodine
    (R)-(+)-Tolterodine (R)-2,3-BIS(1-METHYLETHYL)AMINO-1-PHENYLPROPYL-4-METHYLPHENOL (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-methylphenol
    (r)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-methylphenol 124937-51-5 124937-52-6
    124937-53-7 2-[(1R)-3-(di(propan-2-yl)amino)-1-phenylpropyl]-4-methylphenol 2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-methylphenol
    2-[(1R)-3-[BIS(1-METHYLETHYL)AMINO]-1-PHENYLPROPYL]-4-METHYL-PHENOL TARTRATE; 2-[(1R)-3-[bis(propan-2-yl)amino]-1-phenylpropyl]-4-methylphenol 2-[3-[Bis(1-Methylethyl)Amino]-1-Phenylpropyl]-4-Methyl Phenol Monohydrobromide
    2-{(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl}-4-methylphenol 27817-EP2269989A1 27817-EP2298767A1
    27817-EP2314587A1 937T515 AB00698547-12
    AB00698547_13 AC-3472 ACT04387
    AKOS015841711 AKOS015895578 API0004447
    BDBM50165008 BIDD:GT0318 C07750
    CAS-124937-51-5 CHEBI:9622 CHEMBL1382
    CS-1799 D00646 DB01036
    DSSTox_CID_3687 DSSTox_GSID_23687 DSSTox_RID_77147
    DTXSID3023687 Detrol Detrusitol
    FT-0082150 FT-0082998 FT-0602571
    FT-0675276 GTPL360 HMS2230E24
    HY-A0024 J-005184 KS-5165
    Kabi 2234 Kabi-2234 LS-187278
    MFCD07771985 MLS001195620 MLS001304745
    NCGC00159519-02 NCGC00263557-01 OOGJQPCLVADCPB-HXUWFJFHSA-N
    PHA-686464B PNU 200583 PNU-200583E
    Phenol, 2-((1R)-3-(bis(1-methylethyl)amino)-1-phenylpropyl)-4-methyl- Phenol, 2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-methyl- PubChem20792
    Q-200223 Q424312 RT-015598
    S-(-)-Tolterodine SC-18999 SCHEMBL3064
    SMR000596518 Tolterodina Tolterodina [INN-Spanish]
    Tolterodine (USAN/INN) Tolterodine L-Tartrate Tolterodine [USAN:INN:BAN]
    Tolterodine tartrate Tolterodinum Tolterodinum [INN-Latin]
    Tolterondine Tartrate Tox21_111737 Tox21_111737_1
    UNII-WHE7A56U7K Unidet Urotrol
    WHE7A56U7K ZINC968336 s-tolterodine
    tolterodin tolterodine tolterodine extended release capsules

    DrugBank Name tolterodine
    DrugBank DB01036
    CAS Number 124936-74-9, 124937-51-5, 124937-52-6, 124937-53-7, 75-25-2
    PubChem Compound 443879
    KEGG Compound ID C07750
    KEGG Drug D00646
    ChEBI 9622
    PharmGKB PA164746757